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Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-min Xing Hai-Dong Qian Qiao Gao Sheng-lan Xu Hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

Regulating crystallization and retarding oxidation in Sn-Pb perovskite via 1D cation engineering for high performance all-perovskite tandem solar cells

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Journal of Energy Chemistry 2025年第1期100卷 646-652页

作者： Ranran Liu Xin Zheng Zaiwei Wang Miaomiao Zeng Chunxiang lan Shaomin Yang Shangzhi Li Awen Wang min Li Jing Guo Xuefei Weng Yaoguang Rong Xiong Li Michael Gr?tzel Center for Mesoscopic Solar Cells Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Institute of Technology for Carbon Neutrality Shenzhen Institute of Advanced Technology Chinese Academy of Sciences School of Physics and Optoelectronic Engineering Hainan University Suzhou Institute of Nano-Tech and Nano-Bionics (SINANO) Chinese Academy of Sciences School of Chemistry Chemical Engineering and Life Sciences State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology

All-perovskite tandem solar cells have the potential to surpass the theoretical efficiency limit of single junction solar cells by reducing thermalization ***,the challenges encompass the oxidation of Sn2+to Sn4+and uncontrolled crystallization kinetics in Sn-Pb perovskites,leading to nonradiative recombination and compositional heterogeneity to decrease photovoltaic efficiency and operational ***,we introduced an ionic liquid additive,1-ethyl-3-methylimidazolium iodide （EMIMI） into Sn-Pb perovskite precursor to form low-dimensional Sn-rich/pure-Sn perovskites at grain boundaries,which mitigates oxidation of Sn2+to Sn4+and regulates the film-forming dynamics of Sn/Pb-based perovskite *** optimized single-junction Sn-Pb perovskite devices incorporating EMIMI achieved a high efficiency of 22.87%.Furthermore,combined with wide-bandgap perovskite sub-cells in tandem device,we demonstrate 2-terminal all-perovskite tandem solar cells with a power conversion efficiency of 28.34%,achieving improved operational stability.

关键词： All-perovskite tandem solar cells Sn-Pb perovskite 1D Regulated crystallization Antioxidation

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云南簇蕊金花茶饮料的研制

保鲜与加工 2017年第3期17卷 97-102页

作者：刘云司佳颖杨敏阚欢蓝增全秦晓绍西南林业大学林学院云南昆明650224 红河五里冲生态茶叶有限公司云南红河661100

在单因素试验的基础上选取试验因素和水平,根据中心组合(Box-Benhnken)试验设计原理,采用三因素三水平的响应面分析法,以可溶性干物质提取率为响应值,对云南簇蕊金花茶茶叶中可溶性干物质的水浸提工艺进行优化。结果表明,将预处理过的... 详细信息

在单因素试验的基础上选取试验因素和水平,根据中心组合(Box-Benhnken)试验设计原理,采用三因素三水平的响应面分析法,以可溶性干物质提取率为响应值,对云南簇蕊金花茶茶叶中可溶性干物质的水浸提工艺进行优化。结果表明,将预处理过的云南簇蕊金花茶茶叶粉碎后,在料液比1∶111.3(g/m L)、浸提温度87.2℃、浸提时间10.4 min的条件下浸提效果最佳,可溶性干物质的提取率可达12.89%。通过对该浸提液进行过滤、调配等制作工艺生产的簇蕊金花茶饮料呈黄绿色、清亮透明、茶香浓郁、酸甜适口。

关键词：簇蕊金花茶可溶性干物质浸提工艺优化

Physarum polycephalum-inspired adaptive optimization design of artificial microtubular networks

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Science China Chemistry 2025年

作者： Si-min Zeng Di-Wei Zheng Ting Pan Xing-lan Ding Yun Zhang Chi-Hui Yang Si-Xue Cheng Xian-Zheng Zhang Key Laboratory of Biomedical Polymers of ministry of Education&Department of Chemistry Wuhan University

