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Effect of Stable Magnetic Field on the Phase Transformation of Sr3 Steel

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材料热处理学报 2004年第5期25卷 638-640页

作者： WANGYa-nan LIAODai-qiang WUZhan-jun AnshanUniversityofScienceandTechnology Anshan114044China

The experimental equipment designed by the author was used to carry out quenching treatments on Sr3 steel, with and without magnet it field in different quenching mediums. The effect of steady magnetic field on the phase transformation of Sr3 steel was studied by metallographic microscope and scanning electron microscope. The result shows: the application of magnetic field can obviously increase the volume fraction of ferrite during the austenite to ferrite transformation of Sr3 steel, promote the ferrite grains refining and homogenization, and get the pearlite beam much homogeneously and much compact, when Sr3 steel is quenched in the water.

关键词：稳定磁场 Sr3钢相变淬火

18 MHz彩色多普勒超声检查对黄斑前膜的临床诊断价值

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国际眼科杂志 2025年第1期25卷 144-147页

作者：赵骏李亚楠贾洪强刘敏白俊平沧州市眼科医院功能科 061001 沧州市眼科医院眼底病科 061001

目的:探讨18 MHz彩色多普勒超声对黄斑前膜的诊断价值。方法:收集2020-01/2022-01期间在我院经眼底检查拟诊白内障和玻璃体混浊的患者44例80眼,分别通过光学相干断层扫描法(OCT)与18 MHz彩色多普勒超声对患眼进行检查,比较18 MHz彩色多... 详细信息

目的:探讨18 MHz彩色多普勒超声对黄斑前膜的诊断价值。方法:收集2020-01/2022-01期间在我院经眼底检查拟诊白内障和玻璃体混浊的患者44例80眼,分别通过光学相干断层扫描法(OCT)与18 MHz彩色多普勒超声对患眼进行检查,比较18 MHz彩色多普勒超声与OCT对黄斑前膜诊断敏感度、特异性、准确度的差异。结果:经18 MHz彩色多普勒超声检测80眼中,62眼为黄斑前膜,18眼为非黄斑前膜;经OCT确诊确实为黄斑前膜的54眼,非黄斑前膜的13眼,漏诊5眼,误诊8眼;18 MHz彩色多普勒超声与OCT诊断一致性较高(Kappa=0.892,P0.05)。结论:18 MHz彩色多普勒超声对黄斑前膜病变具有一定鉴定价值,与OCT检验具有一致性。

关键词： 18 MHz彩色多普勒超声黄斑前膜光学相干断层扫描法(OCT)

Ferroelectricity and multiferroicity： Broader way to go beyond

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Frontiers of physics 2012年第4期7卷 373-374页

作者： jun-ming Liu Ce-Wen nan Department of Physics Nanjing University Nanjing 210093 China Department of Materials Science and Engineering Tsinghua University Beijing 100084 China

Ferroelectrics and magnetics represent two major classes of functional materials which peo- ple find everywhere in daily life, though they are usually beyond the views of people and hidden inside the hearts of most devices. While spintronies [1] comes into being, reviving magnetism which has been as old as ferroelectricity, since decades ago the physics of fer- roeleetries has turned its attention to the domain scale from the atomic level at which the physics was believed to be well understood [2]. As is well known, it is a small world, and ferroelectricity finally has its marriage with magnetism at a proper time [3], giving birth to multiferroicity, a concurrent and aggressive field of condensed matter physics where both ferroelectricity and magnetism can find their fans [4]. Consequently, multiferroicity bridges ferroelectricity and magnetism in an extraordinary manner, generating a number of novel phenomena and raising a pocket of key issues.

关键词： condensed matter physics functional materials atomic level small world

Hedgehog pathway orchestrates the interplay of histone modifications and tailors combination epigenetic therapies in breast cancer

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Acta Pharmaceutica Sinica B 2023年第6期13卷 2601-2612页

作者： Xiaomin Wang jun Xu Yiming Sun Siyuwei Cao Hanlin Zeng nan Jin Matthew Shou Shuai Tang Yi Chen min Huang Cancer Research Center State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Division of Diabetes Endocrinology and MetabolismDepartment of Molecular Physiology and BiophysicsVanderbilt University Medical CenterNashvilleTN 37232USA

