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Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi Huang Meiyu Zhang Yanyu Zhang Yan Zeng Xingxing chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

Laparoscopic liver resection utilizing the ventral avascular area of the inferior vena cava:A retrospective cohort study

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World Journal of Gastroenterology 2025年第1期31卷 42-57页

作者： Kun Huang Zhu chen Heng Xiao Hai-Yang Hu Xing-Yu chen cheng-You Du Xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400000China Department of General Surgery Mianyang Hospital of Traditional Chinese MedicineMianyang 621000Sichuan ProvinceChina

BACKGROUND Laparoscopic liver resection(LLR)can be challenging due to the difficulty of establishing a retrohepatic tunnel under *** the third hepatic hilum before parenchymal transection often leads to significant liver mobilization,tumor compression,and bleeding from the short hepatic veins(SHVs).This study introduces a novel technique utilizing the ventral avascular area of the inferior vena cava(IVC),allowing SHVs to be addressed after parenchymal transection,thereby reducing surgical complexity and improving outcomes in in situ *** To introduce and evaluate a novel LLR technique using the ventral avascular area of the IVC and compare its short-term outcomes with conventional *** The clinical cohort data of patients with pathologically confirmed hepatocellular carcinoma or intrahepatic cholangiocarcinoma who underwent conventional LLR and novel LLR between July 2021 and July 2023 at the First Affiliated Hospital of Chongqing Medical University were retrospectively *** novel LLR,we initially separated the caudate lobe from the IVC using dissecting forceps along the ventral avascular area of the ***,we transected the parenchyma of the left and right caudate lobes from the caudal side to the cephalic side using the avascular area as a ***,we addressed the SHVs and finally dissected the root of the right hepatic vein or left hepatic *** short-term postoperative outcomes and oncological results of the two approaches were evaluated and *** A total of 256 patients were included,with 150(58.59%)undergoing conventional LLR and 106(41.41%)undergoing novel *** novel technique resulted in significantly larger tumor resections(6.47±2.96 cm vs 4.01±2.33 cm,Pminutes vs 262.33±83.90 minutes,P<0.001),less intraoperative blood loss(206.92±37.09 mL vs 363.34±131.27 mL,P<0.001),and greater resection volume(345.11±31.40 mL vs 264.38±31.98 mL,P<0.001)comp

关键词： Laparoscopic liver resection Inferior vena cava Retrohepatic tunnel Short hepatic veins Complex liver tumors Intraoperative bleeding control

Tungsten pnictides for water electrolysis:advances and perspectives

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Tungsten 2024年第4期6卷 675-695页

作者： Xue Kang Xi-Han Tan Ning Han Jian-Feng Hou chen-min Yao Zhi-jie chen Bing-jie Ni Department of Chemistry and Chemical Engineering Lyuliang UniversityLvliang033001China Department of Materials Engineering KU LeuvenLouvain3001Belgium State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyWuhan UniversityWuhan430079China School of Civil and Environmental Engineering The University of New South WalesSydneyNSW 2052Australia

Hydrogen fuel is recognized as a promising energy carrier for the sustainable development of global energy system and the green hydrogen production via water electrolysis attracts great *** development of cost-effective electrocatalysts for water electrolysis is important for enhancing green hydrogen production ***,tungsten pnictides(phosphides and nitrides)have emerged as promising catalysts for water electrolysis,and efficient tungsten pnictide-based catalysts with different nanostructures,compositions,and surface chemical properties have been *** this review,recent progress in the design of tungsten pnictide-based electrocatalysts for water electrolysis is comprehensively *** synthesis of tungsten pnictide-based electrocatalysts are discussed ***,current achievements in developing efficient tungsten pnictide electrocatalysts for water electrolysis are detailed,and four key catalyst design strategies(i.e.,nanostructure control,heteroatom doping,defect engineering,and heterostructure design)are *** physicochemical properties-catalytic performance relationship of tungsten pnictide-based electrocatalysts is also *** last,perspectives in this field are put forward for guiding further research on the design and application of high-performance tungsten pnictide-based electrocatalysts.

