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Chloroplast DNA-based genetic variation of Rosa roxburghii in Southwest China:Phylogeography and conservation implications

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Horticultural Plant Journal 2021年第4期7卷 286-294页

作者： min lu Huaishan Zhang Huaming An Agricultural College Guizhou UniversityGuiyang 550025China Guizhou Engineering Research Center for Fruit Crops Guiyang 550025China

Rosa roxburghii *** a well-known commercial horticultural crop in China with nutritional and medicinal *** germplasms of this species are mainly distributed in Southwest China but the population is decreasing due to continuous exploitation,habitat destruction,and ***,assessing the genetic diversity and phylogeography is essential for efficient ***,two chloroplast intergenic spacers(trnL-trnF and accD-psaI)were investigated in 255 individuals from 29 *** populations and 18 haplotypes(H1–H18)were *** levels of haplotype diversity(Hd=0.829)and nucleotide diversity(π=1.3×10^(−3))were detected in these ***,the genetic variation representing 86.4%of the total variation was detected by an analysis of molecular variance.A significant correlation was established between genetic divergence and geographic distance by the Mantel test(r=0.204,P=0.04,9999 permutations),suggesting the isolation-by-distance model.A significantly higher Nst than Gst(Nst=0.257,Gst=0.136,Pluded restricted gene flow with isolation distance within clades 1-8,2-3,and overall,contiguous expansion within clades 1-3 and 3-2,past fragmentation,and/or long-distance colonization within clades 1-9 and *** priority should be given to the core populations GZ,FQ,DF,DS,xy,AL,LC,PB,and XY in the Yunnan-Guizhou Plateau,NZ and MX in the Qingling-Bashan mountains,and MN in the Hengduan mountains,where an in situ preservation and management strategy should be applied.

关键词： Chloroplast DNA Genetic diversity Core population Phylogeography Rosa roxburghii

Spectroscopic investigation on chirality transfer in additive-driven self-assembly of block polymers

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Chinese Chemical Letters 2017年第7期28卷 1358-1364页

作者： Li-Hua Pang Jing-min Li Xue-min lu Qing-Hua lu School of Chemistry and Chemical Engineering State Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong UniversityShanghai 200240China

Chiral supramolecules prepared by the additive-driven self-assembly of block copolymers provide a facile method to construct helical nanostructures. In this study, we investigated the chiral transfer from chiral tartaric acid to poly（styrene）-b-poly（ethylene oxide） using small-angle X-ray scattering,transmission electron microscopy, circular dichroism, and vibrational circular dichroism. The results showed that the chirality was transferred to both the segments of block copolymer irrespective of the interaction with the chiral additives and formation of helical phase structure. However, the chirality transfer was carried out using different methods： for poly（ethylene oxide） segments, the chirality transfer was carried out via direct hydrogen bond formation; for polystyrene segments, the chirality transfer was carried out via the cooperative motion of block copolymers during the thermal annealing.

关键词： Block polymer Chirality Additive-driven Hydrogen bond Helical structure

Effects of concave and convex substrate curvature on cell mechanics and the cytoskeleton

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Chinese Chemical Letters 2017年第4期28卷 818-826页

作者： Shuang-Shuang Chen Xue-min lu Qing-Hua lu School of Chemistry and Chemical Engineering State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong University Shanghai 200240 China

In order to understand how cells respond to concave and convex subcellular surface structures,colloidal crystal array and honeycomb-structured surfaces composed of highly ordered hexagonal units with completely inverse curvature were fabricated via facile self-assembly and breath figure approaches,*** influence of hexagonal surface curvature on cell fate was subsequently *** underwent more extensive spreading on the convex colloidal crystal array surface,while adhesive forces were higher on the concave honeycomb *** behaviors of cells on the different surfaces were investigated by comparing cell morphology,cellular adhesive force and cytoskeleton *** results revealed comprehensive differences in cell behavior between those on concave honeycomb surfaces and convex colloidal crystal arrays.

