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Rare Metals 2024年第3期43卷 1017-1029页

作者： Xiang Han min Xu Lan-Hui Gu Chao-Fei Lan min-feng chen Jun-Jie Lu Bi-Fu Sheng Peng Wang Song-Yan chen Ji-Zhang chen College of Materials Science and Engineering Co-Innovation Center of Efficient Processing and Utilization of Forestry ResourcesNanjing Forestry UniversityNanjing210037China Department of Physics Xiamen UniversityXiamen361005China Western Digital Corporation MilpitasCA95035USA

Silicon has ultrahigh capacity,dendrite-free alloy lithiation mechanism and low cost and has been regarded as a promising anode candidate for solid-state *** to the low infiltration of solid-state electrolyte(SSE),not the unstable solid-electrolyte interphase(SEI),but the huge stress during lithiation-and delithiation-induced particle fracture and conductivity lost tend to be the main *** this study,starting with micron-Si,a novel monothetic carbon conductive framework and a MgO coating layer are designed,which serve as electron pathway across the whole electrode and stress releasing layer,*** addition,the in situ reaction between Si and SSE helps to form a LiF-rich and mechanically stable SEI *** a result,the mechanical stability and charge transfer kinetics of the uniquely designed Si anode are significantly ***,high initial Coulombic efficiency,high capacity and durable cycling stability can be achieved by applying the Si@MgO@C anode in *** example,high specific capacity of 3224.6 mAh·g^(-1)and long cycling durability of 200 cycles are *** work provides a new concept for designing alloy-type anode that combines surface coating on particle and electrode structure design.

关键词： Lithium-ion battery(LIB) Solid-state electrolyte(SSE) Silicon anode Stress relief Coating

Liquid metal welding enabling high loading binder/carbon-free layered oxide cathode toward high-performance liquid and solid-state battery

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Rare Metals 2023年第5期42卷 1583-1593页

作者： Xiang Han Lan-Hui Gu min Xu min-feng chen Ji-Zhang chen College of Materials Science and Engineering Co-Innovation Center of Efficient Processing and Utilization of Forest ResourcesNanjing Forestry UniversityNanjing210037China

High loading cathode with high active material proportion is a practical demand but far below the desirable value to achieve high energy density lithium-ion batteries(LIBs).Normally,the Li^(+)/electron transport between active materials and electrolyte/c arbon,however,it is poor and areal resistance is extremely high for a high loading/thick *** this manuscript,taking high-voltage lithium cobalt oxide LiCoO_(2)(LCO)as an example,we design a facile liquid metal welding method enabled by a low melting-point indium-tin oxide In_(2)O_(3)/SnO_(2)(ITO)during a thermal treatment process,the strongly adhesion active particles show robust mechanical property for the free-standing LCO cathode with a pellet *** also demonstrate that the O_(2)atmosphere plays a critical role on the interfacial property,that is preventing the layered structure to rock-salt Co_(3)O_(4)as well as further enhancing the interfacial mechanical *** expected,the LCO-ITO free-standing cathode not only shows robust mechanical property with densely packed configuration but also provides a fast Li^(+)/electron pathway at the ***,the LCO-ITO composite cathode exhibits excellent electrochemical cycling performance in both liquid and solid-state *** example,even at a high active material mass of 56 mg·cm^(-2),the LCO cathode still delivers a specific capacity of 151 mAh·g^(-1)and maintains132.5 mAh·g^(-1)(corresponding to 7.4 mAh·cm^(-2))after *** LCO-ITO-O_(2)cathode is also applicable to a solidstate cell,which exhibits a high capacity of 100.4 mAh·g^(-1)after 200 cycles of long-term *** excellent electrochemical of the LCO-ITO-O_(2)reveals the successful engineering mechanical architecture and interfacial carriers transport,which may be expected as an alternative approach to achieve high energy density LIBs.

关键词： Lithium-ion battery(LIB) High loading cathode Liquid metal welding Mechanical property Interfacial carriers transport

Parasitism-induced effects on host growth and metabolic efficiency in Plutella xylostella larvae parasitized by Cotesia vestalis or Diadegma semiclausum

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Insect Science 2008年第3期15卷 237-243页

作者： Fang Huang Ting-Ting Cao min Shi Ya-feng chen Xue-xin chen Institute of Insect Sciences Zhejiang University Hangzhou China