关键词： Tungsten nitrides Tungsten phosphides Hydrogen evolution reaction Oxygen evolution reaction Electrocatalysts

Development and multicenter validation of a nomogram for preoperative prediction of lymph node positivity in pancreatic cancer(NeoPangram)

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Hepatobiliary & Pancreatic Diseases International 2021年第2期20卷 163-172页

作者： jie Hua Xue-min chen Yun-jie chen Bao-Chun Lu Jin Xu Wei Wang Si Shi Xian-Jun Yu Department of Pancreatic Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical College of Fudan UniversityShanghai 200032China Shanghai Pancreatic Cancer Institute Shanghai 200032China Department of Hepatobiliary and Pancreatic Surgery The First People’s Hospital of ChangzhouChangzhou 213004China Department of minimally Invasive Hepatobiliary and Pancreatic Surgery Ningbo No.2 HospitalNingbo 315010China Department of Hepatobiliary and Pancreatic Surgery Shaoxing People’s HospitalShaoxing 312000China

Background:Neoadjuvant therapy is associated with nodal downstaging and improved oncological outcomes in patients with lymph node(LN)-positive pancreatic *** study aimed to develop and validate a nomogram to preoperatively predict LN-positive ***:A total of 558 patients with resected pancreatic cancer were randomly and equally divided into development and internal validation *** logistic regression analysis was used to construct the *** performance was evaluated by discrimination,calibration,and clinical *** independent multicenter cohort consisting of 250 patients was used for external ***:A four-marker signature was built consisting of carbohydrate antigen 19–9(CA19–9),CA125,CA50,and CA242.A nomogram was constructed to predict LN metastasis using three predictors identified by multivariate analysis:risk score of the four-marker signature,computed tomography-reported LN status,and clinical tumor *** prediction model exhibited good discrimination ability,with C-indexes of 0.806,0.742 and 0.763 for the development,internal validation,and external validation cohorts,*** model also showed good calibration and clinical usefulness.A cut-off value(0.72)for the probability of LN metastasis was determined to separate low-risk and high-risk ***-Meier survival analysis revealed a good agreement of the survival curves between the nomogram-predicted status and the true LN ***:This nomogram enables the identification of pancreatic cancer patients at high risk for LN positivity who may have more advanced disease and thus could potentially benefit from neoadjuvant therapy.

关键词： Lymph node metastasis Pancreatic ductal adenocarcinoma Nomogram Neoadjuvant therapy

7YSZ coating prepared by PS-PVD based on heterogeneous nucleation

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Chinese Journal of Aeronautics 2018年第4期31卷 820-825页

作者： Ziqian DENG Xiaofeng ZHANG Kesong ZHOU min LIU Chunming DENG jie MAO Zhikun chen School of Materials and Energy Guangdong University of Technology Guangzhou 510006 China National Engineering Laboratory for Modern Materials Surface Engineering Technology & the Key Lab of Guangdong for Modern Surfuce Engineering Technology Guangdong Institute of New Materials Guangzhou 510650 China School of Materials Science and Engineering South China University of Technology Guangzhou 510640 China

Plasma spray-physical vapor deposition（PS-PVD） as a novel coating process based on low-pressure plasma spray（LPPS） has been significantly used for thermal barrier coatings（TBCs）.A coating can be deposited from liquid splats, nano-sized clusters, and the vapor phase forming different structured coatings, which shows obvious advantages in contrast to conventional technologies like atmospheric plasma spray（APS） and electron beam-physical vapor deposition（EBPVD）. In addition, it can be used to produce thin, dense, and porous ceramic coatings for special applications because of its special characteristics, such as high power, very low pressure, etc. These provide new opportunities to obtain different advanced microstructures, thus to meet the growing requirements of modern functional coatings. In this work, focusing on exploiting the potential of gas-phase deposition from PS-PVD, a series of 7 YSZ coating experiments with various process conditions was performed in order to better understand the deposition process in PS-PVD, where coatings were deposited on different substrates including graphite and zirconia. Meanwhile, various substrate temperatures were investigated for the same substrate. As a result, a deposition mechanism of heterogeneous nucleation has been presented showing that surface energy is an important influencing factor for coating structures. Besides, undercooling of the interface between substrate and vapor phase plays an important role in coating structures.

