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Development of a valid and reliable seven emotions impairment questionnaire and assessment of its predictability for phlegm and blood stasis

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Journal of Traditional Chinese Medicine 2016年第4期36卷 547-554页

作者： Byoung-hee Lee min-Yong Kim Young-Bae park Young-Jae park Department of Diagnosis and Biofunctional Medicine College of Korean MedicineKyung Hee University Seou102447 Korea Business School Kyung Hee UniversitySeou 102447 Korea Department of Diagnosis and Biofunctional Medicine College of Korean Medicine Kyung Hee University Seoul 02447 Korea Department of Diag-nosis and Biofunctional Medicine Kyung Hee UniversityHospital at Gangdong Seoul 05278 Korea.

OBJECTIVE:To develop and validate a Seven Emotions Impairment questionnaire(SEIQ),to define an optimum cut-off point for the SEIQ,and to examine whether SEI was predictive of Phlegm and Blood Stasis(BS).METHODS:Two hundred outpatients and 75 college students were asked to complete the SEIQ,the Profile of Mood States(POMS),Phlegm Pattern Questionnaire(PPQ),and BS Questionnaire(BSQ).Twelve clinicians determined whether the outpatients exhibited *** data were used to examine the internal consistency and determine validity for the ***,POMS,PPQ,and BSQ data were used to examine concurrent validity and predictability of SEI for Phlegm and BS in the college *** SEIQ scores and the clinicians' diagnoses of the outpatients were considered to define an optimum cut-off score for the ***:The 18-item SEIQ had satisfactory internal consistency(α = 0.905) and concurrent *** the construct validity test,four factors(chest-anxiety,fatigue-depression,working-family-troubles,and sleep-memory) were *** the receiver operator characteristic curve curve analysis,the sensitivity,specificity,and area under the curve of the SEIQ were 67.2%,72.1%,and 73%,*** optimum cut-off score was defined as nine *** scores were strongly predictive of Phlegm and BS(β = 0.862 and 0.673,respectively).CONCLUSION:Based on our results,we concluded that the SEIQ is a reliable and valid instrument for evaluating SEI,and is strongly predictive of Phlegm and BS.

关键词： Seven emotions Intermingled phlegm and blood-stasis Surveys and questionnaires Diagnosis Reference standards Mental health

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中老年群体的BMI、久坐行为、身体活动水平、年龄歧视和老龄化焦虑的关系研究

中老年群体的BMI、久坐行为、身体活动水平、年龄歧视和老龄化焦...

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第二届陕西省体育科学大会

作者：李静 Seung-Yong KIM Chae-hee park

随着人口老龄化现象以惊人的速度席卷全球,各国都在积极推动健康老龄化和积极老龄化,身体活动不足和久坐行为已严重影响到人们的健康,甚至与全因死亡率和跌倒风险有关。年龄歧视和老龄化焦虑是实现健康老龄化的主要阻碍因素之一,老年人... 详细信息

随着人口老龄化现象以惊人的速度席卷全球,各国都在积极推动健康老龄化和积极老龄化,身体活动不足和久坐行为已严重影响到人们的健康,甚至与全因死亡率和跌倒风险有关。年龄歧视和老龄化焦虑是实现健康老龄化的主要阻碍因素之一,老年人的身心健康问题直接影响到整个社会的健康,是我们面临的重大课题。研究目的:调查中老年群体的BMI、久坐行为、身体活动水平,年龄歧视和老龄化焦虑的现状及其相互间的关联性,为即将步入老年阶段的中老年群体提高晚年幸福感,构建积极健康的老年生活提供基础资料。研究方法:采取随机抽样的方法于2023年在中国S地区选取264名中老年人(男性87名,女性177名)为调查对象。根据性别、BMI(kg/m2)、婚姻状况、吸烟状况、受教育程度、主观健康状况等因素分层对中老年群体的身体活动水平、年龄歧视和老龄化焦虑程度进行问卷测量。身体活动水平分为高强度(VPA)、中强度(MPA)、低强度(LP A),每次至少持续10分钟才记录为有效。数据分析使用SPSS 22.0和AMOS 25.0统计软件进行因子分析、t检验、Pearson's r、方差分析(ANOVA)和路径分析。研究结果:结果表明,61.8%的中老年群体的BMI值高于正常数值范围;中老年群体的久坐行为、身体活动水平的调查结果显示,男性的久坐行为、VPA、MPA均高于女性的水平;中老年群体的BMI与VPA呈负相关关系(r=-.148, p=.016),BMI与MPA呈负相关关系(r=-.164, p=.008),久坐行为与LPA成负相关关系(r=-.135, p=.028);中老年群体的年龄歧视与老龄化焦虑呈正相关关系(r=.539,p=.000)。结论:VPA和MPA不同程度会影响中老年群体的BMI指数,适当增加身体活动量,减少久坐行为,能有效降低老年人的BMI指数。为改善老龄化社会结构中的老龄化焦虑,实现健康老龄化,不仅需要社会结构层面的努力,还需要减少社会群体中的年龄歧视,提高个体对健康老龄化的再认识,促使中老年人为今后步入健康老年生活做好充分准备。

