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Food Science and Human Wellness 2024年

作者： Rongrong fu Lechen Wang Wenqing xue Jingjie Liang Jing Meng min Zhang State Key Laboratory of Food Nutrition and Safety， College of Food Science and Engineering， Tianjin University of Science and Technology Tianjin International Joint Academy of Biomedicine China-Russia Agricultural Processing Joint Laboratory， Tianjin Agricultural University

Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. Gut microbiota and its metabolites alteration are closely related to NAFLD. Nootkatone is an edible flavorants derived from grapefruit which has a variety of biological activities. However， the precise mechanisms of nootkatone on NAFLD remains to be defined. Our results showed that nootkatone prevented body weight gain and decreased serum lipid level， hepatic lipogenesis， hepatic proinflammatory cytokines secretion in NAFLD mice. Also， nootkatone attenuated inflammatory response via inhibiting TLR4/NF-κB/NLRP3 pathway. Moreover， nootkatone restored intestinal barrier damage through increasing tight junction proteins and SCFAs contents. further 16S rRNA sequencing of colonic content suggested that nootkatone recovered the disturbed gut microbiota to improve NAFLD. Spearman correlation analysis between gut microbiota and NAFLD related parameters indicated that nootkatone regulated lipid metabolism and immunity via altering the gut microbiota. In conclusion， these findings revealed that nootkatone alleviated hepatic lipid homeostasis and inflammatory response in NAFLD mice， which associated with intestinal barrier integrity and the regulation of gut microbiota. This study provides new perspectives that nootkatone has efficacy on NAFLD via “gut-liver axis”， and nootkatone is expected to be developed as a functional food additive.

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Optimization of water-urban-agricultural-ecological land use pattern:A case study of Guanzhong Basin in the southern Loess Plateau of Shaanxi Province,China

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China Geology 2024年第3期7卷 480-493页

作者： Sai Wang Bin Wu Hai-xue Li min-min Zhao Lei Yuan Xi Wu Tao Ma fu-cheng Li Shuang-bao Han Center for Hydrogeology and Environmental Geology Survey China Geological SurveyMinistry of Natural ResourcesTianjin 300304China Center for Groundwater Exploration and Development Engineering Research China Geological SurveyMinistry of Natural ResourcesTianjin 300304China School of Environmental Studies China University of GeosciencesWuhan430078China State Environmental Protection Key Laboratory of Source Apportionment and Control of Aquatic Pollution Hubei Key Laboratory of Yangtze Catchment Environmental Aquatic ScienceChina University of GeosciencesWuhan430078China

Extensive land use will cause many environmental *** is an urgent task to improve land use efficiency and optimize land use *** recent years,due to the flow decrease,the Guanzhong Basin in Shaanxi Province is confronted with the problem of insufficient water resources *** on the Coupled Ground-Water and Surface-Water Flow Model(GSFLOW),this paper evaluates the response of water resources in the basin to changes in land use patterns,optimizes the land use pattern,improves the ecological and economic benefits,and the efficiency of various spatial development,providing a reference for ecological protection and high-quality development of the Yellow River *** research shows that the land use pattern in the Guanzhong Basin should be further *** the condition of considering ecological and economic development,the percentage change of the optimum area of farmland,forest,grassland,water area,and urban area compared with the current land use area ratio is+2.3,+2.4,-6.1,+0.2,and+1.6,*** economic and ecological value of land increases by14.1%and 3.1%,respectively,and the number of water resources can increase by 2.5%.

关键词： Coupled Ground-Water and Surface-Water Flow Model(GSFLOW) Land use patterns Water resources optimization Ecological and economic benefits Coupling model Hydrological environmental engineering Guanzhong Basin Southern Loess Plateau Yellow River basin

First-principles study on the heterogeneous formation of environmentally persistent free radicals(EPFRs)overα-Fe2O3(0001)surface:Effect of oxygen vacancy

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Journal of Environmental Sciences 2024年第8期142卷 279-289页

作者： Wenxiao Pan Shuming He Qiao xue Xian Liu Jianjie fu Kang Xiao Aiqian Zhang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China School of Environment Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310012China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China Beijing Yanshan Earth Critical Zone National Research Station University of Chinese Academy of SciencesBeijing 101408China

