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Epigenetics and environmental health

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Frontiers of Medicine 2024年第4期18卷 571-596页

作者： min.zhang Ting Hu Tianyu Ma Wei Huang Yan Wang Key Laboratory of Cancer and Microbiome State Key Laboratory of Molecular OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100021China Beijing Key Laboratory of Cancer Invasion and Metastasis Research Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesCapital Medical UniversityBeijing100069China

Epigenetic modifications including DNA methylation,histone modifications,chromatin remodeling,and RNA modifications complicate gene regulation and heredity and profoundly impact various physiological and pathological *** recent years,accumulating evidence indicates that epigenetics is vulnerable to environmental changes and regulates the growth,development,and diseases of individuals by affecting chromatin activity and regulating gene *** exposure or induced epigenetic changes can regulate the state of development and lead to developmental disorders,aging,cardiovascular disease,Alzheimer's disease,cancers,and so ***,epigenetic modifications are *** use of specific epigenetic inhibitors targeting epigenetic changes in response to environmental exposure is useful in disease ***,we provide an overview of the role of epigenetics in various ***,we summarize the mechanism of epigenetic alterations induced by different environmental exposures,the influence of different environmental exposures,and the crosstalk between environmental variation epigenetics,and genes that are implicated in the body's ***,the interaction of multiple factors and epigenetics in regulating the initiation and progression of various diseases complicates clinical *** discuss some commonly used epigenetic drugs targeting epigenetic modifications and methods to prevent or relieve various diseases regulated by environmental exposure and epigenetics through diet.

关键词： epigenetics environmental exposure health prevention and therapy

Traceable Lactate-Fueled Self-Acting Photodynamic Therapy against Triple-Negative Breast Cancer

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Research 2024年第3期2024卷 723-733页

作者： Yifan zhang Guangle Feng Ting He min Yang Jing Lin Peng Huang Marshall Laboratory of Biomedical Engineering International Cancer CenterShenzhen Key Laboratory of Tumor Visualization Molecular MedicineLaboratory of Evolutionary Theranostics(LET)School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen UniversityShenzhen518055China.

The depth of light penetration and tumor hypoxia restrict the efficacy of photodynamic therapy(PDT)in triple-negative breast cancer(TNBC),while the overproduction of lactate(LA)facilitates the development,aggressiveness,and therapy resistance of *** address these issues,a self-acting PDT nanosystem(HL@hMnO_(2)-LO_(x)@HA)is fabricated by loading 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-alpha(HPPH),luminol,and LA oxidase(LO_(x))in a hyaluronic acid(HA)-coated hollow manganese dioxide(hMnO_(2))***_(x) catalyzes the oxidation of LA into pyruvate and hydrogen peroxide(H_(2)O_(2)),thus depleting the overproduced intratumoral *** the acidic tumor microenvironment,H_(2)O_(2) reacts with luminol and hMnO_(2) to yield blue luminescence as well as O_(2) and Mn^(2+),***^(2+)could further enhance this *** is then excited by the chemiluminescence through chemiluminescence resonance energy transfer for self-illuminated *** generated O_(2) alleviates the hypoxia state of the TNBC tumor to produce sufficient 1O_(2) for self-oxygenation *** Mn^(2+)performs T1 magnetic resonance imaging to trace the self-acting PDT *** work provides a biocompatible strategy to conquer the limits of light penetration and tumor hypoxia on PDT against TNBC as well as LA overproduction.

