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生长激素对小鼠结肠腺癌肝转移瘤的影响

实用肿瘤杂志 2001年第2期16卷 90-93页

作者：许勤马利民桑剑峰吴文溪南京医科大学第一附属医院胃肠外科江苏南京210029

目的　研究重组人生长激素 (rh GH)对小鼠结肠腺癌肝转移瘤的影响。方法　 BAL B/ c小鼠 2 8只随机分为对照组和实验组 ,利用小鼠结肠腺癌细胞 (CT2 6 )经脾接种建立肝转移动物模型后 ,GH实验组每日皮下注射rh GH 2 U / kg,对照组皮下... 详细信息

目的　研究重组人生长激素 (rh GH)对小鼠结肠腺癌肝转移瘤的影响。方法　 BAL B/ c小鼠 2 8只随机分为对照组和实验组 ,利用小鼠结肠腺癌细胞 (CT2 6 )经脾接种建立肝转移动物模型后 ,GH实验组每日皮下注射rh GH 2 U / kg,对照组皮下注射生理盐水 ,均 7天。各组部分小鼠 (n=8)于瘤细胞接种 2周后处死 ,观察肝转移瘤数目、肝脏重量 ,并采用流式细胞术作肿瘤细胞 DNA周期分析 ,各组其余小鼠 (n=6 )待其自然死亡 ,记录生存期。结果　 GH组小鼠体重增加显著 ,其血浆总蛋白 (5 4.6 6± 2 .2 1) g/ L明显高于对照组 (47.2 4± 4.93) g/ L (P0 .0 5 ) ,但 GH组肝脏重量 (3.5 3± 2 .2 0 ) g较对照组 (2 .2 0± 0 .77) g增加。 DNA细胞周期分析显示 GH组分裂期 (G2 / M期 )细胞百分比 (9.97± 4.5 1)高于对照组(5 .40± 1.95 ,P0 .0 5 )。结论　 rh GH促使肿瘤细胞进入分裂期 ,肿瘤病人如无其他抗肿瘤治疗应尽量避免单独使用 rh GH。

关键词：重组人生长激素结肠肿瘤肿瘤转移动物模型肝转移瘤

Fulvic acid degradation using nanoparticle TiO_2 in a submerged membrane photocatalysis reactor

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Journal of Environmental Sciences 2005年第6期17卷 942-945页

作者： FU jian-feng JI min AN Ding-nian School of Environmental Science and Engineering Tianjin University Tianjin 300072 China

The degradation of fulvic acid（FA） by nanoparticle TiO2 in a submerged membrane photocatalysis（SMPC） reactor was studied. In this reactor, photocatalytic oxidation and membrane separation co-occured. The continuous air supplier provided O2 for the photocatalytical reaction and mixed the solution through an airflow controller. The particle TiO2 could automatically settle due to gravity without particle agglomeration so it could be easily separated by microfiltration（MF） membrane. It was efficient to maintain high flux of membranes. The effects of operational parameters on the photocatalytic oxidation rate of FA were investigated. Results indicated that photocatalyst at 0.5 g/L and airflow at 0.06 m^3/h were the optimum condition for the removal of fulvic acid, the removal efficiency was higher in acid media than that in alkaline media. The effects of different filtration duration on permeate flux rate of MF with P25 powder and with nanoparticle TiO2 were compared. Experimental results indicated that the permeate flux rate of MF was improved and the membrane fouling phenomenon was reduced with the addition of nanoparticle TiO2 catalyst compared with conventional P25 powder. Therefore, this submerged membrane photocatalysis reactor can faciliate potential application of photocatalytic oxidation process in drinking water treatment.

关键词： fulvic acid microfiltration membrane nanoparticle TiO2 photocatalytic oxidation reactor

Electron beam irradiation induced metastable phase in a Mg-9.8 wt%Sn alloy

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Journal of Materials Science & Technology 2021年第25期84卷 133-138页

作者： Chaoqiang Liu Houwen Chen min Song jian-feng Nie State Key Laboratory of Powder Metallurgy Central South UniversityChangsha410083China College of Materials Science and Engineering Chongqing UniversityChongqing400044China Electron Microscopy Center Chongqing UniversityChongqing400044China Department of Materials Science and Engineering Monash UniversityVictoria3800Australia

Aberration-corrected scanning transmission electron microscopy has been used to study a novel metastable phase,designated asβ’’phase,induced to form by electron beam irradiation in a Mg-9.8 wt.%Sn *** phase is spherical in three dimensions,having a D019 structure with the lattice parameters of a=0.642 nm,c=0.521 nm and space group of P63/*** chemical formula is Mg_(3)Sn,like theβ’metastable precipitate *** orientation relationship between theβ’’phase and theα-Mg matrix is such that■_(β)’’//■_(α)and(0001)_(β)’’//(0001)_(α).Its formation involves solely the ordering of Sn atoms in the solid solution magnesium ***-principles calculations indicate that the formation of theβ’’phase is energetically favored.