Metal oxides with oxygen vacancies have a significant impact on catalytic activity for the transformation of organic pollutants in waste-to-energy(WtE)incineration *** study aims to investigate the influence of hematite surface oxygen point defects on the formation of environmentally persistent free radicals(EPFRs)from phenolic compounds based on the first-principles *** oxygen-deficient conditions were considered:oxygen vacancies at the top surface and on the *** simulations indicate that the adsorption strength of phenol on theα-Fe_(2)O_(3)(0001)surface is enhanced by the presence of oxygen ***,the presence of oxygen vacancies has a negative impact on the dissociation of the phenol molecule,particularly for the surface with a defective point at the top ***-kinetic parameters were established over a temperature range of300-1000 K,and lower reaction rate constants were observed for the scission of phenolic O-H bonds over the oxygen-deficient surfaces compared to the pristine *** negative effects caused by the oxygen-deficient conditions could be attributed to the local reduction of FeⅢto FeⅡ,which lower the oxidizing ability of surface reaction *** findings of this study provide us a promising approach to regulate the formation of EPFRs.

关键词： EPFR formation Phenol dissociation Oxygen-vacancy impact Hematite surface First-principles calculation

Photocatalytic degradation of methylene blue over MIL-100(Fe)/GO composites: a performance and kinetic study

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International Journal of Coal Science & Technology 2024年第3期11卷 208-222页

作者： Yuxue Wei Zhiyuan fu Yingzi Meng Chun Li fu Yin xue Wang Chenghua Zhang Lisheng Guo Song Sun School of Chemistry and Chemical Engineering Anhui UniversityHefei230601AnhuiChina Anhui Tanxin Technology Co. LtdHuaibei235141AnhuiChina

Adsorption coupled with photocatalytic degradation is proposed to fulfill the removal and thorough elimination of organic ***,we report a facile hydrothermal synthesis of MIL-100(Fe)/GO *** adsorption and photocatalytic degradation process of methylene blue(MB)on MIL‐100(Fe)/GO composites were systematically studied from performance and kinetic perspectives.A possible adsorption‐photocatalytic degradation mechanism is *** optimized 1M8G composite achieves 95%MB removal(60.8 mg/g)in 210 min and displays well recyclability over ten *** obtained MB adsorption and degradation results are well fitted onto Langmuir isotherm and pseudo‐second order kinetic *** study shed light on the design of MOFs based composites for water treatment.

关键词： Graphene oxide Metal organic frameworks Methylene blue Adsorption Photocatalytic degradation

Lightweight Cross-Modal Multispectral Pedestrian Detection Based on Spatial Reweighted Attention Mechanism

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Computers, Materials & Continua 2024年第3期78卷 4071-4089页

作者： Lujuan Deng Ruochong fu Zuhe Li Boyi Liu Mengze xue Yuhao Cui School of Computer and Communication Engineering Zhengzhou University of Light IndustryZhengzhou450002China

Multispectral pedestrian detection technology leverages infrared images to provide reliable information for visible light images, demonstrating significant advantages in low-light conditions and background occlusion scenarios. However, while continuously improving cross-modal feature extraction and fusion, ensuring the model’s detection speed is also a challenging issue. We have devised a deep learning network model for cross-modal pedestrian detection based on Resnet50, aiming to focus on more reliable features and enhance the model’s detection efficiency. This model employs a spatial attention mechanism to reweight the input visible light and infrared image data, enhancing the model’s focus on different spatial positions and sharing the weighted feature data across different modalities, thereby reducing the interference of multi-modal features. Subsequently, lightweight modules with depthwise separable convolution are incorporated to reduce the model’s parameter count and computational load through channel-wise and point-wise convolutions. The network model algorithm proposed in this paper was experimentally validated on the publicly available KAIST dataset and compared with other existing methods. The experimental results demonstrate that our approach achieves favorable performance in various complex environments, affirming the effectiveness of the multispectral pedestrian detection technology proposed in this paper.

