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Portable Analyzer for Rapid Analysis of Total Protein, Fat and Lactose Contents in Raw Milk Measured by Non-dispersive Short-wave Near-infrared Spectrometry

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Chemical Research in Chinese Universities 2013年第1期29卷 15-19页

作者： FENG Xu-dong SU Rui XU Nan WANG Xing-hua YU Ai-min ZhanG han-qi CAO Yan-bo College of Chemistry Jilin University Changchun 130012 P. R. China

A novel portable analyzer for raw milk quality control during the material purchase at dairy plants was developed, by which the percentages（mass fraction） of main components including total protein, fat, and lactose of an unhomogenized milk sample could be determinated in 1 min with the help of non-dispersive short-wave near-infrared （NDSWNIR） spectrometry in a wavelength range from 600 nm to 1100 nm and multivariate calibration. The analyzer was designed with a single-beam optical system, which comprised a temperature control module, a multi-channel narrow-band light source（16 wavelengths）, a glass absorption cell with 15 mm sample thickness, a silicon photodiode detector, several compound lenses and a recorder module. A total of 80 raw milk samples were collected at a dairy farm twice a month for 4 months. The samples were scanned with a common UV-Vis-NIR spectrometer and analyzed according to China GB standard methods. The uninformative variables elimination（UVE） method was carried out on the spectrum data and the percentages of main components of all the samples to choose the peak emitting wavelength of each channel of the light source. Another 90 raw milk samples were collected from the same dairy farm thrice a month for 3 months. The samples were analyzed according to China GB standard methods and with the proposed analyzer. The percentages of the main components and the NDSWNIR absorption data of the samples were used for the construction and validation of the multivariate calibration model with partial least squares（PLS） method. The root-mean-square errors of prediction（RMSEP） of total protein, fat and lactose were 0.201, 0.172 and 0.247 and the coefficients of correlation（R） were 0.932, 0.981 and 0.933, respectively.

关键词： Portable analyzer Raw milk Non-dispersive short-wave near-infrared(NDSWNIR) spectrometry Multiva-riate calibration

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Redundant prepuce increases the odds of chronic prostatitis/chronic pelvic pain syndrome （CP/CPPS）

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Asian Journal of Andrology 2014年第5期16卷 774-777,I0011页

作者： Yu-Yang Zhao Dong-Liang Xu Fu-Jun Zhao Bang-min han Yi Shao Wei Zhao Shu-Jie Xia Department of Urology Shanghai First People's Hospital Institute of Urology Shanghai Jiao Tong University Shanghai China

Some published evidence has revealed that the dendritic cells can interact with pathogens that exist in the inner foreskin. This information provides a new vision that pathogens could play a role through the redundant prepuce; numerous studies have failed to find pathogens in prostates of patients who had chronic prostatitis/chronic pelvic pain syndrome （CP/CPPS）. However, no studies have reported an association between foreskin length and CP/CPPS. Hence, we conducted a retrospective case-control study of clinical data from 322 CP/CPPS patients （case group） and 341 nonCP/CPPS patients （control group）. Demographic characteristics, lifestyle factors, and foreskin lengths were collected and analyzed. Multivariate logistic regression was adopted to calculate the odds of foreskin length for CP/CPPS. According to the multivariate logistic regression results, when the foreskin length covered up more than half of the glans penis, the odds for CP/CPPS were higher with an increased foreskin （odds ratio （OR）： 1.66, 95% confidence interval （CI）： 1.04-2.66）. In comparison, when the glans penis was completely covered by the foreskin, the OR value increased to 1.86 （95% CI, 1.2-2.88）. The study results showed an association between foreskin length and the odds of CP/CPPS. When the foreskin length covered up more than half of the glans penis, there were greater odds for CP/CPPS. This possible mechanism might result from interaction between pathogens and DCs in the inner foreskin, consequently activating T-cells to mediate allergic inflammation in the prostate and producing the autoimmunizations causing CP/CPPS.

