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Humanβ-defensin-1 affects the mammalian target of rapamycin pathway and autophagy in colon cancer cells through long noncoding RNA TCONS_00014506

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1465-1478页

作者： yu-Xin Zhao Yan Cui Xin-Hong Li Wen-Hong Yang Shi-Xiang An Jia-Xian Cui min-yu zhang Jing-Kun Lu Xuan zhang Xiu-Mei Wang Li-Li Bao Peng-Wei Zhao Department of Anesthesiology Inner Mongolia Chest HospitalThe Fourth HospitalHohhot 010035Inner Mongolia Autonomous RegionChina College of Humanities and Education Inner Mongolia Medical UniversityHohhot 010059Inner Mongolia Autonomous RegionChina Department of Radiotherapy The Affiliated Hospital of Inner Mongolia Medical UniversityHohhot 010059Inner Mongolia Autonomous RegionChina School of Basic Medical Science Inner Mongolia Medical UniversityHohhot 010059Inner Mongolia Autonomous RegionChina Department of Medical Oncology The Affiliated Cancer Hospital of Inner Mongolia Medical UniversityHohhot 010050Inner Mongolia Autonomous RegionChina

BACKGROUND Colorectal cancer has a low 5-year survival rate and high ***β-defensin-1(hBD-1)may play an integral function in the innate immune system,contributing to the recognition and destruction of cancer *** non-coding RNAs(lncRNAs)are involved in the process of cell differentiation and *** To investigate the effect of hBD-1 on the mammalian target of rapamycin(mTOR)pathway and autophagy in human colon cancer SW620 *** CCK8 assay was utilized for the detection of cell proliferation and determination of the optimal drug *** formation assay was employed to assess the effect of hBD-1 on SW620 cell *** was used to screen potentially biologically significant lncRNAs related to the mTOR ***,p-mTOR(Ser2448),Beclin1,and LC3II/I expression levels in SW620 cells were assessed through Western blot *** hBD-1 inhibited the proliferative ability of SW620 cells,as evidenced by the reduction in the colony formation capacity of SW620 cells upon exposure to ***-1 decreased the expression of p-mTOR(Ser2448)protein and increased the expression of Beclin1 and LC3II/I ***,bioinformatics analysis identified seven lncRNAs(2 upregulated and 5 downregulated)related to the mTOR *** lncRNA TCONS_00014506 was ultimately *** the inhibition of the lncRNA TCONS_00014506,exposure to hBD-1 inhibited p-mTOR(Ser2448)and promoted Beclin1 and LC3II/I protein *** hBD-1 inhibits the mTOR pathway and promotes autophagy by upregulating the expression of the lncRNA TCONS_00014506 in SW620 cells.

关键词： Colon cancer Humanβ-defensin-1 LncRNA Mammalian target of rapamycin Autophagy

Role of angiotensin receptor-neprilysin inhibitor in diabetic complications

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World Journal of Diabetes 2024年第5期15卷 867-875页

作者： Ying Liu Cun-yu Lu Yi Zheng yu-min zhang Ling-Ling Qian Ku-Lin Li Gary Tse Ru-Xing Wang Tong Liu Department of Cardiology Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular DiseaseTianjin Institute of CardiologySecond Hospital of Tianjin Medical UniversityTianjin 300211China Department of Cardiology Xuzhou No.1 Peoples HospitalXuzhou 221005Jiangsu ProvinceChina Department of Cardiology Wuxi 9^(th)People’s Hospital Affiliated to Soochow UniversityWuxi 214062Jiangsu ProvinceChina Department of Cardiology Wuxi People’s Hospital Affiliated to Nanjing Medical UniversityWuxi 214023Jiangsu ProvinceChina School of Nursing and Health Studies Metropolitan UniversityHong Kong 999077China Kent and Medway Medical School Kent CT27NTCanterburyUnited Kingdom

Diabetes mellitus is a prevalent disorder with multi-system manifestations,causing a significant burden in terms of disability and deaths ***-tensin receptor-neprilysin inhibitor(ARNI)belongs to a class of medications for treating heart failure,with the benefits of reducing hospitalization rates and *** review mainly focuses on the clinical and basic investigations related to ARNI and diabetic complications,discussing possible physiological and molecular mechanisms,with insights for future applications.

