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改良骨牵引技术治疗兔胫骨骨折的疗效研究

中国中医骨伤科杂志 2024年第3期32卷 1-6页

作者：赵庆祚文志李梓欧邓卓旺王林华卢敏苏智杰湖南中医药大学长沙410208 宁乡市中医医院湖南中医药大学第一附属医院

目的:观察改良骨牵引治疗技术对兔胫骨斜形骨折复位效果的影响,探讨对胫骨斜形骨折患者实施一种新的骨牵引方案的可能性。方法:选取体型和体重相近的家兔24只,通过截骨术进行胫骨斜形骨折造模,造模成功后随机分为对照组和观察组各12只,... 详细信息

目的:观察改良骨牵引治疗技术对兔胫骨斜形骨折复位效果的影响,探讨对胫骨斜形骨折患者实施一种新的骨牵引方案的可能性。方法:选取体型和体重相近的家兔24只,通过截骨术进行胫骨斜形骨折造模,造模成功后随机分为对照组和观察组各12只,对照组用传统轴向骨牵引技术治疗,观察组用改良骨牵引技术治疗,均采取持续14 d的仰卧位牵引,观察牵引前后两组家兔的骨折复位效果、伤肢周径及血清中血管内皮生长因子(VEGF)、白细胞介素6(IL-6)的含量改变。结果:两组模型兔胫骨骨折复位有效率,观察组(83.33%)大于对照组(75.00%),差异有统计学意义(P=0.002);两组模型兔牵引第1,3,5,7,14天的伤肢周径,观察组(14.38,12.95,11.49,9.59,9.26 cm)小于对照组(14.66,13.84,12.68,11.70,11.29 cm),两组家兔在牵引第1,3,5,7,14天后的伤肢周径比较差异有统计学意义(P<0.05);两组模型兔牵引前后的血清中VEGF、IL-6显著改善,差异有统计学意义(P<0.05)。结论:改良骨牵引技术治疗胫骨斜形骨折复位疗效显著,治疗后骨折复位效果优于传统轴向骨牵引技术,治疗后伤肢肿胀周径小于传统轴向骨牵引技术,可作为治疗胫骨骨折新的有效牵引方法。

关键词：动静结合改良骨牵引胫骨骨折斜形骨折

盐酸戊乙奎醚对腰硬联合麻醉剖宫产产妇呼吸功能的影响

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武汉大学学报（医学版） 2024年第3期45卷 360-365页

作者：蒋梦笔刘琼杨先涛龚园三峡大学麻醉与急危重症医学研究所/宜昌市中心人民医院麻醉科湖北宜昌443003 宜昌市中心人民医院产科湖北宜昌443003 宜昌市中心人民医院新生儿科湖北宜昌443003

目的:探讨盐酸戊乙奎醚预处理对腰硬联合麻醉剖宫产产妇呼吸功能的影响。方法:纳入2022年11月至2023年3月于宜昌市中心人民医院接受择期腰硬联合麻醉剖宫产产妇80例并随机分为2组(n=40)。盐酸戊乙奎醚组(P组)于麻醉前30 min静脉注射盐... 详细信息

目的:探讨盐酸戊乙奎醚预处理对腰硬联合麻醉剖宫产产妇呼吸功能的影响。方法:纳入2022年11月至2023年3月于宜昌市中心人民医院接受择期腰硬联合麻醉剖宫产产妇80例并随机分为2组(n=40)。盐酸戊乙奎醚组(P组)于麻醉前30 min静脉注射盐酸戊乙奎醚0.01 mg/kg,生理盐水组(N组)于麻醉前30 min静脉注射等容量生理盐水。观察并记录产妇给药前、麻醉成功即刻、胎儿取出即刻、5 min及20 min收缩压、舒张压、心率和指脉血氧饱和度;给药前、胎儿取出5 min及20 min动脉血氧分压(PaO_(2))和动脉二氧化碳分压(PaCO_(2));记录产妇呼吸困难及其他不适;记录新生儿出生情况。结果:两组产妇胎儿取出5min及20min产妇PaO_(2)比给药前高(Pmin及20 min产妇PaO_(2)比N组高(P0.05)。结论:麻醉前应用盐酸戊乙奎醚对剖宫产产妇的呼吸功能有一定的益处,且不会影响新生儿的转归。

关键词：戊乙奎醚呼吸功能腰硬联合麻醉剖宫产

Studies on the Interaction of Tyr and oligopeptides with ct-DNA

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Studies on the Interaction of Tyr and oligopeptides with ct-...