关键词： Colloidal crystal array Honeycomb structure Substrate curvature Cytoskeleton Adhesive force

Thermodynamics and Kinetics of Bacterial Cellulose Adsorbing Persistent Pollutant from Aqueous Solutions

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Chemical Research in Chinese Universities 2015年第2期31卷 298-302页

作者： lu min lu Xuan XU Xiaohui GUAN Xiaohui School of Chemical Engineering Northeast Dianli University Jilin 132012 P. R. China

The adsorption capability of bacterial cellulose（BC） for anionic dye acid fuchsine was studied. Meanwhile, the processes of the adsorption were investignted and fitted by adsorption isotherm models, adsorption thermodynamics and adsorption kinetics models, respectively. The changes of BC before and after adsorbing acid fuchsine were investigated via scanning electron microscopy（SEM） and Fourier transform infrared spectroscopy（FTIR） to further explain the adsorption mechanism. The results show that acid fuchsine could be effectively adsorbed by BC. The adsorption process was fitted well by Langmuir equation and the pseudo-second order kinetics, indicating that the adsorption process was monolayer molecule adsorption with the main action of chemical adsorption. The adsorption process was spontaneous and endothermic. Glucuronic acid groups and hydroxyl groups were responsible for the adsorption of acid fuchsine on BC.

关键词： Adsorption thermodynamics Adsorption kinetics Persistent pollutant Bacterial cellulose

Temporal scatterplots

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Computational Visual Media 2020年第4期6卷 385-400页

作者： Or Patashnik min lu Amit H.Bermano Daniel Cohen-Or Tel-Aviv University Tel-AvivIsrael Shenzhen University ShenzhenChina

Visualizing high-dimensional data on a 2D canvas is generally *** becomes significantly more difficult when multiple time-steps are to be presented,as the visual clutter quickly ***,the challenge to perceive the significant temporal evolution is even *** this paper,we present a method to plot temporal high-dimensional data in a static scatterplot;it uses the established PCA technique to project data from multiple *** key idea is to extend each individual displacement prior to applying PCA,so as to skew the projection process,and to set a projection plane that balances the directions of temporal change and spatial *** present numerous examples and various visual cues to highlight the data trajectories,and demonstrate the effectiveness of the method for visualizing temporal data.

关键词： scatterplot temporal data visual clutter principle component analysis(PCA)

MOLECULAR STATIC SIMULATION OF ENERGY FEATURESOF INTERACTION BETWEEN GRAIN BOUNDARYAND DISLOCATIONS IN Ni＿3Al ALLOY

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中国有色金属学会会刊：英文版 1994年第3期4卷 67-70,76页

作者： Chen, Da lu, min Lin, Dongliang Shanghai Jiao Tong Univ Shanghai China

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关键词： Ni3Al Intermetullics grain boundary structure dislocation computer simulation

The survival and prognostic factors of primary testicular lymphoma- two-decade single-center experience

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Asian Journal of Andrology 2018年第6期20卷 615-620页

作者： Run-Zhuo Ma Lei Tian Li-Yuan Tao Hui-Ying He min Li min lu lu-Lin Ma Hui Jiang Jian lu Department of Urology Peking University Third Hospital Beijing 100191 China Department of Hematology Peking University Third Hospital Beijing 100191 China Department of Biostatistics Peking University Third Hospital Beijing 100191 China Department of Pathology Peking University Third Hospital Beijing 100191 China

This study aims to investigate the effect of different local testicular treatments and validate common prognostic factors on primary testicular lymphoma （PTL） patients. We retrospectively reviewed the clinical records of 32 patients from 1993 to 2017 diagnosed with PTL and included 22 patients for analysis. The Kaplan-Meier method, Log-rank test, and multivariate Cox proportional hazard regression analysis were applied to evaluate progression-free survival （PFS）, overall survival （OS）, and determine prognosis predictors. The median follow-up time was 30 months. Median OS and PFS were 96 months and 49 months, respectively. In univariate analysis, advanced Ann Arbor stage （Ill/IV）（P 〈 0.001）, B symptoms （P 〈 0.001）, and extranodal involvement other than testis （P = 0.001） were significantly associated with shorter OS and PFS. In multivariate analysis, Ann Arbor stage was significantly associated with OS （OR = 11.58, P = 0.049）, whereas B symptom was significantly associated with PFS （OR = 11.79, P = 0.049）. In the 10 patients with the systemic usage of rituximab, bilateral intervention could improve median OS from 16 to 96 months （P = 0.032）. The study provides preliminary evidence on bilateral intervention in testes in the rituximab era and validates common prognostic factors for Chinese PTL patients.

