检索结果-南通市图书馆

水动力学研究与进展（A辑） 1989年第4期4卷 69-82页

作者：庄礼贤贾明祥张剑峰中国科技大学近代力学系

本文提出了计算双自由度二维振动平板绕流的一种半解析非线性方法;讨论了非定常流Kutta条件的自洽处理问题;模拟了尾涡的脱泻、变形和配对过程;并对振动平板的推进运动方式进行了优化分析,给出了优化推进参数的选择范围。

关键词：流体自由度振动平板绕流

Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

在线全文

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年第1期68卷 300-302页

作者： Ze-min Lin Mai Xiang Wen-Hui Wei Shu-Hui Fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

关键词：

Two-Stage Algorithm for Correlating the Intrusion Alerts

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Two-Stage Algorithm for Correlating the Intrusion Alerts

施用无害化污泥影响土壤碳库组分和碳库管理指数的演变

The 1st Chinese Conference on Trusted Computing and Information Security

作者： WANG Liang-min, MA jian-feng The Key Laboratory of Computer Network and Information Security. Xiclian University. Xi '' an 710071, Shaanxi, China School of Computer. jiangsu University. Zhenjiang 212013,jiangsu.China

＜正＞ To solve the problem of the alert flooding and information semantics in the existing Intrusion Detection System（ IDS）, we present a two-stage algorithm for correlating the alerts. In the first stage, the high-level alerts is integrated by using the Chronicle patterns based on time intervals, which describe and match the alerts with the temporal time constrains of an input sequence. In the second stage, the preparing relationship between the high-level alerts is defined, which is applied to correlate the high-level alerts, and the attack scenario is constructed by drawing the attack graph. In the end a given example shows the performances of this twostage correlation algorithm in decreasing the number and improving the information semantic of the intrusion alerts produced by the IDS.

关键词： intrusion detection alert correlation partial ordering

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

环境科学 2017年第3期38卷 1218-1226页

作者：刘晓黄林郭康莉张雪凌杨俊诚姜慧敏张建峰中国农业科学院农业资源与农业区划研究所耕地培育技术国家工程实验室北京100081 郑州市污水净化有限公司郑州450000 四川农业大学环境学院成都611130

以小麦-玉米轮作体系下的沙质潮土为研究对象,选用经无害化处理后符合国家标准且在推荐量范围内的商业化污泥产品,通过2013~2015年田间定位试验,研究无害化污泥施用对沙质潮土土壤碳库组分和碳库管理指数的影响,为无害化污泥资源化利用... 详细信息

以小麦-玉米轮作体系下的沙质潮土为研究对象,选用经无害化处理后符合国家标准且在推荐量范围内的商业化污泥产品,通过2013~2015年田间定位试验,研究无害化污泥施用对沙质潮土土壤碳库组分和碳库管理指数的影响,为无害化污泥资源化利用提供理论和技术依据.结果表明,与不施无害化污泥处理(CK)相比,土壤总有机碳(TOC)、微生物量碳(SMBC)、易氧化有机碳(LOC)和可溶性有机碳(DOC)施用污泥各处理分别显著增加到了8.40~14.74 g·kg-1、164.45~257.45 mg·kg-1、3.58~4.88 g·kg-1和81.16~101.58 mg·kg-1(P<0.05),其中各活性有机碳组分SMBC、LOC和DOC分别显著提高了84.00%~188.07%,26.26%~58.03%和109.58%~185.39%(P<0.05),其中45 t·hm^(-2)污泥(W3)处理提升效果最明显;施污泥各处理土壤微生物量熵(SMBC/TOC)和易氧化有机碳有效率(LOC/TOC)均有升高趋势,提高范围分别为8.02%~2.77%和13.75%~46.48%,土壤可溶性有机碳有效率(DOC/TOC)施污泥各处理分别显著降低了17.06%~40.94%(P<0.05),并且随污泥施用量的增大,SMBC/TOC、LOC/TOC和DOC/TOC呈下降趋势,说明施用45 t·hm^(-2)污泥增大了土壤中稳定态碳含量,导致其比值降低;施污泥各处理土壤碳库活度(L)和碳库指数(LI)随污泥施用量增大而降低,说明施用45 t·hm^(-2)污泥其土壤稳定态碳含量高,有利于沙质潮土土壤有机碳的积累;施污泥各处理土壤碳库管理指数(CMPI)显著提高了153.45%~195.40%,其中W3处理提升效果最为明显;通过相关性分析及冗余分析得出,用CMPI来表征土壤肥力的变化比用TOC更灵敏、直接,能更好地反映出土壤养分及碳库的动态变化.综上,施用15~45 t·hm^(-2)污泥可以显著提高沙质潮土土壤活性碳库各组分含量和碳库管理指数,尤以施用45 t·hm^(-2)(W3)污泥效果最为显著.