Parotid mammary analogue secretory carcinoma:A case report and review of literature

河南省化学会2016年学术年会

作者： SUN zhi-jie LV ming-xiu jiang Jia-min LU Kui College of Chemistry and Molecular Engineering Zhengzhou University School of Material and Chemical Engineering Henan University of Engineering

Small peptides are the basic ligands of life and biological active substances involving various of cellular functions. Small peptides can activate the related enzyme systems, promote the permeability of intermediary metabolism and influence the DNA transcription to generate specific physiological and pharmacological effects. The peptide Tyr-Tyr-Tyr-Tyr plays an important role in biomedicine, functional foods and life science field. In this study, Tyr-Tyr-Tyr-Tyr was synthesized by Fmoc solid-phase synthesis, which was purified and separated by reverse phase high performance liquid chromatography,and characterized by ESI-MS. The interaction between peptide and ct-DNA was studied by using UV-Vis absorption spectra, CD, fluorescence spectra. The results obtained showed that there was a hyperchromic effect on UV spectra with the increase of peptide concentration, fluorescence quenching and a blue shift of CD, Tyr-Tyr-Tyr-Tyr and Tyr might interact with ct-DNA by groove binding,compared with Tyr, the interaction between Tyr-Tyr-Tyr-Tyr and ct-DNA was stronger.

关键词： Tyr-Tyr-Tyr-Tyr Tyr ct-DNA Interaction

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World Journal of Clinical Cases 2021年第16期9卷 4052-4061页

作者： Feng-He min Jia Li Bo-Qiang Tao Hui-min Liu zhi-Jing Yang Lu Chang Yu-Yang Li Ying-Kun Liu Yi-Wen Qin Wei-Wei Liu Department of Oral and Maxillofacial Surgery Hospital of StomatologyJilin UniversityChangchun 130021Jilin ProvinceChina Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling Changchun 130021Jilin ProvinceChina Department of Oral Implant Hospital of StomatologyJilin UniversityChangchun 130021Jilin ProvinceChina Department of Stomatology Chongqing Medical UniversityChongqing 400016China

BACKGROUND Mammary analogue secretory carcinoma(MASC)is a rare low-grade malignant salivary gland *** morphological and immunohistochemical features of MASC closely resemble those of breast secretory *** key characteristics of the lesion are a lack of pain and slow *** is no obvious specificity in the clinical manifestations and imaging *** diagnosis of the disease mainly depends on the detection of the MASC-specific ETV6-NTRK3 fusion *** SUMMARY This report describes a rare case of a 32-year-old male patient who presented with a gradually growing lesion that was initially diagnosed as breast-like secretory carcinoma of the right parotid *** and histological investigations were used to overcome the diagnostic *** lesion was managed with right parotidectomy,facial nerve preservation,biological patch implantation to restore the resulting defect,and postoperative *** postoperative follow-up,the patient reported a mild facial deformity with no complications,signs of facial paralysis,or Frey’s *** The imaging and histological diagnostic challenges for MASC are discussed.

关键词： Mammary analogue secretory carcinoma Salivary gland Immunohistochemistry Total lobectomy of right parotid gland Case report

Expression characteristics of neutrophil and mononuclear-phagocyte related genes mRNA in the stable angina pectoris and acute myocardial infarction stages of coronary artery disease

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Journal of Geriatric Cardiology 2015年第3期12卷 279-286页

作者： Chuan-Rong LI Le-min WANG Zhu GONG Jin-Fa jiang Qiang-Lin DUAN Wen-Wen YAN Xiao-Hui LIU Department of Cardiology Tongji Hospital Tongji University School of Medicine Shanghai China

Objective To investigate expression differences of neutrophil and mononuclear phagocyte related gene mRNAs among acute myocardial infarction （AMI）, stable angina （SA） and control groups, and then discuss their expression characteristics in the stable angina pectoris （SAP） and AMI stages of coronary artery disease （CAD）. Methods Whole Human Genome Oligo Microarrays were applied to assess the differential expression characteristics of neutrophil and mononuclear phagocyte related mRNAs in patients with AMI （n = 20）, SA （n = 20） and controls （n = 20）. Results （1） Almost all colony-stimulating factors （CSF） and their receptors related mRNAs was up-regulated in AMI and SA groups compared with the control group, and the expression of granulocyte-macrophage colony stimulating factor receptor （GM-CSFR） and granulocyte colony stimulating factor receptor （G-CSFR） mRNAs in the AMI group was significantly up-regulated compared with the other two groups （P 〈 0.01）. （2） The expression of mRNAs related to monocyte chemoattractant protein-1 （MCP-1）, CCR2 （MCP-1 receptor） and CXCR2 （IL-8 receptor） was significantly up-regulated （P 〈 0.01） in AMI group compared with SA and control groups IL-8 mRNA expression in the AMI group was clearly higher than the controls （P 〈 0.05）. （3） All mRNAs expression related to opsonic re- ceptors （IgG FoR and C3bR/C4bR） was significantly up-regulated in AMI group compared with SA and control group （P 〈 0.01）, and the SA group showed an upward trend compared with controls. （4） Most pattern recognition receptor （PRR）-related mRNAs expression was up-regulated in AMI group compared with SA and control groups. Most toll-like receptor （TLR） mRNAs expression was significantly up-regulated （P 〈 0.01） than the SA and control groups, macrophage scavenger receptor （MSR） mRNA was significantly up-regulated in AMI group compared with the control group （P 〈 0.01）, and the SA group showed an upward trend compared with the controls. Conclusions The expression of most n

