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Journal of Rock Mechanics and Geotechnical Engineering 2021年第4期13卷 937-944页

作者： Van Thanh Hoang Wankun Liu jang min Park School of Mechanical Engineering Yeungnam UniversityDaehak-ro 280Gyeongsan38541Republic of Korea Department of Mechanical Engineering The University of Danang-University of Science and TechnologyNguyen Luong Bang Street 54DanangViet Nam

Recently,Zou et al.(2020 a)published a theoretical analysis on the radial flow of a Bingham fluid,where they argued that the classical analysis by Dai and Bird(1981)violates the mass *** present discussion aims to clarify this conflict between those two *** is noted that Zou et al.(2020 a)presumed the gap-wise mass flux is negligible in the mass conservation equation,while Dai and Bird(1981)did not require so in their model,and this is found to be the origin of the *** fact,Dai and Bird(1981)’s model is shown to not violate the mass ***,those two models should be viewed as separate models derived from different *** of the major difference between the two models are discussed.

关键词： Rock grouting Radial flow Bingham fluid Analytical solution

Therapeutic benefit of repetitive transcranial magnetic stimulation for severe mirror movements A case report

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Neural Regeneration Research 2013年第6期8卷 569-574页

作者： Han sun Kim sung Ho jang Zee-Ihn Lee Mi Young Lee Yun Woo Cho Migyoung Kweon Su min Son Department of Physical Medicine and Rehabilitation College of MedicineYeungnam University Department of Pediatrics College of MedicineYeungnam University Department of Physical Medicine and Rehabilitation Daegu Fatima Hospital Department of Physical therapy College of Health and TherapyDaegu Haany University

Congenital mirror movements retard typical hand functions, but no definite therapeutic modality is available to treat such movements. We report an 8-year-old boy with severe mirror movements of both hands. His mirror movements were assessed using the Woods and Teuber grading scale and his fine motor skills were also evaluated by the Purdue Pegboard Test. A 2-week regimen of repetitive transcranial magnetic stimulation produced markedly diminished mirror movement symptoms and increased the fine motor skills of both hands. Two weeks after the completion of the regimen, mirror movement grades had improved from grade 4 to 1 in both hands and the Purdue Pegboard Test results of the right and left hands also improved from 12 to 14 or 13. These improvements were maintained for 1 month after the 2-week repetitive transcranial magnetic stimulation regimen. After 18 months, the mirror movement grade was maintained and the Purdue Pegboard test score had improved to 15 for the right hand while the left hand score was maintained at 13. This occurred without any additional repetitive transcranial magnetic stimulation or other treatment. These findings suggest that repetitive transcranial magnetic stimulation for this patient had a therapeutic and long-term effect on mirror movements.

关键词： neural regeneration neurorehabilitation clinical practice mirror movements Purdue Pegboard test hand transcranial magnetic stimulation hand function cortex suppression corticospinal tract grants-supported paper neuroregeneration

Development of micro milling force model and cutting parameter optimization

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中国有色金属学会会刊：英文版 2012年第S3期22卷 851-858页

作者： Shih-ming WANG Da-fun CHEN min-chang jang Shambaljamts TSOOJ Department of Mechanical Engineering Chung Yuan Christian University

Taking the minimum chip thickness effect,cutter deflection,and spindle run-out into account,a micro milling force model and a method to determine the optimal micro milling parameters were *** micro milling force model was derived as a function of the cutting coefficients and the instantaneous projected cutting area that was determined based on the machining parameters and the rotation trajectory of the cutter *** an allowable micro cutter deflection is defined,the maximum allowable cutting force can be *** optimal machining parameters can then be computed based on the cutting force model for better machining efficiency and *** verify the proposed cutting force model and the method to determine the optimal cutting parameters,micro-milling experiments were conducted,and the results show the feasibility and effectiveness of the model and method.

