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Effect of nocturia in patients with different severity of obstructive sleep apnea on polysomnography: A retrospective observational study

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Asian Journal of Urology 2024年第3期11卷 486-496页

作者： Chin-Heng Lu Hung-min Chang Kuang-Hsi Chang Yen-Chuan Ou Chao-Yu Hsu min-che tung Frank cheau-Feng Lin Stella Chin-Shaw Tsai Division of Urology Department of SurgeryTungs’Taichung Metroharbor HospitalTaichungTaiwanChina Rong Hsing Research Center for Translational Medicine Chung Hsing UniversityTaichungTaiwanChina College of Life Sciences Chung Hsing UniversityTaichungTaiwanChina Department of Otolaryngology Tungs’Taichung Metroharbor HospitalTaichungTaiwanChina Department of Medical Research Tungs’Taichung Metroharbor HospitalTaichungTaiwanChina General Education Center Jen-Teh Junior College of MedicineNursing and ManagementMiaoliTaiwanChina Graduate Institute of Biomedical Sciences China Medical UniversityTaichungTaiwanChina Department of Post-Baccalaureate Medicine College of MedicineChung Hsing UniversityTaichungTaiwanChina Department of Nursing Jen-Teh Junior College of MedicineNursing and ManagementMiaoliTaiwanChina Department of Surgery Chung Shan Medical UniversityTaichungTaiwanChina College of Medicine Chung Shan Medical UniversityTaichungTaiwanChina

Patients with suspected OSA were examined using *** were divided into two groups based on the presence of *** was defined as a patient who needed to void at least *** index(AHI)was employed to classify patients according to degrees of severity:AHIminimum arterial blood oxygenation saturation(p=0.046),and decreased AHI of non-rapid eye movement(p=0.047),AHI of total sleep time(p=0.010),and desaturation index(p=0.012).In moderate OSA patients,nocturia related to increased age(p<0.001),awake time(p=0.025),stage 1 sleep(p=0.033),and sleep latency(p=0.033),and decreased height(p=0.044),weight(p=0.025),and sleep efficiency(p=0.003).In severe OSA patients,nocturia related to increased weight(p=0.011),body mass index(p=0.009),awake time(p=0.008),stage 1 sleep(p=0.040),arousal number(p=0.030),arousal index(p=0.013),periodic limb movement number(p=0.013),and periodic limb movement index(p=0.004),and decreased baseline arterial blood oxygenation saturation(p=0.046).Conclusion:Our study revealed that there were more correlated factors related to nocturia with increasing severity of *** study helps in clinical education and treatment for OSA patients with different severity.

关键词： Nocturia Obstructive sleep apnea Polysomnography Apneaehypopnea index International Prostate Symptom Score

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Concurrent occurrence of adenocarcinoma and urothelial carcinoma of the prostate gland:A case report

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World Journal of Clinical Cases 2024年第26期12卷 5952-5959页

作者： Jhe Yuan Hsu Yi Sheng Lin Li Hua Huang Tang Yi Tsao Chao Yu Hsu Yen Chuan Ou min che tung Division of Urology Department of SurgeryTungs'Taichung MetroHarbor HospitalTaichung 435403Taiwan Department of Pathology Tungs'Taichung MetroHarbor HospitalTaichung 435403Taiwan

BACKGROUND Adenocarcinoma is the most common subtype of prostate *** urothelial carcinoma(UC)typically originates from the prostatic *** concurrent occurrence of adenocarcinoma and UC of the prostate gland is *** SUMMARY We present the case of an 82-year-old male patient with simultaneous adenocarcinoma and UC of the prostate *** patient underwent a transrectal ultrasound-guided biopsy,and the pathology test revealed ***,transurethral laser prostatectomy was performed,and the pathology test indicated adenocarcinoma of the prostate with a Gleason score of 3+4 and highgrade ***,the patient was treated with androgen deprivation therapy,systemic chemotherapy,and *** resonance imaging performed during follow-up revealed a prostate tumor classified as cT2cN1M0,stage ***,the patient underwent robotic-assisted radical prostatectomy and bilateral pelvic lymph node *** final pathology test of the prostate gland revealed acinar-type adenocarcinoma,Gleason pattern 4+3,pT2N0M0,and high-grade *** patient regularly presented to the clinic for postoperative follow-up *** did not experience any urinary *** According to our literature review,this is the first reported case of coexisting adenocarcinoma and UC of the prostate gland.