关键词： 7YSZ Deposition mechanism Heterogeneous nucleation PS-PVD TBC

A Nano-Micro Engineering Nanofiber for Electromagnetic Absorber,Green Shielding and Sensor

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Nano-Micro Letters 2021年第2期13卷 112-123页

作者： min Zhang chen Han Wen-Qiang Cao Mao-Sheng Cao Hui-Jing Yang jie Yuan School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China Department of Physics Tangshan Normal UniversityTangshan 063000People’s Republic of China School of Information Engineering Minzu University of ChinaBeijing 100081People’s Republic of China

It is extremely unattainable for a material to simultaneously obtain efficient electromagnetic(EM)absorption and green shielding performance,which has not been reported due to the competition between conduction loss and ***,by tailoring the internal structure through nano-micro engineering,a NiCo2O4 nanofiber with integrated EM absorbing and green shielding as well as strain sensing functions is *** the improvement of charge transport capability of the nanofiber,the performance can be converted from EM absorption to shielding,or even ***,as the conductivity rising,the reflection loss declines from −52.72 to −10.5 dB,while the EM interference shielding effectiveness increases to 13.4 dB,suggesting the coexistence of the two EM ***,based on the high EM absorption,a strain sensor is designed through the resonance coupling of the patterned NiCo2O4 *** strategies for tuning EM performance and constructing devices can be extended to other EM functional materials to promote the development of electromagnetic driven devices.

关键词： Electromagnetic absorber Electromagnetic shielding NiCo2O4 nanofiber Sensor

Kinetics of phytohemaglutinin-induced IFN-γ and TNF-a expression in peripheral blood mononuclear cells from patients with chronic hepatitis B after liver transplantation

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World Journal of Gastroenterology 2005年第29期11卷 4574-4578页

作者： Ying-Mei Tang min-Hu chen Gui-Hua chen Chang-jie Cai Xiao-Shun He min-Giang Lu Wei-min Bao Department of Gastroenterology the First Affiliated Hospital of Sun-Yat Sen University Guangzhou 510080 Guangdong Province China Department of Liver Transplantation Center the Third Affiliated Hospital of Sun-Yat Sen University Guangzhou 510080 Guangdong Province China Department of Organ Transplantation the First Affiliated Hospital of Sun-Yat Sen University Guangzhou 510080 Guangdong Province China

AIM： To study the association between host immunity and hepatitis B virus （HBV） recurrence after liver transplantation. METHODS： Peripheral blood mononuclear cells （PBMC） were isolated from 40 patients with hepatitis B and underwent orthotopic liver transplantation （OLT） before and 2, 4, 8 wk after surgery. After being cultured in vitro for 72 h, the levels of INF-γ and TNF-α in culture supematants were detected with ELISA. At the same time, the quantities of HBV DNA in serum and PBMCs were measured by real time PCR. RESULTS： The levels of INF-γ and TNF-α in PBMC culture supernatants decreased before and 2, 4 wk after surgery in turns （INF-γ 155.52±72.32 ng/L vs 14.76±9.88 ng/L vs 13.22±10.35 ng/L, F= 6.946, P= 0.027〈0.05; TNF-α 80.839±46.75 ng/L vs18.59±17.29 ng/L vs9.758±7.96 ng/L, F= 22.61, P = 0.0001〈0.05）. The levels of INF-γ and TNF-α were higher in groups with phytohemagglutinin （PHA） than in those without PHA before surgery. However, the difference disappeared following OLT. Furthermore, INF-γ and TNF-α could not be detected in most patients at wk 4 and none at wk 8 after OLT. The HBV detection rate and virus load in PBMC before and 2, 4 wk after surgery were fluctuated （HBV detected rate： 51.4%, 13.3%, 50% respectively; HBV DNA： 3.55±0.674 log（10） copies/mL vs 3.00±0.329 log（10） copies/mL vs 4.608±1.344 log（10） copies/mL, F= 7.582, P= 0.002〈0.05）. HBV DNA in serum was 4.48±1.463 log（10） copies/mL before surgery and 〈 10^3 copies/mL after OLT except for one with 5.72×10^6 copies/mL 4 wk after OLT who was diagnosed as HBV recurrence. The levels of INF-γ and TNF-α were lower in patients with a high HBV load than in those with a low HBV load （HBV DNA detected/undetected in PBMCs： IFN-γ 138.08±72.44 ng/L vs 164.24±72.07 ng/L, t = 1.065, P= 0.297〉0.05, TNF-α 80.75±47.30 ng/L vs 74.10±49.70 ng/L, t= 0.407, P= 0.686〉 0.05; HBV DNA positive/negative： IFN-γ 136.77±70.04 ng/L vs 175.27±71.50 ng/L, t= 1.702, P= 0.097〉0.05; TNF-α 75.37±43.02 ng/L vs 81.53±52.46 ng/L, t