关键词： Mg-Sn alloys Metastable phase Irradiation HAADF-STEM Density functional theory

Is it possible to foot reflexology for infants with sensorineural hearing loss?

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World Journal of Clinical Cases 2025年第2期13卷 1-4页

作者： min Ai Hang-Hang Zhang Jun-Bang feng Chuan-ming Li Wen-Jing Wang Meng-Die Hu Department of Anesthesiology Nanan District People's Hospital of ChongqingChongqing 400060China Department of Breast and Thyroid Surgery Chongqing Bishan District Maternal and Child Health Care HospitalChongqing 402760China Department of Medical Imaging Chongqing University Central HospitalChongqing 400014China

Foot reflexology is a non-invasive and safe complementary therapy that works by massaging the reflex zones of the feet and exerts systemic or whole-body regulation through meridian nerve *** therapy is commonly used in the treatment of various conditions such as autism and Parkinson's ***,there is limited reporting on the use of foot reflexology therapy for infants with sensorineural hearing loss(SNHL).Currently,there is no definitive conclusion on how foot reflexology therapy can influence *** editorial holds some guiding significance regarding this clinical *** aim is to present physiological evidence of how foot reflexology therapy can impact infants with SNHL,thereby enhancing clinician’s awareness of foot reflexology in treating infants with SNHL.

关键词： Foot reflexology Sensorineural Hearing Loss Future perspectives Limitations Neural conduction

Fabricating biopolymer-inorganic hybrid microspheres for enzyme immobilization:Connect membrane emulsification with biomimetic mineralization

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Particuology 2022年第5期20卷 171-177页

作者： jian Li Tiantian feng Lin Han min Zhang Tao jiang College of Chemical Engineering and Materials Science Tianjin University of Science and TechnologyTianjin 300457China

The organic-inorganic hybrid composites displayed great potential for biotechnological and biomedical *** this research,a gelatin/alginate/silica hybrid microsphere was developed by a synergy of membrane emulsification process and biomimetic mineralization *** gelatin was mixed and complexed with alginate solutions(water phase).The water phase was extruded through a Shirasu Porous Glass(SPG)membrane,and then was crosslinked,which formed gelatin/alginate *** biomimetic mineralization was occurred in situ by immersing gelatin/alginate complex in a Na_(2)SiO_(3) solution,while silica was formed around the organic microspheres,resulting in the final gelatin/alginate/silica hybrid *** microspheres were characterized by SEM,TEM,EDS,TGA/DTA,and *** hybrid microcapsules present a more than 40%mass fraction of the inorganic component,and displayed superior swelling resistance to biopolymer complex *** dehydrogenase(GlyDH)was immobilized in the obtained novel gelatin/alginate-silica hybrid microspheres as the model *** to the protective effect of carriers,the pH tolerance stability,storage and recycling stability of the immobilized GlyDH were all improved in comparison with free GlyDH.

关键词： Membrane emulsification Immobilized enzyme Biomimetic mineralization Gelatin Alginate Microspheres

MODIFIED NEWTON＇S ALGORITHM FOR COMPUTING THE GROUP INVERSES OF SINGULAR TOEPLITZ MATRICES

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Journal of Computational Mathematics 2006年第5期24卷 647-656页

作者： jian-feng Cai Michael K. Ng Yi-min Wei Department of Mathematics The Chinese University of Hong Kong Hong Kong Department of Mathematics Hong Kong Baptist University Hong Kong School of Mathematical Sciences Fudan University Shanghai 200433 China ~ Key Laboratory of Mathematics for Nonlinear Sciences (Fudan University) Ministry of Education

Newton＇s iteration is modified for the computation of the group inverses of singular Toeplitz matrices. At each iteration, the iteration matrix is approximated by a matrix with a low displacement rank. Because of the displacement structure of the iteration matrix, the matrix-vector multiplication involved in Newton＇s iteration can be done efficiently. We show that the convergence of the modified Newton iteration is still very fast. Numerical results are presented to demonstrate the fast convergence of the proposed method.

关键词： Newton's iteration Group inverse Toeplitz matrix Displacement rank.

胸腰椎骨折术后伤椎上终板骨缺损的生物力学有限元分析

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中国现代医学杂志 2017年第7期27卷 72-79页

作者：王鹏王静成冯新民杨建东陶玉平张志强扬州大学临床医学院苏北人民医院脊柱外科江苏扬州225001

目的利用有限元法对胸腰椎骨折术后合并伤椎上终板塌陷骨缺损患者是否适合取出内固定进行生物力学分析。方法选取健康男性志愿者1名,通过影像学检查,排除脊柱骨骼畸形、损伤等病变,利用64排螺旋CT提取胸_(11)~腰_2(T_(11)~L_3)水平薄层... 详细信息

