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Color Doppler sonography and angioscintigraphy in hepatic Hodgkin's lymphoma

World Journal of Gastroenterology 2009年第26期15卷 3269-3275页

作者： Mirjana V Stojkovi Vera M Artiko Irena B Radoman Slavko J Knezevi Snezana M Luki Mirko D Kerkez nebojsa S Leki Andrija A Anti Marinko M Zuvela Vitomir I Rankovi milorad n petrovi Dragana P obi Vladimir B Obradovi Institute for Digestive Diseases Clinical Center of Serbia Institute for nuclear Medicine Clinical Center of Serbia Gastroenterology Department Clinical Center Podgorica Gastroenterology Department Clinical Center Kragujevac

AIM： To estimate the characteristics of Color Doppler findings and the results of hepatic radionuclide angiography （HRA） in secondary Hodgkin＇s hepatic lymphoma. METHODS： The research included patients with a diagnosis of Hodgkin＇s lymphoma with metastatic focal lesions in the liver and controls. Morphologic characteristics of focal liver lesions and hemodynamic parameters were examined by pulsed and Color Doppler in the portal, hepatic and splenic veins were examined. Hepatic perfusion index （HPI） estimated by HRA was calculated. was observed. Lesions were mostly hypoechoic and mixed, solitary or multiple. Some of the patients presented with dilated splenic veins and hepatofugal blood flow. A pulse wave was registered in the centre and at the margins of lymphoma. The average velocity of the pulse wave was higher at the margins （P 〉 0.05）. A continuous venous wave was found only at the margins of lymphoma. There was no linear correlation between lymphoma size and velocity of pulse and continuous wave （r = 390, P 〈 0.01）. HPI was significantly lower in patients with lymphomas than in controls （P 〈 0.05）, pointing out increased arterial perfusion in comparison to portal perfusion. COnCLUSIOn： Color Doppler ultrasonography is a sensitive method for the detection of neovascularization in Hodgkin＇s hepatic lymphoma and estimation of its intensity. Hepatic radionuclide angiography can additionally help in the assesment of vascularisation of liver lesions.

关键词： Color Doppler ultrasonography Hodgkin's disease Lymphoma Liver Radionuclide angiography Velocity Hepatic artery Portal vein Blood flow Splenomegaly

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Prolonged intermittent theta burst stimulation restores the balance between A_(2A)R-and A_(1)R-mediated adenosine signaling in the 6-hydroxidopamine model of Parkinson's disease

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neural Regeneration Research 2025年第7期20卷 2053-2067页

作者： Milica Zeljkovic Jovanovic Jelena Stanojevic Ivana Stevanovic Milica ninkovic Tihomir V.Ilic nadezda nedeljkovic milorad Dragic Laboratory for neurobiology Department of General Physiology and BiophysicsFaculty of BiologyUniversity of BelgradeBelgradeSerbia Medical Faculty of Military Medical Academy University of DefenceBelgradeSerbia

An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's *** therapeutic approaches fail to alter disease progression,demonstrating the need for novel approaches in *** transcranial magnetic stimulation is a non-invasive approach that has been shown to improve motor and non-motor symptoms of Parkinson's ***,the underlying mechanisms of the beneficial effects of repetitive transcranial magnetic stimulation remain *** purpose of this study is to investigate the extent to which the beneficial effects of prolonged intermittent theta burst stimulation in the 6-hydroxydopamine model of experimental parkinsonism are based on modulation of adenosine-mediated *** with unilateral 6-hydroxydopamine lesions underwent intermittent theta burst stimulation for 3 weeks and were tested for motor skills using the Rotarod ***,quantitative reverse transcription polymerase chain reaction,immunohistochemistry,and biochemical analysis of components of adenosine-mediated signaling were performed on the synaptosomal fraction of the lesioned caudate *** intermittent theta burst stimulation improved motor symptoms in 6-hydroxydopamine-lesioned animals.A 6-hydroxydopamine lesion resulted in progressive loss of dopaminergic neurons in the caudate *** with intermittent theta burst stimulation began 7 days after the lesion,coinciding with the onset of motor *** treatment with prolonged intermittent theta burst stimulation,complete motor recovery was *** improvement was accompanied by downregulation of the e n/CD73-A_(2A)R pathway and a return to physiological levels of A_(1)R-adenosine deaminase 1 after 3 weeks of intermittent theta burst *** results demonstrated that 6-hydroxydopamine-induced degeneration reduced the expression of A_(1)R and elevated the expression of A_(2A)***

关键词： A_(1)R A_(2A)R adenosine receptors adenosine ecto-5′-nucleotidase intermittent theta burst stimulation non-invasive brain stimulation Parkinson's disease purinergic signalling

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Monoclonal immunoscintigraphy for detection of metastasis and recurrence of colorectal cancer

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World Journal of Gastroenterology 2011年第19期17卷 2424-2430页

