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A pilot clinical study to evaluate feasibility of using single patient classifier as a prognostic test in stage Ⅱ-Ⅲ gastric cancer patients

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Chinese Journal of Cancer Research 2024年第4期36卷 368-378页

作者： Ji Yeong An Sung Eun Oh Soomin Ahn Hyoung-II Kim Yoo Min Kim minah cho Keun Won Ryu Hong Man Yoon Young Kyu Park In Gyu Kwon Sung Hoon Noh Kyung Hee Lee In cho Myoung Won Son Jong Won Kim Young-Woo Kim Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Department of Pathology and Translational Genomics Samsung Medical Center Sungkyunkwan University School of Medicine Department of Surgery Yonsei University College of Medicine Gastric Cancer Center Yonsei Cancer CenterYonsei University Health System Center for Gastric Cancer National Cancer Center Department of Surgery Chonnam National University Hwasun Hospital Chonnam National University College of Medicine Department of Surgery Gangnam Severance Hospital Yonsei University College of Medicine Department of Hematology-Oncology Yeungnam University Medical Center Department of Surgery Soonchunhyang University College of Medicine Department of Surgery Soonchunhyang University Cheonan Hospital Soonchunhyang University College of Medicine Department of Surgery Chung-Ang University Hospital Chung-Ang University College of Medicine

Objective: Precision medicine approaches emphasize the importance of reliable prognostic tools for guiding individualized therapy decisions. In this study, we evaluated the clinical feasibility of the single patient classifier(SPC) test, a new clinical-grade prognostic assay, in stage Ⅱ-Ⅲ gastric cancer ***: A prospective multicenter study was conducted, involving 237 patients who underwent gastrectomy between September 2019 and August 2020 across nine hospitals. The SPC test was employed to stratify patients into risk groups, and its feasibility and performance were evaluated. The primary endpoint was the proportion of the cases in which the test results were timely delivered before selecting postoperative treatment. Furthermore, 3-year disease-free survivals of risk groups were ***: The SPC test met the primary endpoint criteria. The 99.5% of SPC tests were timely delivered to hospitals before the postoperative treatment started. In a clinical setting, the median time from the specimen transfer to laboratory to the result delivery to hospital was 4 d. Furthermore, 3-year disease-free survivals were significantly different between risk groups classified with SPC ***: This study highlights the SPC test's feasibility in offering crucial information timely delivered for making informed decisions regarding postoperative treatment strategies. It also provides evidence to support the implementation of a future prospective clinical trial aimed at evaluating the clinical utility of the SPC test in guiding personalized treatment decisions for gastric cancer patients.

关键词： Prognostic test adjuvant chemotherapy advanced gastric cancer feasibility gastrectomy

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Lichen Planus Pigmentosus Inversus:Two Case Reports

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International Journal of Dermatology and Venereology 2022年第2期5卷 116-118页

作者： Se Hoon Lee minah cho Yu Jin Han Yu Ri Woo Sang Hyun cho Jeong Deuk Lee Hei Sung Kim Department of Dermatology Incheon St.Mary’s HospitalThe Catholic University of KoreaSeoulSouth Korea Department of Biomedicine&Health Sciences The Catholic University of KoreaSeoulSouth Korea.

Introduction:Lichen planus pigmentosus inversus(LPPI)is a rare a rare variant of lichen planus characterized by hyperpigmented patches with predominating localization in intertriginous *** to its rarity,only a few LPPI cases are *** herein describe two rare cases of *** presentation:The two patients were all with a brownish macular lesion on the intertriginous area.A diagnosis of LPPI was made based on their clinical manifestations,dermoscopic features,and histopathologic features,which revealed an interface change,lichenoid infiltration,and pigmentary ***:LPPI is pruritic or asymptomatic,hyperpigmented macules and patches on the flexural *** axillae and flanks were the most commonly affected areas,followed by the groin and *** half of the female patients had inframammary fold *** shows higher female predominance than Lichen planus *** were fewer cases that lasted more than 3 years compared to ***:LPPI is a rare variant of lichen planus,with a locational characteristic and female ***,in the case of a pigmented disease occurring in the flexural folds,it should be placed in the differential diagnosis.