关键词： Angiotensin receptor-neprilysin inhibitor Diabetic mellitus Complication

Analysis of quality of life in patients after transgastric natural orifice transluminal endoscopic gallbladder-preserving surgery

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World Journal of Gastrointestinal Endoscopy 2024年第6期16卷 318-325页

作者： min-yu zhang Sen-yuan Zheng Zheng-yu Ru Zhi-Qiang zhang Department of Gastroenterology The First Affiliated Hospital of Xinjiang Medical UniversityUrimuqi 830011Xinjiang Uygur Autonomous RegionChina

BACKGROUND At present,laparoscopic cholecystectomy(LC)is the main surgical treatment for ***,after gallbladder removal,there are many ***,it is hoped to remove stones while preserving the function of the gallbladder,and with the development of endoscopic technology,natural orifice transluminal endoscopic surgery came into *** To compare the quality of life,perioperative indicators,adverse events after LC and transgastric natural orifice transluminal endoscopic gallbladder-preserving surgery(EGPS)in patients with *** Patients who were admitted to The First Affiliated Hospital of Xinjiang Medical University from 2020 to 2022 were retrospectively *** adopted propen-sity score matching(1:1)to compare EGPS and LC *** A total of 662 cases were collected,of which 589 cases underwent LC,and 73 cases underwent *** score matching was performed,and 40 patients were included in each of the *** the EGPS group,except the gastr-ointestinal defecation(P=0.603),the total score,physical well-being,mental well-being,and gastrointestinal digestion were statistically significant compared with the preoperative score after surgery(P<0.05).In the LC group,except the mental well-being,the total score,physical well-being,gastrointestinal digestion,the gastrointestinal defecation was statistically significant compared with the preoperative score after surgery(P<0.05).When comparing between groups,gastrointestinal defecation had significantly difference(P=0.002)between the two groups,there was no statistically significant difference in the total postoperative score and the other three *** the surgery duration,hospital stay and cost,LC group were lower than EGPS *** recurrence factors of gallstones after EGPS were analyzed:and recurrence was not correlated with gender,age,body mass index,number of stones,and preoperative *** Whether EGPS or LC,it can improve the patient’s symp

关键词： Gallstones Natural orifice transluminal endoscopic surgery Gallbladder preservation Cholecystolithotomy Laparoscopic cholecystectomy Gastrointestinal quality of life index

Biotransformation of nonylphenol ethoxylates during sewage treatment under anaerobic and aerobic conditions

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Journal of Environmental Sciences 2008年第2期20卷 135-141页

作者： zhang Jing YANG min zhang yu CHEN Meixue State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

Biotransformation of nonylphenol ethoxylates （NPEOs） during continuous anaerobic sewage treatment was compared with the aerobic treatment of sewage spiked with 23 μmol/L technical NPEOs over a period of 90 d. Immediate degradation of NPEOs was observed under both anaerobic and aerobic conditions, indicating that the enzymes and bacteria required for NPEO degradation existed abundantly in both aerobic and anaerobic sludge. Both treatments achieved high removal （〉 92%） of the spiked NPEO9 mixture. Liquid chromatography-mass spectrometry （LC-MS） analysis showed that short-chain NPEOs （NPEO1-NPEO3） accumulated in anaerobic （2.01-2.56 μmol/L） and aerobic （1.62-2.03 μmol/L） effluents, with nonylphenol （NP）（0.24-0.31 μmol/L） as another group of metabolites in the anaerobic effluent, and nonylphenoxy carboxylates （NPECs）（2.79-3.30 μmol/L） in the aerobic effluent. Significant accumulation of NP in the anaerobic sludge and NPEO1-3 in the sludge of two reactors was observed. These results indicated that it was difficult to control these harmful metabolites in the conventional treatment processes. Denaturing gradient gel electrophoresis profiles of sludge samples support the speculation that the NPEO degradation bacteria might be the dominant indigenous species.

关键词： biodegradation nonylphenol nonylphenol ethoxylate nonylphenoxy carboxylates sewage treatment

Immunocytochemical Identification and Localization of Diffuse Neuroendocrine System (DNES) Cells in Gastrointestinal Tract of Channel Catfish (Ictalurus punctatus)

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Agricultural Sciences in China 2009年第2期8卷 238-243页

作者： HE min WANG Kai-yu zhang yu College of Veterinary Medicine Sichuan Agricultural University Ya＇an 625014 P.R.China

To detect distribution and relative frequency of diffuse neuroendocrine system （DNES） cells in the gastrointestinal tract of channel catfish （lctalurus punctatus）, the intestinal tract of channel catfish was divided into seven portions from proximal to distal： the enlarged area after oesophagus, cardia, fundus, pylorus, and anterior, middle, and posterior intestine. Immunohistochemical method using the strept avidin-biotin-complex （SABC） was employed. All antisera between seven portions of the channel catfish were compared statistically using statistical package for the social science （SPSS）. Five types of DNES ceils were determined： neuropeptide Y-immunoreactive （NPY-IR） cells were demonstrated in both anterior and middle intestine; serotonin （5-HT） immunoreactive cells were detected throughout the whole gastrointestinal tract; vasoactive intestinal peptide （VIP） positive cells were at the highest frequency in pylorus; glucagon-immunoreactive （GLU-IR） cells were moderate in number in the fundus and anterior, middle intestine, and no immunoreactivity was determined in the other portions; somatostatin （SOM） positive cells were more abundant in the anterior and middle intestine. The regional distribution and relative frequency of immunoreactive cells in the channel catfish, Ictalurus punctatus, are essentially similar to those of other fish. However, some characteristics are observed in this species, which further proved that the diversity of the physiological function of DNES cells was based on their morphology.

