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Ileal collision tumor associated with gastrointestinal bleeding: A case report and review of literature

World Journal of Gastrointestinal Surgery 2024年第2期16卷 628-634页

作者： Yu-Qi Wu Hong-Yan Wang Mu-min shao Lin Xu Xiao-Yan Jiang shao-Ju Guo Department of Gastroenterology Shenzhen Traditional Chinese Medicine HospitalThe Fourth Clinical Medical College of Guangzhou University of Chinese MedicineShenzhen 518033Guangdong ProvinceChina Department of Pathology Shenzhen Traditional Chinese Medicine HospitalThe Fourth Clinical Medical College of Guangzhou University of Chinese MedicineShenzhen 518033Guangdong ProvinceChina

BACKGROUND Collision tumors involving the small intestine,specifically the combination of a hamartomatous tumor and a lipoma,are extremely *** our knowledge,no previous case report has described a collision tumor composed of two benign tumors of different origins in the small *** SUMMARY Here,we present the case of an 82-year-old woman who presented with hemorrhagic shock and was found to have a mass measuring approximately 50 mm×32 mm×30 mm in the terminal *** on computed tomography scan findings,the mass was initially suspected to be a lipoma.A subsequent colonoscopy revealed a pedunculated submucosal elevation consisting of two distinct parts with a visible demarcation line.A biopsy of the upper portion suggested a juvenile polyp(JP).Owing to the patient’s advanced age,multiple comorbidities,and poor surgical tolerance,a modified endoscopic submucosal dissection was *** examination of the excised mucosal mass revealed a lipoma at the base and a JP at the top,demonstrating evidence of rupture and associated *** patient’s overall health remained satisfactory,with no recurrence of hematochezia during the six-month follow-up *** This case report provides new evidence for the understanding of gastrointestinal collision tumors,emphasizing their diverse clinical presentations and histopathological *** also offers diagnostic and therapeutic insights as well as an approach for managing benign collision tumors.

关键词： Collision tumor Gastrointestinal bleeding Hamartomatous tumor Lipoma Modified endoscopic submucosal dissection Case report

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Progress in mechanisms of acetylcholinesterase inhibitors and memantine for the treatment of Alzheimer’s disease

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Neuroimmunology and Neuroinflammation 2015年第1期2卷 274-280页

作者： shao-min Li ming-Shu Mo Ping-Yi Xu Center for Neurologic Disease Department of NeurologyBrigham and Women’s HospitalHarvard Medical SchoolBostonMassachusetts 02115USA Department of Neurology The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080GuangdongChina

Alzheimer’s disease(AD)is the most common causes of dementia in the ***,only two classes of drugs,acetylcholinesterase inhibitors(AChEIs)and memantine are *** ameliorate cognitive and psychiatric symptoms in AD patients through activation of acetylcholine(ACh)receptors by increased synaptic ACh levels and also have protective effects against glutamate neurotoxicity and inflammation,whereas memantine appears to mainly protect against excitotoxicity and ***,we review the pharmacologic properties of the available AChEIs and memantine,and focus on recent progress in the mechanisms of AD in relation to acetylcholinergic and glutamatergic involvement.

关键词： Alzheimer’s disease amyloid‑βpeptide donepezil memantine tau

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Direct identification of total and missing OH reactivities from light-duty gasoline vehicle exhaust in China based on LP-LIF measurement

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Journal of Environmental Sciences 2023年第11期133卷 107-117页

作者： Xuehui Liu Zibing Yuan Qing’e Sha Shengrong Lou Hongli Wang Xin Li Junyu Zheng Bin Yuan min shao School of Environment and Energy South China University of TechnologyGuangzhou 510006China Institute of Environmental and Climate Research Jinan UniversityGuangzhou 511443China State Environmental Protection Key Laboratory of the Cause and Prevention of Urban Air Pollution Complex Shanghai Academy of Environmental SciencesShanghai 200233China College of Environmental Science and Engineering Peking UniversityBeijing 100871China

