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New Isoflavonoid Glycosides from the Rhizomes of Iris leptophylla Lingelsh.

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Journal of Integrative Plant Biology 2007年第2期49卷 213-217页

作者： min-jian qin Rong Li Xin Wang Wen-Cai Ye College of Traditional Chinese Medicines China Pharmaceutical University Nanjing 210038 China Key Laboratory of Modern Traditional Chinese Medicines Ministry of Education China Pharmaceutical University Nanjing 210038 China Institute of Traditional Chinese Medicine Jinan University Guangzhou 510632 China

Two new isoflavonoid glucosides, 5-hydroxy-6,7-methylenedioxy-isoflavone-4＇-O-D-glucopyranosyl （2→〉l）-L-rhamnoside （irilone-bioside）（compound 1） and 5,4＇-methoxy-6,7-methylenedioxyisoflavone-3＇-O-β-D-glucoside （irisleptophyllidin）（compound 2）, together with five known compounds, nigricanin- 4＇-O-β-D-glucoside （compound 3）, irifloside （compound 4）, irigenin （compound 5）, 5, 3＇, 4＇-trimethoxy-6,7-methylenedioxyisoflavone （compound 6）, and nigricanin （compound 7） were isolated from the alcoholic extract of rhizomes of Iris leptophylla Lingelsh. Their structures were elucidated by spectroscopic methods.

关键词： 5-hydroxy-6,7-methylenedi-oxy-isoflavone-4'-O-D-glucopyranosyl (2→1)-L-rhamnoside (irilone-bioside) 5,4'-methoxy-6,7- methylenedioxyisoflavone-3'-O-β-D-glucoside (irisleptophyllidin) Iridaceae Iris leptophylla isoflavonoid glycosides.

Two new C-glycosylflavones from the leaves of Iris lactea var. chinensis

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Chinese Chemical Letters 2008年第7期19卷 821-824页

作者： Wen Juan Shen min jian qin Pan Shu Chao Feng Zhang Department of Resources Science of Traditional Chinese Medicines China Pharmaceutical University Nanjing 210038 China Key Laboratory of Modern Traditional Chinese Medicines （ministry of Education） China Pharmaceutical University Nanjing 210038 China

Two new acylated C-glycosylflavones were isolated from the leaves of Iris lactea var. chinensis, and their structures were elucidated on the basis of extensive NMR experiments and mass spectrometry methods and were assigned as 5-hydroxy-4＇- methoxyflavone-7-O-（β-D-2＇＇＇＇4＇＇＇＇-diacetylrhamnopyranosyl）-6-C-[ O-（α-L-6＇＇＇-acetyl-glucpyranosyl）-1→2-β-D-glucopyrano- side] （irislactin A） and 5-hydroxy-4＇,7-dimethoxyflavone-6-C-[O-（α-L-2＇＇＇,3＇＇＇-diacetylrhanmo-pyranosyl）-1→ 2-β-D-glucopyranoside] （irislactin B）.

关键词： Iris lactea Iridaceae Acylated C-glycosylflavone

NONLINEAR DYNAMICS RESPONSE OF CASING PIPE UNDER COMBINED WAVE-CURRENT

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Applied Mathematics and Mechanics(English Edition) 2005年第8期26卷 1040-1046页

作者： TANG You-gang（唐友刚） GU Jia-yang（谷家扬） ZUO jian-li（左建立） min jian-qin（闵建琴） Department of Naval Architecture and Ocean Engineering School of Civil Engineering Tianjin University Tianiin 300072. P. R. China

The vortex-induced nonlinear vibration of casing pipes in the deep water was studied considering the loads of current and combined wave-current. The vortex-induced vibration equation of a casing pipe was set up considering the beam mode and Morison＇s nonlinear fluid loads as well as the vortex-excited loads. The approach of calculating vortex-excited nonlinear vibration by Galerkin＇s method was proposed. The natural vibration frequencies and modes were obtained, and the response including primary resonance induced by current and the composite resonance under combined wave-current for the 170 m long casing pipe in the 160 m depth of water were investigated. The results show that the dynamics response of casing pipe obviously increases, and the complicated response behaviors of casing pipe are described under combined wavecurrent.