作者： Vera Artiko Ana Koljevic Markovi Dragana obi-aranovi milorad petrovi Andrija Anti Mirjana Stojkovi Marinko Zuvela Djordjije aranovi Milica Stojkovi neboja Radovanovi Danijel Galun Aleksandar Milovanovi Jovica Milovanovi Anica Bobi-Radovanovi Zoran Krivokapic Vladimir Obradovi School of Medicine University of BelgradeClinical Center of Serbia national Research Cancer Center Institute for Ocupational Medicine Belgrade University School of Medicine Paterova 2 11000 BelgradeSerbia

AIM:To assess the clinical role of monoclonal immunoscintigraphy for the detection of metastasis and recurrence of colorectal ***:Monoclonal immunoscintigraphy was performed in patients operated on for colorectal adenocar-cinoma suspected of local recurrence and metastatic *** results were compared with conventional ***:Immunoscintigraphic investigation was done in 53 *** recurrence occurred in 38 patients,and was confirmed by other diagnostic modalities in *** 15 patients,immunoscintigraphic findings were negative,and confirmed in 14 with other diagnostic *** analysis confirmed good correlation of immunoscintigraphic findings and the results of conventional diagnostics and the level of tumor marker carcinoembryonic *** analysis of parameters of radiopharmaceutical groups imacis,indimacis and oncoscint presented homogenous characteristics all of three *** analysis of immunoscintigraphic target focus was clearly improved using ***:Immunoscintigraphy is highly specific and has a good predictive value in local recurrence of colorectal cancer.

关键词： Immunoscintigraphy Monoclonal antibodies Colorectal carcinoma Tumor metastasis Tumor recurrence

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Statistical Safety Analysis of Maintenance Management Process of Excavator Units

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International Journal of Automation and computing 2010年第2期7卷 146-152页

作者： Ljubisa Papic milorad Pantelic Joseph Aronov Ajit Kumar Verma Research Center of Dependability and Quality Management Kolubara Metal Company Federal Scientific Research Institute of Standardization Indian Institute of Technology Bombay

Within this paper, the process of statistical safety analysis has been presented, which involves the following steps： formulation of basic principles of statistical safety analysis, initial events analysis, accident sceneries progress analysis, risk calculation, and risk calculation results analysis. On this basis, it has been concluded that the bucket wheel excavator SRs 1200×24/4×0（400 kW）＋VR safety criteria is the mechanism for the hoist of rotor＇s arrow failure modes, because in that case whole bucket wheel excavator failure would necessarily happen （excavator falling down on counterweight）. Therefore, excavator units statistical safety analysis is accomplished preventively to obtain its effective maintenance management.

关键词： Safety maintenance management statistical analysis event tree accident scenarios risk analysis excavator units.

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Structural Integrity Assessment of Welded Pressure Vessel Produced of HSLA Steel

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Journal of Iron and Steel Research International 2011年第S1期18卷 888-892页

作者： Milovi Ljubica Vuherer Tomaz Zrili milorad Momilovi Dejan Jakovi Dragan Faculty of Technology and Metallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia Welding Laboratory University of MariborFaculty of Mechanical EngineeringSmetanova 17Maribor 2000Slovenia Institute for Testing of Materials IMS Blvd.vojvode Mi i a 4311000 BelgradeSerbia

Welded joint is a critical region of a welded *** operational safety of welded pressure equipment mostly depends on the behaviour of loaded *** of welded structure is dependent on the properties of welded joint as whole and of its constituents (parent metal,heat affected zone and weld metal).In this paper the behaviour of welded joint cracked constituents is *** integrity assessment procedure is applied to welded pressure vessel produced of high-strength low-alloyed steel,operating at-40°C,comparing crack driving force and material crack resistance,using path-independent contour J-integral as fracture mechanics *** comparison of crack driving force,expressed by J-integral and material resistant curve,J-R curve,provide the possibility to determine the extent of the stable crack as well as the critical crack size for its final fast propagation and also to assess the structural integrity of a cracked pressure vessel.

关键词： pressure vessel residual strength J integral crack driving force

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Clinical analysis of propofol deep sedation for 1,104 patients undergoing gastrointestinal endoscopic procedures:A three year prospective study

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World Journal of Gastroenterology 2006年第2期12卷 327-330页

作者： Stojanka Gaparovi nadan Rustemovi milorad Opai Marina Premuzi Andelko Korui Jadranka Bozikov Tamara Bates Department of Anesthesiology Dubrava University HospitalZagrebCroatia Department of Gastroenterology Zagreb University Hospital CenterZagrebCroatia "Andrija tampar" School of Public Health Zagreb University School of MedicineZagrebCroatia "Bates" Clinic ZagrebCroatia

AIM： To analyze the hemodynamic and respiratory effects of propofol on patients undergoing gastroscopy and colonoscopy. METHODS： In this prospective study, conducted over a period of three years, 1,104 patients referred for a same day GI endoscopy procedure were analyzed. All patients were given a propofol bolus （0.5-1.5 mg/kg）. Arterial blood pressure （BP） was monitored at 3 rain intervals and heart rate and oxygen saturation （SpO2） were recorded continuously by pulse oximetry. Analyzed data acquisition was carried out before, during, and after the procedure. RESULTS： A statistically significant reduction in mean arterial pressure was demonstrated （P〈0.001） when compared to pre-intervention values, but severe hypotension, defined as a systolic blood pressure below 60mmHg, was noted in only 5 patients （0.5%）. Oxygen saturation decreased from 96.5% to 94.4 % （P〈0.001）. A critical decrease in oxygen saturation （〈90%） was documented in 27 patients （2.4%）. COnCLUSIOn： Our results showed that propofol provided good sedation with excellent pain control, a short recovery time and no significant hemodynamic side effelts if carefully titrated. All the patients （and especially ASA Ⅲ group） require monitoring and care of an anesthesiologist.