关键词： case control study chronic pelvic pain syndrome chronic prostatitis, prepuce

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一种参数摄动的混沌异结构同步方法

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物理学报 2008年第11期57卷 6824-6829页

作者：韩敏牛志强韩冰大连理工大学电子与信息工程学院大连116023

研究了参数摄动情形下的混沌异结构同步问题,基于Lyapunov稳定性定理并结合范数理论给出了系统参数摄动下实现混沌异结构同步的一个充分条件,为同步控制器的设计提供了一般方法.只要两混沌系统维数相等,状态变量可测,就可利用所提方法... 详细信息

研究了参数摄动情形下的混沌异结构同步问题,基于Lyapunov稳定性定理并结合范数理论给出了系统参数摄动下实现混沌异结构同步的一个充分条件,为同步控制器的设计提供了一般方法.只要两混沌系统维数相等,状态变量可测,就可利用所提方法实现系统参数摄动下的异结构同步,并能够保证在同步实现后同步控制量伴随误差变量一同收敛至零.该方法鲁棒性强,适用范围广,通过对混沌系统、超混沌系统的同步仿真,证实了该方法的有效性.

关键词：混沌超混沌同步 Lyapunov函数

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Decomposition of pre-existing Au-P clusters induced in situ a-Fe grains uniformization in Fe-P-based nanocrystalline alloys

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Rare Metals 2024年第10期43卷 5242-5255页

作者： min-Hao han Cheng Sun Guo-Guo Xi Yang Meng Qiang Luo Xue-Qian Yu Wen-Feng Zhang Hao Liu Hong-Jie Xu Tao Zhang Key Laboratory of Aerospace Materials and Performance(ministry of Education) School of Materials Science and EngineeringBeihang UniversityBeijing 100191China Laboratory of Functional Fiber Materials Institute of Bast Fiber CropsChinese Academy of Agricultural ScienceChangsha 410205China School of Materials Science and Engineering Jiangsu Key Laboratory for Advanced Metallic MaterialsSoutheast UniversityNanjing 211189China Institute for Advanced Materials North China Electric Power UniversityBeijing 102206China Center for Advanced Analysis and Computational Science Zhengzhou UniversityZhengzhou 450001China

In Fe-based amorphous-/nanocrystalline ribbons,the uniformization and refinement of a-Fe grains are key aspects for optimizing their soft magnetic and mechanical ***,the Fe-P-C-B nanocrystalline alloy system was selected for *** produced as-spun ribbons with pre-existing nanocrystals through melt-quenching and then obtained a well-distributed a-Fe nanocrystalline structure through annealing below the first crystallization onset temperature(633 K)resulting in excellent magnetic properties(saturation magnetization of 1.65 T and coercivity of 1.6 A·m^(-1))ultra-wide annealing temperature window(from 613 to 733 K),and extremely high annealing stability(up to 480 min at 633 K).Furthermore,we propose a new in situ two-step mechanism for the uniformization of a-Fe nanocrystals,which is separately induced by the decomposition of the Au-P clusters and the pre-existing a-Fe nanocrystals during *** work underscores the crucial significance of micro-alloying via metastable clusters primarily influenced by metal-phosphide interactions in the process of refining a-Fe ***,i introduces a new principle for optimizing the comprehensive properties of Fe-based amorphous/nanocrystalline alloys.

关键词： Fe-based nanocrystalline alloys Soft magnetic property In-situ nano-crystallization Microalloying

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Membrane fusion reverse micelle platforms as potential oral nanocarriers for efficient internalization of free hydrophilic peptides

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Nano Research 2023年第7期16卷 9768-9780页

作者： Mengting Lin Linjie Wu Yiying Lu Xiaoyan Bao Haiqing Zhong Qi Dai Qiyao Yang Yiyi Xia Xin Tan Yaxin Qin Ruolin Jiang min han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Pharmacy Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China The Second Affiliated Hospital College of MedicineZhejiang UniversityHangzhou 310058China

Orally administered peptides or proteins are garnering increasing preference owing to their superiority in terms of patient compliance and ***,the development of oral protein formulations has stalled due to the low bioavailability of macromolecules that encounter the aggressive gastrointestinal environment and harsh mucus villi ***,we propose an ideal reverse micelle/self-emulsifying drug delivery system(RM/SEDDS)nanoplatform that is capable of improving the oral bioavailability of hydrophilic peptides by preventing enzymatic degradation and enhancing mucosal *** the passage through the mucus,the self-emulsifying drug delivery system with optimal surface properties effectively penetrates the viscoelastic mucosal barrier,followed by the exposure of the inner reverse micelle amphipathic vectors,which autonomously form continua with the lipidic cell membrane and facilitate the internalization of *** membrane-fusion mechanism inaugurates a new way for hydrophilic peptide delivery in the free form,circumventing the traditional impediments of the cellular internalization of nanocarriers and subsequent poor release of *** more importantly,reverse micelles are not spatially specific to the laden drugs,which enables their delivery for a myriad of peptide clinical *** conclusion,as an exquisitely designed nanoplatform,RM/SEDDS overcomes multiple physiological barriers and opens a new path for drug cellular entry,providing new prospects for the development of oral drug delivery systems.