关键词： Breast Therapy manganese

TULAM:trajectory-user linking via attention mechanism

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Science China(Information Sciences) 2024年第1期67卷 51-68页

作者： Hao LI Shuyu CAO Yaqing CHEN min.zhang Dengguo FENG Trusted Computing and Information Assurance Laboratory Institute of SoftwareChinese Academy of Sciences University of Chinese Academy of Sciences

Recently,the application of location-based services(LBS) has become a prevalent means to provide convenience in customers’ everyday ***,because massive volumes of location information are collected by LBS applications,users may suffer from serious privacy *** studies have shown that the identities of users can be inferred from historical anonymous trajectories,which is formulated as the trajectory-user linking(TUL) *** some recurrent neural network(RNN)-based models have been proposed to capture implicit movement patterns among trajectories to improve TUL performance,they cannot learn the sequential and contextual semantics within any individual trajectory completely,leaving the advantages of RNNs *** therefore propose an RNN model with an attention mechanism called TULAM to improve the accuracy of the TUL *** learns sequential relationships within individual trajectories via RNN and captures contextual semantics from trajectories via a multi-head attention ***,we propose a novel location encoding method called approximate one-hot to solve the corpus shortage problem of trajectory *** were conducted on real datasets from the Gowalla and Foursquare LBS *** experimental results indicate that TULAM is a practical solution that achieves significant improvements over existing methods with satisfactory model complexity and convergence.

关键词： information security data security and privacy trajectory-user linking deep learning recurrent neural network attention mechanism

Efficient optimization of electron transfer pathway by constructing phosphide/ceria interface boosts seawater hydrogen production

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Journal of Energy Chemistry 2024年第8期95卷 490-498,I0011页

作者： Yifan Zhao Lingfeng Yang Youyu Long min Xi Anran Chen Hua zhang School of Materials and Energy Yunnan UniversityKunming 650091YunnanChina Electron Microscopy Centre of Yunnan University Yunnan UniversityKunming 650091YunnanChina

Developing efficient and durable hydrogen evolution reaction(HER)electrocatalysts is one of the most important issues for the commercialization of seawater electrolysis,but it remains ***,we report a CeO_(2)-CoP nanoneedle array catalyst loaded on Ti mesh(CeO_(2)-CoP/TM)with workfunction-induced directional charge transport *** CeO_(2)-CoP/TM catalyst showed superior HER catalytic activity and stability,with over potentials of 41 and 60 mV to attain 10 mA cm^(-2),in 1 M KOH and 1 M KOH+seawater electrolyte,*** results and theoretical calculations reveal that the work function drives the charge transfer from CeO_(2)to CoP,which effectively balances the electronic density of CoP and CeO_(2),optimizes the d-band center,and accelerates the water activation kinetics,thus enhancing the HER *** solar-driven water electrolysis device displays a high and stable solar-to-hydrogen conversion efficiency of 19.6%.This study offers a work function-induced directional charge transport strategy to design efficient and durable catalysts for hydrogen production.

关键词： Work function Heterostructure Charge transport Seawater splitting Solar-to-hydrogen

Data-driven surrogate model for aerodynamic design using separable shape tensor method

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CHINESE JOURNAL OF AERONAUTICS 2024年第9期37卷 41-58页

作者： Pang, Bo zhang, Yang Li, Junlin Wang, Xudong Chang, min Bai, Junqiang Xi An Jiao Tong Univ State Key Lab Strength & Vibrat Mech Struct Xian 710049 Peoples R China Northwestern Polytech Univ Unmanned Syst Res Inst Xian 710072 Peoples R China

In the context of increasing dimensionality of design variables and the complexity of constraints, the efficacy of Surrogate-Based Optimization (SBO) is limited. The traditional linear and nonlinear dimensionality reduction algorithms are mainly to decompose the mathematical matrix composed of design variables or objective functions in various forms, the smoothness of the design space cannot be guaranteed in the process, and additional constraint functions need to be added in the optimization, which increases the calculation cost. This study presents a new parameterization method to improve both problems of SBO. The new parameterization is addressed by decoupling affine transformations (dilation, rotation, shearing, and translation) within the Grassmannian submanifold, which enables a separate representation of the physical information of the airfoil in a highdimensional space. Building upon this, Principal Geodesic Analysis (PGA) is employed to achieve geometric control, compress the design space, reduce the number of design variables, reduce the dimensions of design variables and enhance predictive performance during the surrogate optimization process. For comparison, a dimensionality reduction space is defined using 95% of the energy, and RAE 2822 for transonic conditions are used as demonstrations. This method significantly enhances the optimization efficiency of the surrogate model while effectively enabling geometric constraints. In three-dimensional problems, it enables simultaneous design of planar shapes for various components of the aircraft and high-order perturbation deformations. Optimization was applied to the ONERA M6 wing, achieving a lift-drag ratio of 18.09, representing a 27.25% improvement compared to the baseline configuration. In comparison to conventional surrogate model optimization methods, which only achieved a 17.97% improvement, this approach demonstrates its superiority. (c) 2024 Production and hosting by Elsevier Ltd. on behalf of Chine

