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Safety of endoscopic ultrasound-guided ethanol ablation for pancreatic cystic lesions: A single-center experience of 214 patients

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Hepatobiliary & Pancreatic Diseases International 2019年第6期18卷 562-568页

作者： Jin Ho choi Sang Hyub Lee Young Hoon choi min Su You Bang-Sup Shin Woo Hyun Paik Ji Kon Ryu Yong-Tae Kim Department of Internal Medicine Liver Research Institute Seoul National University College of Medicine

Background:Endoscopic ultrasound-guided ethanol ablation(EUS-EA)for pancreatic cystic lesions(PCLs)has been used in recent years as a feasible treatment modality for low malignant probability PCLs or patients considered high-risk for *** present study aimed to confirm the safety of EUS-EA and to find predictive factors for adverse event(AE).Methods:A retrospective review was performed from the prospectively maintained database of patients who underwent EUS-EA for PCLs from June 2006 to April 2018 at Seoul National University *** primary outcomes of the study were the rates of AEs and severe AEs by *** secondary outcome was the predictive factors of AEs including acute pancreatitis and abdominal ***:A total of 214 patients were evaluated and the diagnoses of PCLs according to cystic fluid analysis and clinical features were as follows:serous cystic neoplasm(32.2%),mucinous cystic neoplasm(26.6%),branch duct type intraductal papillary mucinous neoplasm(BD-IPMN)(29.4%),and pseudocyst(11.7%).Three patients(1.4%)experienced severe ***,AEs occurred in 71(33.2%)***-IPMN(OR:2.87;95%CI:1.05–7.84;P=0.040),multilocular cysts(OR:3.59;95%CI:1.09–11.85;P=0.036),suspected ethanol leakage during procedure(OR:10.68;95%CI:1.98–57.53;P=0.006),and sticky cystic fluid(OR:3.83;95%CI:1.20–12.24;P=0.024)were predictive factors for post-procedural acute *** of uncinate process(OR:2.99;95%CI:1.22–7.35;P=0.017)and PCLs with exophytic portion(OR:3.70;95%CI:1.96–7.01;Pminal ***:EUS-EA is a safe procedure with a very low rate of severe *** seems possible to predict the AEs according to the features of the procedure and PCLs.

关键词： Pancreatic cyst EUS-guided ethanol ablation Adverse events

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GLP inhibits heterochromatin clustering and myogenic differentiation by repressing MeCP2

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Journal of Molecular Cell Biology 2018年第2期10卷 161-174页

作者： min Hee choi Monica Palanichamy Kala Jin Rong Ow Vinay Kumar Rao Sudha Suriyamurthy Reshma Taneja Department of Physiology Yong Loo Lin School of Medicine National University of Singapore 117597 Singapore NUS Graduate School for Integrative Sciences and Engineering National University of Singapore 117456 Singapore

Myogenic differentiation is accompanied by alterations in the chromatin states, which permit or restrict the transcriptional machinery and thus impact distinctive gene expression profiles. The mechanisms by which higher-order chromatin remodeling is associated with gene activation and silencing during differentiation is not fully understood. In this study, we provide evidence that the euchromatic lysine metbyltransferase GLP regulates heterocbromatin organization and myogenic differentiation. Interestingly, GLP represses expression of the methyl-binding protein MeCP2 that induces heterochromatin clustering during differentiation. Consequently, MeCP2 and HP1γ localization at major satellites are altered upon modulation of GLP expression. In GLP knockdown cells, depletion of MeCP2 restored both chromatin organization and myogenic differentiation. These results identify a novel regulatory axis between a histone methylation writer and DNA methylation reader, which is important for beterochromatin organization during differentiation.

