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Chinese Chemical Letters 2007年第1期18卷 41-44页

作者： Hao Fang min yong li lin Xia School of Pharmacy Shandong University Jinan 250012 China Department of Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China

A series of arylpiperazinesquinazoline-2,4-diamine compounds were designed and synthesized based on pharmacophore for m-selective α1-adrenoceptor antagonists and 3D chemical database searching. The in vitro functional analysis showed that compounds 9 and 14 showed better and similar α1-AR antagonistic activity compared with prazosin.

关键词： α1-Adrcnoceptor Antagonists Pharmacophore-guided design

BioLeT: A new design strategy for functional bioluminogenic probes

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Chinese Chemical Letters 2015年第8期26卷 919-921页

作者： Tian-Chao Zhang Lu-Pei Du min-yong li Department of Medicinal Chemistry Key Laboratory of Chemical Biology (MOE) School of Pharmacy Shandong University

By integrating photoinduced electron transfer（PET） into the design of functional bioluminogenic probes,Urano and his coworkers recently developed a new rational design strategy, BioLeT. It is expected that this BioLeT strategy will enable us to design and develop new bioluminescence probes for detecting various biomolecules with no catalytic or reactive activity.

关键词： probes detecting enable integrating rational utilized challenging instead absolute moiety

Enantiomeric Separation of Four Chiral Compounds Using Immobilized Cellulose 3, 5-Dimethylphenylcarbamate as Chiral Stationary Phase

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Chinese Chemical Letters 2006年第9期17卷 1213-1216页

作者： yong Fei minG liang ZHAO Hong li ZHANG Yan Ping SHI yong min li li Ren CHEN Key Laboratory for Natural Medicine of Gansu Province Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanzhou 730000 The Graduate School of Chinese Academy of Sciences Beijing 100039

A new chiral stationary phase of 3, 5-dimethylphenylcarbamates of cellulose, chemically bonded to 3-aminopropylsilica gel at the 6-positions of the glucose units, was prepared. The solvent versatility of the CSP was investigated for the enantioselective separation of four pairs of enantiomers using THF and chloroform as non-standard mobile phase eluent in HPLC. The influence of temperature on the resolution was investigated.

关键词： HPLC immobilized enantiomeric separation.

Synthesis of Some New Derivatives of 1,3-Dichloro-1,1,3,3-tetraphenyldisilazane

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Chinese Chemical Letters 2001年第1期12卷 35-38页

作者： Cai Hong XU Zhi Jie ZHANG yong min li Zhi min ZHENG Ze min XIE Center for Molecular Science Institute of ChemistryThe Chinese Academy of SciencesBeijing 100080

The reactive properties of 1,3-dichloro-1,1,3,3-tetraphenyldisilazane (DCTPS) with water, methanol, phenylamine and lithium salt of hexamethylcyclotrisilazane (D-3(Nli)) were investigated, and four new derivatives wer... 详细信息

关键词： 1,3-dichloro-1,1,3,3-tetraphenyldisilazane derivatives reactive properties

Luminescence of coelenterazine derivatives with C-8 extended electronic conjugation

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Chinese Chemical Letters 2016年第4期27卷 550-554页

作者： ming-liang Yuan Tian-Yu Jiang Lu-Pei Du min-yong li Department of Medicinal Chemistry Key Laboratory of Chemical Biology (MOE) School of Pharmacy Shandong University

Replacement of the methylene group at the C-8 position with an extended electronic conjugation is a new promising method to develop red-shifted coelenterazine derivatives. In this paper, we have described an oxygen-containing coelenterazine derivative with a significant red-shifted（63 nm）bioluminescence signal maximum relative to coelenterazine 400a（Deep Blue C^（TM）, 1）. In cell imaging, the sulfur-containing coelenterazine derivative displayed a significantly（1.77 ± 0.09;P≤0.01） higher luminescence signal compared to coelenterazine 400 a and the oxygen-containing coelenterazine derivative exhibited a slightly（0.74 ± 0.08; P≤0.05） lower luminescence signal. It is beneficial to understand further the underlying mechanisms of bioluminescence.

关键词： Bioluminescence imaging Coelenterazine derivatives Relative quantum yield Chemiluminescence Red-shifted

The Optical Resolution of Chiral Tetrahedrone-type Clusters Contai- ning SCoFeM (M=Mo or W) Using High Performance liquid Chromatography Chiral Stationary Phase

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Chinese Chemical Letters 2002年第12期13卷 1193-1194页

作者： Xiao Qian HAN yong min li Yu Hua ZHANG Sheng Xiang JIANG li Ren CHEN Lanzhou Institute of Chemical Physics Chinese Academy of SciencesLanzhou 730000

Amylose tris (phenylcarbamate) chiral stationary phase (ATPC-CSP) was prepared and used for optical resolution of clusters 1 and 2. n-Hexane/2-propanol ( 99/1; v/v) were found to be the most suitable mobile phase on ... 详细信息

关键词： Optical resolution amylose tris (phenylcarbamate) chiral stationary phase chiral tetrahedrone type cluster.