关键词： Liver transplantation HBV Recurrence PBMC

Verification of workflow nets with transition conditions

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Journal of Zhejiang University-Science C(Computers and Electronics) 2012年第7期13卷 483-509页

作者： Zhao-xia WANG Jian-min WANG Xiao-chen ZHU Li-jie WEN School of Software Tsinghua UniversityBeijing 100084China Department of Computer Science and Technology Tsinghua UniversityBeijing 100084China MOE Key Laboratory for Information System Security Tsinghua UniversityBeijing 100084China National Laboratory for Information Science and Technology Tsinghua UniversityBeijing 100084China SDepartment of Logistical Information&Engineering Logistical Engineering UniversityChongqing 400016China

Workflow management is concerned with automated support for business *** management systems are driven by process models specifying the tasks that need to be executed,the order in which they can be executed,which resources are authorised to perform which tasks,and data that is required for,and produced by,these *** workflow instances may run over a sustained period of time,it is important that workflow specifications be checked before they are *** verification is usually concerned with control-flow dependencies only;however,transition conditions based on data may further restrict possible choices between *** this paper we extend workflow nets where transitions have concrete conditions associated with them,called *** then demonstrate that we can determine which execution paths of a WTC-net that are possible according to the control-flow dependencies,are actually possible when considering the conditions based on ***,we are able to more accurately determine at design time whether a workflow net with transition conditions is sound.

关键词： Workflow nets Transition condition Verification Process model

Influence of asymmetric blockage of the drainage system of a deep-buried tunnel on water gushing

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Journal of Mountain Science 2022年第7期19卷 2075-2085页

作者： FU He-lin AN Peng-tao WU Yi-min LI jie chen Long School of Civil Engineering Central South UniversityChangsha410075China National Engineering Laboratory for Construction Technology of High Speed Railway Central South UniversityChangsha410075China

Asymmetric blockage of drainage systems occasionally occurs,which seriously threatens the safety of tunnel *** on theoretical analysis,a calculation expression of tunnel water inflow involving clogging parameters was *** of the analytical solution was analysed with the Taylor equation and series expansion theorem,and a tunnel under construction was considered to conduct field tests to verify the rationality of the established model and correctness of the derived *** have demonstrated that with increasing drainage system blockage degree,the amount of water inflow in the nonblocked area slowly increases,and the total amount of water in the tunnel gradually *** hydrodynamic pressure in the blocked area non-linearly decreased,and the water inrush velocity and hydraulic gradient in the non-blocked area gradually *** the drainage system was not blocked,the result of tunnel water inflow calculated by the formula derived in this paper was 8.3% higher than the measured *** the drainage system was blocked,the theoretical water inflow was 10.5% higher than the measured *** difference between the measured value and the theoretical value is small,which verifies the effectiveness of the calculation formula of water inflow deduced in this paper.

关键词： Drainage system Asymmetric blockage Water inflow Field test