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Tongxinluo promotes mesenchymal stem cell tube formation in vitro

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第8期12卷 644-651页

作者： Xin-yang HU Wen-xia WANG min-jia yu Xian-bao LIU Rong-rong WU Feng GAO Xin HUANG jiang CAO Xiao-jie XIE jian-an WANG Cardiovascular Key Lab of Zhejiang Province the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China Department of Cardiology the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China

Objective： To study whether Tongxinluo （TXL） can induce angiogenesis in bone marrow mesenchymal stem cells （MSCs）, and to investigate the underlying mechanism. Methods： Bone marrow MSCs were obtained from male Sprague-Dawley rats. We established an angiogenesis model in vitro via matrigel experiment. MSCs were seeded on matrigel coated 24-well plates, and treated by TXL 50 and 100 mg/L. After 24 h, we observed the tube formations of MSCs in the matrigel. Cell migration ability was examined by wound scratch test and transwell assay. Expressions of vascular endothelial growth factor （VEGF）, fetal liver kinase-1 （FIk-1）, matrix metalloproteinase-2 （MMP-2）, MMP-9, and tissue inhibitor of metalloproteinase-2 （TIMP-2） were analyzed at the protein level by Western blot. Gelatin zymography assay was applied to investigating the MSC paracrine abilities of pro-MMP-2 and activated MMP-2. Results： TXL promoted MSC tube formation in matrigel. The ratio of TXL 100 mg/L treated-MSC tubular length was increased 3.04-fold compared to the control group （P〈0.05）. Scratch test and transwell assay showed that TXL could improve the cell migration ability of MSCs. Western blot experiments showed that TXL promoted MSC synthesis of MMP-2, but it had no influence on the expressions of MMP-9 and TIMP-2. This effect was confirmed by gelatin zymography assay, which showed that TXL increased MSC secretion of pro-MMP-2 and activated MMP-2. VEGF expression of TXL treated-MSCs was increased compared to the control group. The expression of FIk-1 was not different among the groups. Conclusions： This study demonstrates that TXL can promote the tube formation of MSCs, and the underlying mechanisms are associated with increased migration ability of MSCs and the up-regulation of MMP-2 and VEGF expressions.

关键词： Bone marrow mesenchymal stem cells Tongxinluo Angiogenesis Migration Tube formation

Ideal Bi‑Based Hybrid Anode Material for Ultrafast Charging of Sodium‑Ion Batteries at Extremely Low Temperatures

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Nano-Micro Letters 2025年第3期17卷 152-167页

作者： Jie Bai jian Hui jia yu Wang Chun Cheng Yang Qing jiang Key Laboratory of Automobile Materials(Jilin University) Ministry of EducationSchool of Materials Science and EngineeringJilin UniversityChangchun 130022People’s Republic of China

Sodium-ion batteries have emerged as competitive substitutes for low-temperature applications due to severe capacity loss and safety concerns of lithium-ion batteries at−20°C or ***,the key capability of ultrafast charging at ultralow temperature for SIBs is rarely ***,a hybrid of Bi nanoparticles embedded in carbon nanorods is demonstrated as an ideal material to address this issue,which is synthesized via a high temperature shock *** a hybrid shows an unprecedented rate performance(237.9 mAh g^(−1)at 2 A g^(−1))at−60℃,outperforming all reported SIB anode *** with a Na_(3)V_(2)(PO_(4))_(3)cathode,the energy density of the full cell can reach to 181.9 Wh kg^(−1)at−40°*** on this work,a novel strategy of high-rate activation is proposed to enhance performances of Bi-based materials in cryogenic conditions by creating new active sites for interfacial reaction under large current.