关键词： BMI 久坐行为身体活动年龄歧视老化焦虑

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Optimization of thermoelectric properties of n-type Bi_2(Te,Se)_3 with optimizing ball milling time

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Rare Metals 2018年第4期37卷 351-359页

作者： Ji-hee Son min-Wook Oh Bong-Seo Kim Su-Dong park Thermoelectric Conversion Research Center Korea Electrotechnology Research Institute Department of Materials Science and Engineering Hanbat National University

The thermoelectric properties at elevated temperature were investigated for n-type Bi2（Te,Se）3 which is obtained from ball milling processed powder with various milling times. Electrical properties such as electrical resistivity and Seebeck coefficient are clearly dependent on milling time, in which the carrier concentration is attributed to the change of the electrical properties. The concentrations of the defects are also varied with the ball milling time, which is the origin of the carrier concentration variation. Even though finer grain sizes are obtained after the long ball milling time, the temperature dependence of the thermal conductivity is not solely understood with the grain size, whereas the electrical contribution to the thermal conductivity should be also considered. The highest figure of merit value of ZT = 0.83 is achieved at 373 K for the optimized samples, in which ball milling time is 10 h. The obtained ZT value is 48% improvement over that of the 0.5-h sample at 373 K.

关键词： Thermoelectric properties Ball milling Bi2Te3 Seebeck coefficient Grain size Thermalconductivity

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Bidirectional rotating direct-current triboelectric nanogenerator with self-adaptive mechanical switching for harvesting reciprocating motion

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International Journal of Extreme Manufacturing 2024年第4期6卷 324-335页

作者： Donghan Lee Joonmin Chae Sumin Cho Jong Woo Kim Awais Ahmad Mohammad Rezaul Karim Moonwoo La Sung Jea park Dongwhi Choi Department of Mechanical Engineering(Integrated Engineering Program) Kyung Hee University1732 Deogyeong-daeroYonginGyeonggi 17104Republic of Korea Department of Chemistry University of LahoreLahorePakistan Department of Mechanical Engineering College of EngineeringKing Saud UniversityRiyadh 11421Saudi Arabia School of Mechanical Engineering Korea University of Technology and Education1600 Chungjeol-roCheonanChungnam 31253Republic of Korea

Amid the growing interest in triboelectric nanogenerators(TENGs)as novel energy-harvesting devices,several studies have focused on direct current(DC)TENGs to generate a stable DC output for operating electronic ***,owing to the working mechanisms of conventional DC TENGs,generating a stable DC output from reciprocating motion remains a ***,we propose a bidirectional rotating DC TENG(BiR-TENG),which can generate DC outputs,regardless of the direction of rotation,from reciprocating *** distinct design of the BiR-TENG enables the mechanical rectification of the alternating current output into a rotational-direction-dependent DC ***,it allows the conversion of the rotational-direction-dependent DC output into a unidirectional DC output by adapting the configurations depending on the rotational *** to these tailored design strategies and subsequent optimizations,the BiR-TENG could generate an effective unidirectional DC *** of the BiR-TENG for the reciprocating motions of swinging doors and waves were demonstrated by harnessing this *** study demonstrates the potential of the BiR-TENG design strategy as an effective and versatile solution for energy harvesting from reciprocating motions,highlighting the suitability of DC outputs as an energy source for electronic devices.

