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Unraveling the ties between irritable bowel syndrome and intestinal microbiota

World Journal of Gastroenterology 2014年第10期20卷 2470-2481页

作者： sung Noh hong Poong-Lyul Rhee Division of Gastroenterology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 135-710 South Korea

Irritable bowel syndrome (IBS) is the most prevalent functional gastrointestinal disorder. It is a multifactorial disorder. Intestinal microbiota may cause the pathogenesis of IBS by contributing to abnormal gastrointestinal motility, low-grade inflammation, visceral hypersensitivity, communication in the gut-brain axis, and so on. Previous attempts to identify the intestinal microbiota composition in IBS patients have yielded inconsistent and occasionally contradictory results. This inconsistency may be due to the differences in the molecular techniques employed, the sample collection and handling methods, use of single samples that are not linked to fluctuating symptoms, or other factors such as patients’ diets and phenotypic characterizations. Despite these difficulties, previous studies found that the intestinal microbiota in some IBS patients was completely different from that in healthy controls, and there does appear to be a consistent theme of Firmicutes enrichment and reduced abundance of Bacteroides. Based on the differences in intestinal microbiota composition, many studies have addressed the roles of microbiota-targeted treatments, such as antibiotics and probiotics, in alleviating certain symptoms of IBS. This review summarizes the current knowledge of the associations between intestinal microbiota and IBS as well as the possible modes of action of intestinal microbiota in the pathogenesis of IBS. Improving the current level of understanding of host-microbiota interactions in IBS is important not only for determining the role of intestinal microbiota in IBS pathogenesis but also for therapeutic modulation of the microbiota.

关键词： Irritable bowel syndrome Intestinal microbiota Dysbiosis Antibiotics Probiotics

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Research and Development Trend of Shape Control for Cold Rolling Strip

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Chinese Journal of Mechanical Engineering 2017年第5期30卷 1248-1261页

作者： Dong-Cheng Wang hong-min Liu Jun Liu National Engineering Research Center for Equipment and Technology of Cold Rolling Strip Yanshan University State Key Laboratory of Metastable Materials Science and Technology Yanshan University Anshan Iron and Steel Co.Ltd

Shape is an important quality index of cold rolling strip. Up to now, many problems in the shape control domain have not been solved satisfactorily, and a review on the research progress in the shape control domain can help to seek new breakthrough directions. In the past 10 years, researches and applications of shape control models, shape control means, shape detection technology, and shape con- trol system have achieved significant progress. In the aspect of shape control models, the researches in the past improve the accuracy, speed and robustness of the models. The intelligentization of shape control models should be strengthened in the future. In the aspect of the shape control means, the researches in the past focus on the roll opti- mization, mill type selection, process optimization, local strip shape control, edge drop control, and so on. In the future, more attention should be paid to the coordination control of both strip shape and other quality indexes, and the refinement of control objective should be strengthened. In the aspects of shape detection technology and shape control system, some new types of shape detection meters and shape control systems are developed and have successfully indus- trial applications. In the future, the standardization of shape detection technology and shape control system should be promoted to solve the problem of compatibility. In general,the four expected development trends of shape control for cold roiling strip in the future are intelligentization, coordi- nation, refinement, and standardization. The proposed research provides new breakthrough directions for improv- ing shape quality.

关键词： Cold rolling strip - Shape control Development trend Theory models Shape detectionControl system

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Material properties of friction stir spot welded joints of dissimilar aluminum alloys

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中国有色金属学会会刊：英文版 2012年第S3期22卷 605-613页

作者： Chi-sung JEON sung-Tae hong Yong-Jai KWON Hoon-Hwe CHO Heung Nam HAN Technical Research Center Hyundai Steel Company School of Mechanical Engineering University of Ulsan Department of Materials Science and Engineering University of Ulsan Department of Materials Science and Engineering Seoul National University

Mechanical properties and material mixing patterns of friction stir spot welded (FSSW) joints of dissimilar aluminum alloys were *** aluminum alloys typically used in automotive applications,5052-H32 and 6061-T6,were *** the experiment,the process parameters including the z-axis force and torque histories were measured as a function of the tool *** mechanical properties were investigated by microhardness measurements of the joint,and the material mixing in the stir zone was investigated by *** experimental results illustrate different process parameter histories,material mixing in the stir zone and material properties including microhardness distributions for FSSW joints of dissimilar aluminum alloys,likely due to different mechanical behaviors of the selected aluminum alloys in the FSSW process temperature range.

关键词： friction stir spot welding dissimilar aluminum alloys force histories torque histories microhardness

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New limonoids isolated from the bark of Melia toosendan

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Chinese Journal of Natural Medicines 2018年第12期16卷 946-950页

作者： ZHANG Qiong ZHENG Qing-hong SANG Yi-Shu sung Herman Ho-Yung min Zhi-Da Department of Pharmaceutical Science Shanxi Medical University Department of Natural Medicinal Chemistry China Pharmaceutical University Department of Chemistry Hong Kong University of Science and Technology

Two new limonoids, 12-ethoxynimbolinins G and H(compounds 1 and 2), and one known compound, toosendanin(Chuanliansu)(compound 3), were isolated from the bark of Melia toosendan. Their structures were elucidated by spectroscopic analysis and X-ray techniques. The absolute configuration of toosendanin(3) was established by single-crystal X-ray diffraction. Compounds 1-3 were evaluated for their cytotoxicity against five tumor cell lines.