关键词： channel catfish lctalurus punctatus gastrointestinal tract DNES cells immunocytochemistry

t(4;11)translocation in hyperdiploid de novo adult acute myeloid leukemia:A case report

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World Journal of Clinical Cases 2022年第32期10卷 11980-11986页

作者： min-yu zhang yue Zhao Ji-Hong zhang Hematology Laboratory Shengjing Hospital of China Medical UniversityShenyang 110022Liaoning ProvinceChina

BACKGROUND MLL gene rearrangement is a common genetic abnormality of acute myeloid leukemia(AML),which predicts poor prognosis and is important in clinical *** rearrangement involves many chromosomes,among which,t(4;11)translocation is rare in *** present case was t(4;11)AML,accompanied by a hyperdiploid *** cases have not been reported *** SUMMARY An adult male with self-reported symptoms of fatigue,febrility and hyperleukocytosis was diagnosed with AML by morphology and confirmed by immunophenotype ***,chromosomal and fluorescence in situ hybridization(FISH)analysis showed a hyperdiploid karyotype with t(4;11)translocation and MLL rearrangement,and a negative MLL–AF4 fusion gene *** patient died of respiratory and circulatory failure 5 days after *** t(4;11)AML with hyperdiploid karyotype has not been *** this case,t(4;11)was only detected by karyotype analysis and FISH,suggesting their importance in MLL rearrangement detection.

关键词： Acute myeloid leukemia MLL gene rearrangement Translocation t(4 11) Hyperdiploid FISH Case report

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伤痛的开阖:《边城》疗愈性研究

郑州师范教育 2024年第1期13卷 48-52页

作者：吴佳于敏章黄彦妮西华师范大学文学院四川南充637002 成都师范学院文学与新闻学院四川成都611130

作为沈从文的经典之作,《边城》依托于现实,其中又适当地加入了作者的想象,将上个世纪初湘西及湘西人民的生活状态展现在读者面前,这种模式脱离了宏大叙事,在那个特定时代语境下展现出其独特意义。通过对沈从文《边城》创作前的个人创... 详细信息

作为沈从文的经典之作,《边城》依托于现实,其中又适当地加入了作者的想象,将上个世纪初湘西及湘西人民的生活状态展现在读者面前,这种模式脱离了宏大叙事,在那个特定时代语境下展现出其独特意义。通过对沈从文《边城》创作前的个人创伤经历和创作心理的把握和分析,立足于作品本身,以探究《边城》的疗愈性及其疗愈意义为指归。《边城》中蕴藏着巨大情感和文化力量,沈从文用其来疗愈自我、疗愈时代文化。囿于特殊时代语境,这种疗愈可能存在不彻底性,但《边城》背后作者所寄托的文化理想值得玩味和发人深思。

关键词：伤痛《边城》疗愈性文化理想

A Multi-model,Large-range Flexible Strain Sensor Based on Carbonized Silk Habotai for Human Health Monitoring

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Chinese Journal of Polymer Science 2023年第8期41卷 1238-1249,I0008页

作者： Shi-Dong Ma yu-Ting Wu Jian Tang yu-min zhang Tao Yan Zhi-Juan Pan College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123China National Engineering Laboratory for Modern Silk Suzhou 215123China

In recent years,flexible strain sensors have received considerable attention owing to their excellent flexibility and ***,it is still a great challenge for them to accurately monitor multi-model deformations with high sensitivity and *** this study,the industrial insulating silk habotai was successfully converted into carbonized silk habotai(CSH)for use in strain sensors.A strain sensor created using CSH exhibited excellent sensing performance under multi-model deformations,including stretching,twist and *** maximum tensile strain was 434%.The gauge factors were 14.6 in the wide tensile range of 0%–400%with a high linearity of *** addition,the CSH strain sensor exhibited an extremely fast response time(110 ms)and could accurately detect bending(0°–180°)and torsional(0°–180°)*** durability and repeatability were observed for the multi-model ***,a new type of smart pillow was developed to accurately record head movement and breathing during *** sensor may also be used for auxiliary training in table *** proposed CSH strain sensor has shown great potential for applications in smart devices and human-machine interactions.

关键词： Carbonized silk habotai Strain sensor Smart pillow Human motions

Synthesis of diethers derived from furoin by phase transfer catalysis under microwave irradiation

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Chinese Chemical Letters 2007年第7期18卷 791-794页

作者： Feng zhang Ya Zhuo Li Da Wei Gao Ji Kui Sun yu min zhang College of Chemistry Jilin University Changchun Jilin 130012 China

A series of new diethers were obtained by alkylation of furoin under microwave irradiation （MWI） in phase transfer catalysis （PTC） conditions. The products of alkyl halides were synthesized in good yields （〉75%） within a few minutes, and the products of dihalides were synthesized in fair yields （about 45%）. The yields are dramatically improved compared to conventional heating under the same conditions, in spite of similar profiles of rising in temperature.

关键词： Microwave irradiation Furoin Phase transfer catalysis O-Alkylation