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Three-dimensional label-free morphology of CD8+T cells as a sepsis biomarker

Light(Science & Applications) 2023年第12期12卷 2565-2576页

作者： mindong sung Jong Hyun Kim Hyun-Seok Min Sooyoung Jang JaeSeong Hong Bo Kyu Choi JuHye Shin Kyung Soo Chung Yu Rang Park Division of Pulmonary and Critical Care Medicine Department of Internal MedicineYonsei University College of MedicineSeoulRepublic of Korea Department of Biomedical Systems Informatics Yonsei University College of MedicineSeoulRepublic of Korea Tomocube Inc155 Sinseong-roShinsung-dongYuseong-guDaejeonRepublic of Korea

Sepsis is a dysregulated immune response to infection that leads to organ dysfunction and is associated with a high incidence and mortality *** lack of reliable biomarkers for diagnosing and prognosis of sepsis is a major challenge in its *** aimed to investigate the potential of three-dimensional label-free CD8+T cell morphology as a biomarker for *** study included three-time points in the sepsis recovery cohort(N=8)and healthy controls(N=20).Morphological features and spatial distribution within cells were compared among the patients'*** developed a deep learning model to predict the diagnosis and prognosis of sepsis using the internal cell *** between the morphological features and clinical indices were *** morphological features and spatial distribution differed significantly between patients with sepsis and healthy controls and between the survival and non-survival *** model for predicting the diagnosis and prognosis of sepsis showed an area under the receiver operating characteristic curve of nearly 100%with only a few cells,and a strong correlation between the morphological features and clinical indices was *** study highlights the potential of three-dimensional label-free CD8+T cell morphology as a promising biomarker for *** approach is rapid,requires a minimum amount of blood samples,and has the potential to provide valuable information for the early diagnosis and prognosis of sepsis.

关键词： sepsis diagnosis Morphological

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Mn-Ce-Nb-O_x/P84 catalytic filters prepared by a novel method for simultaneous removal of particulates and NO

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Journal of Rare Earths 2019年第3期37卷 273-281页

作者： Bo Yang Qiong Huang mindong Chen Yuesong Shen Shemin Zhu Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technology (CICAEET) Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control School of Environmental Science and Engineering Nanjing University of Information Science & Technology Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) College of Materials Science and Engineering Nanjing Tech University

The Mn-Ce-Nb-O_x/P84 catalytic filter for removal of particulates and NO simultaneous was prepared by a novel method(foam coating method). The process parameters including the concentrations of PTFE emulsion, particle size of catalyst and calcination temperature for preparation of catalytic filters were analyzed. In addition, the physical properties and performance for removal of NO(NH_3-SCR) and particulates of Mn-Ce-Nb-O_x/P84 catalytic filter prepared under the optimized parameters, were also systematic studied. Results show that the process parameters had significant influences on stability and performance of catalytic filter, The Mn-Ce-Nb-O_x/P84 catalytic filter prepared by foam coating method under the optimized parameters, has satisfactory physical properties and catalytic performance for removal of NO and particulates at 140-220 ℃. The NO removal efficiency of catalytic filter can reach95.3% at 200 ℃ as the catalyst loading amount is 450 g/m^2, Moreover,the dust removal efficiency of MnGe-Nb-O_x/P84 catalytic filter reaches as high as 99.98%, and the PM2.5 removal efficiency also reaches99.98%. The anti-sulfur performance of Mn-Ce-Nb-O_x catalytic filter is also attractive, after injecting150 ppm SO_2, the NO removal efficiency still retains up to 85%. It is indicated that the foam coating method can not only make a bond of high strength between catalyst and filter, but also make the catalytic filter possessing an excellent and stable performance for removal of NO and particulates.

关键词： Foam coating method Simultaneous removal Mn-Ce-Nb-O_x/P84 catalytic filters NO Particulates Preparation method

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Data mining to effect of key alloying elements on corrosion resistance of low alloy steels in Sanya seawater environmentAlloying Elements

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Journal of Materials Science & Technology 2021年第5期64卷 222-232页

作者： Xin Wei Dongmei Fu mindong Chen Wei Wu Dequan Wu Chao Liu School of Automation and Electrical Engineering University of Science and Technology BeijingBeijing100083China Beijing Engineering Research Center of Industrial Spectrum Imaging University of Science and Technology BeijingBeijing 100083China SINOPEC Research Institute of Safety Engineering Qingdao266100China Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing100083China

In this paper,the relationship model between seawater environment,chemical composition and corrosion potential of low alloy steel is established and the distribution of corrosion potential of low alloy steel with changes in key alloying elements is *** research was carried out with the following steps:Firstly,the relationship model between corrosion potential of low alloy steel and its influencing factors was established by data dimension reduction and artificial neural network(ANN).Secondly,key alloying elements of experimental steels were selected out by Pearson correlation analysis,then the corrosion resistance element model was visualized to show the effect of key alloying elements on corrosion potential of low alloy ***,corrosion potential of low alloy steel with the change of key alloying elements was classified and visualized by classification *** mining results can reflect the validity of the proposed mining methods to a certain extent and provide an intuitive data basis for the development of high-quality and low-cost low alloy steels.