Epigenetic therapies that cause genome-wide epigenetic alterations,could trigger local interplay between different histone marks,leading to a switch of transcriptional outcome and therapeutic responses of epigenetic ***,in human cancers with diverse oncogenic activation,how oncogenic pathways cooperate with epigenetic modifiers to regulate the histone mark interplay is poorly *** herein discover that the hedgehog(Hh)pathway reprograms the histone methylation landscape in breast cancer,especially in triple-negative breast cancer(TNBC).This facilitates the histone acetylation caused by histone deacetylase(HDAC)inhibitors and gives rise to new therapeutic vulnerability of combination ***,overexpression of zinc finger protein of the cerebellum 1(ZIC1)in breast cancer promotes Hh activation,facilitating the switch of H3K27 methylation(H3K27me)to acetylation(H3K27ac).The mutually exclusive relationship of H3K27me and H3K27ac allows their functional interplay at oncogenic gene locus and switches therapeutic *** multiple in vivo breast cancer models including patient-derived TNBC xenograft,we show that Hh signaling-orchestrated H3K27me and H3K27ac interplay tailors combination epigenetic drugs in treating breast ***,this study reveals the new role of Hh signaling-regulated histone modifications interplay in responding to HDAC inhibitors and suggests new epigenetically-targeted therapeutic solutions for treating TNBC.

关键词： HDAC inhibitors Drug resistance Histone methylation Histone acetylation Epigenetic interplay Hedgehog pathway ZIC1 LIFR Combination therapy Breast cancer

Optimized nanoparticle-mediated delivery of CRISPR- Cas9 system for B cell intervention

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nano Research 2018年第12期11卷 6270-6282页

作者： min Li Ya-nan Fan Zhi-Yao Chen Ying-Li Luo Yu-Cai Wang Zhe-Xiong Lian Cong-Fei Xu jun Wang School of Life Sciences University of Science and Technology of ChinaHefei230027China Institutes for Life Sciences School of MedicineSouth China University of TechnologyGuangzhou 510006China School of Biomedical Sdence and Engineering South China University of TechnologyGuangzhou 510006China National Engineering Research Center for 7issue Restoration and Reconstruction South China University of TechnologyGuangzhou 570006China Key Laboratory of Biomedical Engineering of Guangdong Province South China University of TechnologyGuangzhou 510006China

B cells exert multiple effector functions, and dysfunctions of B cells often lead to initiation and progression of diseases, including autoimmune and inflammatory diseases. Therefore, B cell intervention may be an effective strategy to treat diseases involving B cells. The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 gene editing system has been widely used for DNA deletion, insertion, and replacement. nanocarriers have been developed as relatively mature systems and may be applied to deliver the CRISPR-Cas9 system to B cells in vivo. In this study, we created a library of nanoparticles (NPs) with different polyethylene glycol densities and zeta potentials and screened an optimal NP for in vivo B cell targeting. The selected NP could deliver the CRISPR-Cas9 system to B cells and induce Cas9 expression inside the cell environment. Injection of the NP encapsulated with Cas9/gB220 (NPCas9/gB220) into mice could disrupt B220 expression in B cells, suggestive of its applications to intervene the expression of the target molecule in B cells. Moreover, the treatment with NPCas9/gBAFFR could decrease the number of B cells and exert therapeutic effect in rheumatoid arthritis, as B-cell activating factor receptor (BAFFR) is vital for the survival and functions of B cells. In conclusion, we developed a carrier for the delivery of the CRISPR-Cas9 gene editing system for B cell intervention that could be used for the treatment of diseases related to B cell dysfunctions.

关键词： B cell gene editing nanoparticle immune intervention autoimmunity ABSTRACT

Recent advances in the application of metal organic frameworks using in advanced oxidation progresses for pollutants degradation

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Chinese Chemical Letters 2022年第12期33卷 5013-5022页

作者： Heshan Zheng Yunying Hou Shuo Li jun Ma jun nan Tong Li College of Chemistry and Chemical Engineering Qiqihar UniversityQiqihar 161006China Urban Water Resources Development and Northern National Engineering Research Center Harbin 150090China School of Environment Harbin Institute of TechnologyHarbin 150090China School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China

Metal-organic frameworks(MOFs)materials with highly ordered and porous crystalline structure,have excellent performance in advanced oxidation progresses(AOPs)for organic contaminants degradation in water *** review intends to summarize the timely references and insights for the recent advances in MOFs that are used in *** with the preparation methodologies,including conventional hydrothermal method,electrochemical method,sol-gel method,and emerging microwave and ultrasound assisted synthesis *** and mechanism for MOFs using in various AOPs of Fenton-like,photocatalysis,catalytic ozonation,persulfate catalysis and other emerging oxidation methods are emphatically *** hope this review can comprehensively summarize the research and application progress of MOFs in AOPs,deepen the understanding of the catalytic mechanisms.