Considerable efforts have been devoted to characterising the chemical components of vehicle ***,these components may not accurately reflect the contribution of vehicle exhaust to atmospheric reactivity because of the presence of species not accounted for(“missing species”)given the limitations of analytical *** this study,we improved the laser photolysis–laser-induced fluorescence(LP-LIF)technique and applied it to directly measure the total OH reactivity(TOR)in exhaust gas from light-duty gasoline vehicles in *** TOR for China Ⅰ to Ⅵ-a vehicles was 15.6,16.3,8.4,2.6,1.5,and 1.6×10^(4) sec^(-1),respectively,reflecting a notable drop as emission standards were *** TOR was comparable between cold and warm *** missing OH reactivity(MOR)values for China Ⅰ to Ⅳ vehicles were close to zero with a cold start but were much higher with a warm *** variations in oxygenated volatile organic compounds(OVOCs)under different emission standards and for the two start conditions were similar to those of the MOR,indicating that OVOCs and the missing species may have similar production *** measurement revealed that the duration of the stable driving stage was the primary factor leading to the production of OVOCs and missing *** findings underscore the importance of direct measurement of TOR from vehicle exhaust and highlight the necessity of adding OVOCs and other organic reactive gases in future upgrades of emission standards,such that the vehicular contribution to atmospheric reactivity can be more effectively controlled.

关键词： Total OH reactivity LP-LIF Missing OH reactivity Emission standard Light-duty gasoline vehicle

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The centrosymmetric to non-centrosymmetric transformation induced by alkaline-earth cations producing infrared nonlinear optical AeMn_(6)Ga_(6)S_(16)(Ae=Ca,Sr)

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Science China Chemistry 2024年第9期67卷 2941-2948页

作者： Yang-Ping Zhang shao-min Pei Wen-Fa Chen Bin-Wen Liu Xiao-ming Jiang Guo-Cong Guo State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China School of Physical Science and Technology Shanghai Tech UniversityShanghai 201210China

Non-centrosymmetric(NCS)structure is an indispensable prerequisite for second-order nonlinear optical(NLO)***,the mainstream approach for designing new NCS structures still relies on chemical substitution,necessitating an urgent infusion of fresh *** this work,two isomorphic sulfides AeMn_(6)Ga_(6)S_(16)(Ae=Ca,1;Sr,2)are afforded by modifying the skeleton of centrosymmetric(CS)Mn_(2)Ga_(2)S_(5) via introducing strong electropositive alkaline-earth ***,the incorporation of Ca^(2+)/Sr^(2+)cations allows the elementary[MnGaS_(9)]_(∞)chains to reconfigure into bumpy[MnS_(6)]-[GaS_(4)]layers in a new engagement manner,thus enabling the conversion from CS to NCS *** modifications cause not only strong second-harmonic generation(SHG)responses(~1.5×benchmark AgGaS_(2)@1,700 nm),but also significantly feasible bandgaps(2.60-2.64 e V)compared to the sulfide Mn_(2)Ga_(2)S_(5)(1.36 e V),which ultimately facilitate ultrahigh laser-induced damage thresholds(4.4-6.6×AgGaS_(2)@1,064 nm for compounds 1 and 2).The present study offers an ingenious approach for the transformation of CS to NCS structure.

关键词： second-harmonic generation non-centrosymmetrical structure NLO functional motif solid-state method

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Space view of the decadal variation for typical air pollutants in the Pearl River Delta （PRD） region in China

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Frontiers of Environmental Science & Engineering 2016年第5期10卷 129-142页

作者： Zifeng WANG min shao Liangfu CHEN minghui TAO Liuju ZHONG Duohong CHEN Meng FAN Yang WANG Xinhui WANG State Key Laboratory of Remote Sensing Science Jointly Sponsored by Institute of Remote Sensing and Digital Earth of Chinese Academy of Sciences and Beijing Normal University Beijing 100101 China College of Environmental Sciences and Engineering Peking University Beijing 100876 China Guangdong Environmental Monitoring Center Guangzhou 510308 China