关键词： direct-current triboelectric nanogenerator mechanical rectification self-adaptive mechanical design harvesting reciprocation motion

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Rationally designed bioactive milk-derived protein scaffolds enhanced new bone formation

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Bioactive Materials 2023年第2期20卷 368-380页

作者： min Suk Lee Jin Jeon Sihyeon park Juhan Lim hee Seok Yang Department of Nanobiomedical Science&BK21 FOUR NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonan31116Republic of Korea Medical Laser Research Center College of MedicineDankook UniversityCheonan31116Republic of Korea Center for Bio-Medical Engineering Core-Facility Dankook UniversityCheonan31116Republic of Korea

Recently,a number of studies reported that casein was composed of various multifunctional bioactive peptides such as casein phosphopeptide andβ-casochemotide-1 that bind calcium ions and induce macrophage chemotaxis,which is crucial for bone homeostasis and bone fracture repair by cytokines secreted in the *** hypothesized that the effects of the multifunctional biopeptides in casein would contribute to improving bone ***,we designed a tissue engineering platform that consisted of casein and polyvinyl alcohol,which was a physical-crosslinked scaffold(milk-derived protein;MDP),via simple freeze-thaw cycles and performed surface modification using 3,4-dihydroxy-L-phenylalanine(DOPA),a mussel adhesive protein,for immobilizing adhesive proteins and cytokines for recruiting cells in vivo(MDP-DOPA).Both the MDP and MDP-DOPA groups proved indirectly contribution of macrophages migration as RAW 264.7 cells were highly migrated toward materials by contained bioactive *** implanted MDP and MDP-DOPA in a mouse calvarial defect orthotopic model and evaluated whether MDP-DOPA showed much faster mineral deposition and higher bone density than that of the no-treatment and MDP *** MDP-DOPA group showed the accumulation of host M2 macrophages and mesenchymal stem cells(MSCs)around the scaffold,whereas MDP presented mostly M1 macrophages in the early stage.

关键词： Casein Bioactive peptides Bone regeneration Protein based scaffold Physical crosslinking

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Symptom Experience and Quality of Life in Colorectal Cancer Patients Undergoing Chemotherapy-A Secondary Publication

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Proceedings of Anticancer Research 2024年第1期8卷 117-128页

作者： Ayoung Lee Jin-hee park College of Nursing Ajou UniversitySuwonSouth Korea College of Nursing Research Institute of Nursing ScienceAjou UniversitySuwonSouth Korea

Objective:To evaluate symptom experience and quality of life(QoL)and to identify the predictors of QoL among colorectal cancer patients undergoing ***:A cross-sectional study was conducted on 107 colorectal cancer patients at a university-affiliated hospital between June 1 and July 30,*** Assessment of Cancer Therapy-Colorectal(FACT-C)and Memorial Symptom Assessment Scale-Short Form(MSAS-SF)were used to assess symptom experience and QoL of these *** were analyzed using Pearson’s correlation,t-test,ANOVA,and hierarchical multiple ***:The mean QoL score for colorectal cancer patients was 88.78±*** most frequently experienced physical and psychological symptoms were numbness/tingling and *** and psychological symptoms have a significant negative association with *** economic status was significantly associated with QoL in patients’general *** regression analyses showed that high psychological symptoms(β=-0.63,P<0.001),middle perceived economic status(β=-0.22,P=0.009),and low perceived economic status(β=-0.36,P<0.001)were statistically significant in predicting patients’low ***:Symptom experience and QoL are essential variables that should be acknowledged when delivering health care to colorectal cancer *** attention to the reduction and comprehensive symptom management of psychological distress could improve QoL among colorectal cancer patients.