关键词：无害化污泥沙质潮土土壤碳库碳素有效率碳库管理指数

在线全文

学校读者我要写书评

暂无评论

基于DSP处理器的导弹天线罩误差补偿系统

系统工程与电子技术 2001年第8期23卷 102-104,F004页

作者：刘军李旻秦建丰陈忠飞陶本仁郑成华上海航天局第八设计部 200233

介绍一种基于高速信号处理器TMS3 2 0C3 1的战术导弹天线罩瞄准线误差补偿系统。它采集导引头俯仰和偏航两伺服通道的角反馈电位计和多普勒频率信号及输出俯仰和偏航两指令通道的补偿信号。系统输入数据经A/D定时采集进入数据缓存器 ,CP... 详细信息

介绍一种基于高速信号处理器TMS3 2 0C3 1的战术导弹天线罩瞄准线误差补偿系统。它采集导引头俯仰和偏航两伺服通道的角反馈电位计和多普勒频率信号及输出俯仰和偏航两指令通道的补偿信号。系统输入数据经A/D定时采集进入数据缓存器 ,CPU采用读存储器的方式读进数据 ,经过运算后D/A输出并与导引头指令相加送给自动驾驶仪。利用射频仿真系统对该补偿系统进行动态实物联试 ,试验表明该补偿系统达到了很高的补偿精度。

关键词：误差补偿系统战术导弹天线罩数字信号处理器

Tolerance Induction by Exosomes from Immature Dendritic Cells and Rapamycin in a Mouse Cardiac Allograft Model

在线全文

学校读者我要写书评

暂无评论

Tolerance Induction by Exosomes from Immature Dendritic Cell...

Engineering high-performance chemiluminescent probes via enzymatic pocket targeting: high-throughput screening for ultralong afterglow imaging of orthotopic hepatocellular carcinoma

2012中国器官移植大会

作者： Xiao Li,Wei-min Li,jian-feng Wang,Wei Han,Zhuo-Chao Zhang,Yong Yu,Ben Ma,Ke-feng Dou Department of Hepatobiliary Surgery,Xijing Hospital,Fourth Military Medical University,127 Changle West Road,Xi’an,Shaanxi Province 710032,China

【Background】Dendritic cells(DCs) release bioactive exosomes that play an important role in immune *** they express low levels of class I major histocompatibility complex(MHC) and co-stimulatory molecules,exosomes derived from donor immature DCs(imDex) prolong allograft survival by inhibiting T-cell ***,this effect is limited and does not induce immunological tolerance when imDex are administered ***,we tested the effect of combined treatment with donor imDex and low-dose rapamycin on inducing tolerance in a mouse cardiac transplantation model.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Shuai Huang Shuaige Bai Ting Luo Bin feng min Liu Fan Zheng Shuang Huang Yanpeng Fang Dan Ding Wenbin Zeng Xiangya School of Pharmaceutical Sciences Central South University College of Life Sciences Nankai University

Hepatocellular carcinoma （HCC） is a highly aggressive liver malignancy and the main form of liver cancer. Early diagnosis and treatment of HCC can effectively reduce mortality. Carboxylesterase （CE）-specific detection and imaging can be used for early diagnosis and image-guided surgical of HCC. However, traditional optical probes suffer from poor selectivity and low imaging signal-to-noise ratio. Here, we have constructed a series of chemiluminescent probes for carboxylesterase detection based on the strategy of enzymatic pocket-oriented steric tailoring techniques. The probes with different unique and excellent properties have been obtained through the structure-based steric hindrance adjustment on the recognition site. Here, CE-2 has been successfully used for high-throughput screening of rapid carboxylesterase inhibitors due to its extremely low detection limit (2.5×10-4U mL-1) and fast recognition ability. CE-3 has been successfully used for image-guided surgery of orthotopic hepatocellular carcinoma due to its ultra-long chemiluminescence imaging （over 12 h） of hepatocellular carcinoma. This study may promote advances in the rapid detection and screening of inhibitory drugs for CE and the field of surgical navigation in HCC.

关键词：

妊娠期高血压孕妇宫颈感染对妊娠结局及术后感染的影响

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中华医院感染学杂志 2017年第12期27卷 2805-2808页

作者：杨建敏冯磊张辉郭小芬袁爽郑州大学附属南阳医院南阳市中心医院妇产科河南南阳473200

目的探讨不同程度宫颈感染对妊娠期高血压孕妇的妊娠结局与术后感染的影响。方法收集2015年1月-2016年8月收治的伴宫颈感染80例妊娠期高血压孕妇为观察组,根据感染程度将其中40例轻中度孕妇为观察A组,40例重度孕妇为观察B组;同时取本科... 详细信息