关键词： Adenocarcinoma Urothelial carcinoma Prostate Coexist Case report

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Improvement of lenvatinib-induced nephrotic syndrome after adaptation to sorafenib in thyroid cancer:A case report

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World Journal of Clinical Cases 2020年第20期8卷 4883-4894页

作者： che Hseuh Yang Kuo tung chen Yi Sheng Lin Chao Yu Hsu Yen Chuan Ou min che tung Division of Urology Department of SurgeryTungs'Taichung MetroHarbor HospitalTaichung City 435403Taiwan Division of General Surgery Department of SurgeryTungs'Taichung MetroHarbor HospitalTaichung City 435403Taiwan

BACKGROUND Target therapy is licensed by United States Food and Drug Administration on certain *** sorafenib and lenvatinib are tyrosine kinase inhibitor and indicated on radioactive iodine(RAI)-refractory differentiated thyroid cancer(DTC).Lenvatinib is more effective in cancers'control than sorafenib,but causes more nephrotoxicity than sorafenib *** case is the second published case about the serial adaptions from lenvatinib to sorafenib for improving the proteinuria and,meanwhile,achieving the therapeutic *** SUMMARY A 56-year-old man suffered from bilateral edematous lower extremities after 1-mo prescription of lenvatinib of 20 mg/d for RAI-refractory *** from this symptom,he also developed *** laboratory showed grade-3 proteinuria(estimated 24-h urine protein:9993 mg),hypoalbuminemia and ***-vascular endothelial growth factor(VEGF)therapyinduced nephrotic syndrome was *** reduced dosage of lenvatinib of 10 mg/d and related symptomatic drugs,limited improvement was observed in both adverse effects and caner *** this condition,we substituted sorafenib of 400 mg/d for lenvatinib of 10 mg/*** a 5-mo prescription,not only hypertension and peripheral edema were greatly improved,but also proteinuria was improved from grade three to grade one(estimated 24-h urine protein:962 mg).At the same time the cancer control was achieved,judged from computed tomography and laboratory evidence[thyroglobulin(Tg)before prescription of sorafenib:354.7 ng/m L;Tg after prescription of sorafenib:108.9 ng/m L].CONCLUSION Adaption from lenvatinib to sorafenib is a feasible method to improve the antiVEGF therapy-induced nephrotic syndrome and achieve the therapeutic goal at the same time.

关键词： Molecular targeted therapy/methods Receptors Vascular endothelial growth factor/drug effects Vascular endothelial growth factor/therapeutic use Vascular endothelial growth factor A/drug effects Nephrotic syndrome/drug therapy Case report

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Renal pseudoaneurysm after rigid ureteroscopic lithotripsy:A case report

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World Journal of Clinical Cases 2022年第27期10卷 9954-9960页

作者： Yi Hong Li Yi Sheng Lin Chao Yu Hsu Yen Chuan Ou min che tung Division of Urology Department of SurgeryTungs'Taichung MetroHarbor HospitalTaichung 43503Taiwan