Discovery of naphthalimide conjugates as fluorescent probes for α_1-adrenoceptors

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Chinese Chemical Letters 2016年第2期27卷 185-189页

作者： Wei Zhang Xin-Yang Zhou Qin-Ying Yu Lu-Pei Du min-yong li Department of Medicinal Chemistry Key Laboratory of Chemical Biology (MOE) School of Pharmacy Shandong University

α1-Adrenoceptors（α1-ARs）, including at least three subtypes, α（1A）, α（1B） and α（1D）, which play essential roles in G protein-coupled receptors（GPCRs）, can convey multiple pivotal extracellular signals in varied tissues and organs. In this research, a series of napthalimide-based small-molecule fluorescent probes（1a-1f） for α1-ARs, including two parts, a pharmacophore（quinazoline and phenylpiperazine） for α1-AR recognition and a fluorophore（naphthalimide） for visualization, were designed and synthesized successfully. These compounds display excellent fluorescence property and high affinity to receptors,which were used successfully for in vitro visualization of α1-adrenoceptors.

关键词： α1-Adrenergic receptors Fluorescent probes High affinity Cell imaging

Large-disturbance Stability Analysis of Power Systems with Synchronous Generator and Converter-interfaced Generation

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 997-1002页

作者： Lei Chen yong min liangshuai Hao Guangzheng Xing Yalou li Shiyun Xu Department of Electrical Engineering Tsinghua UniversityBeijing 100084China China Electric Power Research Institute Beijing 100192China

This letter studies large-disturbance stability of the power system with a synchronous generator(SG)and a converter-interfaced generation(CIG)connected to infinite *** power system is multi-timescale and first *** is shown that the boundary of region of attraction(ROA)of the simplified model is composed of stable manifolds of unstable equilibrium point(UEP)or semi-singular point(SSP),named anchor points,and singular surface *** type of anchor point determines the dominant instability pattern of the power *** the anchor point is UEP or SSP,the dominant instability pattern is the instability of rotor angle of SG or the instability of phase-locked loop and outer control loop(OCL)of CIG,*** of dominant instability pattern can be analyzed with the relative position relationship between UEP and *** effect of OCL is *** the OCL is activated,the ROA becomes smaller and the system is more prone to instability of *** is necessary to consider the OCL when studying the large-disturbance stability of the power system.

关键词： Converter-interfaced generation large-disturbance stability outer control loop phase-locked loop synchronous generator voltage source converter

Diagnostic Techniques for COVID-19:A mini-review of Early Diagnostic Methods

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Journal of Analysis and Testing 2021年第4期5卷 314-326页

作者： Gao-Pan Dong Xiu-Juan Guo Ying-Ai Sun Zheng Zhang Lu-Pei Du min-yong li Department of Medicinal Chemistry Key Laboratory of Chemical Biology(MOE)School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China School of Pharmacy Xinxiang Medical UniversityXinxiang 453003HenanChina

The outbreak of severe pneumonia at the end of 2019 was proved to be caused by the SARS-CoV-2 virus spreading out the *** COVID-19 spread rapidly through a terrible transmission way by human-to-human,which led to many suspected cases waiting to be diagnosed and huge daily samples needed to be tested by an eff ective and rapid detection *** an increasing number of COVID-19 infections,medical pressure is ***,more e fficient and accurate diagnosis methods were keen urgently *** this review,we summarized several methods that can rapidly and sensitively identify COVID-19;some of them are widely used as the diagnostic techniques for SARS-CoV-2 in various countries,some diagnostic technologies refer to SARS(Severe Acute Respiratory Syndrome)or/and MERS(Middle East Respiratory Syndrome)detection,which may provide potential diagnosis ideas.

关键词： COVID-19 Severe respiratory disease SARS-CoV-2 virus Rapid and accurate methods Diagnostic approach

Application of High Performance liquid Chromatography to Separation of Novel Chiral Tetrahedral Heterometal Clusters

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Chinese Chemical Letters 2003年第9期14卷 942-945页

作者： Xin Yi ZHU, Wei Qiang ZHANG, Yu Hua ZHANG, li Ren CHEN, yong min li Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000 Lanzhou Inst. of Chemical Physics Chinese Academy of Sciences Lanzhou 730000 China

A series of novel chiral tetrahedral heterometal clusters have firstly been separated on cellulose tris-(3,5-dimethylphenylcarbamate) stationary phase by high performance liquid chrom-atography, using hexane as the mo... 详细信息

关键词： Chiral stationary phase cellulose tris-(3 5-dimethylphenylcarbamate) mobile-phase composition chiral tetrahedral clusters enantioseparation.