关键词： casing pipes in the deep water fluid dynamics combined wave-current vortex-excited vibration composite resonance

A New Isoflavonoid from Belamcanda chinensis （L.） DC.

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Journal of Integrative Plant Biology 2005年第11期47卷 1404-1408页

作者： min-jian qin Wen-Liang JI Zheng-Tao WANG Wen-Cai YE College of Traditional Chinese Medicine China Pharmaceutical University Nanjing 210038 China Shanghai University of Traditional Chinese Medicine Shanghai 201203 China Institute of Traditional Chinese Medicine Jinan University Guangzhou 510632 China

A new isoflavonoid, 5, 6, 7, 3＇-terahydroxy-8, 4＇, 5＇-trimethoxyisoflavone （1）, along with 10 known isoflavonoids, namely 5, 6, 7, 4＇-tetrahydroxy-8-methoxyisoflavone （2）, irilone （3）, genistein （4）, tectorigenin （5）, irigenin （6）, irisflorentin （7）, dichotomitin （8）, dimethyltectorigenin （9）, iridin （10）, and tectoridin （11）, was isolated from the alcohol extract of the rhizomes of Belamcanda chinensis （L.） DC. The structures of these compounds were elucidated on the basis of results of spectroscopic analysis.

关键词： Belamcanda chinensis isoflavonoid 5, 6, 7, 3'-terahydroxy-8, 4', 5'-trimethoxyisoflavone.

Analysis of risk factors for polypoid lesions of gallbladder among health examinees

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World Journal of Gastroenterology 2012年第23期18卷 3015-3019页

作者： Hua-Li Yang Hui-Fang Shen Yu Wang Xin-Gang Gu jian-min qin Pei-Hao Yin Qi Li Lei Kong Li-Li Hou Department of Ultrasonography Putuo Hospital Shanghai Univer- sity of Traditional Chinese Medicine Shanghai 200062 China Department of General Surgery Putuo Hospital Shanghai University of Traditional Chinese Medicine Shanghai 200062 China Department of Oncology Putuo Hospital Shanghai University of Traditional Chinese Medicine Shanghai 200062 China

AIM: To investigate the prevalence and risk factors of polypoid lesions of gallbladder (PLG) among the health examinees in the Shanghai region, China. METHODS: A total of 11 816 subjects who underwent health examinations in our hospital between August 2010 and February 2011 were analyzed retrospectively. Among them, there were 7174 men and 4642 women. PLG was diagnosed by the real-time ultrasonography. Those with the body mass index (BMI) ≥ 28 were considered to be obese. Blood biochemical indices were detected with the fully automatic biochemical analyzer and hepatitis B surface antigen (HBsAg) was tested by the automated enzyme immunoassay. The correlations between the prevalence of PLG and age, sex, BMI, serum cholesterol (T-Cho), triglycerides (TG),blood sugar, HBsAg, high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), gallstone and fatty liver were investigated. After univariate analysis of 11 variables, stepwise logistic regression analysis was performed to explore the risk factors of PLG. RESULTS: There was a significant difference in sex, T-Cho, HBsAg, HDL-C, LDL-C and fatty liver between the PLG-positive group and the PLG-negative group (332/163 vs 6842/4479, P = 0.003; 22/473 vs 295/11 026, P =0.013; 92/403 vs 993/10 328, P = 0.001; 47/448 vs 332/10 989, P = 0.001; 32/463 vs 381/10 940, P = 0.001; 83/412 vs 3260/8061, P = 0.001). No significant difference was found in the age, BMI, TG, blood sugar and gallstone between the two groups (47.3 ± 26 vs 45.1 ± 33, P = 0.173; 59/436 vs 1097/10 224, P = 0.102; 52/443 vs 982/10 339, P = 0.158; 17/478 vs 295/11 026, P = 0.26; 24/471 vs 395/10 926, P = 0.109). Logistic regression analysis showed that the sex, HBsAg and HDL-C were independent risk factors for the development of PLG in a descending order of HDL-C > HBsAg > sex. CONCLUSION: In healthy people, the male gender, positive HBsAg, and low HDL-C confer higher risks of PLG development.