关键词： Low alloy steel Corrosion potential Key alloying elements Corrosion-resistant alloy Artificial neural network Data-driven model

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Improved Visible Transparency of SiO_2/ZnO:Al/CeO_2-TiO_2/SiO_2 Multilayer Films with High UV Absorption and Infrared Reflection Rate

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Journal of Wuhan University of Technology(Materials Science) 2015年第5期30卷 941-946页

作者：倪佳苗赵修建 ZHAO Qingnan ZHENG mindong State Key Laboratory of Silicate Materials for Architectures (Wuhan University of Technology) Department of Architecture and Material Engineering Hubei University of Education National Engineering Laboratory for Fiber Optic Sensing Technology Wuhan University of Technology

New visible transparent, UV absorption, and high infrared reflection properties have been realized by depositing multilayer Si O2/Zn O: Al/Ce O2-Ti O2/Si O2 films onto glass substrates at low temperature by radio frequency magnetron sputtering. Optimum thickness of Si O2, Zn O: Al(ZAO) and Ce O2-Ti O2(CTO) films were designed with the aid of thin film design software. The degree of antireflection can be controlled by adjusting the thickness and refractive index. The outer Si O2 film can diminish the interference coloring and increase the transparency; the inner Si O2 film improves the adhesion of the coating on the glass substrate and prevents Ca2+, Na+ in the glass substrate from entering the ZAO film. The average transmittance in the visible light range increases by nearly 18%-20%, as compared to double layer ZAO/CTO films. And the films display high infrared reflection rate of above 75% in the wavelength range of 10-25 μm and good UV absorption(> 98%) properties. These systems are easy to produce on a large scale at low cost and exhibit high mechanical and chemical durability. The triple functional films with high UV absorption, antireflective and high infrared reflection rate will adapt to application in flat panel display and architectural coating glass, automotive glass, with diminishing light pollution as well as decreasing eye fatigue and increasing comfort.

关键词： Si O2/Zn O:Al /Ce O2-Ti O2/Si O2 transparency high infrared reflection rate ultraviolet absorption optimization

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Rationally designed/constructed MnO_x/WO_3 anode for photoelectrochemical water oxidation

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Chinese Chemical Letters 2018年第6期29卷 811-814页

作者： Xiaohu Cao Xiangyu Zang Xichen Zhou mindong Chen Yong Ding State Key Laboratory of Applied Organic Chemistry Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province College of Chemistry and Chemical Engineering Lanzhou University Collaborative Innovation Center of Atmospheric Environment and Equipment Technology Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control (AEMPC) Nanjing University of Information Science & Technology

Photoelectrocatalytic water splitting is an effective way to utilize the solar energy to solve the energy shortage. The valence band edge of WO3 located at 3V vs. normal hydrogen electrode（NHE）, which can offer enough potential to kinetically oxidize water for oxygen evolution reaction. However, water oxidation reaction kinetics is sluggish when only WO3 is used as the photoanode. It is highly desirable to use cocatalyst to promote the kinetics. Mn Oxloaded on the WO3 photoanode through photodeposition methods improves the photoelectrochemical water oxidation performance. A maximum photocurrent density of composite photoanode is achieved with a deposition time of 3 min, which is higher than that of pristine WO3 photoanode around 40%. Mn O2 is not only a cocatalyst for water splitting but also for improving oxidation selectivity. We tried to use two means to load Mn Oxon WO3 photoanode material. It is observed that loading a moderate amount of Mn Oxon the WO3 by photodeposition can promote the performance of the WO3 photoanode.