The nutritional physiology of the diamondback moth, Plutella xylostella, larvae was examined after parasitization by the solitary endoparasitoids Cotesia vestalis or Diadegma semiclausum. Examinations were performed in two phases, one was examined at the time point of 24 h post-parasitization, and the other was done at the end of the 4th instar larvae of host. Rates of growth, food consumption, assimilation, excretion, and respiration were calculated as well as approximate digestibility and the rate ratios ECI （percent efficiency of conversion of ingested food to body substance）, and ECD （percent efficiency of conversion of digested food to body substance）. Parasitization by C. vestalis resulted in significant decrease in the rates of growth, feeding, excretion, assimilation, and respiration, but the final dry rate of respiration at the end of last larval stadium was elevated. The ECI and ECD were also reduced as the result of parasitization, but digestibility was increased. All these parameters in the larvae parasitized by D. semiclausum at 24 h post-parasitization were also significantly changed compared to the control; however, these differences were quantitatively, but not qualitatively before pupation, similar to those resulted from parasitization by C. vestalis. In spite of the similarities of the parasitism-induced effects caused by these endoparasitoids, the final metabolic rate, that is, the rate of intake of nutrients required to compensate for metabolism, was much lower in the larvae parasitized by C. vestalis than that of the larvae parasitized by D. semiclausum. All of the results discussed here will contribute toward explaining the different ways these two wasps regulate the parasitoid-host relationship.

关键词： approximate digestibility Cotesia vestalis Diadegma semiclausum foodconsumption Plutella xylostella

Short-time maritime target detection based on polarization scattering characteristics

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Journal of Systems Engineering and Electronics 2024年第1期35卷 55-64页

作者： chen Shichao LUO feng TIAN min LYU Wanghan College of Computer and Information Engineering(College of Artificial Intelligence) Nanjing Tech UniversityNanjing 211816China Hangzhou Institute of Technology Xidian UniversityHangzhou 311200China

In this paper,a detection method combining Cameron decomposition based on polarization scattering characteristics in sea clutter background is ***,the Cameron decomposition is exploited to fuse the radar echoes of full polarization channels at the data *** to the artificial material structure on the surface of the target,it can be shown that the non-reciprocity of the target cell is stronger than that of the clutter ***,based on the analysis of the decomposition results,a new feature with scattering geometry characteristics in polarization domain,denoted as Cameron polarization decomposition scattering weight(CPD-SW),is extracted as the test statistic,which can achieve more detailed descriptions of the clutter scattering characteristics utilizing the difference between their scattering ***,the superiority of the proposed CPD-SW detector over traditional detectors in improving detection performance is verified by the IPIX measured dataset,which has strong stability under short-time observation in threshold detection and can also improve the separability of feature space zin anomaly detection.

关键词： sea clutter small target radar detection Cameron decomposition characteristics analysis

Dauricine can inhibit the activity of proliferation of urinary tract tumor cells

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Asian Pacific Journal of Tropical Medicine 2012年第12期5卷 973-976页

作者： Jun Wang Yuan Li Xiong-Bing Zu min-feng chen Lin Qi Department of Urology Xiangya HospitalCentral South University

Objective:To explore the anti-tumor effects of asiatic moonseed rhizome extraction-dauricine on bladder cancer EJ cell strain,prostate cancer PC-3Mcell strain and primary cell culture ***:The main effective component-phenolic alkaloids of Menispermum dauricum was extracted and separated from asiatic moonseed rhizome by chemical *** method was used to detect dauricine anti-tumor ***:Dauricine had an obvious proliferation inhibition effect on the main tumor cells in urinary *** minimum drug sensitivity concentration was between ***μg/mL,and the inhibition ratio increased with the increase of ***:Dauricine,the main effective component extracted from asiatic moonseed rhizome,had a good inhibition effect on tumor cells in urinary *** the same time,Dauricine has certain inhibition effects on the primary cultured tumor cell.

关键词： PAMD Dauricine Urinary system EJ cell strain PC-3Mcell strain

TULAM:trajectory-user linking via attention mechanism

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Science China(Information Sciences) 2024年第1期67卷 51-68页

作者： Hao LI Shuyu CAO Yaqing chen min ZHANG Dengguo feng Trusted Computing and Information Assurance Laboratory Institute of SoftwareChinese Academy of Sciences University of Chinese Academy of Sciences

Recently,the application of location-based services(LBS) has become a prevalent means to provide convenience in customers’ everyday ***,because massive volumes of location information are collected by LBS applications,users may suffer from serious privacy *** studies have shown that the identities of users can be inferred from historical anonymous trajectories,which is formulated as the trajectory-user linking(TUL) *** some recurrent neural network(RNN)-based models have been proposed to capture implicit movement patterns among trajectories to improve TUL performance,they cannot learn the sequential and contextual semantics within any individual trajectory completely,leaving the advantages of RNNs *** therefore propose an RNN model with an attention mechanism called TULAM to improve the accuracy of the TUL *** learns sequential relationships within individual trajectories via RNN and captures contextual semantics from trajectories via a multi-head attention ***,we propose a novel location encoding method called approximate one-hot to solve the corpus shortage problem of trajectory *** were conducted on real datasets from the Gowalla and Foursquare LBS *** experimental results indicate that TULAM is a practical solution that achieves significant improvements over existing methods with satisfactory model complexity and convergence.