关键词： local treatment modalities prognostic factors prophylaxis contralateral orchiectomy prophylaxis contralateral radiotherapy testicular lymphoma

Broad-spectrum rescue compounds for structural p53 mutations: perspective on ‘Arsenic trioxide rescues structural p53 mutations through a cryptic allosteric site’

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Journal of Molecular Cell Biology 2021年第2期13卷 155-157页

作者： Jia-Le Wu Shuo Chen min lu Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine(Shanghai)Ruijin Hospital affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China

Precision medicine targeting gene mutations holds the promise of changing the landscape of cancer care and prognosis,but currently approved drugs in this category are efficacious in only a very small percentage of all cancer patients(Tannock and Hickman,2016).TP53,encoding the tumor suppressor and transcription factor p53,is the most frequently mutated gene in human cancers(Joerger and Fersht,2016;Sabapathy and Lane,2018;Levine,2019).Pharmacologically rescuing mutant p53 by restoring wild-type function could therefore potentially be widely applicable in cancer treatment and is considered to be a holy grail of cancer research(Joerger and Fersht,2010).Indeed,at least 17 compounds that can rescue mutant p53 variants were reported by 2018(Sabapathy and Lane,2018).Unfortunately,p53 mutations still remain therapeutically nonactionable due to challenges such as heterogeneous mechanisms of inactivation by different mutations and the absence of obvious targetable drug-binding pockets(except Y220C mutant).In a recent publication(Chen et al.,2021),we reported the identification of small-molecule compounds that rescue a broad class of p53 ***,these include arsenic trioxide(ATO),which is used to treat acute promyelocytic leukemia(de Théet al.,2017).The study differentiates itself from previous reports in:(i)rescuing mutant p53 at striking levels when benchmarked against previously reported rescue compounds;(ii)providing a structural mechanism,wherein the arsenic atom binds to a cryptic allosteric site connecting the loop–sheet–helix(LSH)motif with theβ-sandwich skeleton to increase the thermostability of mutant p53;(iii)offering a largely defined spectrum of applicable p53 mutations—the structural mutations that compromise the wild-type structure of p53 and collectively account for more than half of all clinically relevant p53 alterations.

关键词： structural spectrum collective

Invasive bark beetle-associated microbes degrade a host defensive monoterpene

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Insect Science 2016年第2期23卷 183-190页

作者： Le-Tian Xu min lu Jiang-Hua Sun State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of Zoology Chinese Academy of Sciences University of Chinese Academy of Sciences Beijing China

Conifers respond to herbivore attack with defensive chemicals, which are toxic to both insects and their associated microorganisms. Microorganisms associated with insects have been widely reported to metabolize toxic chemicals, which may help both microorganisms and host insects overcome host conifer defense. Dendroctonus valens LeConte, an introduced exotic pest from North America to China, has killed millions of healthy pines. Alpha-pinene is the most abundant defensive monoterpene in Chinese Pinus tabuliformis. Although microorganisms associated with D. valens have already been investigated, little is known about their bioactivities when encountering host defensive monoterpenes. In this study, we evaluated the influences of different concentrations ofα- pinene to D. valens and the three most frequently isolated yeasts and bacteria ofD. valens, and further assayed microorganisms＇ capabilities to degrade α-pinene. Results showed that the gallery lengths and body weight changes of bark beetles were significantly affected by 6 mg/mL and 12 mg/mL of α-pinene applied in media compared to controls. The tolerance of experimental microorganisms to α-pinene varied depending on the microbial species. Two out of three yeast strains and all three bacterial strains degraded 20%-50% of α-pinene compared to controls in 24 h in vitro. The microorganisms capable of α-pinene degradation in vitro and their tolerance to high levels ofα-pinene suggested that D. valens- associated microorganisms may help both microorganisms and the bark beetle overcome host α-pinene defense.

关键词： α-pinene associated microorganisms Dendroctonus valens