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Optimal sequential therapy using tyrosine kinase inhibitors as the first-line treatment in patients with metastatic renal cell carcinoma: A nationwide multicenter study

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Asian Journal of Urology 2024年第3期11卷 450-459页

作者： Jung Ki Jo Seong Il Seo minyong kang Jinsoo Chung Cheol Kwak Sung-Hoo Hong Cheryn Song Jae Young Park Chang Wook Jeong Seok Hwan Choi Sung Han Kim Eu Chang Hwang Chan Ho Lee Hakmin Lee Department of Urology Medical and Digital EngineeringCollege of MedicineHanyang UniversitySeoulRepublic of Korea Department of Urology Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Department of Urology National Cancer CenterGoyangRepublic of Korea Department of Urology Seoul National University HospitalSeoulRepublic of Korea Department of Urology Kangnam St Mary’s HospitalSeoulRepublic of Korea Department of Urology Asan Medical CenterSeoulRepublic of Korea Department of Urology Korea University Ansan HospitalAnsanRepublic of Korea Department of Urology Kyungpook National University HospitalDaeguRepublic of Korea Department of Urology Chonnam National University Hwasun HospitalHwasunRepublic of Korea Department of Urology Inje University Busan Paik HospitalBusanRepublic of Korea Department of Urology Seoul National University Bundang HospitalSeongnamRepublic of Korea

Objective:The purpose of the study was to identify the best sequence of therapy beginning with a tyrosine kinase inhibitor(TKI)as the first-line therapy for patients with metastatic renal cell carcinoma(mRCC)in terms of overall survival(OS),progression-free survival(PFS),and rates of discontinuation and adverse effects during the treatment ***:This is a retrospective,nationwide multicenter study of patients with mRCC after diagnosis at 10 different tertiary medical centers in Korea from January 1992 to December *** focused on patients at either“favorable”or“intermediate”risk according to the International mRCC Database Consortium criteria,and they were followed up(median 335 days).Finally,a total of 1409 patients were selected as the study *** generated a Cox proportional hazard model adjusted for covariates,and the different therapy schemes were statistically tested in terms of OS as well as *** addition,frequencies of discontinuation and adverse events were compared among the therapy ***:Of the primary patterns of treatment sequences(24 sequences),“sunitinib epazopanib”and“sunitinibeeverolimuseimmunotherapy”showed the most beneficial results in both OS and PFS with significantly lower hazards than“sunitinib”,which is the most commonly treated agent in *** that the“TKIeTKI”structure showed relatively higher discontinuation rates with higher adverse effects,the overall beneficial sequence would be“sunitinibeeverolimuseimmunotherapy”.Conclusion:Among several sequential therapy starting with TKIs,“sunitinibeeverolimuse immunotherapy”was found to be the best scheme for mRCC patients with“favorable”or“intermediate”risks.

关键词： Tyrosinekinase inhibitor Metastaticrenalcell carcinoma Overall survival Progression-free survival

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A privacy-preserving method for publishing data with multiple sensitive attributes

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CAAI Transactions on Intelligence Technology 2024年第1期9卷 222-238页

作者： Tong Yi minyong Shi Wenqian Shang Haibin Zhu School of Computer Science and Engineering Guangxi Normal UniversityGuilinChina School of Computer Science Communication University of ChinaBeijingChina Department of Computer Science and Mathematics Nipissing UniversityNorth BayOntarioCanada

The overgeneralisation may happen because most studies on data publishing for multiple sensitive attributes(SAs)have not considered the personalised privacy ***,sensitive information disclosure may also be caused by these personalised *** address the matter,this article develops a personalised data publishing method for multiple *** to the requirements of individuals,the new method partitions SAs values into two categories:private values and public values,and breaks the association between them for privacy *** the private values,this paper takes the process of anonymisation,while the public values are released without this *** algorithm is designed to achieve the privacy mode,where the selectivity is determined by the sensitive value frequency and undesirable *** experimental results show that the proposed method can provide more information utility when compared with previous *** theoretic analyses and experiments also indicate that the privacy can be guaranteed even though the public values are known to an *** overgeneralisation and privacy breach caused by the personalised requirement can be avoided by the new method.

关键词： data privacy data publishing

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Observational signatures of rotating black holes in the semiclassical gravity with trace anomaly

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Chinese Physics C 2024年第8期48卷 257-265页

作者： Zhenyu Zhang Yehui Hou minyong Guo Department of Physics Peking UniversityBeijing 100871China Department of Physics Beijing Normal UniversityBeijing 100875China

In a recent work by Fernandes[***.D 108(6),L061502(2023)],an exact stationary and axisymmetric solution was discovered in semiclassical gravity with type-A trace *** was identified as a quantum-corrected version of the Kerr black *** this study,we explore the observational signatures of this black hole *** investigation reveals that prograde and retrograde light rings exist,whose radii increase monotonically with the coupling parameterα.Whenαis negative,the shadow area for the quantum-corrected black hole is smaller than that of the Kerr black hole,whereas whenαis positive,the area is *** a near-extremal black hole,its high-spin feature(the NHEKline)is found to be highly susceptible to disruption byα.Furthermore,we discuss the images of the quantum-corrected black hole in the presence of a thin accretion disk and compare them to those of the Kerr black *** study highlights the importance of near-horizon emission sources in detecting the effects of quantum corrections by black hole images.