BACKGROUND Ureteroscopic lithotripsy(URSL) is a common surgical treatment for ureteral *** flexible ureteroscopy can be used to treat ureteral and renal stones in a single procedure,rigid ureteroscopy can only be used to treat ureteral stones;nonetheless,rigid ureteroscopy remains mainstream in Taiwan owing to its late introduction and flexible ureteroscopy is not covered by national health *** is a common complication that occurs when the scope passes through stricture sites or when mucosal damage occurs during lithotripsy,but this is usually *** hematuria requiring intervention is termed persistent *** hematuria is less common and few studies have reported the development and etiology of renal pseudoaneurysm after flexible ureteroscopy for renal ***,we present the first reported case of renal pseudoaneurysm after rigid URSL for ureteral *** SUMMARY The patient was a 57-year-old man who developed renal pseudoaneurysm with active bleeding after rigid *** presented with gross hematuria and intolerable left flank pain after left *** anemia was noted(hemoglobin level,6.8 g/d L).Contrast enhanced computed tomography revealed one pseudoaneurysm each in the upper and lower renal *** was managed via transcatheter arterial embolization with microcoils,which relieved the *** To the best of our knowledge,ours is the first case report on renal pseudoaneurysm after rigid *** renal pseudoaneurysms are difficult to access,underlying hypertension,clinical signs such as refractory flank pain,and gross hematuria should be carefully monitored following similar endourological procedures.

关键词： Aneurysm False Ureteroscopy Lithotripsy Intraoperative complication Embolization Therapeutic Case report

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Biochemical recurrence of pathological T2+localized prostate cancer after robotic-assisted radical prostatectomy:A 10-year surveillance

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World Journal of Clinical Cases 2021年第5期9卷 1026-1036页

作者： che Hseuh Yang Yi Sheng Lin Yen Chuan Ou Wei Chun Weng Li Hua Huang Chin Heng Lu Chao Yu Hsu min che tung Division of Urology Department of SurgeryTungs'Taichung MetroHarbor HospitalTaichung 435403Taiwan

BACKGROUND pT2+prostate cancer(PCa),a term first used in 2004,refers to organ-confined PCa characterized by a positive surgical margin(PSM)without extracapsular *** with a PSM are vulnerable to biochemical recurrence(BCR)following radical prostatectomy(RP);however,whether adjuvant radiotherapy(aRT)is imperative to PSM after RP remains *** study had the longest follow-up on pT2+PCa after robotic-assisted RP since ***,we discussed our viewpoints on pT2+PCa based on real-world *** To conclude a 10-year surveillance on pT2+PCa and compare our results with those of the published *** Forty-eight patients who underwent robotic-assisted RP between 2008 and 2011 were *** serial tests of prostate specific antigen(PSA)≥0.2 ng/mL were defined as *** designed factors were analyzed using statistical tools for BCR *** 9.4 was applied and significance was defined as P<***,multivariate,linear regression,and receiver operating characteristic(ROC)curve analyses were performed for statistical *** With a median follow-up period of 9 years,25(52%)patients had BCR(BCR group),and the remaining 23(48%)patients did not(non-BCR group).The median time for BCR test was 4 years from the first postoperative PSA *** PSA was significantly different between the BCR and non-BCR groups(P<0.001),and ROC curve analysis of preoperative PSA suggested a cutoff value of 19.09 ng/mL(sensitivity,0.600;specificity:0.739).The linear regression analysis showed no correlation between time to BCR and preoperative PSA(Pearson’s correlation,0.13;adjusted R2=0.026).CONCLUSION Robotic-assisted RP in pT2+PCa of worse conditions can provide better BCR-free survival.A surgical technique limiting the PSM in favorable situations is warranted to lower the pT2+PCa BCR *** PSA cut-off value of 19.09 ng/mL is a predictive factor for *** on our experiences and review of the literat

关键词： Prostatectomy/methods Robotic surgical procedures Prostatic neoplasms/pathology Prostate-specific antigen/metabolism Margins of excision Retrospective study

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The surgical learning curve for robotic-assisted laparoscopic radical prostatectomy： experience of a single surgeon with 500 cases in Taiwan, China

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Asian Journal of Andrology 2014年第5期16卷 728-734,I0009页