关键词： Chemotherapy Colorectal neoplasms Quality of life Symptoms

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Highly efficient gene silencing and bioimaging based on fluorescent carbon dots in vitro and in vivo

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Nano Research 2017年第2期10卷 503-519页

作者： Seongchan Kim Yuri Choi Ginam park Cheolhee Won Young-Joon park Younghoon Lee Byeong-Su Kim DaI-hee min Center for RNA Research Institute for Basic Sciences (IBS) Department of Chemistry Seoul National University Seou108826 Republic of Korea Department of Energy Engineering and Department of Chemistry Ulsan National Institute of Science and Technology (UNIST) Ulsan 44919 Republic of Korea Institute of Nanobio Convergence Technology Lemonex Inc. Seou108826 Republic of Korea College of Pharmacy Ajou University Worldcuplo 206 Yeongtong-gu Suwon 16499 Republic of Korea Department of Chemistry Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea

Small interfering RNA （siRNA） is an attractive therapeutic candidate for sequence- specific gene silencing to treat incurable diseases using small molecule drugs. However, its efficient intracellular delivery has remained a challenge. Here, we have developed a highly biocompatible fluorescent carbon dot （CD）, and demonstrate a functional siRNA delivery system that induces efficient gene knockdown in vitro and in vivo. We found that CD nanoparticles （NPs） enhance the cellular uptake of siRNA, via endocytosis in tumor cells, with low cytotoxicity and unexpected immune responses. Real-time study of fluorescence imaging in live cells shows that CD NPs favorably localize in cytoplasm and successfully release siRNA within 12 h. Moreover, we demonstrate that CD NP-mediated siRNA delivery significantly silences green fluorescence protein （GFP） expression and inhibits tumor growth in a breast cancer cell xenograft mouse model of tumor-specific therapy. We have developed a multifunctional siRNA delivery vehicle enabling simultaneous bioimaging and efficient downregulation of gene expression, that shows excellent potential for gene therapy.

关键词： bioimaging carbon dot gene delivery RNA interference targeted cancer therapy

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An effective method to generate controllable levels of ROS for the enhancement of HUVEC proliferation using a chlorin e6-immobilized PET film as a photo-functional biomaterial

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Regenerative Biomaterials 2021年第2期8卷 94-103页

作者： Seung hee Hong min-Ah Koo Mi hee Lee Gyeung Mi Seon Ye Jin park HaKyeong Jeong Dohyun Kim Jong-Chul park Cellbiocontrol Laboratory Department of Medical Engineering Department of Medical Engineering Graduate School of Medical ScienceBrain Korea 21 Project Department of Medical Device Engineering and Management Yonsei UniversityCollege of MedicineSeoul 03722Republic of Korea

Reactive oxygen species(ROS)are byproducts of cellular metabolism;they play a significant role as secondary messengers in cell *** cells,high concentrations of ROS induce apoptosis,senescence,and contact inhibition,while low concentrations of ROS result in angiogenesis,proliferation,and cytoskeleton ***,controlling ROS generation is an important factor in cell *** designed a chlorin e6(Ce6)-immobilized polyethylene terephthalate(PET)film(Ce6-PET)to produce extracellular ROS under red-light *** application of Ce6-PET films can regulate the generation of ROS by altering the intensity of light-emitting diode *** confirmed that the Ce6-PET film could effectively promote cell growth under irradiation at 500 μW/cm^(2) for 30 min in human umbilical vein endothelial *** also found that the Ce6-PET film is more efficient in generating ROS than a Ce6-incorporated polyurethane film under the same ***6-PET fabrication shows promise for improving the localized delivery of extracellular ROS and regulating ROS formation through the optimization of irradiation intensity.

关键词： reactive oxygen species chlorin e6 dopamine covalent bond HUVEC proliferation

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Prenatal and postnatal factors associated with sudden infant death syndrome:an umbrella review of meta-analyses

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World Journal of Pediatrics 2024年第5期20卷 451-460页