关键词： Polypoid Gallbladder Risk factors UItraso-nography Health examination

Gene and protein expressions of p28^(GANK)in rat with liver regeneration

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World Journal of Gastroenterology 2003年第11期9卷 2523-2527页

作者： jian-min qin Xiao-Yong Fu Shen-Jing Li Shu-qin Liu Jin-Zhang Zeng Xiu-Hua Qiu Meng-Chao Wu Hong-Yang Wang, International Co-operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai, 200438, China International Co-operation Laboratory on Signal Transduction Eastern Hepatobiliary Surgery Institute Second Military Medical University Shanghai 200438 China.

AIM: To observe the gene and protein expression changes of p28GANK in regenerating liver tissues, and to reveal the biological function of p28GANK on the regulation of liver ***: One hundred and thirty two adult male Sprague-Dawley rats were selected, weighing 200-250 g,and divided randomly into sham operation (SO) group and partial hepatectomy (PH) group. Each group had eleven time points: 0, 2, 6, 12, 24, 30, 48, 72, 120, 168 and 240 h,six rats were in each time point. The rats were undergone 70 % PH under methoxyflurane anesthesia by resection of the anterior and left lateral lobes of the liver. SO was conducted by laparotomy plus slight mobilization of the liver without resection. Liver specimens were collected at the indicated time points after PH or SO. The expression level of p28GANK mRNA was determined by Northern blot as well as at protein level via immunohistochemical *** expressions of p28GANK mRNA in these tissues were analyzed by imaging analysis system of FLA-2000 FUJIFILM and one way analysis of variance. The protein expressions of p28GANK in these tissues were analyzed with Fromowitz'method and Rank sum ***: The expression of p28GANK mRNA in bhe regenerating liver tissues possessed two transcripts, which were 1.5 kb and 1.0 kb. There was a significantly different expression patterns of p28GANK mRNA between SO and PH groups (P<0.01). The expression of p28GANK mRNA increased 2 h after PH, the peak time was 72 h (SO group: 163.83±1.4720; PH group: 510.5±17.0499, P<0.01). There was a significant difference in the 1.5 kb transcript, which decreased gradually after 72 hours. The protein expression of p28GANK was mainly in the cytoplasm of regenerating hepatocytes, and increased near the central region 24 h after PH, and became strongly positive at 48 h (+++, vs the other time points P<0.05),but decreased 72 h after ***: The expression of p28GANK mRNA increases in the early stage of rat liver regeneration, the pr

关键词： p28GANK 肝组织重建基因表达动物实验细胞增殖作用机制

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肝细胞癌切除术后复发的原因与防治策略

世界华人消化杂志 2019年第23期27卷 1407-1418页

作者：秦建民海军军医大学第三附属医院普外科

肝细胞癌(hepatocellular carcinoma,HCC)是临床上常见的恶性肿瘤之一,HCC切除术后3年复发率约为50%,5年复发率超过70%,居高不下的高复发率严重影响HCC患者手术疗效和长期生存,是导致HCC患者术后死亡的首要原因.HCC术后复发是一个多步... 详细信息