关键词： Acute myocardial infarction Coronary atherosclerosis Mononuclear-macrophage Neutrophil

New limonoids isolated from the bark of Melia toosendan

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Chinese Journal of Natural Medicines 2018年第12期16卷 946-950页

作者： ZHANG Qiong ZHENG Qing-Hong SANG Yi-Shu SUNG Herman Ho-Yung min zhi-Da Department of Pharmaceutical Science Shanxi Medical University Department of Natural Medicinal Chemistry China Pharmaceutical University Department of Chemistry Hong Kong University of Science and Technology

Two new limonoids, 12-ethoxynimbolinins G and H(compounds 1 and 2), and one known compound, toosendanin(Chuanliansu)(compound 3), were isolated from the bark of Melia toosendan. Their structures were elucidated by spectroscopic analysis and X-ray techniques. The absolute configuration of toosendanin(3) was established by single-crystal X-ray diffraction. Compounds 1-3 were evaluated for their cytotoxicity against five tumor cell lines.

关键词： Melia toosendan Meliaceae Limonoid Toosendanin Absolute configuration

Polylactic-co-glycolic acid microspheres containing three neurotrophic factors promote sciatic nerve repair after injury

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Neural Regeneration Research 2015年第9期10卷 1491-1497页

作者： Qun Zhao zhi-yue Li Ze-peng Zhang Zhou-yun Mo Shi-jie Chen Si-yu Xiang Qing-shan Zhang min Xue Health Management Center Third Xiangya Hospital of Central South University Department of Orthopedics Third Xiangya Hospital of Central South University Department of Orthopedics Yiyang Municipal Central Hospital Department of Gynecology Third Xiangya Hospital of Central South University

A variety of neurotrophic factors have been shown to repair the damaged peripheral nerve. However, in clinical practice, nerve growth factor, neurotrophin-3 and brain-derived neuro- trophic factor are all peptides or proteins that may be rapidly deactivated at the focal injury site; their local effective concentration time following a single medication cannot meet the required time for spinal axons to regenerate and cross the glial scar. In this study, we produced polymer sustained-release microspheres based on the polylactic-co-glycolic acid copolymer; the micro- spheres at 300-pm diameter contained nerve growth factor, neurotrophin-3 and brain-derived neurotrophic factor. Six microspheres were longitudinally implanted into the sciatic nerve at the anastomosis site, serving as the experimental group; while the sciatic nerve in the control group was subjected to the end-to-end anastomosis using 10/0 suture thread. At 6 weeks after implanta- tion, the lower limb activity, weight of triceps surae muscle, sciatic nerve conduction velocity and the maximum amplitude were obviously better in the experimental group than in the control group. Compared with the control group, more regenerating nerve fibers were observed and dis- tributed in a dense and ordered manner with thicker myelin sheaths in the experimental group. More angiogenesis was also visible. Experimental findings indicate that polylactic-co-glycolic acid composite microspheres containing nerve growth factor, neurotrophin-3 and brain-derived neurotrophic factor can promote the restoration of sciatic nerve in rats after injury.

关键词： nerve regeneration biological compatibility microspheres nervepolylactic-co-glycolic acid copolymer nerve growth facwr neurotrophin-3 brainfactorinjury nerve repazr .derived neurotrophic

深圳市大气污染物暴露对慢性病老年人群身体健康的影响

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毒理学杂志 2024年第1期38卷 30-35页

作者：姜帅田江马玥陈国敏季佳佳郭寅生祝慧萍逯建华深圳市疾病预防控制中心广东深圳518055 首都医科大学公共卫生学院流行病与卫生统计学系北京100069 首都医科大学公共卫生学院儿少卫生与妇幼保健学系北京100069