关键词： Melia toosendan Meliaceae Limonoid Toosendanin Absolute configuration

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Relationship between longitudinal changes in lipid composition and ischemic stroke among hypertensive patients

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World Journal of Clinical Cases 2025年第4期13卷 18-27页

作者： Cheng-Cheng Wei Yu-Qing Huang Cheng-hong Yu Department of Cardiology Tongxiang First People's HospitalTongxiang 314500Zhejiang ProvinceChina Department of Cardiology Guangdong Cardiovascular InstituteGuangzhou 510080Guangdong ProvinceChina

BACKGROUND Dyslipidemia was strongly linked to stroke,however the relationship between dyslipidemia and its components and ischemic stroke remained *** To investigate the link between longitudinal changes in lipid profiles and dyslipidemia and ischemic stroke in a hypertensive *** Between 2013 and 2014,6094 hypertension individuals were included in this,and ischemic stroke cases were documented to the end of *** changes of lipid were stratified into four groups:(1)Normal was transformed into normal group;(2)Abnormal was transformed into normal group;(3)Normal was transformed into abnormal group;and(4)Abnormal was transformed into abnormal *** examine the link between longitudinal changes in dyslipidemia along with its components and the risk of ischemic stroke,we utilized multivariate Cox proportional hazards models with hazard ratio(HR)and 95%*** The average age of the participants was 62.32 years±13.00 years,with 329 women making up 54.0%of the *** the course of a mean follow-up of 4.8 years,143 ischemic strokes *** normal was transformed into normal group was used as a reference,after full adjustments,the HR for dyslipidemia and ischemic stroke among abnormal was transformed into normal group,normal was transformed into abnormal group and abnormal was transformed into abnormal Wei CC et *** changed and ischemic stroke WJCC https://*** 2 February 6,2025 Volume 13 Issue 4 group were 1.089(95%CI:0.598-1.982;P=0.779),2.369(95%CI:1.424-3.941;P<0.001)and 1.448(95%CI:1.002-2.298;P=0.047)(P for trend was 0.233),*** In individuals with hypertension,longitudinal shifts from normal to abnormal in dyslipidemia-particularly in total and low-density lipoprotein cholesterol-were significantly associated with the risk of ischemic stroke.

关键词： Longitudinal change Hypertension Dyslipidemia Lipid profile Ischemic stroke

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Three-Dimensional Numerical Model for Tsunami Propagation Passing Through An Obstacle

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China Ocean Engineering 2006年第3期20卷 509-516页

作者： sung Jin hong Byung Ho CHOI Fumihiko IMAMURA Department of Civil and Environmental Engineering Sungkyunkwan University Chunchun-dong 300 Jangan-gu Suwon 440-746 Korea Disaster Control Research Center Graduate School of Engineering Tohoku University Aoba 06 Sendai 980-8579 Japan

A three-dimensional numerical tsunami model is developed to analyze the nonlinear behavior of flow around obstacles with the Marker and Cell （MAC） method based on the Navier-Stokes equations. Tnrough a comparison with experimental data for the cases of dam break and solitary wave propagation, verification of the three-dimensional numerical model is given. Numerical experiment is performed for the analysis of the nonlinear behavior of flow around obstacles and compared with experimental data. The velocity and pressure around obstacles are presented with sufficient accuracy for tstmami propagation passing through an obstacle.

关键词： three-dimensional numericxtl model tsunami Navier-Stokes equations Marker and Ceml (MAC) method

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Global parameter estimation of the Cochlodinium polykrikoides model using bioassay data

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Acta Oceanologica Sinica 2016年第2期35卷 39-45页

作者： CHO hong-Yeon PARK Kwang-Soon KIM sung Coastal and Environmental Engineering Division Korea Institute of Ocean Science and Technology Coastal Disaster Research Center Korea Institute of Ocean Science and Technology Biological Oceanography and Marine Biology Division Korea Institute of Ocean Science and Technology

Cochlodinium polykrikoides is a notoriously harmful algal species that inflicts severe damage on the aquacultures of the coastal seas of Korea and Japan. Information on their expected movement tracks and boundaries of influence is very useful and important for the effective establishment of a reduction plan. In general, the information is supported by a red-tide（a.k.a algal bloom） model. The performance of the model is highly dependent on the accuracy of parameters, which are the coefficients of functions approximating the biological growth and loss patterns of the C. polykrikoides. These parameters have been estimated using the bioassay data composed of growth-limiting factor and net growth rate value pairs. In the case of the C. polykrikoides, the parameters are different from each other in accordance with the used data because the bioassay data are sufficient compared to the other algal species. The parameters estimated by one specific dataset can be viewed as locally-optimized because they are adjusted only by that dataset. In cases where the other one data set is used, the estimation error might be considerable. In this study, the parameters are estimated by all available data sets without the use of only one specific data set and thus can be considered globally optimized. The cost function for the optimization is defined as the integrated mean squared estimation error, i.e., the difference between the values of the experimental and estimated rates. Based on quantitative error analysis, the root-mean squared errors of the global parameters show smaller values, approximately 25%–50%, than the values of the local parameters. In addition, bias is removed completely in the case of the globally estimated parameters. The parameter sets can be used as the reference default values of a red-tide model because they are optimal and representative. However, additional tuning of the parameters using the in-situ monitoring data is highly *** opposed to the bioassay d