关键词： lichen planus pigmentosus lichen planus pigmentosus inversus

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Direct 4D printing of functionally graded hydrogel networks for biodegradable,untethered,and multimorphic soft robots

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International Journal of Extreme Manufacturing 2024年第2期6卷 407-416页

作者： Soo Young cho Dong Hae Ho Sae Byeok Jo Jeong Ho cho Department of Chemical and Biomolecular Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Mechanical Engineering Virginia TechBlacksburgVA 24061United States of America School of Chemical Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwon 16419Republic of Korea

Recent advances in functionally graded additive manufacturing(FGAM)technology have enabled the seamless hybridization of multiple functionalities in a single *** robotics can become one of the largest beneficiaries of these advances,through the design of a facile four-dimensional(4D)FGAM process that can grant an intelligent stimuli-responsive mechanical functionality to the printed ***,we present a simple binder jetting approach for the 4D printing of functionally graded porous multi-materials(FGMM)by introducing rationally designed graded multiphase feeder *** graded cross-linking agents gradually form stable porous network structures within aqueous polymer particles,enabling programmable hygroscopic deformation without complex mechanical ***,a systematic bed design incorporating additional functional agents enables a multi-stimuli-responsive and untethered soft robot with stark stimulus *** biodegradability of the proposed 4D-printed soft robot further ensures the sustainability of our approach,with immediate degradation rates of 96.6%within 72 *** proposed 4D printing concept for FGMMs can create new opportunities for intelligent and sustainable additive manufacturing in soft robotics.

关键词： intelligent and sustainable additive manufacturing multi-material four-dimensional printing untethered soft robot multi-stimuli-responsive soft robot biodegradable soft robotics

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Thermodynamic model for deoxidation of liquid steel considering strong metal-oxygen interaction in the quasichemical model framework

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 988-1002页

作者： Yong-Min cho Youn-Bae Kang Graduate Institute of Ferrous and Eco Materials Technology Pohang University of Science and TechnologyPohangKyungbuk37673Rep.of Korea N.EX.T Hub POSCO HoldingsPohangKyungbuk37673Rep.of Korea Department of Materials Science and Engineering Pohang University of Science and TechnologyPohangKyungbuk37673Rep.of Korea

Herein,a thermodynamic model aimed at describing deoxidation equilibria in liquid steel was *** model provides explicit forms of the activity coefficient of solutes in liquid steel,eliminating the need for the minimization of internal Gibbs energy preliminarily when solving deoxidation *** elimination of internal Gibbs energy minimization is particularly advantageous during the coupling of deoxidation equilibrium calculations with computationally intensive approaches,such as computational fluid *** model enables efficient calculations through direct embedment of the explicit forms of activity coefficient in the computing *** proposed thermodynamic model was developed using a quasichemical approach with two key approximations:random mixing of metallic elements(Fe and oxidizing metal) and strong nonrandom pairing of metal and oxygen as nearest *** these approximations,the quasichemical approach yielded the activity coefficients of solutes as explicit functions of composition and temperature without requiring the minimization of internal Gibbs energy or the coupling of separate *** model was successfully applied in the calculation of deoxidation equilibria of various elements(Al,B,C,Ca,Ce,Cr,La,Mg,Mn,Nb,Si,Ti,V,and Zr).The limitations of the model arising from these assumptions were also discussed.

关键词： deoxidation equilibria thermodynamics quasichemical approach computational fluid dynamics

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Ungraded Matrix Factorizations as Mirrors of Non-orientable Lagrangians

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Acta Mathematica Sinica,English Series 2024年第1期40卷 26-42页

作者： Lino AMORIM Cheol-Hyun cho Department of Mathematics Kansas State University138 Cardwell Hall1228 N.17th StreetManhattanKS 66506USA Department of Mathematical Sciences Research Institute of MathematicsSeoul National UniversitySan 56-1ShinrimdongGwanakguSeoul 47907South Korea

We introduce the notion of ungraded matrix factorization as a mirror of non-orientable Lagrangian *** ungraded matrix factorization of a polynomial W,with coefficients in a field of characteristic 2,is a square matrix Q of polynomial entries satisfying Q^(2)=W·*** then show that non-orientable Lagrangians correspond to ungraded matrix factorizations under the localized mirror functor and illustrate this construction in a few *** main example is the Lagrangian submanifold RP^(2)⊂CP^(2)and its mirror ungraded matrix factorization,which we construct and *** particular,we prove a version of Homological Mirror Symmetry in this setting.