关键词： information security data security and privacy trajectory-user linking deep learning recurrent neural network attention mechanism

Regioselective and asymmetric allylic alkylation of vinyl epoxides for the construction of allylic alcohols via synergistic catalysis

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Science China Chemistry 2024年第2期67卷 542-550页

作者： min chen Longqing Yang Yuzhen Li Yinhe Qu Guihua Pan Xiaoming feng Xiaohua Liu Key Laboratory of Green Chemistry&Technology Ministry of EducationCollege of ChemistrySichuan UniversityChengdu610064China

A highly efficient asymmetric allylic alkylation of cyclic and acyclic carbon nucleophiles with vinyl epoxides has been developed,which exhibits good functional group compatibility,high atomic and step *** protocol utilizes a strategy of synergistic catalysis with a chiral N,N'-dioxide/Ni~Ⅱ complex and an achiral Pd~0 catalyst,generating a series of multisubstituted allylic alcohols with a quaternary carbon stereocenter in high yield and excellent regio-,Z/E-and enantioselectivity under mild *** transformations of the product demonstrate the potential utility of this protocol in the synthesis of allyl alcohol derivatives and natural product *** studies revealed that the N,N′-dioxide/metal complexes play an important role in controlling the Z/E-and *** density functional theory(DFT) calculations further demonstrated that multiple C–H···π interactions between the aromatic rings of the two substrates and the amide moiety in the ligand stabilized the dominant transition state.

关键词： asymmetric allylic alkylation synergistic catalysis vinyl epoxides allyl alcohol multiple weak interactions

Paeoniflorin,the Main Monomer Component of Paeonia lactiflora,Exhibits Anti-inflammatory Properties in Osteoarthritis Synovial Inflammation

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Chinese Journal of Integrative Medicine 2024年第5期30卷 433-442页

作者： chen Pu ZHOU Jun RUAN An-min MA Yu-feng WANG Qing-fu Department of Orthopaedic Surgery Beijing University of Chinese Medicine Third Affiliated HospitalBeijing 100029China Department of Orthopaedic Surgery Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Department of Orthopaedic Surgery Beijing Longfu HospitalBeijing 100010China

Objective:To explore the mechanism of paeoniflorin(PF)on osteoarthritis(OA)synovial inflammation from network pharmacology to experimental ***:Targets of OA were constructed by detecting the database of network database platforms(Therapeutic Target database,Drug Bank and Gene Cards),and the targets of PF were constructed by Pub Chem and Herbal Ingredients'Targets *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis of these co-targeted genes were conducted via Database for Annotation,Visualization,and Integrated Discovery(DAVID)database,and protein-protein interaction(PPI)networks were conducted via the search tool for the retrieval of interacting genes(STRING)*** counting kit-8(CCK-8)assay was performed to assess the potential toxicity of PF on human OA fibroblast-like synoviocytes(FLS),quantitative real-time polymerase chain reaction(q PCR),enzyme-linked immunosorbent assay(ELISA)and Western blot were used to verify the potential mechanism of PF in synovial ***:Twenty-six co-targeted genes were *** enrichment results showed that these co-targeted genes were most likely localized in the cytoplasm,and the biological processes mainly involved'cellular response to hypoxia''lipopolysaccharide(LPS)-mediated signaling pathway'and'positive regulation of gene expression'.KEGG pathway analysis indicated that these co-targeted genes may function through pathways associated with'hypoxia-inducible factor-1(HIF-1)signaling pathway'and'tumornecrosis factor(TNF)signaling pathway'.The PPI network showed that the top 3 hub genes were TP53,TNF,and *** docking results showed that PF was well docking with ***-8 showed no potential toxicity of 10,20 and 50μmol/L PF on human OA *** PF significantly decreased the expression levels of interleukin-1β,interleukin-6,TNF-αmatrix metalloproteinase 13(MMP13),and a disintegrin and metalloproteinase with thrombospondin motifs 5(ADAMTS5)and TNF

关键词： paeoniflorin osteoarthritis synovial inflammation tumor necrosis factor-α network pharmacology Paeonia lactiflora