关键词： myogenic differentiation chromatin methylation

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Sex disparity in viral load, inflammation and liver damage in transgenic mice carrying full hepatitis B virus genome with the W4P mutation in the preS1 region

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World Journal of Gastroenterology 2018年第10期24卷 1084-1092页

作者： Seoung-Ae Lee So-Young Lee Yu-min choi Hong Kim Bum-Joon Kim Department of Microbiology and Immunology Biomedical Sciences Liver Research Institute and Cancer Research Institute Seoul National University College of Medicine

AIM To study sex disparity in susceptibility to hepatocellular carcinoma(HCC), we created a transgenic mouse model that expressed the full hepatitis B virus(HBV) genome with the W4P *** Transgenic mice were generated by transferring the p HY92-1.1 x-HBV-full genome plasmid(genotype A2) into C57 Bl/6 N mice. We compared serum levels of hepatitis B surface antigen(HBs Ag), interleukin(IL)-6, and the liver enzymes alanine aminotransferase(ALT) and aspartate transaminase(AST), as well as liver histopathological features in male and female transgenic(W4PTG) mice and in nontransgenic littermates of 10 mo of age. RESULTS W4PTG males exhibited more pronounced hepatomegaly, significantly increased granule generation in liver tissue, elevated HBs Ag expression in the liver and serum, and higher serum ALT and IL-6 levels compared to W4PTG females or littermate control groups. CONCLUSION Together, our data indicate that the W4 P mutation in pre S1 may contribute to sex disparity in susceptibility to HCC by causing increased HBV virion replication and enhanced IL-6-mediated inflammation in male individuals. Additionally, our transgenic mouse model that expresses full HBV genome with the W4 P mutation in pre S1 could be effectively used for the studies of the progression of liver diseases, including HCC.

关键词： Hepatitis B virus W4P mutation of preS1 transgenic mice Hepatocellular carcinoma

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Usefulness of transcatheter arterial embolization for eighty-three patients with secondary postpartum hemorrhage:Focusing on difference in angiographic findings

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World Journal of Clinical Cases 2023年第15期11卷 3471-3480页

作者： Bong Man Kim Gyeong Sik Jeon min Jeong choi Nam-Soo Hong Department of Radiology Dankook University HospitalDankook University College of MedicineCheonan-si 31116Chungcheongnam-doSouth Korea Department of Radiology CHA Bundang Medical CenterCollege of MedicineCHA UniversitySeongnam-si 13496Gyeonggi-doSouth Korea Department of Preventive Medicine School of MedicineKyungpook National UniversityDaegu 41944South Korea

BACKGROUND Transcatheter arterial embolization(TAE)has been widely used as an effective and a safe treatment method and was often used as an alternative to the surgical management,but there are limited studies on the efficacy and the safety for patients undergoing their secondary postpartum hemorrhage(PPH).AIM To evaluate the usefulness of TAE for secondary PPH focusing on the angiographic *** We conducted a research from January 2008 to July 2022 on all 83 patients(mean:32 years,range:24-43 years)presented with secondary PPH and they were treated with TAE in two university *** medical records and angiography were retrospective reviewed in order to evaluate the patients’characteristics,delivery details,clinical status and peri-embolization management,angiography and embolization details,technical/clinical success and *** group with active bleeding sign and the group without it were also compared and *** On angiography,46(55.4%)patients showed active bleeding signs such as contrast extravasation(n=37)or pseudoaneurysm(n=8)or both(n=1),and 37(44.6%)patients showed non-active bleeding signs such as only spastic uterine artery(n=2)or hyperemia(n=35).In the active bleeding sign group there were more multiparous patients,low platelet count,prothrombin time prolongation,and high transfusion *** technical success rates were 97.8%(45/46)in active bleeding sign group and 91.9%(34/37)in non-active bleeding sign group,and the overall clinical success rates were 95.7%(44/46)and 97.3%(36/37).An uterine rupture with peritonitis and abscess formation occurred to one patient after the embolization,therefore hysterostomy and retained placenta removal were performed which was a major *** TAE is an effective and a safe treatment method for controlling secondary PPH regardless of angiographic findings.