作者： Tae Hyeon Kim Hyeri Lee Selin Woo Hayeon Lee Jaeyu park Guillaume Fond Laurent Boyer Jong Woo Hahn Jiseung Kang Dong Keon Yon Department of Medicine Kyung Hee University College of MedicineSeoulSouth Korea Center for Digital Health Medical Science Research InstituteKyung Hee University College of MedicineSeoulSouth Korea Department of Regulatory Science Kyung Hee UniversitySeoulSouth Korea Department of Biomedical Engineering Kyung Hee UniversityYonginSouth Korea CEReSS-Health Service Research and Quality of Life Center Assistance Publique des Hôpitaux de MarseilleAix-Marseille UniversityMarseilleFrance Department of Pediatrics Seoul National University College of MedicineSeoulSouth Korea Department of Pediatrics Seoul National University Bundang HospitalSeongnamSouth Korea Department of Anesthesia Critical Care and Pain MedicineMassachusetts General Hospital14913th StreetRoom 4140CharlestownBostonMAUSA Division of Sleep Medicine Harvard Medical SchoolBostonMAUSA Department of Pediatrics Kyung Hee University Medical CenterKyung Hee University College of Medicine23 Kyungheedae-roDongdaemun-guSeoul02447South Korea Department of Precision Medicine Kyung Hee University College of MedicineSeoulSouth Korea

Background Comprehensive quantitative evidence on the risk and protective factors for sudden infant death syndrome(SIDS)effects is *** investigated the risk and protective factors related to *** We conducted an umbrella review of meta-analyses of observational and interventional studies assessing SIDS-related ***/MEDLINE,Embase,EBSCO,and Google Scholar were searched from inception until January 18,*** extraction,quality assessment,and certainty of evidence were assessed by using A Measurement Tool Assessment Systematic Reviews 2 following PRISMA *** to observational evidence,credibility was graded and classified by class and quality of evidence(CE;convincing,highly suggestive,suggestive,weak,or not significant).Our study protocol was registered with PROSPERO(CRD42023458696).The risk and protective factors related to SIDS are presented as equivalent odds ratios(eORs).Results We identified eight original meta-analyses,including 152 original articles,covering 12 unique risk and protective factors for SIDS across 21 countries/regions and five *** risk factors,including prenatal drug exposure[eOR=7.84(95%CI=4.81–12.79),CE=highly suggestive],prenatal opioid exposure[9.55(95%CI=4.87–18.72),CE=suggestive],prenatal methadone exposure[9.52(95%CI=3.34–27.10),CE=weak],prenatal cocaine exposure[4.38(95%CI=1.95–9.86),CE=weak],prenatal maternal smoking[2.25(95%CI=1.95–2.60),CE=highly suggestive],postnatal maternal smoking[1.97(95%CI=1.75–2.22),CE=weak],bed sharing[2.89(95%CI=1.81–4.60),CE=weak],and infants found with heads covered by bedclothes after last sleep[11.01(95%CI=5.40–22.45),CE=suggestive],were *** the other hand,three protective factors,namely,breastfeeding[0.57(95%CI=0.39–0.83),CE=non-significant],supine sleeping position[0.48(95%CI=0.37–0.63),CE=suggestive],and pacifier use[0.44(95%CI=0.30–0.65),CE=weak],were also *** Based on the evidence,we propose several risk and protecti

关键词： Infant Protective factor Risk factor Sudden infant death syndrome Umbrella review

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Inverse Problem of Flame Surface Properties of Wood using a Repulsive Particle Swarm Optimization Algorithm

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Journal of Thermal Science 2015年第2期24卷 173-178页

作者： Kyung-Beom Yoon Won-hee park Korea Conformity Laboratories 199Gasan-digital 1-roGeumcheon-guSeoul 153-803Korea Korea Railroad Research Institute 176 Cheoldobangmulgwan-roUiwang-siGyeonggi-do 437-757Korea Korea University of Science and Technology (UST) 217 Gajeong-roYuseong-guDaejeon 305-350 Korea

The convective heat transfer coefficient and surface emissivity before and after flame occurrence on a wood specimen surface and the flame heat flux were estimated using the repulsive particle swarm optimization algorithm and cone heater test results. The cone heater specified in the ISO 5660 standards was used, and six cone heater heat fluxes were tested. Preservative-treated Douglas fir 21 mm in thickness was used as the wood specimen in the tests. This study confirmed that the surface temperature of the specimen, which was calculated using the convective heat transfer coefficient, surface emissivity and flame heat flux on the wood specimen by a repulsive particle swarm optimization algorithm, was consistent with the measured temperature. Considering the measurement errors in the surface temperature of the specimen, the applicability of the optimization method considered in this study was evaluated.

关键词： Repulsive particle swarm optimization Cone calorimeter Flame heat flux Flame surface properties

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