关键词： Multispectral pedestrian detection convolutional neural networks depth separable convolution spatially reweighted attention mechanism

Rational design of vitamin C/defective carbon van der Waals heterostructure for enhanced activity,durability and storage stability toward oxygen reduction reaction

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Journal of Energy Chemistry 2024年第1期88卷 103-111,I0003页

作者： Ruiqi Cheng Kaiqi Li Huanxin Li Tianshuo Zhao Yibo Wang Qingyue xue Jiao Zhang Chaopeng fu Shanghai Key Laboratory of Advanced High-temperature Materials and Precision Forming School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Christopher Ingold Laboratory Department of ChemistryUniversity College LondonLondon WC1H 0AJUK Department of Chemistry Physical&Theoretical Chemistry LaboratoryUniversity of OxfordSouth Parks RoadOxford OX13QZUK

Metal-free defective carbon materials with abundant active sites have been widely studied as low-cost and efficient oxygen reduction reaction(ORR)electrocatalysts in metal-air ***,the active sites in defective carbon are easily subjected to serious oxidation or hydroxylation during ORR or storage,leading to rapid degradation of ***,we design a van der Waals heterostructure comprised of vitamin C(VC)and defective carbon(DC)to not only boost the activity but also enhance the durability and storage stability of the DC-VC *** formation of VC van der Waals between DC and VC is demonstrated to be an effective strategy to protect the defect active sites from oxidation and hydroxylation degradation,thus significantly enhancing the electrochemical durability and storage anti-aging ***,the DC-VC van der Waals can reduce the reaction energy barrier to facilitate the *** findings are also confirmed by operando Fourier transform infrared spectroscopy and density functional theory *** is necessary to mention that the preparation of this DC-VC electrocatalyst can be scaled up,and the ORR performance of the largely produced electrocatalyst is demonstrated to be very ***,the DC-VC-based aluminum-air batteries display very competitive power density with good performance maintenance.

关键词： Van der Waals heterostructure Oxygen reduction reaction Stability Scalable production Aluminum-air battery

Paeoniflorin,the Main Monomer Component of Paeonia lactiflora,Exhibits Anti-inflammatory Properties in Osteoarthritis Synovial Inflammation

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Chinese Journal of Integrative Medicine 2024年第5期30卷 433-442页

作者： CHEN Pu ZHOU Jun RUAN An-min MA Yu-feng WANG Qing-fu Department of Orthopaedic Surgery Beijing University of Chinese Medicine Third Affiliated HospitalBeijing 100029China Department of Orthopaedic Surgery Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Department of Orthopaedic Surgery Beijing Longfu HospitalBeijing 100010China

Objective:To explore the mechanism of paeoniflorin(PF)on osteoarthritis(OA)synovial inflammation from network pharmacology to experimental ***:Targets of OA were constructed by detecting the database of network database platforms(Therapeutic Target database,Drug Bank and Gene Cards),and the targets of PF were constructed by Pub Chem and Herbal Ingredients'Targets *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis of these co-targeted genes were conducted via Database for Annotation,Visualization,and Integrated Discovery(DAVID)database,and protein-protein interaction(PPI)networks were conducted via the search tool for the retrieval of interacting genes(STRING)*** counting kit-8(CCK-8)assay was performed to assess the potential toxicity of PF on human OA fibroblast-like synoviocytes(FLS),quantitative real-time polymerase chain reaction(q PCR),enzyme-linked immunosorbent assay(ELISA)and Western blot were used to verify the potential mechanism of PF in synovial ***:Twenty-six co-targeted genes were *** enrichment results showed that these co-targeted genes were most likely localized in the cytoplasm,and the biological processes mainly involved'cellular response to hypoxia''lipopolysaccharide(LPS)-mediated signaling pathway'and'positive regulation of gene expression'.KEGG pathway analysis indicated that these co-targeted genes may function through pathways associated with'hypoxia-inducible factor-1(HIF-1)signaling pathway'and'tumornecrosis factor(TNF)signaling pathway'.The PPI network showed that the top 3 hub genes were TP53,TNF,and *** docking results showed that PF was well docking with ***-8 showed no potential toxicity of 10,20 and 50μmol/L PF on human OA *** PF significantly decreased the expression levels of interleukin-1β,interleukin-6,TNF-αmatrix metalloproteinase 13(MMP13),and a disintegrin and metalloproteinase with thrombospondin motifs 5(ADAMTS5)and TNF

关键词： paeoniflorin osteoarthritis synovial inflammation tumor necrosis factor-α network pharmacology Paeonia lactiflora

Comparative observation of the effectiveness and safety of remimazolam besylate versus dexmedetomidine in gastrointestinal surgery in obese patients

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1320-1327页

作者： Yu-fu Deng xue-Run Jiang Zeng-Guang Feng Department of Anesthesiology Xiangtan Central HospitalXiangtan 411100Hunan ProvinceChina