Natural biological microtubular networks have undergone adaptive evolutionary selection and may offer viable solutions to design challenges in artificial microtubular networks. The plasmodium of the slime mold Physarum polycephalum(P. polycephalum) extends continuously to form a protoplasmic microtubular network structure, directly connecting food *** simulations revealed that the formation of this adaptive P. polycephalum microtubular network could be captured by a mathematical algorithm. Inspired by the P. polycephalum microtubular networks, we propose an adaptive optimization design method for artificial microtubular networks. Specifically, we utilized hydrogels with biodegradable and tissue-adhesive properties to replicate the P. polycephalum microtubular networks via photomask. In Rhodamine B diffusion and glucosecatalyzed reaction experiments, we found that the P. polycephalum microtubular networks exhibited significantly enhanced efficiency compared to vascular and artificial networks. Furthermore, we demonstrated the potential for uric acid(UA) degradation of the hydrogels with a real P. polycephalum microtubular network loaded with urate oxidase(UOx) in a rodent model of hyperuricemia. And this network achieved more than double the effect of the artificial network. This underscores the potential of natural microtubular networks to replace artificial microtubular networks.

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Corrosion Behavior of a Low-Carbon Steel in Simulated Marine Splash Zone

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Acta Metallurgica Sinica(English Letters) 2017年第6期30卷 585-593页

作者： huan-huan Wang min Du Key Laboratory of Marine Chemistry Theory and Technology Ministry of EducationCollege of Chemistry and Chemical EngineeringOcean University of ChinaQingdao 266100China

Experiments were designed to simulate the corrosion of a low-carbon steel exposed to a marine splash zone. The composition and morphology of the rust were investigated using Raman spectroscopy, X-ray photoelectron spectroscopy, energy-dispersive spectrometry and scanning electron microscopy. Corrosion resistance of the rust films was demonstrated by the electrochemical impedance spectroscopy. The wettability of the steel surface was calculated from the data conceruing the wetting degree and the conductivity. The results showed that, in the initial stage, the products of the outer rust layer were mainly made up of Fe（Ⅲ） oxyhydroxide, while the main component of the inner rust layer was magnetite. With an increase in the corrosion time, the inner rust layer continuously turned into the outer rust layer. In addition, both rust layers became dense, thus playing a protective role with respect to matrix. The existence of the rust layer significantly prolonged the residence time of the seawater on the sample surface, a result that tends to improve the cathodic protection effect for steel structures exposed to marine splash zones.

关键词： Marine splash zone Low-carbon steel Corrosion behavior Electrochemical impedance spectroscopy (EIS) Wetting degree

Calibration of soft sensor by using Just-in-time modeling and Ada Boost learning method

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Chinese Journal of Chemical Engineering 2016年第8期24卷 1038-1046页

作者： huan min Xionglin Luo Department of Automation China University of PetroleumBeijing

Soft sensor is an efficacious solution to predict the hard-to-measure target variable by using the process *** practical application scenarios, however, the feedback cycle of target variable is usually larger than that of the process variables, which causes the deficiency of prediction errors. Consequently soft sensor cannot be calibrated timely and deteriorates. We proposed a soft sensor calibration method by using Just-in-time modeling and Ada Boost learning method. A moving window consisting of a primary part and a secondary part is *** primary part is made of history data from certain number of constant feedback cycles of target variable and the secondary part includes some coarse target values estimated initially by Just-in-time modeling during the latest feedback cycle of target variable. The data set of the whole moving window is processed by Ada Boost learning method to build an auxiliary estimation model and then target variable values of the latest corresponding feedback cycle are reestimated. Finally the soft sensor model is calibrated by using the reestimated target variable values when the target feedback is unavailable; otherwise using the feedback value. The feasibility and effectiveness of the proposed calibration method is tested and verified through a series of comparative experiments on a pH neutralization facility in our laboratory.