关键词： Bi nanoparticles High temperature shock High-rate activation Ultrafast charging Low-temperature sodium-ion batteries

Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-min Qin Zhongliang Li Wen‑Xia Su jia‑min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan yue‑Peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

Integration of Electrical Properties and Polarization Loss Modulation on Atomic Fe–N‑RGO for Boosting Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第2期17卷 517-532页

作者： Kaili Zhang yuefeng Yan Zhen Wang Guansheng Ma Dechang jia Xiaoxiao Huang yu Zhou State Key Laboratory of Precision Welding&Joining of Materials and Structures Harbin Institute of TechnologyHarbin 150001People’s Republic of China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001People’s Republic of China MIIT Key Laboratory of Advanced Structural‑Functional Integration Materials&Green Manufacturing Technology Harbin Institute of TechnologyHarbin 150001People’s Republic of China

Developing effective strategies to regulate graphene’s conduction loss and polarization has become a key to expanding its application in the electromagnetic wave absorption(EMWA)*** on the unique energy band structure of graphene,regulating its bandgap and electrical properties by introducing heteroatoms is considered a feasible ***,metal-nitrogen doping reduced graphene oxide(M–N-RGO)was prepared by embedding a series of single metal atoms M–N_(4) sites(M=Mn,Fe,Co,Ni,Cu,Zn,Nb,Cd,and Sn)in RGO using an N-coordination atom-assisted *** composites had adjustable conductivity and polarization to optimize dielectric loss and impedance matching for efficient EMWA *** results showed that the minimum reflection loss(RL_(min))of Fe–N-RGO reaches−74.05 dB(2.0 mm)and the maximum effective absorption bandwidth(EAB_(max))is 7.05 GHz(1.89 mm)even with a low filler loading of only 1 wt%.Combined with X-ray absorption spectra(XAFS),atomic force microscopy,and density functional theory calculation analysis,the Fe–N_(4) can be used as the polarization center to increase dipole polarization,interface polarization and defect-induced polarization due to d-p orbital hybridization and structural ***,electron migration within the Fe further leads to conduction loss,thereby synergistically promoting energy *** study demonstrates the effectiveness of metal-nitrogen doping in regulating the graphene′s dielectric properties,which provides an important basis for further investigation of the loss mechanism.

关键词： Electromagnetic wave absorption Fe-N-RGO Dipole polarization Conduction loss Impedance matching

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舟山风力智能网格精细化订正释用技术

海洋预报 2021年第6期38卷 48-55页

作者：於敏佳刘菡李晓丽舟山市气象局浙江舟山316000

介绍了一种智能网格订正释用技术,该技术对EC细网格风力资料进行线性加密,对比其结果和站点平均风实况,采用逐时加权滚动更新的方法,利用站点平均风和极大风关系,进行订正释用。检验浙江省气象局指定的12个考核关键点0~6 h、0~12 h、0~2... 详细信息

介绍了一种智能网格订正释用技术,该技术对EC细网格风力资料进行线性加密,对比其结果和站点平均风实况,采用逐时加权滚动更新的方法,利用站点平均风和极大风关系,进行订正释用。检验浙江省气象局指定的12个考核关键点0~6 h、0~12 h、0~24 h和0~48 h的平均极大风绝对误差分别为1.14 m/s、1.23 m/s、1.48 m/s和1.72 m/s。开发的舟山风力智能网格精细化订正释用平台对2020年台风“美莎克”的风力预报较为精准,4个县区局预报过程极大风力绝对误差平均仅为1.25 m/s,对9月11日小尺度低压风力预报的修正效果显著,嵊泗站点极大风力由9~10级修正到7级以下。

关键词： EC细网格线性加密平均风极大风订正释用平台

Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

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Neural Regeneration Research 2025年第10期20卷 3025-3039页

作者： jia Fang Zhuangzhuang Li Pengjun Wang Xiaoxu Zhang Song Mao Yini Li Dongzhen yu Xiaoyan Li Yazhi Xing Haibo Shi Shankai Yin Department of Otolaryngology Head and Neck Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina Department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron

《中医体质分类与判定》标准颁布后5年内中医体质学的文献计量学分析

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中华中医药杂志 2016年第2期31卷 599-601页