关键词： Mirror symmetry non-orientable Lagrangian submanifold matrix factorization

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An Empirical Study on the Effectiveness of Adversarial Examples in Malware Detection

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 3535-3563页

作者： Younghoon Ban Myeonghyun Kim Haehyun cho School of Software Soongsil UniversitySeoul06978Korea

Antivirus vendors and the research community employ Machine Learning(ML)or Deep Learning(DL)-based static analysis techniques for efficient identification of new threats,given the continual emergence of novel malware *** the other hand,numerous researchers have reported that Adversarial Examples(AEs),generated by manipulating previously detected malware,can successfully evade ML/DL-based *** antivirus systems,in particular,have been identified as vulnerable to such *** paper firstly focuses on conducting black-box attacks to circumvent ML/DL-based malware *** attack method utilizes seven different perturbations,including Overlay Append,Section Append,and Break Checksum,capitalizing on the ambiguities present in the PE format,as previously employed in evasion attack *** directly applying the perturbation techniques to PE binaries,our attack method eliminates the need to grapple with the problem-feature space dilemma,a persistent challenge in many evasion attack *** a black-box attack,our method can generate AEs that successfully evade both DL-based and ML-based ***,AEs generated by the attack method retain their executability and malicious behavior,eliminating the need for functionality *** thorogh evaluations,we confirmed that the attack method achieves an evasion rate of 65.6%against well-known ML-based malware detectors and can reach a remarkable 99%evasion rate against well-known DL-based malware ***,our AEs demonstrated the capability to bypass detection by 17%of vendors out of the 64 on VirusTotal(VT).In addition,we propose a defensive approach that utilizes Trend Locality Sensitive Hashing(TLSH)to construct a similarity-based defense *** several experiments on the approach,we verified that our defense model can effectively counter AEs generated by the perturbation *** conclusion,our defense model alleviates the limitation of the mos

关键词： Malware classification machine learning adversarial examples evasion attack cybersecurity

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A New Framework for Software Vulnerability Detection Based on an Advanced Computing

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Computers, Materials & Continua 2024年第6期79卷 3699-3723页

作者： Bui Van Cong cho Do Xuan Department of Information Technology University of Economics and Technical IndustriesHanoi100000Vietnam Faculty of Information Security Posts and Telecommunications Institute of TechnologyHanoi100000Vietnam

The detection of software vulnerabilities written in C and C++languages takes a lot of attention and interest *** paper proposes a new framework called DrCSE to improve software vulnerability *** uses an intelligent computation technique based on the combination of two methods:Rebalancing data and representation learning to analyze and evaluate the code property graph(CPG)of the source code for detecting abnormal behavior of software *** do that,DrCSE performs a combination of 3 main processing techniques:(i)building the source code feature profiles,(ii)rebalancing data,and(iii)contrastive *** which,the method(i)extracts the source code’s features based on the vertices and edges of the *** method of rebalancing data has the function of supporting the training process by balancing the experimental ***,contrastive learning techniques learn the important features of the source code by finding and pulling similar ones together while pushing the outliers *** experiment part of this paper demonstrates the superiority of the DrCSE Framework for detecting source code security vulnerabilities using the Verum *** a result,the method proposed in the article has brought a pretty good performance in all metrics,especially the Precision and Recall scores of 39.35%and 69.07%,respectively,proving the efficiency of the DrCSE *** performs better than other approaches,with a 5%boost in Precision and a 5%boost in ***,this is considered the best research result for the software vulnerability detection problem using the Verum dataset according to our survey to date.

关键词： Source code vulnerability source code vulnerability detection code property graph feature profile contrastive learning data rebalancing

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Advancements in hemostatic strategies for managing upper gastrointestinal bleeding: A comprehensive review

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World Journal of Gastroenterology 2024年第15期30卷 2087-2090页

作者： Ah Young Lee Joo Young cho Division of Gastroenterology Department of Internal MedicineCha Gangnam Medical CenterCha University College of MedicineSeoul 06135Korea

Upper gastrointestinal(GI)hemorrhage presents a substantial clinical *** management typically involves resuscitation and endoscopy within 24 h,although the benefit of very early endoscopy(<12 h)for high-risk patients is *** goals include stopping acute bleeding,preventing rebleeding,and using a multimodal approach encompassing endoscopic,pharmacological,angiographic,and surgical *** agents such as vasopressin,prostaglandins,and proton pump inhibitors are effective,but the increase in antithrombotic use has increased GI bleeding *** hemostasis,particularly for nonvariceal bleeding,employs techniques such as electrocoagu-lation and heater probes,with concerns over tissue injury from monopolar *** methods such as Hemospray and Endoclot show promise in creating mechanical tamponades but have ***,the first-line therapy includes thermal probes and hemoclips,with over-the-scope clips emerging for larger ulcer *** gold probe,combining bipolar electrocoagulation and injection,offers targeted coagulation but has faced device-related *** advancements involve combining techniques and improving endoscopic imaging,with studies exploring combined approaches showing *** research is crucial for developing standardized and effective hemorrhage management strategies.