作者： Yen-Chuan OU Chun-Kuang Yang Kuangh-Si Chang John Wang Siu-Wan Hung min-che tung Ashutosh K Tewari Vipul R Patel Division of Urology Department of Surgery Taichung Veterans General Hospital Taichung Taiwan China School of Medicine National Yang-Ming University Taipei Taiwan China Department of Research Taichung Veterans General Hospital Taichung Taiwan China Department of Pathology Taichung Veterans General Hospital Taichung Taiwan China Department of Radiation Taichung Veterans General Hospital Taichung Taiwan China Division of Urology Department of Surgery Tungs' Taichung MetroHarbor Hospita Taichung Taiwan China New York Presbyterian Hospital Weill Cornell Medical College New York NY USA Global Robotics Institute Florida Hospital Orlando Florida USA

To analyze the learning curve for cancer control from an initial 250 cases （Group I） and subsequent 250 cases （Group II） of robotic-assisted laparoscopic radical prostatectomy （RALP） performed by a single surgeon. Five hundred consecutive patients with clinically localized prostate cancer received RALP and were evaluated. Surgical parameters and perioperative complications were compared between the groups, Positive surgical margin （PSM） and biochemical recurrence （BCR） were assessed as cancer control outcomes. Patients in Group II had significantly more advanced prostate cancer than those in Group I （22.2% vs 14.2%, respectively, with Gleason score 8-10, P = 0.033; 12.8% vs 5.6%, respectively, with clinical stage T3, P = 0.017）. The incidence of PSM in pT3 was decreased significantly from 49% in Group I to 32.6% in Group Ih A meaningful trend was noted for a decreasing PSM rate with each consecutive group of 50 cases, including pT3 and high-risk patients. Neurovascular bundle （NVB） preservation was significantly influenced by the PSM in high-risk patients （84.1% in the preservation group vs 43.9% in the nonpreservation group）. The 3-year, 5-year, and 7-year BCR-free survival rates were 79.2%, 75.3%, and 70.2%, respectively. In conclusion, the incidence of PSM in pT3 was decreased significantly after 250 cases. There was a trend in the surgical learning curve for decreasing PSM with each group of 50 cases. NVB preservation during RALP for the high-risk group is not suggested due to increasing PSM.

关键词： cancer control learning curve prostate cancer prostatectomy robotics surgical margin

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<i>Survivin</i>promoter rs9904341 polymorphism is associated with tumor stage and grade in patients with bladder cancer

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Advances in Bioscience and Biotechnology 2013年第1期4卷 1-5页

作者： Zhon-min Huang Yi-Te Chiang min-che tung Chia-Chang Wu Kuan-Chou chen ming-Te Huang Yuan-Hung Wang cheng-Huang Shen Department of Urology Chia-Yi Christian Hospital Chiayi City Taiwan Department of Urology Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan Department of Urology Tung’s Taichung MetroHarbor Hospital Taichung County Taiwan Division of General Surgery Department of Surgery Shuang Ho Hospital Taipei Medical University Taipei Taiwan Division of General Surgery Department of Urology Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan

Survivin is an inhibitor of apoptosis protein and also plays a important role in the development of several malignancies. To investigate the association between survivin promoter –31 G/C (rs9904341) polymorphism and bladder cancer (BC) risk. A total of 200 pathologically confirmed BC cases and 200 unrelated cancer-free controls were recruited in Chiayi Christian Hospital from August 2002 to May 2009. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to determine the –31 G/C polymorphism at survivin promoter region. There was a significant difference in the frequency distribution of survivin promoter –31 G/C polymorphism in BC cases as compared to controls. Among BC cases, individuals with the C/C genotype of survivin promoter have a significantly higher prevalence of invasive (T2-T4) or high-grade (G2-G3) tumors as compared to those who carried the G/G genotype. In conclusion, our findings suggest that the survivin promoter –31 G/C polymorphism was not only associated with clinical stage and pathological grade but also involved in the development of bladder cancer.