作者：闵佳钰孙淑娴包蕾王济北京中医药大学北京100029

目的:分析2009年《中医体质分类与判定》标准发布后,国内中医体质研究的特征、规律、及发展趋势。方法:以中国知识基础设施工程(CNKI)数据库为资料来源,对2009年4月9日至2014年4月9日国内正式发表的2 369篇中医体质文献进行文献计量学... 详细信息

目的:分析2009年《中医体质分类与判定》标准发布后,国内中医体质研究的特征、规律、及发展趋势。方法:以中国知识基础设施工程(CNKI)数据库为资料来源,对2009年4月9日至2014年4月9日国内正式发表的2 369篇中医体质文献进行文献计量学分析。结果:中医体质文献数量近5年来呈快速增长趋势,覆盖多个学科领域和研究方向,获得多项科研基金资助,已形成核心作者,北京、广州等地区对其研究处于领先地位。结论:中医体质学已基本形成核心论坛,成为中医学研究领域的热点,在临床及基础各学科中被广泛应用,但尚存在研究深度不足的问题。应加强辨体调治以及体质基础实验的研究。

关键词：中医体质分类与判定中医体质学文献计量学

EC细网格产品在复杂海岛地形条件下的大风滚动订正释用

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海洋预报 2021年第2期38卷 55-61页

作者：於敏佳刘菡王倩胡潇杰舟山市气象局浙江舟山316000

应用EC细网格资料和站点实况资料,结合风速高度订正和分风向误差风速分析,建立考虑地形的PP法模型。释用结果表明:考虑地形的PP法模型能有效提高EC细网格产品大风预报精度,平均绝对误差低至2.57 m/s;应用卡尔曼滤波法实时吸收最新资料,... 详细信息

应用EC细网格资料和站点实况资料,结合风速高度订正和分风向误差风速分析,建立考虑地形的PP法模型。释用结果表明:考虑地形的PP法模型能有效提高EC细网格产品大风预报精度,平均绝对误差低至2.57 m/s;应用卡尔曼滤波法实时吸收最新资料,能实现释用模型回归系数的滚动更新,预报风速平均绝对误差由2.91 m/s降至2.66 m/s。

关键词： EC细网格风速误差高度订正 PP法地形卡尔曼滤波法

阿奇霉素与红霉素治疗小儿支原体肺炎的疗效比较

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中国新药与临床杂志 1999年第5期18卷 265-266页

作者：陆敏余嘉飞上海市儿童医院呼吸科!上海200040

目的 :比较阿奇霉素与红霉素治疗小儿支原体肺炎的疗效。方法 :79例支原体病人分 2组 ,阿奇霉素组 41例 (男性 2 2例 ,女性 19例 ,年龄 7.9a±s 1.6a)用阿奇霉素 10mg/kg ,po ,qd× 3d。红霉素组 38例 (男性 2 1例 ,女性 17例 ,年龄 7.8... 详细信息

目的 :比较阿奇霉素与红霉素治疗小儿支原体肺炎的疗效。方法 :79例支原体病人分 2组 ,阿奇霉素组 41例 (男性 2 2例 ,女性 19例 ,年龄 7.9a±s 1.6a)用阿奇霉素 10mg/kg ,po ,qd× 3d。红霉素组 38例 (男性 2 1例 ,女性 17例 ,年龄 7.8a±2 .3a)用红霉素 2 5～ 30mg/ (kg·d) ,iv ,qd× 10d。结果 :有效率前者 98% ,后者 95 % (P >0 .0 5 ) ,显效率分别为 76%和 5 3% (P <0 .0 5 ) ,不良反应发生率分别为 7%和 39% (P <0 .0 1)。结论 :阿奇霉素治疗小儿支原体肺炎显效率优于红霉素 ,不良反应较红霉素小。

关键词：阿奇霉素红霉素支原体属肺炎