肝细胞癌(hepatocellular carcinoma,HCC)是临床上常见的恶性肿瘤之一,HCC切除术后3年复发率约为50%,5年复发率超过70%,居高不下的高复发率严重影响HCC患者手术疗效和长期生存,是导致HCC患者术后死亡的首要原因.HCC术后复发是一个多步骤、多环节、多因素和多分子参与的复杂过程,涉及机体、微环境和肿瘤组织三个方面因素,包括机体免疫力、局部pH值、间质压力、血管渗透压、炎性反应、肿瘤细胞黏附、细胞外基质降解、细胞迁移、细胞增殖和肿瘤血管形成等,与多个基因表达异常和相关分子功能改变密切相关,但HCC术后复发的分子机制仍未完全阐明,需要更深入的研究.HCC术后复发如何治疗直接影响HCC患者预后,涉及再次手术、肝移植、局部微创治疗、放疗、分子靶向药物、免疫和中医药治疗,单一治疗方法难以达到治愈或控制肿瘤进展,需要两种或两种以上治疗方法有机地联合,达到协同增效的治疗效果.针对患者的具体情况,分析其个体特性,结合临床医生的临床经验和最佳证据,采取个体化的治疗方案,选择合适的治疗方法是提高疗效的关键.对于存在高危复发因素的HCC患者,术后选择适当的治疗方法预防HCC复发,是降低HCC术后复发率,延长患者生存期的重要措施,才能使术后HCC患者最大程度获益.

关键词：肝细胞癌复发原因治疗预防

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原发性肝癌转化治疗指征与选择策略

世界华人消化杂志 2021年第10期29卷 501-510页

作者：秦建民海军军医大学第三附属医院普外科上海市201805

原发性肝癌发病隐匿,早期无特异性症状,多数患者确诊时已属中晚期,符合根治性切除术的患者20%-40%.目前外科切除仍是原发性肝癌主要根治性治疗手段,但由于肝功能失代偿、肿瘤体积过大、剩余肝体积过小、肝内多发转移、癌栓侵及大血管或... 详细信息

原发性肝癌发病隐匿,早期无特异性症状,多数患者确诊时已属中晚期,符合根治性切除术的患者20%-40%.目前外科切除仍是原发性肝癌主要根治性治疗手段,但由于肝功能失代偿、肿瘤体积过大、剩余肝体积过小、肝内多发转移、癌栓侵及大血管或胆管、远处转移等因素限制手术切除或肝移植.近年来,随着原发性肝癌发生、发展机制研究的不断深入,外科技术和器械发展,以及新的分子靶向药物、免疫治疗药物的研制,使得一部分无法手术切除或肝移植的原发性肝癌患者经过转化治疗,改善肝功能、缩小肿瘤体积、使脉管癌栓缩小或消失、促进剩余肝脏体积代偿性增大,最终得以手术切除或肝移植,极大提高了原发性肝癌治疗效果和患者生存期.

关键词：原发性肝癌转化治疗指征策略

胰十二指肠切除术后出血的原因与临床诊治策略

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世界华人消化杂志 2024年第7期32卷 457-467页

作者：秦建民海军军医大学第三附属医院普外科上海市201805

胰十二指肠切除术后出血是其严重并发症之一,发病急、病情重、处理困难、死亡率高,严重影响患者手术疗效和预后,引起术后出血的相关因素较多,涉及患者、手术和术后并发症处理,临床表现为消化道和腹腔出血,需要影像学(增强CT/MRI)和侵袭... 详细信息

胰十二指肠切除术后出血是其严重并发症之一,发病急、病情重、处理困难、死亡率高,严重影响患者手术疗效和预后,引起术后出血的相关因素较多,涉及患者、手术和术后并发症处理,临床表现为消化道和腹腔出血,需要影像学(增强CT/MRI)和侵袭性辅助检查(内镜、血管造影)明确原因,临床处理应根据出血时间、部位、严重程度及生命体征等综合判断,把握合理的治疗时机和选择合理的治疗措施(内镜、介入或手术),加强胰十二指肠切除术前、术中和术后与出血相关危险因素的恰当处理,做好术后出血风险预测和高危出血患者的防治措施,是降低胰十二指肠切除术后出血发生率的关键.

关键词：胰十二指肠切除术出血原因诊断治疗