关键词： Survivin Bladder Cancer Polymorphism Apoptosis

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A computation design method for architectural artifacts adapted from traditional Kagome bamboo basketry techniques

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Frontiers of Architectural Research 2024年第2期13卷 249-264页

作者： Hiroyuki Shinohara tung Hoi Peter Chan School of Architecture The Chinese University of Hong KongHong KongChina

This study is a digital form-finding and manual fabrication experiment in woven architectural design,with one traditional weaving style,Kagome,used to scale the craft up into an architectural-scale bamboo woven *** is a trihexagonal pattern employed in traditional bamboo basketry as a triaxial weaving system,resulting in an object with a self-bracing capacity without the use of fasteners owing to its interlacing *** existing studies and tools have addressed triaxial weaving design and representation,the current consideration of the advantages of weaving with bamboo is *** address this research gap,this study develops a computational design method based on studies on bamboo *** allows for the representation and exploration of design geometries using combinations of regular triangular meshes for the fabrication of Kagome woven bamboo artifacts.A full-scale mock-up was fabricated to evaluate the effectiveness of the *** mock-up demonstrated the self-bracing properties of Kagome,but there were discrepancies between the mock-up and the *** affecting bamboo weaving on an architectural scale have been identified within this study to inform future research on woven bamboo structures.

关键词： Traditionalbamboo craft Triaxialmaterial interlacing Bamboo Computational design methods Mesh block combinationsystem Architecturalwoven artifact

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Experimental study on temperature fluctuations on plate surface induced by coaxial-jet flow

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Nuclear Science and Techniques 2024年第5期35卷 139-153页

作者： Xue-Yao Xiong Zun-Quan Liu Guo-Yan Zhou Xing Luo Shan-tung Tu Key Laboratory of Pressure Systems and Safety(MOE) East China University of Science and TechnologyShanghai 200237China Institute of Thermodynamics Gottfried Wilhelm Leibniz University Hannover30823 GarbsenGermany

In nuclear reactors,temperature fluctuations of fluids may cause fatigue damage to adjacent structures;this is referred to as thermal *** on thermal striping in the upper plenum has mainly focused on fluid *** experimental studies have been reported on solid structures in a fluid field with a coaxial *** study entailed an experimental study of the temperature fluctuations in the fluid and on a plate surface caused by a coaxial *** temperature fluctuations of the fluid and plate surfaces located at different heights were *** cause of the temperature fluctuation was analyzed using a transient temperature *** results show that the mixing of the hot and cold fluids gradually becomes uniform in the positive axial *** average surface temperatures tended to be *** the jet reaches the plate surface,the swing of the jet center,contraction and expansion of the cold jet,and changes in the jet shape result in temperature *** intensity of the temperature fluctuation was affected by the *** attention should be paid when the plate is located at a lower height,and between the hot and cold-fluid nozzles.

关键词： Temperature fluctuation Thermal striping Coaxial jet Thermal mixing The upper plenum of nuclear reactor

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Anti‐sloshing control:Flatness‐based trajectory planning and tracking control with an integrated extended state observer

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IET Cyber-Systems and Robotics 2024年第3期6卷 31-48页

作者： Khanh Nguyen Viet minh Do Duc Thanh Cao Duc tung Lam Nguyen School of Electrical and Electronic Engineering Hanoi University of Science and TechnologyHanoiVietnam Vietnam Maritime University HaiphongVietnam

The phenomenon of sloshing causes a significantly negative impact on a wide range of industries.A time‐optimal flatness‐based trajectory planning and Lyapunov‐based model predictive control(LMPC)is proposed for trajectory tracking of a transmitting cylindrical container filled with ***,this research presents an equivalent discrete model based on a mass‐spring‐damper ***,after the flatness of the adopted non‐linear model for 2D is established,time‐optimal trajectories are introduced.A control method called LMPC is shown to solve the problem of orbital tracking,which allows setting limits for state *** addition,to ensure system performance,a linear extended state observer(LESO)is integrated to cope with system ***,the efficiency of the proposed approach for liquid sloshing suppression and tracking is illustrated by simulations.

关键词： control dynamic model motion planning

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