The Pearl River Delta （PRD） is one of the most industrialized, urbanized and populated regions in China, and thus has been long suffering from severe air pollutions. Space data provide a unique perspective for investigating the atmospheric environment at a regional scale. By utilizing multiple satellite retrievals from 2005 to 2013, this study presented, for the first time, the spatial patterns and temporal trends of typical air pollutants over PRD and its vicinity. As viewed from space, aerosol optical depth （AOD）, NO2 and SO2 all had their higher values at the central part of PRD, and showed clear descending gradients as moving to the outskirt of this region. As to the inter-annual variation, all these pollutants had decreasing trends in PRD during the study period, which generally agreed with the relevant in situ measurements. However, the satellite retrievals differed from ground measurements when addressing NO2 and SO2 in the vicinity of PRD. This work also provides the inter-comparison among PRD and three other metropolitan clusters in China： PRD had relatively high AOD, moderate NO2 and low SO2 levels, and it was the only region achieving the effective reduction of NO2 and SO2 during last decade. Unlike the previous three pollutants, HCHO observed by satellite showed very special patterns： it had a relatively homogeneous spatial distribution over both of PRD and its vicinity, and presented an opposite increasing trend from 2005 to 2010. Moreover, PRD had the highest HCHO level among all the metropolitan clusters, hinting a considerable contribution of biogenic origins of HCHO in PRD.

关键词： The Pearl River Delta (PRD) Satellite monitoring Regional air quality Long-term trend HCHO

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Protective effect of oat bran extracts on human dermal fibroblast injury induced by hydrogen peroxide

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第2期14卷 97-105页

作者： Bing FENG Lai-ji MA Jin-jing YAO Yun FANG Yan-ai MEI shao-min WEI School of Chemical and Material Engineering Jiangnan University R&D Center Shanghai Jahwa United Co.Ltd. Department of Physiology and Biophysics School of Life SciencesFudan University

Oat contains different components that possess antioxidant properties; no study to date has addressed the antioxidant effect of the extract of oat bran on the cellular level. Therefore, the present study focuses on the investi- gation of the protective effect of oat bran extract by enzymatic hydrolysates on human dermal fibroblast injury induced by hydrogen peroxide （H2O2）. Kjeldahl determination, phenol-sulfuric acid method, and high-performance liquid chromatography （HPLC） analysis indicated that the enzymatic products of oat bran contain a protein amount of 71.93%, of which 97.43% are peptides with a molecular range from 438.56 to 1301.01 Da. Assays for 1,1-diphenyl-2-picrylhydrazyl （DPPH） radical scavenging activity indicate that oat peptide-dch extract has a direct and concentration-dependent antioxidant activity. 3-（4,5-Dimethylthiazol-2-yl）-2,5-diphenyl tetrazolium bromide （MTT） colorimetric assay and the TdT-mediated digoxigenin-dUTP nick-end labeling （TUNEL） assay for apoptosis showed that administration of H2O2 in human dermal fibroblasts caused cell damage and apoptosis. Pre-incubation of human dermal fibroblasts with the Oatp for 24 h markedly inhibited human dermal fibroblast injury induced by H2O2, but ap- plication oat peptides with H2O2 at same time did not. Pre-treatment of human dermal fibroblasts with Oatp significantly reversed the H2O2-induced decrease of superoxide dismutase （SOD） and the inhibition of malondialdehyde （MDA）. The results demonstrate that oat peptides possess antioxidant activity and are effective against H2O2-induced human dermal fibroblast injury by the enhanced activity of SOD and decrease in MDA level. Our results suggest that oat bran will have the potential to be further explored as an antioxidant functional food in the prevention of aging-related skin injury.

