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Highly stable hybrid single-micelle:A universal nanocarrier for hydrophobic bioimaging agents

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Nano Research 2022年第5期15卷 4582-4589页

作者： Qiaoyu Zhou Tiancong Zhao Mengli Liu Dongrui Yin minchao Liu Ahmed AElzatahry fan Zhang Dongyuan Zhao Xiaomin Li Department of Chemistry State Key Laboratory of Molecular Engineering of PolymersiChemShanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghai 200433China Materials Science and Technology Program College of Arts and SciencesQatar UniversityPO Box 2713DohaQatar

As the first-line technology,micelles play a pivotal role in in vivo delivery of theranostic agents because of their high biocompatibility and ***,in complex physiological environments(extreme dilution,pH,and oxidation or reduction,etc.),they generally suffer from structural instability and insufficient protection for encapsulated *** is urgent to reinforce the structural stability of the micelles at the single-micelle *** using the FDA-approved Pluronic F127 surfactants and indocyanine green(ICG)bioimaging agents as model,herein,we propose the silane-crosslinking assisted strategy to reinforce the structural stability of the *** from the traditional silane hydrolysis under the harsh experimental conditions(acidic,alkaline,and high temperature hydrothermal,etc.),the ICG loaded F127@SiO_(2) hybrid single-micelles(ICG@H-micelles)with controllable sizes(15-35 nm)are synthesized at neutral pH and room temperature,which is crucial for the maintenance of the physicochemical properties of the encapsulated *** the ultra-thin SiO_(2)(<5 nm)at hydrophilic layer of the single-micelle,the structural and fluorescence stability of ICG@H-micelles are much higher than the conventional micelle(ICG@micelles)in the simulated physiological environments of dilution,oxidation or reduction,and low *** of the high structural and fluorescence stability,the ICG@H-micelles also exhibit longer duration time in the tumor and gastrointestinal tract bioimaging.

关键词： micelle SiO_(2) inorganic-organic hybrid mesoporous material bioimaging

Spatially asymmetric cascade nanocatalysts for enhanced chemodynamic therapy

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Nano Research 2023年第7期16卷 9642-9650页

作者： minchao Liu Hongyue Yu Liang Chen Tiancong Zhao Meng fang Mengli Liu Qiaoyu Zhou Fatemah Farraj AlHarbi Ahmed Mohamed El-Toni fan Zhang Dongyuan Zhao Xiaomin Li Department of Chemistry State Key Laboratory of Molecular Engineering of PolymersiChemShanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghai 200433China Department of Musculoskeletal Cancer Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Department of Physics College of SciencePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia King Abdullah Institute for Nanotechnology King Saud UniversityRiyadh 11451Saudi Arabia

Chemodynamic therapy(CDT)based on cascade catalytic nanomedicine has emerged as a promising cancer treatment ***,most of the reported cascade catalytic systems are designed based on symmetric-or co-assembly of multiple catalytic active sites,in which their functions are difficult to perform independently and may interfere with each *** in cascade catalytic system that involves fragile natural-enzymes,the strong oxidation of free-radicals toward natural-enzymes should be carefully considered,and the spatial distribution of the multiple catalytic active sites should be carefully organized to avoid the degradation of the enzyme catalytic ***,a spatially-asymmetric cascade nanocatalyst is developed for enhanced CDT,which is composed by a Fe_(3)O_(4)head and a closely connected mesoporous silica nanorod immobilized with glucose oxidase(mSiO_(2)-GOx).The mSiO_(2)-GOx subunit could effectively deplete glucose in tumor cells,and meanwhile produce a considerable amount of H_(2)O_(2)for subsequent Fenton reaction under the catalysis of Fe_(3)O_(4)subunit in the tumor *** the advantage of the spatial isolation of mSiO_(2)-GOx and Fe_(3)O_(4)subunits,the catalysis of GOx and freeradicals generation occur at different domains of the asymmetric nanocomposite,minimizing the strong oxidation of free-radicals toward the activity of GOx at the other *** addition,direct exposure of Fe_(3)O_(4)subunit without any shelter could further enhance the strong oxidation of free-radicals toward ***,compared with traditional core@shell structure,the long-term stability and efficiency of the asymmetric cascade catalytic for CDT is greatly increased by 138%,thus realizing improved cancer cell killing and tumor restrain efficiency.