关键词： Aerodynamic design Grassmannian manifold Shape parameterization Surrogate-based optimization Data dimensionality reduction WING DESIGN OPTIMIZATION

Surface reconstruction enabled o-PdTe@Pd core-shell electrocatalyst for efficient oxygen reduction reaction

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Chinese Chemical Letters 2024年第8期35卷 314-318页

作者： min Song Qian zhang Tao Shen Guanyu Luo Deli Wang Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of EducationSchool of Chemistry and Chemical EngineeringHuazhong University of Science and Technology(HUST)Wuhan 430074China

Palladium-based alloy catalysts have been employed as one of the potential candidates for oxygen reduc-tion reaction(ORR),but the dissolution of transition metal hinders their ***,structure or-dered PdTe intermetallic with Pd shell(o-PdTe@Pd)are synthesized via an electrochemical etching driven surface reconstruction *** surface reconstruction could tune the electronic structure,weaken the adsorption energy of reaction intermediates on o-PdTe@Pd,resulting in enhanced electrocatalytic ac-tivity for *** mass activity of o-PdTe@Pd is about 3.3 and 2.7 times higher than that of Pd/C in acid and alkaline,***,the half-potentials for ORR decay only about 44 mV and 12 mV after 30 k cycles accelerated durability test in acid and alkaline media,*** enhanced dura-bility originates from the resistance of Te atoms dissolve in the ordered PdTe intermetallic core and the core-shell *** assembled in a Zn-air battery,o-PdTe@Pd electrode delivers a higher specific capacity(794 mAh/g)and better cycling stability than Pt/C.

关键词： Surface reconstruction Core-shell structure Intermetallic Oxygen reduction reaction Tellurium

Enhanced photocatalytic performance of Bi_(2)O_(2)CO_(3)/Bi_(4)O_(5)Br_(2)/reduced graphene oxide Z-schemehe terojunction via a one-pot room-temperature synthesis

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Journal of Environmental Sciences 2024年第4期138卷 418-427页

作者： Xiaoge Wu Lei Yan Rongrong Qin Qikai zhang Wei Yang Xiaozhi Wang Yongcai zhang min Luo Jianhua Hou College of Environmental Science and Engineering Yangzhou UniversityYangzhouJiangsu 225009China Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization Nanjing 210095China Beijing Xinfeng Aerospace Equipment Co. Ltd.Beijing 100854China Beijing System Design Institute of Electro-Mechanic Engineering Beijing 100005China College of Chemistry and Chemical Engineering Ningxia UniversityYinchuanNingxia 750021China