关键词： Advanced oxidation progresses Metal-organic frameworks Contaminants degradation Synthesis methods Catalysis mechanism

Study on catalytic mechanisms of Fe_(3)O_(4)-rGO_(x) in three typical advanced oxidation processes for tetracycline hydrochloride degradation

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Chinese Chemical Letters 2023年第1期34卷 420-425页

作者： Heshan Zheng Yunying Hou Shuo Li jun Ma jun nan nannan Wang College of Chemistry and Chemical Engineering Qiqihar UniversityQiqihar 161006China Urban Water Resources Development and Northern National Engineering Research Center Harbin 150090China School of Environment Harbin Institute of TechnologyHarbin 150090China Department of Environmental Engineering Beijing Institute of Petrochemical TechnologyBeijing 102617China

This study explored the catalytic mechanism and performance impacted by the materials ratio of Fe_(3)O_(4)-GO_(x) composites in three typical advanced oxidation processes(AOPs)of O_(3),peroxodisulfate(PDS)and photo-Fenton processes for tetracycline hydrochloride(TCH)*** ratio of GO in the Fe_(3)O_(4)-GO_(x) composites exhibited different trends of degradation capacity in each AOPs based on different ***_(3)O_(4)-rGO_(20wt%) exhibited the optimum catalytic performance which enhanced the ozone decomposition efficiency from 33.48%(ozone alone)to 51.83%with the major reactive oxygen species(ROS)of O_(2)·-.In PDS and photo-Fenton processes,Fe_(3)O_(4)-rGO_(5wt%) had the highest catalytic performance in PDS and H_(2)O_(2) decomposition for SO_(4)·–,and·OH generation,*** with using PDS alone,PDS decomposition rate and TCH degradation rate could be increased by 5.97 and 1.73 times under Fe_(3)O_(4)-rGO_(5wt%) *** the photo-Fenton system,Fe_(3)O_(4)-rGO_(5wt%) with the best catalyst performance in H_(2)O_(2) decomposition,and TCH degradation rate increased by 2.02 times compared with blank ***,the catalytic mechanisms in those systems of that the ROS produced by conversion between Fe^(2+)/Fe^(3+)were also analyzed.

关键词： Advanced oxidation progresses Fe_(3)O_(4) Graphene oxide Mechanism Reactive oxygen species

Distributed Adaptive Tracking Control for Unknown Nonlinear Networked Systems

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自动化学报 2013年第10期39卷 1729-1735页

作者： PENG jun-min WANG Jia-nan YE Xu-Dong College of Electrical Engineering Zhejiang University Hangzhou 310027 China Department of Electrical Engineering and Computer Science University of Central Florida Orlando FL 32826 USA

在这份报纸，我们为易于一个积极领导人，其仅仅说罐头的非线性的不明确的联网的系统的一个类调查合作追踪问题部分被测量，输入隧道也被扰乱。由神经网络(NN ) 的优点技术，追随者的动力学适当地在某些基础功能上被建模，他们的输入隧... 详细信息

在这份报纸，我们为易于一个积极领导人，其仅仅说罐头的非线性的不明确的联网的系统的一个类调查合作追踪问题部分被测量，输入隧道也被扰乱。由神经网络(NN ) 的优点技术，追随者的动力学适当地在某些基础功能上被建模，他们的输入隧道被假定也被扰乱。在这个工作，基于观察员的适应控制为可以有非相同的动力学的非线性的联网的系统被建议。它被适当地在一些图状况下面选择参数经由 Lyapunov 理论(UUB ) 显示出全面系统最终一致地合作地被围住。最后，几数字模拟为建议适应控制器的确认被详细描述。

关键词：非线性网络系统自适应跟踪控制 Lyapunov理论分布式自适应控制器一致最终有界网络化系统动力非线性

Sliding Mode Control for Flexible-link Manipulators Based on Adaptive Neural Networks

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International Journal of Automation and computing 2018年第2期15卷 239-248页

作者： Hong-jun Yang min Tan State Key Laboratory of Management and Control for Complex Systems Institute of AutomationChinese Academy of Sciences

This paper mainly focuses on designing a sliding mode boundary controller for a single flexible-link manipulator based on adaptive radial basis function （RBF） neural network. The flexible manipulator in this paper is considered to be an Euler-Bernoulli beam. We first obtain a partial differential equation （PDE） model of single-link flexible manipulator by using Hamiltons approach. To improve the control robustness, the system uncertainties including modeling uncertainties and external disturbances are compensated by an adaptive neural approximator. Then, a sliding mode control method is designed to drive the joint to a desired position and rapidly suppress vibration on the beam. The stability of the closed-loop system is validated by using Lyapunov＇s method based on infinite dimensional model, avoiding problems such as control spillovers caused by traditional finite dimensional truncated models. This novel controller only requires measuring the boundary information, which facilitates implementation in engineering practice. Favorable performance of the closed-loop system is demonstrated by numerical simulations.

关键词： Sliding mode control adaptive control neural network flexible manipulator partial differential equation (PDE).