关键词： oral drug delivery system reverse micelle self-emulsifying drug delivery system membrane fusion hydrophilic peptide

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Establishment of reference mandibular plane for anterior alveolar morphology evaluation using cone beam computed tomography

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第11期13卷 942-947页

作者： Rong-yang WANG min han Hong LIU Chun-ling WANG Hong-hong XIAN Lei ZhanG Shi-jie ZhanG Dong-xu LIU Department of Orthodontics Shandong Provincial Key Laboratory of Oral Biomedicine Shandong University Jinan 250012 China Department of Stomatology Qianfoshan Hospital of Shandong Province Jinan 250014 China Department of Stomatology the Second Hospital of Shandong Uni- versity Jinan 250033 China

To propose a method of establishing the reference mandibular plane (MP), which could be reestablished according to the coordinates of the reference points, and then facilitate the assessment of anterior alveolar morphology using cone beam computed tomography (CBCT), sixty patients with bimaxillary protrusion were randomly selected and CBCT scans were taken. The CBCT scans were transferred to Materialism's interactive medical image control system 10.01 (MIMICS 10.01), and three dimensional models of the entire jaws were constructed. Reference points determining the reference MP were positioned in the coronal, axial, sagittal windows, and the points were exactly located by recording their coordinates in the interfaces of software. The reference MP provided high intra-observer reliability(Pearson's r 0.992 to 0.999), and inter-observer reliability (intra-class correlation coefficients (ICCs) 0.996 to 0.999).

关键词： Reference Plane Cone beam computed tomography Alveolar morphology

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基于单向耦合法的不确定复杂网络间有限时间同步

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自动化学报 2021年第7期47卷 1624-1632页

作者：张檬韩敏沈阳航空航天大学人工智能学院沈阳110135 大连理工大学电子信息与电气工程学部大连116023

针对具有不确定性的复杂网络有限时间同步问题,提出一种新颖的单向耦合控制方法.构建含有未知参量及未知拓扑结构的驱动-响应复杂网络模型,考虑两个网络具有不同的节点数,同时受到时变耦合时滞的影响,并且网络内部分别具有不同的节点系... 详细信息

针对具有不确定性的复杂网络有限时间同步问题,提出一种新颖的单向耦合控制方法.构建含有未知参量及未知拓扑结构的驱动-响应复杂网络模型,考虑两个网络具有不同的节点数,同时受到时变耦合时滞的影响,并且网络内部分别具有不同的节点系统.基于有限时间稳定性理论和线性矩阵不等式变换,通过在响应网络中引入单向耦合项,实现两个网络间的有限时间同步,同时准确辨识未知参量及未知拓扑结构.仿真实验验证所提同步方法的有效性,对比实验结果表明所提方法在减少耦合数量的同时具有更快的同步速率及更小的波动范围.

关键词：复杂网络有限时间同步单向耦合未知参量

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Microarray analysis of New Green Cocoon associated genes in silkworm, Bombyx mori

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Insect Science 2016年第3期23卷 386-395页

作者： Ya-Ru Lu Song-Zhen He Xiao-Ling Tong min-Jin han Chun-Lin Li Zhi-Quan Li Fang-Yin Dai State Key Laboratory of Silkworm Genome Biology College of Biotechnology Southwest University Chongqing China KeyLaboratory for Sericulture Functional Genomics and Biotechnology of Agricultural ministry College of Biotechnology Southwest UniversityChongqing 400715 China