关键词： mesoporous nanocatalytic medicine chemodynamic therapy asymmetric nanostructure core@shell

Self‑Generated Buried Submicrocavities for High‑Performance Near‑Infrared Perovskite Light‑Emitting Diode

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Nano-Micro Letters 2023年第8期15卷 355-367页

作者： Jiong Li Chenghao Duan Qianpeng Zhang Chang Chen Qiaoyun Wen minchao Qin Christopher C.S.Chan Shibing Zou Jianwu Wei Zuo Xiao Chuantian Zuo Xinhui Lu Kam Sing Wong Zhiyong fan Keyou Yan School of Environment and Energy State Key Lab of Luminescent Materials and DevicesGuangdong Provincial Key Laboratory of Solid Wastes Pollution Control and RecyclingSouth China University of TechnologyGuangzhou 510000People’s Republic of China Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongPeople’s Republic of China Department of Physics The Chinese University of Hong KongShatinHong KongPeople’s Republic of China Department of Physics The Hong Kong University of Science and TechnologyClear Water BayKowloon 999077Hong KongPeople’s Republic of China School of Chemistry and Chemical Engineering Guangxi UniversityNanning 530004People’s Republic of China Center for Excellence in Nanoscience(CAS) Key Laboratory of Nanosystem and Hierarchical Fabrication(CAS)National Center for Nanoscience and TechnologyBeijing 100190People’s Republic of China

ABSTRACT Embedding submicrocavities is an effective approach to improve the light out-coupling efficiency(LOCE)for planar perovskite light-emitting diodes(PeLEDs).In this work,we employ phenethylammonium iodide(PEAI)to trigger the Ostwald ripening for the downward recrystallization of perovskite,resulting in spontaneous formation of buried submicrocavities as light output *** simulation suggests the buried submicrocavities can improve the LOCE from 26.8 to 36.2%for near-infrared ***,PeLED yields peak external quantum efficiency(EQE)increasing from 17.3%at current density of 114 mA cm^(−2)to 25.5%at current density of 109 mA cm^(−2)and a radiance increasing from 109 to 487 W sr^(−1)m^(−2)with low *** turn-on voltage decreased from 1.25 to 1.15 V at 0.1 W sr^(−1)m^(−2).Besides,downward recrystallization process slightly reduces the trap density from 8.90×10^(15)to 7.27×10^(15)cm^(−3).This work provides a self-assembly method to integrate buried output coupler for boosting the performance of PeLEDs.

关键词： Perovskite light-emitting diodes Downward recrystallization Buried submicrocavities Light out-coupling efficiency Radiative recombination

Genome-wide association study identifies novel loci and candidate genes for drought stress tolerance in rapeseed

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Oil Crop Science 2021年第1期6卷 12-22页

作者： Ali Shahzad minchao Qian Bangyang Sun Umer Mahmood Shengting Li Yonghai fan Wei Chang Lishi Dai Hong Zhu Jiana Li Cunmin Qu Kun Lu College of Agronomy and Biotechnology Southwest UniversityChongqing400715China Academy of Agricultural Sciences Southwest UniversityChongqing400715China Engineering Research Center of South Upland Agriculture Ministry of EducationChongqing400715China College of Life Sciences Yangtze UniversityJingzhou434025HubeiChina

Rapeseed(Brassica napus)is one of the most important oil crops worldwide;however,drought seriously curtails its growth and *** drought-tolerant germplasm is an efficient strategy for addressing water ***,we phenotyped a panel of 264 *** accessions at full-bloom stage using water loss ratio(WLR)as drought-tolerant *** identified 8 low-WLR and 6 high-WLR accessions,regarded as droughttolerant and drought-sensitive,*** with drought-sensitive accessions at the seedling stage,drought-tolerant accessions had shown better performance in maintaining fresh and dry weights,and performed the higher expression of drought-induced marker genes under drought ***,a total of 139 SNPs(single nucleotide polymorphisms)were identified associated with the WLR using a genome-wide association study(GWAS)among 264 *** accessions,with the largest number SNPs at chromosome A10,and 13 SNPs significantly were associated with the WLR(-log_(10)(p-value)>6).Furthermore,4 putative candidate genes(***6,***,***5 and ***)were screened involving in drought tolerance in ***,our results highlight the WLR's importance in drought tolerance and establish the foundation for improving WLR-associated drought tolerance in rapeseed.