目的利用有限元法对胸腰椎骨折术后合并伤椎上终板塌陷骨缺损患者是否适合取出内固定进行生物力学分析。方法选取健康男性志愿者1名,通过影像学检查,排除脊柱骨骼畸形、损伤等病变,利用64排螺旋CT提取胸_(11)~腰_2(T_(11)~L_3)水平薄层扫描图像。数据导入Mimics 15.0医学图像处理软件建立只包含三维表面单元,不含实体的T_(11)~L_2三维有限元骨骼模型。利用Solid Works进一步建立实体模型。该逆向工程软件可以无损失保留各椎体空间结构,并直接组建装配体,划分网格并补充建立椎间盘、韧带等相关结构。对模型进行赋值并进行验证。在此模型基础上加入椎弓根钉棒系统,同时衍生出具有5种不同缺损大小的包含钉棒系统的模型,以及模拟取出钉棒系统后的5种模型:(缺损体积分别为椎体前柱的1/5、2/5、3/5、4/5、5/5),在该基础上进行生物力学分析。结果内固定取出后随着缺损体积的增加,E组(4/5缺损组→5/5缺损组应力差)的7种工况的综合应力改变幅度最大,当塌陷缺损体积达到椎体前柱4/5时,应力集中明显增加,意味着此时取出内固定后出现伤椎继续压缩甚至再次骨折的风险增加。结论当伤椎上终板缺损体积达到前柱4/5时,应慎重考虑内固定的取出,避免伤椎前柱再次骨折。

关键词：胸腰椎骨折终板塌陷骨缺损有限元分析

Textural and compositional variation of mica from the Dexing porphyry Cu deposit:constraints on the behavior of halogens in porphyry systems

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Acta Geochimica 2023年第2期42卷 221-240页

作者： Yan Liu jian-feng Gao Liang Qi Kang min State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China University of Chinese Academy of Sciences Beijing 100049China

The Dexing porphyry deposit is the largest porphyry Cu–Mo–Au deposit in South *** composition can record the physicochemical conditions and evolution history of magmatic-hydrothermal *** from the Dexing porphyry deposit could be divided to three types:primary magmatic biotite(Bi-M),hydrothermal altered magmatic biotite(Bi-A)and hydrothermal biotite(Bi-H).The temperature of Bi-M and Bi-H range from 719 to 767℃ and 690 to 727℃,*** magmatic and hydrothermal biotite have high Fe^(3+)/Fe^(2+)ratios(from 0.18 to 0.24)and XMgvalues(from 0.57 to 0.66),indicating a high oxygen *** has F lower than Bi-A and Bi-H(up to 0.26 wt%),but has Cl(Cl=0.18–0.30 wt%)similar to Bi-A and Bi-H(Cl=0.21–0.35 wt%),suggesting that high Cl/F ratios of early hydrothermal fluid may result from the exsolution from high Cl *** potassic alteration zone to phyllic and propylitic alteration zones,Cl decreases with increasing Cu,whereas F increases ***,Cl mostly originate from magma,but enrichment of F possibly results from reaction of fluids and Neoproterozoic *** correlation between Cl and Cu indicates that Cl might act as an important catalyst during Cu mineralization *** from Dexing has similar halogen compositions to other porphyry Cu-/Mo deposits in the *** contents of hydrothermal fluid may be critical for Cu transportation and enrichment,while consumption of Cl would promote Cu deposition.

关键词： Halogen Dexing porphyry deposit Biotite Geochemistry Porphyry Cu deposit

Plant immune signaling: Advancing on two frontiers

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Journal of Integrative Plant Biology 2020年第1期62卷 2-24页

作者： Wei Wang Baomin feng jian-min Zhou Dingzhong Tang State Key Laboratory of Ecological Control of Fujian-Taiwan Crop Pests Key Laboratory of Ministry of Education for GeneticsBreeding and Multiple Utilization of CropsPlant Immunity CenterFujian Agriculture and Forestry UniversityFuzhou 350002China The State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

Plants have evolved multiple defense strategies to cope with pathogens, among which plant immune signaling that relies on cell-surface localized and intracellular receptors takes fundamental roles. Exciting breakthroughs were made recently on the signaling mechanisms of pattern recognition receptors(PRRs) and intracellular nucleotide-binding site(NBS) and leucine-rich repeat(LRR)domain receptors(NLRs). This review summarizes the current view of PRRs activation, emphasizing the most recent discoveries about PRRs’ dynamic regulation and signaling mechanisms directly leading to downstream molecular events including mitogen-activated protein kinase(MAPK) activation and calcium(Ca2+) burst. Plants also have evolved intracellular NLRs to perceive the presence of specific pathogen effectors and trigger more robust immune responses. We also discuss the current understanding of the mechanisms of NLR activation, which has been greatly advanced by recent breakthroughs including structures of the first full-length plant NLR complex, findings of NLR sensor-helper pairs and novel biochemical activity of Toll/interleukin-1 receptor(TIR) domain.

关键词： breakthrough activation frontier