Green cocoons in silkworm, Bombyx mori, are caused by flavonoids accumulation in the silk proteins, fibroin and sericin. Despite the economic value of natural green cocoon and medical value of flavonoids, there is limited understanding of the molecular mechanism regulating flavonoids uptake in silkworm, which is tightly associated with the trait of green cocoon. The purpose of this study is to perform a comprehensive analysis to understand the molecular mechanisms of flavonoids uptake in silkworm based on microarray analyses. The study subject was the New Green Cocoon from the silkworm strains, G200 and N100, a new spontaneous dominant green cocoon trait identified in the 2000s. The genes regulating this trait are independent of other green cocoon genes previously reported. Genome-wide gene expression was compared between the New Green Cocoon producing silkworm strains, G200 and NI00, and the control sample, which is the white cocoon producing strain 872B. Among these strains, N100 and 872B are near-isogenic lines. The results showed that 130 genes have consistently changing expression patterns in the green cocoon strains when compared with the white cocoon strain. Among these, we focused on the genes related to flavonoids metabolism and absorption, such as sugar trans- porter genes and UDP-glucosyltransferase genes. Based on our findings, we propose the potential mechanisms for flavonoids absorption and metabolism in silkworm. Our results imply that silkworm might be used as an underlying model for flavonoids in pharmaceutical research.

关键词： flavonoids microarray New Green Cocoon silkworm

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基于核共轭梯度演化模糊系统的混沌时间序列在线预测

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控制与决策 2024年第9期39卷 3099-3107页

作者：胡磊韩敏大连理工大学电子信息与电气工程学部辽宁大连116024 大连理工大学教育部工业设备智能控制与优化重点实验室辽宁大连116024

为了增强演化模糊系统在混沌时间序列中的在线预测性能,提出一种基于核共轭梯度的演化模糊系统模型.该模型通过基于结构演化的前件部分,挖掘并捕获隐藏在时间序列中的模糊规则.同时,基于参数更新的后件部分有机结合稀疏学习策略和核共... 详细信息

为了增强演化模糊系统在混沌时间序列中的在线预测性能,提出一种基于核共轭梯度的演化模糊系统模型.该模型通过基于结构演化的前件部分,挖掘并捕获隐藏在时间序列中的模糊规则.同时,基于参数更新的后件部分有机结合稀疏学习策略和核共轭梯度算法,以降低计算复杂度和提高模型收敛性能.基于核共轭梯度的演化模糊系统不仅剔除了样本中的冗余信息,而且有效平衡了模型的预测精度和预测效率.实验结果表明,所提模型在标杆和真实混沌时间序列的在线预测任务中具有有效性.

关键词：混沌时间序列在线预测演化模糊系统模糊规则稀疏学习策略核共轭梯度

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基于直线特征约束网格变形的航拍图像拼接

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控制与决策 2022年第3期37卷 669-675页

作者：刘强韩敏大连理工大学电子信息与电气工程学部辽宁大连116023 大连理工大学教育部工业设备智能控制与优化重点实验室辽宁大连116023

针对常用航拍图像拼接算法在处理存在视差的复杂图像时会出现鬼影、失真、不自然的问题,在APAP(as-projective-as-possible)算法的基础上,添加全局相似性和直线结构保护约束,提出一种基于直线特征约束网格变形的航拍图像拼接方法.首先,... 详细信息

针对常用航拍图像拼接算法在处理存在视差的复杂图像时会出现鬼影、失真、不自然的问题,在APAP(as-projective-as-possible)算法的基础上,添加全局相似性和直线结构保护约束,提出一种基于直线特征约束网格变形的航拍图像拼接方法.首先,在图像重叠区域检测点、直线特征,并估计单应性扭曲;然后,使用网格将图像划分成多个局部图像块,建立网格优化模型,根据网格顶点坐标集定义一个包含图像扭曲不同特征的总能量函数,在APAP算法提供的局部单应性保证重叠区域对齐的前提下,对非重叠区域借鉴NISwGSP算法的全局相似性约束思想,并辅以直线结构约束提高拼接自然度;最后,在稀疏线性系统中求解能量误差最小化问题,得到最优网格顶点集,指导网格变形并完成航拍图像拼接.实验结果表明,所提出的变形方法能够减少重叠区域鬼影和非重叠区域失真问题,相比AutoStitch、APAP、AANAP、SPHP等经典算法拼接效果更自然,更能适应大视角的航拍图像拼接任务.

关键词：航拍图像拼接 APAP 畸形矫正网格优化全局相似性直线保护

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