关键词： micro-milling cutting force spindle run out cutter deflection optimal parameter

SMARCA4-deficient undifferentiated thoracic tumor:A case report

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World Journal of Clinical Cases 2023年第11期11卷 2521-2527页

作者： Hee Jung Kwon min Hye jang Department of Pathology Yeungnam University Medical CenterDaegu 42415South Korea

BACKGROUND SMARCA4-deficient undifferentiated tumors(SMARCA4-DUTs)present with diverse clinical manifestations and progress to metastasis and even cause death within a few *** novel subset of undifferentiated tumors occurs in the middle-aged population and is strongly associated with a smoking ***-guishing it from other malignancies is *** SUMMARY A 62-year-old man presented with chest pain for 7 *** patient had no respiratory symptoms and normal pulmonary function test *** patient had been a smoker for 8 years and quit smoking 2 years *** computed tomography revealed a huge mass involving the left upper and lower lung lobes with pericardial invasion and multiple *** samples were obtained using open frozen biopsy,after several unsuccessful *** tumor was composed of sheets of undifferentiated disclosive cells with vesicular nuclei and prominent *** differential diagnosis included high-grade lymphoma,germ cell tumor,NUT carcinoma,undifferentiated carcinoma,and *** tumor cells were large,arranged in sheets,and did not exhibit glandular or squamous *** foci of necrosis were *** was no evidence of epithelial differentiation on immunohistochemical *** SMARCA4 stain showed complete loss of expression of SMARCA4,which is *** In the present case,thoracic SMARCA4-DUT was diagnosed based on clinical features,absence of epithelial differentiation,and negative SMARCA4 expression.

关键词： SMARCA4 BRG1 Deficient Undifferentiated tumor Thoracic Case report

Case Report:Congenital atresia of the left main coronary artery in an infant

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第7期11卷 539-541页

作者： Su Ye SOHN Gi Young jang Byung min CHOI Department of Pediatrics Korea University Hospital

Congenital atresia of the left main coronary artery is a rare occurrence, and surgical revascularizationbypass graft is required. We here report a rare case of congenital coronary anomaly in an infant. A lO-month-old male infant was admitted to the hospital with heart failure symptoms. Echocardiographic examinations revealed mitral valve regurgitation and ischemic changes of the anterolateral atresia of the left main coronary artery with a severe papillary muscle and chordae. Coronary angiography showed hypoplastic left anterior descending artery and a circumflex coronary artery. Unfortunately, sudden cardiac arrest occurred after catheterization and the infant did not recover despite of immediate cardiopulmonary resuscitation. Further studies are needed to find a newer diagnostic method to detect coronary anomaly in an infant, and coronary angiography, if necessary, has to be performed very carefully.

关键词： Conqenital heart disease Anomalous coronaries Infant

Computing the User Experience via Big Data Analysis:A Case of Uber Services

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Computers, Materials & Continua 2021年第6期67卷 2819-2829页

作者： jang Hyun Kim Dongyan Nan Yerin Kim Hyung Park min Department of Interaction Science/Department of Human-Artificial Intelligence Interaction Sungkyunkwan UniversitySeoul03063Korea Department of Applied Artificial Intelligence/Department of Human-Artificial Intelligence Interaction Sungkyunkwan UniversitySeoul03063Korea

As of 2020,the issue of user satisfaction has generated a significant amount of ***,we employ a big data approach for exploring user satisfaction among Uber *** develop a research model of user satisfaction by expanding the list of user experience(UX)elements(i.e.,pragmatic,expectation confirmation,hedonic,and burden)by including more elements,namely:risk,cost,promotion,anxiety,sadness,and ***,we collect 125,768 comments from online reviews of Uber services and perform a sentiment analysis to extract the UX *** results of a regression analysis reveal the following:hedonic,promotion,and pragmatic significantly and positively affect user satisfaction,while burden,cost,and risk have a substantial negative ***,the influence of expectation confirmation on user satisfaction is not ***,sadness,anxiety,and anger are positively related to the perceived risk of *** with sadness and anxiety,anger has a more important role in increasing the perceived burden of *** on these findings,we also provide some theoretical implications for future UX literature and some core suggestions related to establishing strategies for Uber and similar *** proposed big data approach may be utilized in other UX studies in the future.

关键词： User satisfaction user experience big data sentiment analysis Uber

Process analysis of direct laser melting to fabricate layered hybrid beads

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中国有色金属学会会刊：英文版 2012年第S3期22卷 813-819页

作者： Jeong-hwan jang sung-min MUN Tae-hyun KIM Young-hoon MOON School of Mechanical Engineering Engineering Research Center for Net Shape and Die ManufacturingPusan National University

The successful fabrication of layered hybrid beads by DLM process is limited by dissimilar melting ranges of different *** the application of DLM process into manufacturing industries,target mechanical properties of final product must be *** analysis was performed for the DLM fabrication of layered hybrid beads by using stainless steel (SS 316L) and titanium *** the analysis of fabrication characteristics,single hybrid bead was formed using SS316L powder onto the base plate and then Ti powder was melted onto the previous melted *** addition,multi-layer hybrid beads were fabricated for the analysis of the layering effects between *** these studies,the effects of the processing parameters,such as laser power,scan rate and scan line spacing on surface morphology were characterized and optimum processing conditions for the DLM fabrication of layered hybrid beads were developed.