关键词： Photoelectrochemical water oxidation Tungsten oxide Manganese oxide Photodeposition Hydrothermal method

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Gravimetric analysis for PM_(2.5) mass concentration based on year-round monitoring at an urban site in Beijing

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Journal of Environmental Sciences 2016年第2期28卷 154-160页

作者： Yanli Wang Wen Yang Bin Han Wenjie Zhang mindong Chen Zhipeng Bai State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences Collaborative Innovation Center of Atmospheric Environment and Equipment Technology Nanjing University of Information Science & Technology

Daily PM_（2.5）（particulate matter with an aerodynamic diameter of below 2.5 μm） mass concentrations were measured by gravimetric analysis in Chinese Research Academy of Environmental Sciences（CRAES）, in the northern part of the Beijing urban area, from December 2013 to April 2015. Two pairs of Teflon（T1/T2） and Quartz（Q1/Q2） samples were obtained, for a total number of 1352 valid filters. Results showed elevated pollution in Beijing,with an annual mean PM_（2.5）mass concentration of 102 μg/m^3. According to the calculated PM_（2.5）mass concentration, 50% of our sampling days were acceptable（PM_（2.5）〈 75 μg/m^3）, 30% had slight/medium pollution（75–150 μg/m^3）, and 7% had severe pollution（〉 250 μg/m^3）. Sampling interruption occurred frequently for the Teflon filter group（75%） in severe pollution periods,resulting in important data being missing. Further analysis showed that high PM_（2.5）combined with high relative humidity（RH） gave rise to the interruptions. The seasonal variation of PM_（2.5）was presented, with higher monthly average mass concentrations in winter（peak value in February, 422 μg/m^3）, and lower in summer（7 μg/m^3 in June）. From May to August, the typical summer period, least severe pollution events were observed, with high precipitation levels accelerating the process of wet deposition to remove PM_（2.5）. The case of February presented the most serious pollution, with monthly averaged PM_（2.5）of 181 μg/m^3 and 32% of days with severe pollution. The abundance of PM_（2.5）in winter could be related to increased coal consumption for heating needs.

关键词： PM_(2.5) Gravimetric analysis Sampling interruption Pollution level Relative humidity(RH) Seasonal variation

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Research situation and progress of non-equilibrium plasma chemistry

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Chinese Science Bulletin 2002年第7期47卷 529-530页

作者： Bai Xiyao Zhang Zhitao Han Hui Bai mindong Environmental Engineering Research Institute Dalian Maritime University Dalian China

Generally, the non-equilibrium plasma is produced at low pressure by a glow discharge (1.33Pa-1.33 kPa) including the radio frequency (13.56 MHz), microwave (2450 MHz), AC or DC high voltage discharges. As a method to directly apply energy to a reaction system, some successful applications have been obtained in the fields such as chemical synthesis and decomposition at plasma, sputtering and filming, deposition at the gas state, polymerization, modification on the material surface, etching, ashing at low temperature and so on. For example,

关键词： CO Research situation and progress of non-equilibrium plasma chemistry high

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Full time-domain nonlinear coupled dynamic analysis of a truss spar and its mooring/riser system in irregular wave

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Science China(Physics,Mechanics & Astronomy) 2014年第1期57卷 152-165页

作者： YANG mindong TENG Bin XIAO LongFei NING DeZhi SHI ZhongMin QU Yan Guangdong Electric Power Design Institute China Energy Engineering Group Co. Ltd. Department of Ocean Engineering Ocean University of China State Key Laboratory of Coastal and Offshore Engineering Dalian University of Technology State Key Laboratory of Ocean Engineering Shanghai Jiao Tong University Technology Research Department China National Offshore Oil Corporation

A new full time-domain nonlinear coupled method has been established and then applied to predict the responses of a Truss Spar in irregular wave. For the coupled analysis, a second-order time-domain approach is developed to calculate the wave forces, and a finite element model based on rod theory is established in three dimensions in a global coordinate system. In nu- merical implementation, the higher-order boundary element method （HOBEM） is employed to solve the velocity potential, and the 4th-order Adams-Bashforth-Moultn scheme is used to update the second-order wave surface. In deriving convergent solu- tions, the hull displacements and mooring tensions are kept consistent at the fairlead and the motion equations of platform and mooring-lines/risers are solved simultaneously using Newmark-fl integration scheme including Newton-Raphson iteration. Both the coupled quasi-static analysis and the coupled dynamic analysis are performed. The numerical simulation results are also compared with the model test results, and they coincide very well as a whole. The slow-drift responses can be clearly ob- served in the time histories of displacements and mooring tensions. Some important characteristics of the coupled responses are concluded.