关键词： GWAS Water loss ratio Drought SNP Rapeseed

高阶条件随机场引导的多分支极化SAR图像分类

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中国图象图形学报 2023年第10期28卷 3267-3280页

作者：张帆闫敏超倪军项德良北京化工大学信息科学与技术学院北京100029 北京化工大学人工智能交叉研究中心北京100029

目的针对极化合成孔径雷达(polarimetric synthetic aperture radar,PolSAR)小样本分类问题,基于充分挖掘有限样本的极化、空间特征考虑,提出一种由高阶条件随机场(conditional random field,CRF)引导的多分支分类网络模型。方法利用Yam... 详细信息

目的针对极化合成孔径雷达(polarimetric synthetic aperture radar,PolSAR)小样本分类问题,基于充分挖掘有限样本的极化、空间特征考虑,提出一种由高阶条件随机场(conditional random field,CRF)引导的多分支分类网络模型。方法利用Yamaguchi非相干目标分解方法,构建每个像素的极化特征向量。设计了由高阶CRF能量函数引导的多卷积分支特征提取网络,将像素点极化特征向量作为输入,分别提取像素点的像素特征、邻域特征和位置特征信息。将以上特征进行加和融合,并输入到softmax分类器中得到预分类结果。利用超像素方法对预分类结果图进行进一步修正和调优,平滑相邻像素之间的特异性和相似性。结果采用1%的采样率对两组真实的极化SAR数据进行测试。同时,为了更好地模拟实际应用中训练样本位置分布不均匀的情况,考虑了空间不相交采样方法作为对比实验。综合两种采样策略的实验结果表明,相较于只利用像素级特征或简单利用空间特征的方法,本文方法总分类精度平均提升7%~10%,不同地物类别的分类精准度均在90%以上,运行速度相比于支持向量机(sup⁃port vector machine,SVM)提高了2.5倍以上。结论通过构建高阶CRF引导的卷积神经网络,将像素特征信息、同质区域特征和地理位置信息进行融合,有效建立了像素级和对象级数据之间的尺度关联,进一步扩充了像素点之间的空间依赖性,提取到了更强大更准确的表征特征,显著提高了标记样本数量较少情况下的卷积网络模型的分类性能,进一步保证了地物目标散射机制表征的全面性和可靠性。

关键词： SAR图像分类卷积神经网络(CNN) 条件随机场(CRF) 超像素分割采样策略 Yamaguchi分解

用纳米Al_2O_3制备超高致密度ZAO靶材

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粉末冶金技术 2005年第1期23卷 44-47页

作者：范锦鹏赵大庆吴敏生董民超清华大学机械工程系北京100084

将ZAO原料粉体中的Al2 O3 粒子的粒径降低到纳米级别后 ,通过无压烧结即可获得超高致密度的ZAO陶瓷靶材 (相对密度高于 99 0 % )。致密度大大提高的原因在于 ,Al2 O3 粒子粒径降到纳米级后 ,比表面积和粒子数目都大大增加 ,从而实现坯... 详细信息

将ZAO原料粉体中的Al2 O3 粒子的粒径降低到纳米级别后 ,通过无压烧结即可获得超高致密度的ZAO陶瓷靶材 (相对密度高于 99 0 % )。致密度大大提高的原因在于 ,Al2 O3 粒子粒径降到纳米级后 ,比表面积和粒子数目都大大增加 ,从而实现坯体同步均匀的烧结 ,避免了大气孔的产生。

关键词：纳米级致密度无压烧结粒径纳米Al2O3 靶材制备气孔粒子比表面积

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铆压重塑形工艺的铆钉优化与试验研究

西安交通大学学报 2016年第3期50卷 94-100页

作者：陈超赵升吨崔敏超韩晓兰贲宁宇范淑琴西安交通大学机械工程学院西安710049

为解决传统机械变形压力连接存在较高凸起的问题并增加连接强度,提出了一种采用特制铆钉的铆压重塑形工艺。该工艺在无铆连接工艺后将铆钉置于连接点的凹坑内,然后压缩凸起处使凸起高度降低。采用DEFORM-2D软件对铆压重塑形工艺进行有... 详细信息