关键词： stainless steel 316L Ti powder energy density surface roughness direct laser melting process layered hybrid beads

Injury of the arcuate fasciculus in a patient with progressive bulbar palsy

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Neural Regeneration Research 2016年第12期11卷 2031-2032页

作者： min Cheol Chang Han Do Lee sung Ho jang Department of Physical Medicine and Rehabilitation College of MedicineYeungnam University

The arcuate fasciculus is the neural tract connecting the two major speech centers（Broca’s and Wernicke’s areas）and plays a critical role in language function（Catani and Mesulam,2008）.Injury of this tract can lead to several types of language impairment,including conduction aphasia,Broca’s aphasia,anomic aphasia,and apraxia of speech（Anderson et al.,1999;Bartha and Benke,2003;Catani and Mesulam,2008;Bernal and Ardila,2009;Kim et al.,2011）.

关键词： arcuate patient progressive

Improvement of hydrogen embrittlement and stress corrosion cracking by annealing for Al-4.4Mg-0.6Mn alloy

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 17-22页

作者： Seong-Jong KIM min-Su HAN Seong-Kweon KIM Seok-Ki jang Division of Marine Engineering Mokpo National Maritime University Media Engineering Seoul National University of Technology

With no annealing treatment, cathodic polarization trends in 5083F A1 alloy revealed concentration polarization and activation polarization. However, the annealed specimens have lower current densities at corrosion protection potential compared to the non-annealed specimen. The results of SSRTs conducted in seawater at the applied potential range of-l.8 V to -0.5 V indicated that the maximum tensile strength, elongation, and time-to-fracture had high values at applied potentials of -0.7 to -1.4 V. The maximum tensile strength, elongation, and time-to-f？acture decreased when the potential values were beyond this range in either anodic or cathodic direction. In general, the increased shear lip caused by annealing treatment indicates elongation. Time-to-fracture would likely increase with elongation. Potentials between -0.5 V to -0.6 V were found to be in the region of stress corrosion cracking. The corrosion protection zone was determined to be -0.7 V to -J,4 V because these potential ranges produced good mechanical properties. Potential less than -1.4 V produced a fractured surface with a mixture of dimples （ductile fractures） and a quasi-cleavage pattern resulting from the effects of hydrogen gas.

关键词： annealing 5083F A1-Mg alloy corrosion seawater slow strain rate tests

Oral TNF-αsiRNA delivery via milk-derived exosomes for effective treatment of inflammatory bowel disease

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Bioactive Materials 2024年第4期34卷 138-149页

作者： Geonhee Han Hyosuk Kim Hochung jang Eun sun Kim sun Hwa Kim Yoosoo Yang KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul02841Republic of Korea Medicinal Materials Research Center Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul02792Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolUniversity of Science and TechnologySeoul02792Republic of Korea Department of Internal Medicine Korea University College of MedicineSeoul02841Republic of Korea

Oral administration facilitates the direct delivery of drugs to lesions within the small intestine and colon,making it an ideal approach for treating patients with inflammatory bowel ***,multiple physical barriers impede the delivery of oral RNA drugs through the gastrointestinal ***,we developed a novel oral siRNA delivery system that protects nucleic acids in extreme environments by employing exosomes derived from milk to encapsulate tumor necrosis factor-alpha(TNF-α)siRNA *** remarkable structural stability of milk-derived exosomes(M-Exos),as opposed to those from HEK293T cells,makes them exceptional siRNA *** demonstrate that milk exosomes loaded with TNF-αsiRNA(M-Exo/siR)can effectively inhibit the expression of TNF-α-related inflammatory ***,given that milk exosomes are composed of unique lipids with high bioavailability,orally administered M-Exo/siR effectively reach colonic tissues,leading to decreased TNF-αexpression and successful alleviation of colitis symptoms in a dextran sulfate sodium-induced inflammatory bowel disease murine ***,milk-derived exosomes carrying TNF-αsiRNA can be effectively employed to treat inflammatory bowel ***,using exosomes naturally derived from milk may shift the current paradigm of oral gene delivery,including siRNA.

关键词： Milk-derived exosome Oral gene delivery siRNA Inflammatory bowel disease TNF-α