Bi_(2)O_(2)CO_(3)(BOC)/Bi_(4)O_5Br_(2)(BOB)/reduced graphene oxide(rGO)Z-scheme heterojunction with promising photocatalytic properties was synthesized via a facile one-pot room-temperature ***-thin nanosheets of BOC and BOB were grown in situ on r *** formed 2D/2D direct Z-scheme heterojunction of BOC/BOB with oxygen vacancies(OVs)effectively leads to lower negative electron reduction potential of BOB as well as higher positive hole oxidation potential of BOC,showing improved reduction/oxidation ***,rGO is an acceptor of the electrons from the conduction band of *** dual roles significantly improve the transfer performance of photo-induced charge carriers and accelerate their *** layered nanosheet structure,rich OVs,high specific surface area,and increased utilization efficiency of visible light,the multiple synergistic effects of BOC/BOB/rGO can achieve effective generation and separation of the electron-holes,thereby generating more·O_(2)^(-)and h^(+).The photocatalytic reduction efficiency of CO_(2)to CO(12.91μmol/(g·hr))is three times higher than that of BOC(4.18μmol/(g·hr)).Moreover,it also achieved almost 100%removal of Rhodamine B and cyanobacterial cells within 2 hours.

关键词： Bi_(2)O_(2)CO_(3) Bi_(4)O_(5)Br_(2) Reduced graphene oxide Z-scheme heterojunction Photocatalysis CO_(2)reduction

High spectral efficiency 4-mode 400-km transmission using hybrid probabilistically and geometrically shaped 128QAM

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Science China(Technological Sciences) 2024年第5期67卷 1628-1630页

作者： DING JunJie YU JianJun WANG Chen LONG JianYu ZHU min.zhang Jiao Pervasive Communication Research Center Purple Mountain LaboratoriesNanjing 211111China Key Laboratory for Information Science of Electromagnetic Waves(MoE) Fudan UniversityShanghai 200433China

Wavelength division multiplexing(WDM)and space division multiplexing(SDM)based on few-mode fiber(FMF)and multi-core fiber(MCF)have been vigorously developed to increase the transmission capacity of optical communication networks[1–5].However,the mode crosstalk generated in the mode division multiplexing(MDM)system causes the correlation between different mode signals,which seriously damages the transmission ***,an effective multiple-input-multiple-output(MIMO)time domain or frequency domain equalizer should be used to eliminate the crosstalk between different mode signals.

关键词： crosstalk fiber multiplexing

Research on a TOPSIS energy efficiency evaluation system for crude oil gathering and transportation systems based on a GA-BP neural network

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Petroleum Science 2024年第1期21卷 621-640页

作者： Xue-Qiang zhang Qing-Lin Cheng Wei Sun Yi Zhao Zhi-min Li Key Lab of ministry of Education for Enhancing the Oil and Gas Recovery Ratio Northeast Petroleum UniversityDaqing163318HeilongjiangChina China Petroleum Pipeline Material and Equipment Co. LtdLangfang065000HebeiChina Research Institute of Petroleum Engineering and Technology Sinopec Northwest Oilfield CompanyUrumqi830011XinjiangChina

As the main link of ground engineering,crude oil gathering and transportation systems require huge energy consumption and complex *** is necessary to establish an energy efficiency evaluation system for crude oil gathering and transportation systems and identify the energy efficiency *** this paper,the energy efficiency evaluation system of the crude oil gathering and transportation system in an oilfield in western China is *** with the big data analysis method,the GA-BP neural network is used to establish the energy efficiency index prediction model for crude oil gathering and transportation *** comprehensive energy consumption,gas consumption,power consumption,energy utilization rate,heat utilization rate,and power utilization rate of crude oil gathering and transportation systems are *** the efficiency and unit consumption index of the crude oil gathering and transportation system,the energy efficiency evaluation system of the crude oil gathering and transportation system is established based on a game theory combined weighting method and TOPSIS evaluation method,and the subjective weight is determined by the triangular fuzzy analytic hierarchy *** entropy weight method determines the objective weight,and the combined weight of game theory combines subjectivity with objectivity to comprehensively evaluate the comprehensive energy efficiency of crude oil gathering and transportation systems and their ***,the weak links in energy utilization are identified,and energy conservation and consumption reduction are *** above research provides technical support for the green,efficient and intelligent development of crude oil gathering and transportation systems.

关键词： Crude oil gathering and transportation system GA-BP neural network Energy efficiency evaluation TOPSIS evaluation method Energy saving and consumption reduction