目的探讨深圳市6种大气污染物暴露对慢性病老年人群身体健康的影响。方法抽取2021年4月~2022年12月深圳市741人的健康体检数据和深圳市环境检测数据,采用主成分回归和广义估计方程分别分析探讨不同大气污染物的短期暴露与老年人群体检... 详细信息

目的探讨深圳市6种大气污染物暴露对慢性病老年人群身体健康的影响。方法抽取2021年4月~2022年12月深圳市741人的健康体检数据和深圳市环境检测数据,采用主成分回归和广义估计方程分别分析探讨不同大气污染物的短期暴露与老年人群体检指标之间的关联。结果参加过1次体检的人群中第一主成分短期暴露(PM_(10)、PM_(2.5)、CO和O_(3))和长期暴露(PM_(10)、PM_(2.5)、CO、O_(3)和NO_(2))与结合胆红素的升高相关(β:0.25,95%CI:0.18~0.32;β:0.24,95%CI:0.16~0.32),第二主成分(SO_(2))长期暴露与结合胆红素的升高(β:0.17,95%CI:0.10~0.24)及血尿素的降低(β:-0.17,95%CI:-0.23~-0.11)相关。在参加过2次体检的人群发现,在污染物的短期暴露下,PM_(2.5)每增加10μg/m^(3),结合胆红素升高3.30μmol/L(95%CI:2.33~4.30);PM_(10)每增加10μg/m^(3),甘油三酯升高2.20 mmol(95%CI:1.30~3.10);NO_(2)每增加10μg/m~(3),结合胆红素升高3.20μmol/L(95%CI:2.10~4.30),尿肌酐升高2.00 mmol/L(95%CI:1.10~2.90),血小板减少0.92×10^(8)/L(95%CI:0.52×10^(8)~1.32×10^(8));在污染物的长期暴露下,NO_(2)平均每增加10μg/m^(3),结合胆红素升高1.90μmol/L(95%CI:1.30~2.50);O_(3)平均每增加10μg/m^(3),结合胆红素升高1.00μmol/L(95%CI:0.60~1.40),非结合胆红素升高2.60(95%CI:1.60~3.60)。结论空气污染物的暴露和深圳市老年人群心血管系统、肾及肝系统的部分代谢指标的异常波动可能密切相关。应进一步加强空气质量的监测力度,加密空气质量监测频率,同时进一步加强老年人的健康管理。

关键词：空气污染老年人体检指标慢性病

Reflectance conversion methods for the VIS/NIR imaging spectrometer aboard the Chang'E-3 lunar rover: based on ground validation experiment data

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Research in Astronomy and Astrophysics 2013年第7期13卷 862-874页

作者： Bin Liu Jian-Zhong Liu Guang-Liang Zhang Zong-Cheng Ling jiang Zhang zhi-Ping He Ben-Yong Yang Yong-Liao Zou National Astronomical Observatories Chinese Academy of Sciences School of Space Science and Physics Shandong University at Weihai Graduate University of Chinese Academy of Sciences Shanghai Institute of Technical Physics Chinese Academy of Sciences Anhui Institute of Optics and Fine Mechanics Chinese Academy of Sciences

The second phase of the Chang＇E Program （also named Chang＇E-3） has the goal to land and perform in-situ detection on the lunar surface. A VIS/NIR imaging spectrometer （VNIS） will be carded on the Chang＇E-3 lunar rover to detect the distri-bution of lunar minerals and resources. VNIS is the first mission in history to perform in-situ spectral measurement on the surface of the Moon, the reflectance data of which are fundamental for interpretation of lunar composition, whose quality would greatly affect the accuracy of lunar element and mineral determination. Until now, in-situ de-tection by imaging spectrometers was only performed by rovers on Mars. We firstly review reflectance conversion methods for rovers on Mars （Viking landers, Pathfinder and Mars Exploration rovers, etc）. Secondly, we discuss whether these conversion methods used on Mars can be applied to lunar in-situ detection. We also applied data from a laboratory bidirectional reflectance distribution function （BRDF） using simu- lated lunar soil to test the availability of this method. Finally, we modify reflectance conversion methods used on Mars by considering differences between environments on the Moon and Mars and apply the methods to experimental data obtained from the ground validation of VNIS. These results were obtained by comparing reflectance data from the VNIS measured in the laboratory with those from a standard spectrometer obtained at the same time and under the same observing conditions. The shape and amplitude of the spectrum fits well, and the spectral uncertainty parameters for most samples are within 8%, except for the ilmenite sample which has a low albedo. In conclusion, our reflectance conversion method is suitable for lunar in-situ detection.

关键词： instrumentation: detectors - lunar in-situ detection: VNIS - re-flectance conversion: BRDF