关键词： Oat bran Extraction Antioxidant Human dermal fibroblasts Cell injury

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Explicit diagnosis of the local ozone production rate and the ozone-NOx-VOC sensitivities

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Science Bulletin 2018年第16期63卷 1067-1076页

作者： Zhaofeng Tan Keding Lu Huabin Dong min Hu Xin Li Yuhan Liu Sihua Lu min shao Rong Su Haichao Wang Yusheng Wu Andreas Wahner Yuanhang Zhang State Key Joint Laboratory of Environmental Simulation and Pollution Control College of Environmental Sciences and Engineering Peking University. Beijing 100871 China Institute of Energy and Climate Research IEK-8: Troposphere Forschungszentrum julich GmbH Julich 52428 Germany Beijing Innovation Center for Engineering Sciences and Advanced Technology Peking University Beijing 100871 China

In the troposphere, ozone is a harmful gas compound to both human health and vegetation. Ozone is produced from the reaction of NO_x(@NO + NO_2) and VOCs(volatile organic compounds) with light. Due to the highly nonlinear relationships between ozone and its precursors, proper ozone mitigation relies on the knowledge of chemical mechanisms. In this study, an observation-based method is used to simulate ozone formation and elucidate its controlling factors for a rural site on the North China Plain. The instantaneous ozone production rate is calculated utilizing a box model using the dataset obtained from the Wangdu campaign. First, the model was operated in a time-dependent mode to calculate the ozone production rate at each time stamp. The calculated ozone formation rate showed a diurnal average maximum value of 17 ppbv/h(1-h diurnal averaged). The contribution of individual peroxy radicals to ozone production was analyzed. In addition, the functional dependence of calculated P(O_3) reveals that ozone production was in a NO_x-limited regime during the campaign. Furthermore, the missing peroxy radical source will further extend NO_x-limited conditions to earlier in the day, making NO_xlimitation dominate more of a day than the current chemical model predicts. Finally, a multiple scenarios mode,also known as EKMA(empirical kinetic modeling approach), was used to simulate the response of P(O_3) to the imaginary change in precursor concentrations. We found that ozone production was in the NO_x-limited region. However, the use of NO_2 measured by the molybdenum converter and/or the absence of a peroxy radical source in the current chemical model could over-emphasize the VOC-limited effect on ozone production.

关键词： Observational-based model Instantaneous ozone production rate (empirical kinetic modeling approach) EKMA

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Long-term organic and inorganic fertilizations enhanced basic soil productivity in a fluvo-aquic soil

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Journal of Integrative Agriculture 2015年第12期14卷 2477-2489页

作者： ZHA Yan WU Xue-ping GONG Fu-fei XU ming-gang ZHANG Hui-min CHEN Li-ming HUANG shao-min CAI Dian-xiong National Engineering Laboratory for Improving Quality of Arable Land Institute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural Sciences School of Environment and Natural Resources The Ohio State UniversityOhio Agricultural Research and Development Center Institute of Plant Nutrition Resources and Environment Henan Academy of Agricultural Sciences

The improvement of soil productivity depends on a rational input of water and nutrients, optimal field management, and the increase of basic soil productivity（BSP）. In this study, BSP is defined as the productive capacity of a farmland soil with its own physical and chemical properties for a specific crop season under local field management. Based on 19-yr data of the long-term agronomic experiments（1989–2008） on a fluvo-aquic soil in Zhengzhou, Henan Province, China, the decision support system for agrotechnology transfer（DSSAT ver. 4.0） crop growth model was used to simulate yields by BSP of winter wheat（Triticum aestivium L.） and summer maize（Zea mays L.） to examine the relationship between BSP and soil organic carbon（SOC） under long-term fertilization. Five treatments were included：（1） no fertilization（control）,（2） nitrogen, phosphorus and potassium fertilizers（NPK）,（3） NPK plus manure（NPKM）,（4） 1.5 times of NPKM（1.5NPKM）, and（5） NPK plus straw（NPKS）. After 19 yr of treatments, the SOC stock increased 16.7, 44.2, 69.9, and 25.2% under the NPK, NPKM, 1.5NPKM, and NPKS, respectively, compared to the initial value. Among various nutrient factors affecting contribution percentage of BSP to winter wheat and summer maize, SOC was a major affecting factor for BSP in the fluvo-aquic soil. There were significant positive correlations between SOC stock and yields by BSP of winter wheat and summer maize（P〈0.01）, and yields by BSP of winter wheat and summer maize increased 154 and 132 kg ha^（–1） when SOC stock increased 1 t C ha^（–1）. Thus, increased SOC accumulation is a crucial way for increasing BSP in fluvo-aquic soil. The manure or straw combined application with chemical fertilizers significantly enhanced BSP compared to the application of chemical fertilizers alone.