关键词： Postpartum hemorrhage Angiography Transcatheter arterial embolization Pseudoaneurysm Nbutylcyanoacrylate

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A conformal titanyl phosphate amorphous overlayer for enhancing photoelectrochemical hydrogen peroxide production

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Journal of Energy Chemistry 2023年第11期86卷 399-408,I0009页

作者： Jaekyum Kim Young Eun Kim minyeong Je Won Tae Hong Chang-Lyoul Lee Tae-Hoon Kim Sung min Cho Chang Hyuck choi Heechae choi Woo-Seok Choe Jung Kyu Kim School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Theoretical Materials&Chemistry Group Institute of Inorganic ChemistryUniversity of CologneGreinstr.650939CologneGermany Advanced Photonics Research Institute(APRI) Gwangju Institute of Science and Technology(GIST)Gwangju 61005Republic of Korea Department of Materials Science and Engineering Chonnam National UniversityGwangju 61186Republic of Korea Department of Chemistry Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Institute for Convergence Research and Education in Advanced Technology(I-CREATE) Yonsei UniversitySeoul 03722Republic of Korea Department of Chemistry Xi’an Jiaotong-Liverpool UniversitySuzhou 215123JiangsuChina

Photoelectrochemical(PEC)H_(2)O_(2)production through water oxidation reaction(WOR)is a promising strategy,however,designing highly efficient and selective photoanode materials remains challenging due to competitive reaction ***,for highly enhanced PEC H_(2)O_(2)production,we present a conformal amorphous titanyl phosphate(a-TP)overlayer on nanoparticulate TiO_(2)surfaces,achieved via lysozyme-molded in-situ surface *** a-TP overlayer modulates surface adsorption energies for reaction intermediates,favoring WOR for H_(2)O_(2)production over the competing O_(2)evolution *** density functional theory calculations reveal that a-TP/TiO_(2)exhibits a substantial energy uphill for the O·*formation pathway,which disfavors O_(2)evolution but promotes H_(2)O_(2)***,the a-TP overlayer strengthens the built-in electric field,resulting in favorable ***,a-TP/TiO_(2)exhibits 3.7-fold higher Faraday efficiency(FE)of 63%at 1.76 V *** hydrogen electrode(RHE)under 1 sun illumination,compared to bare TiO_(2)(17%),representing the highest FE among TiO_(2)-based WOR H_(2)O_(2)production *** the a-TP overlayer constitutes a promising strategy for controlling reaction pathways and achieving efficient solar-to-chemical energy conversion.

关键词： Solar H_(2)O_(2) production In-situ surface reforming Titanyl phosphate Amorphous overlayer Reaction pathway control

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Clinical course of sub-centimeter-sized nodules detected during surveillance for hepatocellular carcinoma

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World Journal of Gastroenterology 2012年第21期18卷 2654-2660页

作者： Yang Won min Geum-Youn Gwak min Woo Lee Moon Seok choi Joon Hyoek Lee Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo Department of Medicine Samsung Medical Center Sungkyunkwan University School of MedicineSeoul 135-710 South Korea Department of Radiology Samsung Medical Center Sungkyunkwan University School of MedicineSeoul 135-710 South Korea

AIM: To evaluate the outcome of sub-centimeter-sized nodules (SCSNs) detected during surveillance for hepatocellular carcinoma (HCC) in patients at risk. METHODS: We retrospectively analyzed a total of 142 patients with liver cirrhosis or chronic hepatitis B or C without a prior history of HCC in whom a SCSN was detected during HCC surveillance. We calculated the rate of HCC development from SCSNs in the study population and analyzed the differences in the baseline clinical characteristics and imaging features between the patients with SCSNs that eventually developed into HCC and patients with SCSNs that did not develop into ***: During 667 person-years of follow-up, HCC developed in 33 patients. The calculated HCC development rate was 4.9% per year. The cumulative one-, two-, three- and five-year HCC development rates were 5.6%, 10.6%, 14.1% and 20.4%, respectively. Upon baseline comparison, the HCC group was older (54.4 ± 8.3 years vs 48.9 ± 9.4 years; P = 0.003) and had lower albumin levels (3.56 ± 0.58 g/dL vs 3.84 ± 0.55 g/dL; P = 0.012) and higher baseline alpha-fetoprotein (AFP) levels (8.5 ng/mL vs 5.4 ng/mL; P = 0.035) compared to the non-HCC group. Nodule pattern and initial radiologic diagnosis also differed between the two groups. Multivariate analysis revealed that age [P = 0.012, odds ratio (OR) =1.075, 95% confidence interval (CI) =1.016-1.137], sex (P = 0.009, OR = 3.969, 95% CI: 1.403-11.226), and baseline AFP level (P = 0.024, OR = 1.039, 95% CI: 1.005-1.073) were independent risk factors for developing HCC. CONCLUSION: The overall risk of HCC development in patients with SCSNs is similar to that in liver cirrhosis patients. Patients with these risk factors need to be closely monitored during follow-up.