关键词： coupled method full time-domain second-order truss spar rod theory irregular wave

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Application of MnCeO_(x)supported on palygorskite and Al(OH)_(3)for HCHO oxidation:Catalytic performance and stability

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Journal of Rare Earths 2022年第12期40卷 1860-1869,I0002页

作者： Qiong Huang Lirui Xu Yao Xiao Jie Zhu Guofang An Peiyang Li Bo Yang mindong Chen Hong Yang Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technologies Jiangsu Key Laboratory of Atmospheric Environmental Monitoring&Pollution ControlSchool of Environmental Science&EngineeringNanjing University of Information Science&TechnologyNanjing 210044China Department of Geography and Environmental Science University of ReadingWhiteknightsReadingRG66ABUK

Indoor formaldehyde(HCHO)is an important air pollutant,while it is very difficult to reduce HCHO to low-level(e.g.<0.08 mg/m^(3)).Catalytic oxidation at ambient temperature has been increasingly recognized as one of the important methods to mitigate HCHO pollution due to its good effectiveness,stability,and *** further improve the activity of catalytic oxidation,this study develops the integrated MnCeO_(x)catalysts supported on palygorskite(Pal)and aluminium hydroxide(Al(OH)_(3)).Our results indicate that the synergistic interaction in MnCeO_(x)through the oxygen transfer mechanism from the oxygen reservoir CeO_(2)to MnOxsignificantly improves the ***,Al(OH)_(3),*** applied as the supports with a focus on their dispersion,microstructure,strength,and relative ***_(x)can be anchored on the surface of Al(OH)_(3)with high *** the integrated catalyst,HCHO concentration decreases from 1.012 to 0.086 mg/m^(3)within 48 *** oxidation activity of MnCeO_(x)powder may be ascribed to the amount of active components on the *** incorporation of ZSM-5 and activated carbon can improve the adsorption of HCHO,and all integrated catalysts exhibit stronger activities,with HCHO being degraded to the level lower than 0.08 mg/m^(3).Meantime,the samples exhibit good stability and strength(20.2 MPa)without obvious decrease over five consecutive stability experiments.

关键词： MnCeOx Integrated catalysts Catalytic oxidation HCHO Ambient temperature Rare earths

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Chrysanthemum indicum ethanol extract attenuates hepatic stellate cell activation in vitro and thioacetamide-induced hepatofibrosis in rats

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Asian Pacific Journal of Tropical Biomedicine 2021年第11期11卷 500-509页

作者： Yun-Jin Chae Sushruta Koppula Myong-Ki Kim Tony Yoon mindong Song Department of Applied Life Science Graduate School of Konkuk University268 Chungwon-daeroChungju-siChungbuk27478Republic of Korea Department of Biotechnology College of Biomedical and Health SciencesKonkuk University268 Chungwon-daeroChungju-siChungbuk27478Republic of Korea Research Institute and College of Biomedical&Health Science Konkuk University268 Chungwon-daeroChungju-siChungbuk27478Republic of Korea Scholar Foxtrot Co. LTD501SinGwan-dong 5FJongam-ro 36-gilSeongbuk-guSeoul02796Republic of Korea Department of Food Science and Engineering Seowon UniversityCheongjuChungbuk 28674Republic of Korea Food One Corp 127Sincheoksandan 5-roDeoksan-eupJincheon-gunChungbuk 27850Republic of Korea

Objective:To investigate the antifibrotic effects of Chrysanthemum indicum ethanol extract(CIEE)against activated hepatic stellate cells(HSC)and thioacetamide(TAA)-induced hepatofibrosis in ***:Cell viability and proliferation of HSC-T6 cells were measured using MTT *** HSCs were used to study ***(200 mg/kg)was used to induced hepatic fibrosis in ***(100 and 500 mg/kg)and silymarin(50 mg/kg)were administered *** functions including alanine transaminase,aspartate transaminase,glutathione,and hydroxyproline levels were measured using commercial *** sections and fibrotic biomarker expression were measured using hematoxylin and eosin staining and real-time polymerase chain ***:In vitro study revealed that CIEE(0.1,0.25,and 0.5 mg/mL)inhibited the proliferation of activated HSCs exposed to transforming growth factor(TGF)-β and restored the activated primary HSC *** in vivo studies,TAA-induced increase in liver/body weight ratio(5.46±0.26)was significantly reduced(4.13±0.22)by CIEE(P<0.05 at 500 mg/kg).CIEE(100 and 500 mg/kg)improved the liver functions by significantly attenuating changes in alanine transaminase,aspartate transaminase,glutathione,and hydroxyproline levels(P<0.05).Further,CIEE(100 and 500 mg/kg)ameliorated the histological changes in liver tissue and TGF-β expression significantly(P<0.05)in TAA-induced ***:CIEE significantly protects against TAA-induced liver damage in rats and can be used in the treatment of liver fibrosis.

关键词： Chrysanthemum indicum Fibrosis Hepatoprotective Hydroxyproline Thioacetamide

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