目的探讨不同程度宫颈感染对妊娠期高血压孕妇的妊娠结局与术后感染的影响。方法收集2015年1月-2016年8月收治的伴宫颈感染80例妊娠期高血压孕妇为观察组,根据感染程度将其中40例轻中度孕妇为观察A组,40例重度孕妇为观察B组;同时取本科室同期接收40例单纯妊娠期高血压孕妇为对照组,40例健康正常妊娠孕妇作为健康组,观察并比较4组孕妇的妊娠结局与术后感染情况。结果观察B组孕妇胎儿宫内窘迫率、新生儿窒息率及围产儿病死率均为22.5%,均显著高于观察A组及对照组相应指标,差异有统计学意义(P<0.05);观察组孕妇胎儿宫内窘迫率、新生儿窒息率及围产儿病死率均显著高于对照组及健康组相应指标,差异有统计学意义(P<0.05);对照组孕妇剖宫产率50.0%,显著高于健康组20.0%,差异有统计学意义(P<0.05);两组胎儿宫内窘迫率、新生儿窒息率及围产儿病死率比较,无显著差异,观察组、对照组、健康组术后感染率依次为25.0%、12.5%、0,观察组术后感染率较对照组与健康组显著更高,差异有统计学意义(P<0.05);观察B组产妇并发症发生率15.0%,显著高于对照组2.5%,差异有统计学意义(P<0.05)。结论妊娠期高血压孕妇伴有宫颈感染程度与其不良妊娠结局发生风险有着密切的联系,且伴宫颈感染的产妇术后感染率更高。

关键词：妊娠期高血压孕妇宫颈感染妊娠结局感染

开发城郊传统村庄的发展规划设计——以南京市高淳区固城镇蒋山社区吴家村规划为例

在线全文

学校读者我要写书评

暂无评论

江苏建筑 2018年第1期 27-29页

作者：周剑敏刘峰赵和生南京工业大学建筑学院江苏南京210009

传统村庄的规划结构承载着地域的文化特色,在当今新的社会、经济、生活方式和观念下,开发旅游型传统村落势必会使得村庄原有聚落肌理的形成结构发生变化。文章通过南京市高淳区固城镇蒋山社区吴家村规划,去探讨开发城郊传统村落的一些... 详细信息

传统村庄的规划结构承载着地域的文化特色,在当今新的社会、经济、生活方式和观念下,开发旅游型传统村落势必会使得村庄原有聚落肌理的形成结构发生变化。文章通过南京市高淳区固城镇蒋山社区吴家村规划,去探讨开发城郊传统村落的一些设计发展策略。在满足乡村旅游的同时,延续甚至是发展地域文化特色,从而形成新的村落规划结构。

关键词：传统村落发展方法规划结构

Application of low-temperature thermochronology on ore deposits preservation framework in South China:a review

在线全文

学校读者我要写书评

暂无评论

Acta Geochimica 2022年第2期41卷 165-184页

作者： Kang min jian-feng Gao State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China University of Chinese Academy of Sciences Beijing 100049China

South China can be divided into four metallogenic belts:The Middle-Lower Yangtze Metallogenic Belt(MLYB),Qinzhou-Hangzhou Metallogenic Belt(QHMB),Nanling Metallogenic Belt(NLMB),and Wuyi Metallogenic Belt(WYMB).The major mineralization in the four metallogenic belts is granite-related Cu–Au–Mo and porphyrite Fe-apatite,porphyry Cu(Au),and epithermal Pb–Zn–Ag,hydrothermal Cu–Au–Pb–Zn–Ag,and granite-related skarn-type and quartz-veins W–Sn,***-temperature thermochronology,including fissiontrack and U-Th/He dating,has been widely used to constrain tectonic thermal evolution and ore deposits *** fission-track annealing and He diffusion kinetics in accessory minerals,such as zircon and apatite,is essential for dating and *** this study,previous zircon fission-track(ZFT)and apatite fission-track(AFT)ages in South China were *** result shows that the ZFT ages are mainly concentrated at140–90 Ma,and the AFT ages are mainly distributed at70–40 *** age distribution and inversion temperature–time paths reveal heterogeneous exhumation histories in South *** MLYB experienced Late CretaceousCenozoic extremely slow exhumation after rapid cooling in the Early *** northern QHMB(*** southern Anhui province to the Hangzhou Bay)had a relatively faster rate of uplifting and denudation than the southern QHMB in the ***,the northern QHMB rapidly exhumed,while the continuously slow exhumation operated the southern QHMB in the *** southern NLMB had a more rapid cooling rate than the northern NLMB during the Cretaceous time,and the whole NLMB experienced rapid cooling in the Cenozoic,except that the southern Hunan province had the most rapid cooling *** WYMB possibly had experienced slow exhumation since the Late *** exhumation thickness of the four metallogenic belts since90 Ma is approximately calculated as follows:the MLYB≤3.5 km,the northern QHMB concentrated at

关键词： Low-temperature thermochronology Fissiontrack annealing and He diffusion kinetics South China Exhumation history Deposits preservation