关键词： global and local estimation gain and loss parameters Cochlodinium polykrikoides bioassay data model performance

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Construction of Optimal Mixed-Level Uniform Designs

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Journal of Systems Science & Complexity 2024年第2期37卷 841-862页

作者： CHATTERJEE Kashinath LIU min-Qian QIN hong YANG Liuqing Department of Population Health Sciences Division of Biostatistics and Data ScienceAugusta UniversityGA 30912USA NITFID LPMC&KLMDASRSchool of Statistics and Data ScienceNankai UniversityTianjin 300071China School of Statistics and Mathematics Zhongnan University of Economics and LawWuhan 430073China

The theory of uniform design has received increasing interest because of its wide application in the field of computer *** generalized discrete discrepancy is proposed to evaluate the uniformity of the mixed-level factorial *** this paper,the authors give a lower bound of the generalized discrete discrepancy and provide some construction methods of optimal mixed-level uniform designs which can achieve this lower *** methods are all deterministic construction methods which can avoid the complexity of stochastic *** saturated mixed-level uniform designs and supersaturated mixed-level uniform designs can be obtained with these ***,the resulting designs are also χ^(2)-optimal and minimum moment aberration designs.

关键词： Generalized discrete discrepancy Hadamard matrix mixed-level design orthogonal array supersaturated design

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Net-C18:A Predicted Two-Dimensional Planar Carbon Allotrope and Potential for an Anode in Lithium-Ion Battery

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Energy & Environmental Materials 2021年第3期4卷 458-464页

作者： Xing hong Cai Qiang Yang Shaohui Zheng min Wang Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies School of Materials and EnergySouthwest UniversityChongqing 400715China

Net-C18,a predicted two-dimensional(2D)graphene-like carbon allotrope,is investigated via first-principles *** space group is *** are 18 carbon atoms per ***-C18 has five-,six-,and eight-membered ***-C18 may be formed by adding even pairs of carbon atoms on the top of hexagons to reconstruct new five-and eight-membered rings,extending the strategy of *** to that of graphene(-9.28 e V atom^(-1)),the total energy of net-C18(-9.15 e V atom^(-1))is only 0.13 e V atom^(-1)higher,revealing that net-C18 is energetically *** calculations of phonon and ab initio molecular dynamics(AIMD)demonstrate dynamical and thermal stability of *** independent elastic constants of net-C18 meet the criterial for the mechanical stability of 2D *** in-plane stiffness along x or y axis is comparably *** AIMD results reveal that net-C18 has good thermal stability at 1500 *** band structure also demonstrates that it is ***,the diffusion of Li atoms on net-C18 has a low energy barrier(0.32 e V),and net-C18 has a low open-circuit voltage(0.024 V)and a high theoretical specific capacity(403 m Ah g^(-1)).Thus,net-C18 may provide high-temperature resistant,flexible electrode in electronics and a promising metallic anode in lithium-ion *** proposed formation of net-C18 may open a new pattern defect for the designs of new carbon allotropes.

关键词： anode material first-principles calculations Li ion batteries two-dimensional materials

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Influence of laterite nickel ore on extracting iron from Bayer red mud by carbothermal smelting reduction

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Journal of Iron and Steel Research International 2021年第6期28卷 661-668页

作者： Ao-ping He Jian-min Zeng Shi-hong Liu Guangxi Key Laboratory of Processing for Non-Ferrous Metal and Featured Materials Guangxi UniversityNanning 530004GuangxiChina

In view of the difficulty of extracting iron from Bayer red mud,a new idea of adding laterite nickel ore into red mud was proposed to prepare a high value-added *** this,the influences of laterite nickel ore on thermodynamic reaction,slagging and smelting reduction of extracting iron from red mud were *** results indicated that the product of extracting iron from red mud(R100)was changed with the addition of laterite nickel ore(R70L30).The slag of R100 was strongly basic,while the R70L30 was weakly acidic with composition closer to the ideal blast furnace *** metal recovery of R100 was 75.16%and that of R70L30 was 94.05%.At the same temperature,the slag viscosity of R70L30 was significantly lower than that of R100,which proved that laterite nickel ore can adjust the basicity,reduce melting point of slag and improve metal *** Fe,Ni and Cr in red mud and laterite nickel ore can be reduced sufficiently,a low Ni–Cr alloy cast iron can be directly prepared.

关键词： Bayer red mud Laterite nickel ore Iron extraction Slagging Carbothermal smelting reduction

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