BACKGROUND Surgery for obese patients carries a higher risk of anesthesia complications compared with surgery for nonobese ***,a safe and effective anesthesia strategy is necessary to improve the medical experience of such patients and ensure their *** To compared the effectiveness and safety of remimazolam besylate versus dexmedetomidine(DEX)in gastrointestinal surgery in obese *** The study cohort included 60 obese patients undergoing gastrointestinal surgery between July 2021 and April 2023,comprising 30 patients who received DEX intervention(control group)and 30 patients who received remimazolam besylate intervention(research group).Heart rate(HR),respiratory rate(RR),mean arterial pressure(MAP),blood oxygen saturation(SpO_(2)),safety(nausea and vomiting,bradycardia,hypotension,and apnea),anesthesia and examination indices[induction time,anesthesia recovery time,and postanesthesia care unit(PACU)discharge time],sedation effect(Ramsay Sedation Scale),and postoperative pain visual analog scale were comparatively analyzed before anesthesia(T0),during anesthesia(T1),and after anesthesia(T2).RESULTS At T1,the research group showed significantly smaller changes in HR,RR,MAP,and SpO_(2) than the control group,with a significantly lower adverse reaction rate and shorter induction,anesthesia recovery,and PACU discharge ***,the intra-and postoperative Ramsay Sedation Scale scores were statistically higher in the research group than in the control *** Remimazolam besylate was significantly more effective than DEX in gastrointestinal surgery in obese patients and had a higher safety profile and value in clinical promotion.

关键词： Remimazolam besylate Dexmedetomidine Obesity Gastrointestinal surgery Effectiveness Safety

An AIEgen nano-assembly for simultaneous detection of ATP and H_(2)S

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Chinese Chemical Letters 2024年第6期35卷 376-379页

作者： Jia-Mei Qin xue Li Wei Lang fu-Hao Zhang Qian-Yong Cao School of Chemistry and Chemical Engineering Nanchang UniversityNanchang 330031China

A new aggregation-induced emission(AIE)-based fluorescence sensor,TPEPy-SS-C14,for simultaneous recognition of adenosine triphosphate(ATP)and hydrogen sulfide(H_(2)S)has been reported via the aggregation-disaggregation *** probe self-assembles nano-structure aggregations in aqueous *** shows fluorescence turn-on response toward ATP for the complexation-enhanced aggregation,but leads to fluorescence quenching of H_(2)S for cleavage the aggregations.

关键词： AIE-based ATP detection H_(2)S detection Fluorescent sensor Cell imaging

Sn-doped cobalt containing perovskite as the air electrode for highly active and durable reversible protonic ceramic electrochemical cells

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Journal of Advanced Ceramics 2024年第1期13卷 63-72页

作者： min fu Wenjing Hu Hua Tong Xin Ling Linggui Tan Fanglin Chen Zetian Tao School of Resources Environment and Safety EngineeringUniversity of South ChinaHengyang 421001China Department of Mechanical Engineering University of South CarolinaColumbia 29208USA

One potential solution to the problems of energy storage and conversion is the use of reversible protonic ceramic electrochemical cells(R-PCEC),which are based on the solid oxide fuel cell(SOFC)technology and offer a flexible route to the generation of renewable ***,the R-PCEC development faces a range of significant challenges,including slow oxygen reaction kinetics,inadequate durability,and poor round-trip efficiency resulting from the inadequacy of an air *** address these issues,we report novel B-sites doped Pr_(0.5)Ba_(0.5)Co_(0.7)Fe_(0.3)O_(3−δ)(PBCF)with varying amounts of Sn as the air electrode for R-PCEC to further enhance electrochemical performance at lower *** 600℃,R-PCEC with an air electrode consisting of Pr_(0.5)Ba_(0.5)Co_(0.7)Fe_(0.25)Sn_(0.05)O_(3+δ)has achieved peak power density of 1.12 W∙cm^(−2) in the fuel cell mode and current density of 1.79 A∙cm^(−2) in the electrolysis mode at a voltage of 1.3 ***,R-PCECs have shown good stability in the electrolysis mode of 100 *** study presents a practical method for developing durable high-performance air electrodes for R-PCECs.

关键词： triple conducting oxide dual-element doping protonic ceramic electrochemical cells(PCECs) catalytic