为解决传统机械变形压力连接存在较高凸起的问题并增加连接强度,提出了一种采用特制铆钉的铆压重塑形工艺。该工艺在无铆连接工艺后将铆钉置于连接点的凹坑内,然后压缩凸起处使凸起高度降低。采用DEFORM-2D软件对铆压重塑形工艺进行有限元分析,得到了连接点的最大拉伸强度;采用正交试验方法对铆钉尺寸进行了设计优化,得到了能实现最大拉伸强度的铆钉尺寸。在铆压重塑形试验中,连接点的凸起高度从1.6 mm降低到了1.1 mm;平均拉伸强度从950.6N提高到1 130.7N,即重塑形后的拉伸强度比重塑形前提高了18.9%;平均剪切强度从1 168.6N提高到2 636.1N,即重塑形后的剪切强度比重塑形前提高了125.6%。由此证明,铆压重塑形工艺可有效降低凸起高度,并且能提高连接点的强度。

关键词：机械变形压力连接重塑形有限元分析铆钉优化

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汽车铝合金板材平压整形无铆连接技术的研究

机械工程学报 2017年第18期53卷 42-48页

作者：陈超赵升吨崔敏超韩晓兰赵旭哲范淑琴西安交通大学机械工程学院西安710049 普渡大学工程技术学院美国西拉法叶47907

无铆连接技术在汽车铝合金板材的连接领域得到了广泛应用。但是,无铆连接技术在连接点处产生的较高的凸起又制约了这项技术的发展。为了降低连接点的凸起高度,提出一种适用于汽车铝合金板材的平压整形无铆连接技术。通过分瓣式模具和平... 详细信息

无铆连接技术在汽车铝合金板材的连接领域得到了广泛应用。但是,无铆连接技术在连接点处产生的较高的凸起又制约了这项技术的发展。为了降低连接点的凸起高度,提出一种适用于汽车铝合金板材的平压整形无铆连接技术。通过分瓣式模具和平滑模具产生平压整形无铆连接点,对无铆连接点进行拉伸试验。通过拉伸试验得到无铆连接点的拉伸强度、能量吸收和失效模式等重要参数,并对连接点的颈厚值和凸起高度进行分析。研究表明,平压整形无铆连接技术可有效提高连接点的强度和能量吸收能力。断裂失效是平压整形无铆连接点的主要失效模式。此外,平压整形无铆连接技术在降低凸起高度的过程中可增加颈厚值,从而增加连接点强度。

关键词：铝合金板材平压整形无铆连接凸起颈厚值

喷丸强化残余应力对疲劳性能和变形控制影响研究进展

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机械工程学报 2023年第6期59卷 46-60页

作者：张吉银姚倡锋谭靓崔敏超周征孙蕴齐李国喜樊怡西北工业大学航空发动机高性能制造工业和信息化部重点实验室西安710072 西北工业大学航空发动机先进制造技术教育部工程研究中心西安710072

作为机械表面强化技术之一,喷丸强化使工件表层发生形变硬化,引入较高的残余压应力,减少了疲劳应力作用下微裂纹的萌生并抑制其扩展,从而显著提高零件的抗疲劳断裂和抗应力腐蚀开裂的能力。基于喷丸残余应力解析计算模型,从余弦函数模... 详细信息

作为机械表面强化技术之一,喷丸强化使工件表层发生形变硬化,引入较高的残余压应力,减少了疲劳应力作用下微裂纹的萌生并抑制其扩展,从而显著提高零件的抗疲劳断裂和抗应力腐蚀开裂的能力。基于喷丸残余应力解析计算模型,从余弦函数模型、接触应力模型和球腔膨胀模型三个方面介绍喷丸强化残余应力的产生,进而对喷丸残余应力的仿真预测及影响规律进行论述。为了提高试件疲劳强度而引入的残余压应力会带来影响形位精度的变形,基于此阐述了喷丸残余应力对疲劳性能的影响及其在疲劳过程中的演化,同时论述了喷丸残余应力变形预测及控制的研究现状,最后对喷丸残余应力未来的研究内容与发展方向进行展望。

关键词：喷丸强化残余应力疲劳性能变形