关键词： Chronic liver disease Hepatocellular carcinoma Risk factor Sub-centimeter-sized nodule

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Light-stabilized FHA2 suppresses miRNA biogenesis through interactions with DCL1 and HYL1

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Molecular Plant 2021年第4期14卷 647-663页

作者： Seung Jun Park Suk Won choi Gu min Kim Christian Moller Hyun-Sook Pai Seong Wook Yang Department of Systems Biology College of Life Science and BiotechnologyYonsei UniversitySeoul 120749Korea EDepartment of Systems Biology Institute of Life Science and BiotechnologyYonsei UniversitySeoul 120-749Korea Department of Plant and Environnental Sciences Faculty of ScienceUniversity of CopenhagenThorvaldsensvei 40DK-1871 FrederiksbergCopenhagenDenmark Pohang University of Science and Technology(POSTECH) 77 Cheongam-RoNam-GuPohangGyeongbuk37673.Korea These authors contributed equally to this article.

The precise regulation of microRNA(miRNA)biogenesis is crucial for plant development,which requires core microprocessors and many fine tuners to coordinate their miRNA processing activity/specificity in fluctuating cellular *** de-etiolation,light triggers a dramatic accumulation of core microprocessors and primary miRNAs(pri-miRNAs)but decreases pri-miRNA processing activity,resulting in relatively constant miRNA *** mechanisms underlying these seemingly contradictory regulatory changes remain *** this study,we identified forkhead-associated domain 2(FHA2)as a light-stabilized suppressor of miRNA *** found that FHA2 deficiency increased the level of mature miRNAs,accompanied by a reduction in pri-miRNAs and target *** assays showed that FHA2 associates with the core microprocessors DCL1,HYL1,and SE,forming a complex to suppress their pri-miRNA processing *** analyses revealed that FHA2 promotes HYL1 binding but inhibits the binding of DCL1-PAZ-RNase-RNA-binding domains(DCL1-PRR)to miRNAs,whereas FHA2 does not directly bind to these ***,we found that FHA2 protein is unstable in the dark but stabilized by light during ***,disruption of FH A led to defects in light-triggered changes in miRNA expression and reduced the survival rate of deetiolated seedlings after prolonged light ***,these data suggest that FHA2 is a novel light-stabilized suppressor of miRNA biogenesis and plays a role in fine-tuning miRNA processing during de-etiolation.

关键词： miRNA biogenesis Suppressor of the microprocessor miRNA-biogenetic inconsistency

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Dual function of a high-contrast hydrophobic-hydrophilic coating for enhanced stability of perovskite solar cells in extremely humid environments

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Nano Research 2017年第11期10卷 3885-3895页

作者： Jin Sun Yoo Gill Sang Han Seongha Lee min Cheol Kim Mansoo choi Hyun Suk Jung Jung-Kun Lee School of Advanced Materials Science amp Engineering Sungkyunkwan University Suwon 440-746 Republic of Korea Department of Mechanical Engineering and Materials Science University of Pittsburgh Pittsburgh Pennsylvania 15261 USA Department of Mechanical and Aerospace Engineering Seoul National University Seoul 08826 Republic of Korea