关键词： Endoscopy Conscious sedation Propofol Hemodynamic adverse effects

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Effect of Distributor Design on Gas-Liquid Distribution in Monolithic Bed at High Gas/Liquid Ratios

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Chinese Journal of Chemical Engineering 2012年第4期20卷 693-700页

作者：周媛 AL-DAHHAn Muthanna DUDUKOVIC milorad 刘辉 Beijing University of Chemical Technology Missouri University of Science and Technology RollaMO 65409USA Washington University in St.Louis MO 63130USA

Experiments were carried out to investigate the liquid flow distribution at high gas/liquid ratios in a cold model monolith bed of a 0.048 m diameter with 62 cells per *** types of distributor for the liquid distribu-tion were used to evaluate their distribution *** liquid saturation in individual channels was meas-ured using 16 single-point optical fiber probes mounted inside the *** results indicate that 1) The optical fiber probe technique can measure phase distribution in the monolith bed;2) Liquid saturation distribution along the radial direction of the monolith bed is not uniform and the extent of non-uniformity depends on the distributor de-sign and phase velocities;and 3) The tube array distributor provides superior liquid distribution performance over the showerhead and nozzle distributors.

关键词： monolith reactor phase distribution optical fiber probe liquid saturation

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Financial Modeling of Accounting Costs Acquisition of Arms

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Journal of Mathematics and System Science 2016年第3期6卷 102-111页

作者： Ivan Milojevic Milan Mihajlovic milorad Zekic Marko Andrejic University of Defence Military Academy Generala Pavia Jurisica Sturma 33 Belgrade Serbia University of Defence Military Academy Generala Pavla Jurisica Sturma 33 Belgrade Serbia Center for Economics and Financial Research Beogradska 27v Belgrade Serbia University of Defence Military Academy Generala Pavia Jurisica Sturma 33 Belgrade Serbia

In case of restrictive defense budget financing, efficient and effective use of funds is now more than ever becoming a crucial question in functioning of the Ministry of Defense and Serbian Armed Forces （MoD and SAF）. Any investment in acquisition of arms and military equipment （AME） due to financial significance does not allow mistakes in decision making. Qualitative analysis of cost of assets through the entire programmed lifecycle is a complex multi-disciplinary and multi-criteria problem whose solving requires application of the model multi-criteria optimization. In our operational practice thus far, solving the said problems there wasn＇t enough the model multi-criteria optimization so the optimal results were lacking. In this paper investment process of AME in the MoD and SAF was analyzed, from the point of cost treatment in the process, its flaws have been pointed out and a more comprehensive - integrated approach has been suggested.

关键词： investment equipping arms and military equipment accounting cost multi-criteria optimization.

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香港地区高层住宅单体建筑风压系数的研究

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暖通空调 2004年第8期34卷 62-65页

作者：杨洁涂光备易伟雄 milorad Bojic 同济大学天津大学香港理工大学 (塞尔维亚和黑山)Kragujevac大学

调查了香港住宅建筑的布局形式 ,使用LES模型对常见布局建筑的外流场进行了数值模拟 ,得到了建筑外表面风压系数的分布。

关键词：香港地区高层住宅自然通风计算流体力学风压系数数值模拟

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液相反应物起限制性作用的滴流床反应器模型评价

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化学反应工程与工艺 1996年第4期12卷 363-368页

作者：包传平吴元欣 milorad P.Dudukovic 武汉化工学院化工系

在实验流床反应器内用含２３％Ｃｕ，１７％Ｃｒ的氧化铝催化剂进行过氧化氢的等温分解，以测试不同操作条件下液相反应物转化率对空时的依赖关系。实验证实过氧化氢分解是一个液相反应物起限制性作用的１级反应。模型预测与实验数据的... 详细信息

在实验流床反应器内用含２３％Ｃｕ，１７％Ｃｒ的氧化铝催化剂进行过氧化氢的等温分解，以测试不同操作条件下液相反应物转化率对空时的依赖关系。实验证实过氧化氢分解是一个液相反应物起限制性作用的１级反应。模型预测与实验数据的比较表明：除催化剂效率因子以外，必须考虑外部质量传递和催化剂外部不完全润湿的影响。Ｄｕｄｕｋｏｖｉｃ提出的考虑催化剂总效率因子的近似模型完全能够模拟上述２种影响。

关键词：滴流床模型流化床反应器液相

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