Discovery of a novel EGFR ligand DPBA that degrades EGFR and suppresses EGFR-positive NSCLC growth

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Signal Transduction and Targeted Therapy 2020年第1期5卷 495-507页

作者： Nan Yao chen-Ran Wang ming-Qun Liu Ying-Jie Li Wei-min chen Zheng-Qiu Li Qi Qi Jin-Jian Lu Chun-Lin Fan min-feng chen ming Qi Xiao-Bo Li Jian Hong Dong-Mei Zhang Wen-Cai Ye College of Pharmacy Jinan UniversityGuangzhouChina Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research Jinan UniversityGuangzhouChina School of Medicine Jinan UniversityGuangzhouChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacaoChina

Epidermal growth factor receptor(EGFR)activation plays a pivotal role in EGFR-driven non-small cell lung cancer(NSCLC)and is considered as a key target of molecular targeted *** tyrosine kinase inhibitors(TKIs)have been canonically used in NSCLC ***,prevalent innate and acquired resistances and EGFR kinase-independent pro-survival properties limit the clinical efficacy of EGFR ***,the discovery of novel EGFR degraders is a promising approach towards improving therapeutic efficacy and overcoming drug ***,we identified a 23-hydroxybetulinic acid derivative,namely DPBA,as a novel EGFR small-molecule *** exerted potent in vitro and in vivo anticancer activity in both EGFR wild type and mutant NSCLC by degrading *** studies disclosed that DPBA binds to the EGFR extracellular domain at sites differing from those of EGF and *** did not induce EGFR dimerization,phosphorylation,and ubiquitination,but it significantly promoted EGFR degradation and repressed downstream survival *** analyses showed that DPBA induced clathrin-independent EGFR endocytosis mediated by flotillin-dependent lipid rafts and unaffected by EGFR *** of the early and late endosome markers rab5 and rab7 but not the recycling endosome marker rab11 was involved in DPBA-induced EGFR lysosomal *** present study offers a new EGFR ligand for EGFR pharmacological degradation and proposes it as a potential treatment for EGFR-positive NSCLC,particularly NSCLC with innate or acquired EGFR TKI *** can also serve as a chemical probe in the studies on EGFR trafficking and degradation.

关键词： NSCLC EGFR positive

Quantitative analysis of transforming growth factor beta 1 mRNA in patients with alcoholic liver disease

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World Journal of Gastroenterology 2002年第2期8卷 379-381页

作者： Wei-Xing chen You-ming Li Chao-Hui Yu Wei-min Cai min Zheng feng-chen,Department of Gastroenterology, The First Affiliated Hospital,Medical College of Zhejiang University,Hangzhou 310003,Zhejiang Province,China Department of Gastroenterology The First Affiliated Hospital Medical College of Zhejiang University Hangzhou 310003 Zhejiang Province China. weixng121@***

AIM: To investigate the expression of the transforming growth factor beta 1(TGF-beta 1) mRNA in different stages of alcoholic liver disease (ALD) and its clinical value. METHODS: One hundred and seven male alcoholics were grouped by clinical findings into four groups: alcohol abusers without liver impairment (n =22), alcoholic steatosis (n =30); alcoholic hepatitis (n=31); and alcoholic cirrhosis(n=24). Using peripheral blood mononuclear cells (PBMC) as samples the gene expression of TGF-beta 1 was examined quantitatively by reverse transcription polymerase chain reaction (RT-PCR) and dot blot. There are 34 healthy subjects served as control. RESULTS: The expression of TGF-beta 1 from all ALD patients was significantly greater than that in controls (1.320 +/- 1.162 vs 0.808 +/- 0.276, P<0.001). The differences of the expressions were significant between the patients from each groups (alcoholic steatosis, alcoholic hepatitis and alcoholic cirrhosis) and the controls (1.168 +/- 0.852, 1.462 +/- 1.657, 1.329 +/- 0.610 vs 0.808 +/- 0.276, P<0.050). No significant differences of TGF -beta 1 mRNA expression were observed between alcohol abusers without liver impairment and controls. The expressions in patients with alcoholic hepatitis and alcoholic cirrhosis were significantly greater than that in alcohol abusers respectively (1.462 +/- 1.657, 1.329 +/- 0.610 vs 0.841 +/- 0.706, P<0.050). No significant differences of TGF-beta 1 mRNA expression were observed between alcoholic fatty liver men and alcohol abusers. CONCLUSION: TGF-beta 1 expression level can be a risk factor for alcoholic liver disease and might be related to the inflammatory activity and fibrosis of the liver in patients.

关键词： Humans Liver Diseases, Alcoholic Male RNA, Messenger Transforming Growth Factor beta