关键词： Upper gastrointestinal bleeding Hemostasis Endoscopy Probe Spray Clip

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Defect Detection Model Using Time Series Data Augmentation and Transformation

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Computers, Materials & Continua 2024年第2期78卷 1713-1730页

作者： Gyu-Il Kim Hyun Yoo Han-Jin cho Kyungyong Chung Department of Computer Science Kyonggi UniversitySuwon-si16227Korea Contents Convergence Software Research Institue Kyonggi UniversitySuwon-si16227Korea Department of Energy IT Engineering Far East UniversityEumsung-gun27601Korea Division of AI Computer Science and Engineering Kyonggi UniversitySuwon-si16227Korea

Time-series data provide important information in many fields,and their processing and analysis have been the focus of much ***,detecting anomalies is very difficult due to data imbalance,temporal dependence,and ***,methodologies for data augmentation and conversion of time series data into images for analysis have been *** paper proposes a fault detection model that uses time series data augmentation and transformation to address the problems of data imbalance,temporal dependence,and robustness to *** method of data augmentation is set as the addition of *** involves adding Gaussian noise,with the noise level set to 0.002,to maximize the generalization performance of the *** addition,we use the Markov Transition Field(MTF)method to effectively visualize the dynamic transitions of the data while converting the time series data into *** enables the identification of patterns in time series data and assists in capturing the sequential dependencies of the *** anomaly detection,the PatchCore model is applied to show excellent performance,and the detected anomaly areas are represented as heat *** allows for the detection of anomalies,and by applying an anomaly map to the original image,it is possible to capture the areas where anomalies *** performance evaluation shows that both F1-score and Accuracy are high when time series data is converted to ***,when processed as images rather than as time series data,there was a significant reduction in both the size of the data and the training *** proposed method can provide an important springboard for research in the field of anomaly detection using time series ***,it helps solve problems such as analyzing complex patterns in data lightweight.

关键词： Defect detection time series deep learning data augmentation data transformation

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Dietary eubiotics of microbial muramidase and glycan improve intestinal villi,ileum microbiota composition and production trait of broiler

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1723-1736页

作者： Sungbo cho Shanmugam Suresh Kumar Santiago Ramirez Rolando Valientes In Ho Kim Department of Animal Resource and Science Dankook UniversityCheonanChungnam 31116Korea Smart Animal Bio Institute Dankook University CheonanKorea DSM Nutritional Products Asia Pacific Mapletree Business CitySingapore 117440Singapore

Background Optimal gut health is important to maximize growth performance and feed efficiency in broiler chickens.A total of 1,365 one-day-old male Ross 308 broiler chickens were randomly divided into 5 treatments groups with 21 replicates,13 birds per *** present research investigated effects of microbial muramidase or a precision glycan alone or in combination on growth performance,apparent total tract digestibility,total blood carotenoid content,intestinal villus length,meat quality and gut microbiota in broiler *** included:NC:negative control(basal diet group);PC:positive control(basal diet+0.02%probiotics);MR:basal diet+0.035%microbial muramidase;PG:basal diet+0.1%precision glycan;and MRPG:basal diet+0.025%MR+0.1%PG,*** MRPG group increased the body weight gain and feed intake(P<0.05)compared with NC ***,it significantly increased total serum carotenoid(P<0.05)and MRPG altered the microbial diversity in ileum *** MRPG treatment group increased the abundance of the phylum Firmicutes,and family Lachnospiraceae,Ruminococcaceae,Oscillospiraceae,Lactobacillaceae,Peptostreptococcaceae and decreased the abundance of the phylum Campilobacterota,Bacteroidota and family *** with the NC group,the chickens fed MRPG showed significantly increased in duodenum villus length at end the *** In this study,overall results showed that the synergetic effects of MR and PG showed enhancing growth performance,total serum carotenoid level and altering gut microbiota composition of *** current research indicates that co-supplementation of MR and PG in broiler diets enhances intestinal health,consequently leading to an increased broiler production.

关键词： Broiler Intestinal morphology Microbial muramidase Precision glycan Probiotics

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