关键词： Process control Measurement Soft sensor Calibration Deterioration Moving window Just-in-time Ada Boost

Efficient Task Decomposition for Sequential Crowdsourced Task Solving

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Chinese Journal of Electronics 2020年第3期29卷 468-475页

作者： JIANG huan ZUO min MATSUBARA Shigeo National Engineering Laboratory for Agri-product Quality Traceability School of Computer and Information EngineeringBeijing Technology and Business University

In order to facilitate crowdsourcing-based task solving, complex tasks are decomposed into smaller subtasks that can be executed by individual *** task into sequential subtasks attracts a plenty of empirical explorations. The absence of formal studies makes it difficult to provide task requesters with explicit guidelines on task decomposition *** formally present the vertical task decomposition model by specifying the positive quality dependencies among sequential subtasks. Our focus is on addressing solutions of low quality intentionally provided by selfinterested workers who are paid equally or based on their contributions. By combining the theoretical analysis on workers’ strategic behaviors and experimental exploration on the efficiency of task decomposition, our study demonstrates the relationship between the incentive and the worker’s performance, and gives the explicit instructions on vertical task decomposition, which show promise on improving the quality of the final outcome.

关键词： Crowdsourcing Task decomposition Subtask dependence Solution quality Revenue sharing

MDP-Based Budget Allocation for Efficient Cooperative Task Solving

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Chinese Journal of Electronics 2017年第5期26卷 966-972页

作者： JIANG huan ZUO min MATSUBARA Shigeo School of Computer and Information Engineering Beijing Technology and Business University

In order to facilitate crowdsourcing-based task solving,complex tasks are decomposed into interdependent subtasks that can be executed cooperatively by individual *** to maximize the quality of the final solution subject to the self-interested worker’s utility maximization,a key challenge is to allocate the limited budget among the subtasks as the rewards for workers having various levels of *** study is the first attempt to show the value of Markov decision processes(MDPs)for the problem of optimizing the quality of the final solution by dynamically determining the budget allocation on sequentially dependent subtasks under the budget constraints and the uncertainty of the workers’ *** simulation-based approach verifies that compared to some offline methods where workers’ abilities are fully known,our proposed MDP-based payment planning is more efficient at optimizing the final quality under the same limited budget.

关键词： Budget allocation Markov decision processes(MDPs) Cooperative task solving Task quality optimization Crowdsourcing

Spray and mixing characteristics of liquid jet in a tubular gas-liquid atomization mixer

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Chinese Journal of Chemical Engineering 2021年第6期34卷 1-11页

作者： Lingzhen Kong Jiaqing Chen Tian lan huan Sun Kuisheng Wang School of Mechanical Engineering Beijing Institute of Petrochemical TechnologyBeijing 102617China Beijing Key Laboratory of Pipeline Critical Technology and Equipment for DeepWater Oil&Gas Development Beijing 102617China College of Mechanical and Electrical Engineering Beijing University of Chemical TechnologyBeijing 100029China

For the design and optimization of a tubular gas-liquid atomization mixer,the atomization and mixing characteristics of liquid jet breakup in the limited tube space is a key *** this study,the primary breakup process of liquid jet columnwas analyzed by high-speed camera,then the droplet size and velocity distribution of atomized droplets were measured by Phase-Doppler anemometry(PDA).The hydrodynamic characteristics of gas flow in tubular gas-liquid atomization mixer were analyzed by computational fluid dynamics(CFD)numerical *** results indicate that the liquid flow rate has little effect on the atomization droplet size and atomization pressure drop,and the gas flowrate is themain influence *** all experimental gas flowconditions,the liquid jet column undergoes a primary breakup process,forming larger liquid blocks and *** the gas flow rate(Qg)is less than 127 m^(3)·h^(−1),the secondary breakup of large liquid blocks and droplets does not occur in venturi throat *** Sauter mean diameter(SMD)of droplets measured at the outlet is more than 140μm,and the distribution is *** Qg>127 m^(3)·h^(−1),the large liquid blocks and droplets have secondary breakup process at the throat *** SMD of droplets measured at the outlet is less than 140μm,and the distribution is *** 127

关键词： Atomization mixing Liquid jet Primary breakup Droplet breakup Droplet size