关键词： quantum-corrected rotating black hole light rings black hole shadow

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Forward modelling of the Cotton-Mouton effect polarimetry on EAST tokamak

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Plasma Science and Technology 2024年第3期26卷 100-117页

作者：沈敏勇张际波张耀揭银先刘海庆谢锦林丁卫星 School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026People's Republic of China Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People's Republic of China

Measurement of plasma electron density by far-infrared laser polarimetry has become a routine and indispensable tool in magnetic confinement fusion *** article presents the design of a Cotton-Mouton polarimeter interferometer,which provides a reliable density measurement without fringe ***-Mouton effect on Experimental Advanced Superconducting Tokamak(EAST)is studied by Stokes equation with three parameters(s_(1),s_(2),s_(3)).It demonstrates that under the condition of a small Cotton-Mouton effect,parameter s_(2)contains information about Cotton-Mouton effect which is proportional to the line-integrated *** a typical EAST plasma,the magnitude of Cotton-Mouton effects is less than 2πfor laser wavelength of 432μ*** effect due to density gradient is calculated to be *** modulation of Stokes parameters(s_(2),s_(3))provides heterodyne *** to the instabilities arising from laser oscillation and beam refraction in plasmas,it is necessary for the system to be insensitive to variations in the amplitude of the detection ***,it is shown that non-equal amplitude of X-mode and O-mode within a certain range only affects the DC offset of Stokes parameters(s_(2),s_(3))but does not greatly influence the phase measurements of Cotton-Mouton effects.

关键词： EAST Cotton-Mouton effect polarimeter interferometer electron density measurement Stokes vector

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隔爆主机壳体优化设计研究

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煤矿机械 2024年第8期45卷 127-129页

作者：谷敏永北京天玛智控科技股份有限公司北京101399

针对煤矿井下隔爆主机重量大、加工成本高、搬运移动便捷性差等问题,对现有的隔爆主机壳体进行理论计算和结构优化设计,实现在保证结构强度的情况下降低壳体质量的目的,并利用有限元方法对隔爆壳体进行仿真分析。结果表明,壳体采用7 mm... 详细信息

针对煤矿井下隔爆主机重量大、加工成本高、搬运移动便捷性差等问题,对现有的隔爆主机壳体进行理论计算和结构优化设计,实现在保证结构强度的情况下降低壳体质量的目的,并利用有限元方法对隔爆壳体进行仿真分析。结果表明,壳体采用7 mm厚的高强度钢板焊接,在壳体内部薄弱处设置加强肋,外部散热部位增加散热肋板同时起到增加强度和散热的作用,在满足性能的前提下壳体质量降低了54%,大幅减少了加工成本。

关键词：隔爆壳体结构强度优化设计仿真分析

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矿用摄像仪智能自清洁系统的研究与应用

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煤炭技术 2024年第8期43卷 245-247页

作者：谷敏永北京天玛智控科技股份有限公司北京101399

针对综采工作面现有摄像仪球罩容易附着煤尘或煤泥,影响视频监控的效果、且需要人工擦拭的问题,提出了采用具有疏水涂层的聚碳酸酯光学球罩,通过在现有的摄像仪壳体上增加喷水自清洁装置,自清洁装置连接支架喷雾系统,由自清洁装置对摄... 详细信息

针对综采工作面现有摄像仪球罩容易附着煤尘或煤泥,影响视频监控的效果、且需要人工擦拭的问题,提出了采用具有疏水涂层的聚碳酸酯光学球罩,通过在现有的摄像仪壳体上增加喷水自清洁装置,自清洁装置连接支架喷雾系统,由自清洁装置对摄像仪球罩进行除尘清洁,开发出可以通过地面监控中心进行远程控制的摄像仪自清洁系统,并在煤矿井下进行了工业性试验。经验证,摄像仪自清洁系统满足现场需求,极大地节省了人力,解决了综采工作面摄像仪“看得见”、“看得清”的问题,为实现智能化无人开采奠定了基础。

关键词：综采工作面摄像仪自清洁除尘

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综采工作面液压支架测高传感器设计

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工矿自动化 2024年第6期50卷 129-135页

作者：高思伟谷敏永李殿鹏北京天玛智控科技股份有限公司北京101399

针对综采工作面液压支架高度测量困难和可靠性、稳定性差等问题,设计了一种基于帕斯卡定律的液压支架测高传感器。该测高传感器内置一根细长液管,液管中充满甲基硅油,测高传感器两端安装压力传感器,通过测量密闭液管的两端压力,得到测... 详细信息