关键词： soil organic carbon basic soil productivity long-term fertilization DSSAT model fluvo-aquic soil wheat-maize rotation

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Quantifying the ambient formaldehyde sources utilizing tracers

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Chinese Chemical Letters 2014年第11期25卷 1489-1491页

作者： Mei Li min shao Ling-Yu Li Si-Hua Lu Wen-Tai Chen Chen Wang State Joint Key Laboratory of Environmental Simulation and Pollution Control College of Environmental Sciences and Engineering Peking University

Formaldehyde（HCHO） is one of the most important intermediate products of atmospheric photochemical reactions in the troposphere, therefore understanding of HCHO sources is essential for effective ozone control measures. The objective of this work is to distinguish between primary and secondary sources of HCHO. Based on about one month of online measurements in winter in Ziyang,Sichuan, the multi-linear regression analysis of ambient concentrations of HCHO and possible tracers（acetonitrile, propane and peroxyacetyl nitrate） was performed. The results show that during winter in Ziyang, biomass burning contributed an average of 53.2% to ambient HCHO levels, while secondary processes contributed about 30.1%, and vehicular sources accounted for 7.1%.

关键词： Formaldehyde Sources Tracers Multi-linear regression

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Automated federated learning‐based adversarial attack and defence in industrial control systems

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IET Cyber-Systems and Robotics 2024年第2期6卷 109-127页

作者： Guo-Qiang Zeng Jun-min shao Kang-Di Lu Guang-Gang Geng Jian Weng College of Cyber Security Jinan UniversityGuangzhouChina National Joint Engineering Research Center of Network Security Detection and Protection Technology Jinan UniversityGuangzhouChina College of Information Science and Technology Donghua UniversityShanghaiChina

With the development of deep learning and federated learning(FL),federated intrusion detection systems(IDSs)based on deep learning have played a significant role in securing industrial control systems(ICSs).However,adversarial attacks on ICSs may compromise the ability of deep learning-based IDSs to accurately detect cyberattacks,leading to serious ***,in the process of generating adversarial samples,the selection of replacement models lacks an effective method,which may not fully expose the vulnerabilities of the *** authors first propose an automated FL-based method to generate adversarial samples in ICSs,called AFL-GAS,which uses the prin-ciple of transfer attack and fully considers the importance of replacement models during the process of adversarial sample *** the proposed AFL-GAS method,a lightweight neural architecture search method is developed to find the optimised replacement model composed of a combination of four lightweight basic ***,to enhance the adversarial robustness,the authors propose a multi-objective neural archi-tecture search-based IDS method against adversarial attacks in ICSs,called MoNAS-IDSAA,by considering both classification performance on regular samples and adver-sarial robustness *** experimental results on three widely used intrusion detection datasets in ICSs,such as secure water treatment(SWaT),Water Distribution,and Power System Attack,demonstrate that the proposed AFL-GAS method has obvious advantages in evasion rate and lightweight compared with other four ***,the proposed MoNAS-IDSAA method not only has a better classification performance,but also has obvious advantages in model adversarial robustness compared with one manually designed federated adversarial learning-based IDS method.

关键词： adversarial attacks adversarial robustness automated federated learning Industrial control system intrusion

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