In spite of a continuous increase in their power conversion efficiency （PCE） and an economically viable fabrication process,organic-inorganic perovskite solar cells （PSCs） pose a significant problem when used in practical applications：They show fast degradation of the PCE when exposed to very humid *** this study,the stability of PSCs under very humid conditions is greatly enhanced by coating the surface of the PSC devices with a multi-layer film consisting of ultrahydrophobic and relatively hydrophilic layers.A hydrophobic composite of poly（methyl methacrylate）（PMMA）,polyurethane （PU）,and SiO2 nanoparticles successfully retards the water molecules from very humid ***,the hydrophilic layer with moderately PMMA captures the residual moisture within the perovskite layer;subsequently,the perovskite layer *** dual function of the coating film keeps the PCE of PSCs at 17.3% for 180 min when exposed to over 95% humidity.

关键词： perovskite solar cell stability surface coating ultrahydrophobic self-recovery

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Practical operating flexibility of a bifunctional freestanding membrane for efficient anion exchange membrane water electrolysis across all current ranges

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Carbon Energy 2024年第9期6卷 306-324页

作者： Hong-Jin Son Jeemin Hwang min Young choi Seung Hee Park Jae Hyuk Jang Byungchan Han Sung Hoon Ahn Department of Bio-Chemical Engineering Chosun UniversityGwangjuRepublic of Korea Fuel Cell Research and Demonstration Center Hydrogen Energy Research DivisionKorea Institute of Energy Research(KIER)Buan-gunJeollabuk-doRepublic of Korea Department of Chemical and Biomolecular Engineering Yonsei UniversitySeoulRepublic of Korea Center for Research Equipment Korea Basic Science InstituteDaejeonRepublic of Korea

This study explores a symmetric configuration approach in anion exchange membrane(AEM)water electrolysis,focusing on overcoming adaptability challenges in dynamic ***,a rapid and mild synthesis technique for fabricating fibrous membrane-type catalyst electrodes is *** method leverages the contrasting oxidation states between the sulfur-doped NiFe(OH)_(2) shell and the metallic Ni core,as revealed by electron energy loss *** evaluations confirm that the S–NiFe(OH)_(2) active sites optimize free energy for alkaline water electrolysis *** technique bypasses traditional energy-intensive processes,achieving superior bifunctional activity beyond current *** symmetric AEM water electrolyzer demonstrates a current density of 2 A cm^(-2) at 1.78 V at 60℃ in 1 M KOH electrolyte and also sustains ampere-scale water electrolysis below 2.0 V for 140 h even in ambient *** results highlight the system's operational flexibility and structural stability,marking a significant advance-ment in AEM water electrolysis technology.

关键词： AEM water electrolysis fibrous membrane iR correction free operational stability symmetric configuration

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Synthesis of Al-doped ZnO Nanorods via Microemulsion Method and Their Application as a CO Gas Sensor

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Journal of Materials Science & Technology 2015年第6期31卷 639-644页

作者： Sang Kyoo Lim Seong Hui Hong Sung-Ho Hwang Won Mi choi Soonhyun Kim Hyunwoong Park min Gi Jeong Division of Nano & Bio Technology Daegu Gyeongbuk Institute of Science and Technology(DGIST) School of Energy Engineering Kyungpook National University Department of Advanced Organic Materials Engineering Yeungnam University

Aluminum doped ZnO(AZO) nanorods were synthesized by microemulsion method with different types of *** phase and the morphology of the above nanorods were investigated by scanning electron microscopy(SEM) and X-ray diffraction(XRD).SEM observations showed that the ZnO nanorods had diameters around about 50—200 nm and lengths up to several *** CO gas sensing properties of the AZO nanorods were tested at operating temperatures of 200,300,350 and 400 ℃.It was found that AZO nanorods based sensor exhibited the highest sensitivity to CO at 350℃.

关键词： Zinc oxide Nanorod Microemulsion Aluminum CO and g

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