针对综采工作面液压支架高度测量困难和可靠性、稳定性差等问题,设计了一种基于帕斯卡定律的液压支架测高传感器。该测高传感器内置一根细长液管,液管中充满甲基硅油,测高传感器两端安装压力传感器,通过测量密闭液管的两端压力,得到测高传感器两端位置的高度差。甲基硅油在环境温度变化时具有明显的热胀冷缩特性,会引起密闭空间内的压力急剧变化,影响测量精度,提出了一种补偿方法:采用波纹管存储一部分甲基硅油,利用波纹管自身的弹性补偿甲基硅油热胀冷缩造成的体积变化;并在软件中通过算法校准甲基硅油体积变化带来的密度变化,从而确保测高传感器的测量精度。试验结果表明:测高传感器可工作在0~40℃环境下,测量误差在4 cm以内。在薄煤层、中厚煤层综采工作面液压支架的现场应用结果表明:与人工测量结果相比,测高传感器的高度测量误差在5 cm以内,说明该传感器可靠性较高。

关键词：综采工作面液压支架测高传感器压力传感器波纹管温度补偿密度校准

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基于模糊综合评价法的电力建设安装工程风险管理研究

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电力设备管理 2024年第13期 197-199页

作者：周岷湧上海电力安装第二工程有限公司

为降低电力建设安装工程进度延误风险,提高风险管理能力,应建立多角度的电力建设安装工程风险管理指标体系,并利用模糊综合评价法与蒙特卡罗模型,设计综合风险评价模型。结果表明,应用改进层次分析与模糊综合评价法的风险管理方法后,工... 详细信息

为降低电力建设安装工程进度延误风险,提高风险管理能力,应建立多角度的电力建设安装工程风险管理指标体系,并利用模糊综合评价法与蒙特卡罗模型,设计综合风险评价模型。结果表明,应用改进层次分析与模糊综合评价法的风险管理方法后,工程整体的进度风险延误率降低0.1120,完工概率提高0.0464,整体工程风险有效降低,以期为电力建设安装工程风险管理提供合理有效的参考价值。

关键词：模糊综合评价法蒙特卡罗模型电力安装工程风险管理

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混凝土冻融作用下冻结应力演化规律及对抗冻性能的影响

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材料导报 2024年第12期38卷 107-111页

作者：戈雪良柯敏勇刘伟宝陆采荣王珩梅国兴杨虎南京水利科学研究院南京210029 水文水资源与水利工程科学国家重点实验室南京210029 水利部应对气候变化研究中心南京210029

为了探究严寒地区混凝土冻害机理及冻结应力对混凝土抗冻性的影响,基于大型极端气候模拟器模拟-40℃低温冻害的条件,采用研制的冻结应力测试装置对F300高抗冻等级混凝土在冻融单次降温阶段及降温-升温冻融循环两种模式下的冻结应力及抗... 详细信息

为了探究严寒地区混凝土冻害机理及冻结应力对混凝土抗冻性的影响,基于大型极端气候模拟器模拟-40℃低温冻害的条件,采用研制的冻结应力测试装置对F300高抗冻等级混凝土在冻融单次降温阶段及降温-升温冻融循环两种模式下的冻结应力及抗冻性能进行研究,同时利用了环境扫描电子显微镜对冻融循环作用下的混凝土微观裂缝进行了测试研究。研究表明:-40℃单次降温过程中降温速率越快,冻结应力出现的时间越早、混凝土内部产生的冻结应力增幅也越大;冻融循环降温阶段产生的冻结应力会随降温-升温冻融作用的不断循环而累积增大,且冻结应力的发展存在转变拐点,在相同降温终了试件中心低温条件下,降温阶段的降温速率越大,冻结应力由增加转入减小的拐点出现越早;冻融过程中的冻结应力与混凝土质量损失、相对动弹性模量两个抗冻性常用评价指标有较好的对应关系;冻结应力逐步使水泥浆体产生损伤,表现为微观裂缝的生成与发展,损伤积聚产生冻害。

关键词：混凝土冻融循环冻结应力演化规律抗冻性能作用机制

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Medical data publishing based on average distribution and clustering

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CAAI Transactions on Intelligence Technology 2022年第3期7卷 381-394页

作者： Tong Yi minyong Shi Haibin Zhu School of Computer Science and Engineering Guangxi Normal UniversityGuilinChina School of Computer Science Communication University of ChinaBeijingChina Department of Computer Science and Mathematics Nipissing UniversityNorth BayOntarioCanada

Most of the data publishing methods have not considered sensitivity protection,and hence the adversary can disclose privacy by sensitivity *** with this problem,this paper presents a medical data publishing method based on sensitivity *** protect the sensitivity,the sensitivity of disease information is determined by *** seek the trade-off between information utility and privacy security,the new method focusses on the protection of sensitive values with high sensitivity and assigns the highly sensitive disease information to groups as evenly as *** experiments are conducted on two real-world datasets,of which the records include various attributes of *** measure sensitivity protection,the authors define a metric,which can evaluate the degree of sensitivity ***,additional information loss and discernability metrics are used to measure the availability of released *** experimental results indicate that the new method can provide better privacy than the traditional one while the information utility is *** value protection,the proposed method can provide sensitivity protection and available releasing for medical data.

关键词： data publishing information utility security semantics sensitive values sensitivity

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