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One size does not fit all: Refining zircon provenance interpretations via integrated grain shape, geochronology, and Hf isotope analysis

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Geoscience Frontiers 2023年第4期14卷 230-244页

作者： Gisela Gartmair milo barham Christopher L.Kirkland Timescales of Mineral Systems Group School of Earth and Planetary SciencesCurtin UniversityGPO Box U1987PerthWA 6845Australia

Sediment provenance studies commonly utilize isotopic signatures to resolve detrital mineral sources and ***,non-unique ages and geochemical characteristics across geographically distinct crystalline source regions can lead to significant ambiguities in mineral provenance *** ambiguity is apparent in southern Australia’s Cenozoic Eucla Basin,which hosts world-class heavy mineral sand ***,new Hf isotope data are provided from four heavy mineral prospects(N=8,n=844[N=samples,n=grains]).Zircon grain shape data are also presented for a suite of detrital Eucla Basin samples(N=22,n=35,604)and the basin’s underlying basement,the Coompana Province(N=13,n=824).The data are integrated with published detrital and non-detrital primary zircon data to investigate the efficacy of grain shape analysis to better resolve the basin’s mineral *** Hf isotope compositions indicate a primary Mesoproterozoic juvenile source for zircon melts(~1250-1000 Ma,-2.5~+5)with additional contributions from a range of juvenile to evolved late Archean to Phanerozoic-aged zircon bearing magmas(-28.0+11).U-Pb geochronology and Hf isotopes are incapable of differentiating Mesoproterozoic-aged source rocks bounding the region for the majority of heavy mineral deposits analyzed as potential sources express overlapping crystallization ages and similarities in Hf-isotope ***,distinct zircon grain shapes(i.e.,perimeter,major axis and circularity)facilitate improved differentiation across these Mesoproterozoic *** of U-Pb age,Hf isotope and shape data implicate the underlying Madura and Coompana provinces as dominant sediment sources for Eucla Basin detritus aged~1400-1000 *** lack of direct sediment pathways between the underlying basement provinces and placer sediments analyzed demonstrates the significance of zircon reworking from intermediate sedimentary basins in the formation of the economically significa

关键词： Isotope fingerprinting Grain shape analysis Sediment provenance Sediment routing Heavy mineral sands Eucla Basin

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Assessing volcanic origins within detrital zircon populations——A case study from the Mesozoic non-volcanic margin of southern Australia

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Geoscience Frontiers 2019年第4期10卷 1371-1381页

作者： milo barham Christopher L. Kirkland Martin Danisík Centre for Exploration Targeting (CET)- Curtin Node The Institute for Geoscience Research (TIGeR)School of Earth and Planetary SciencesCurtin UniversityGPO Box U1987PerthWA 6845Australia GeoHistory Facility John de Laeter CenterCurtin UniversityGPO Box U1987PerthWA 6845Australia

Detrital zircon U/Pb geochronology is a common tool used to resolve stratigraphic questions,inform basin evolution and constrain regional geological *** favourable circumstances,detrital zircon populations can contain a concomitant volcanic contribution that provides constraints on the age of ***,for non-volcanic settings,proving isolated detrital zircon grains are from contemporaneous and potentially remote volcanism is *** we use same grain(U-Th)/He thermochronology coupled with U/Pb geochronology to identify detrital zircon grains of contemporary volcanic origin.(U-Th)/He ages from Cretaceous zircon grains in southern Australia define a single population with a weighted mean age of 104±6.1 *** from zircon U/Pb geochronology and palynology(~104.0-107.5 Ma).Detrital zircon trace-element geochemistry is consistent with a continental signature for parent rocks and coupled with detrital grain ages,supports derivation from a>2000 km distant early-to mid-Cretaceous Whitsunday Volcanic Province in eastern ***,integration of biostratigraphy,single-grain zircon double-dating(geochronology and thermochronology)and grain geochemistry enhances fingerprinting of zircon source region and transport history.A distal volcanic source and rapid continental-scale transport to southern Australia is supported here.

关键词： Provenance Grain history Thermochronology Geochronology Source to sink Trace-elements

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A Laurentian affinity for the Embu Terrane,Ribeira Belt(SE Brazil),revealed by zircon provenance statistical analysis

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Geoscience Frontiers 2023年第1期14卷 149-161页

作者： Bruno V.Ribeiro Frederico M.Faleiros Ginaldo A.C.Campanha Peter A.Cawood Christopher L.Kirkland milo barham Erin L.Martin Marina Seraine Dina I.G.Cabrita Maria T.A.G.Yogi VidyãV.Almeida Anny J.A.Forero-Ortega Elton L.Dantas Timescales of Mineral Systems Group School of Earth and Planetary SciencesCurtin UniversityPerthWA 6102Australia Isotopia Laboratory School of EarthAtmosphere and EnvironmentMonash UniversityClaytonVictoria 3800Australia Department of Mineralogy and Geotectonics University of São PauloRua do Logo 56205508-900 São PauloBrazil Department of Geological Science and Geological Engineering of Queen's University KingstonOntarioCanada Department of Earth Sciences Carleton UniversityOttawaOntarioCanada Geodynamics Division Geological Survey of Brazil(CPRM)Rua Costa 5501304-010 São PauloSPBrazil Institute for Geophysics Pontificia Universidad JaverianaBogotáColombia Institute of Geoscience University of BrasiliaCampus Universitário Darcy RibeiroAna Norte70919-900 BrasiliaDFBrazil

New and compiled detrital zircon U-Pb ages from the southern Neoproterozoic-Cambrian Ribeira Belt,SE Brazil,demonstrate Laurentian affinity of the Embu Terrane which is statistically distinct from the adjoining Apiaíand São Roque terranes with cratonic affinity(e.g.,São Francisco Craton).Zircon provenance results indicate that the type-area of the Embu Terrane is dominated by detrital zircon age modes at ca.1200 Ma,1400 Ma,and 1800 Ma,with maximum depositional age of ca.1000 *** contrast,the Apiaíand São Roque terranes are dominated by Paleoproterozoic detrital zircon ages(ca.2200-2000 Ma age dominant component),with maximum depositional ages of ca.1400 Ma and 1750 Ma,*** scaling(MDS)analysis of non-parametric similarity measurements on zircon age populations indicates for the first time that the Embu Terrane encompass two statistically distinct detrital zircon age spectra,which is also reflected in the metamorphic zircon age *** statistical characterization of the Embu Terrane through populational metrics allow a quantitative comparison with surrounding tectonic domains and rock samples classified such as *** results clearly highlight the distinction between the statistically differentiated Embu Terrane from the Apiaíand São Roque terranes,supporting an allochthonous *** addition,we demonstrate that rocks samples previously classified as Embu-type are significantly dissimilar to the definition of Embu Terrane,failing to support alternative tectonic models(e.g.,intracontinental evolution).Detrital zircon age spectra reveal that the Apiaíand São Roque terranes have similar zircon provenance to domains sourced from the São Francisco Craton,whereas detrital zircon populations from the Embu Terrane have greater affinity with SW Laurentia basins(and their inferred sediment sources),consistent with previous ***,we interpret the Embu Terrane as a Rodinia descendant developed along the active margin o

关键词： Ribeira belt Embu terrane Detrital zircon Multidimensional scaling Rodinia and gondwana Paleogeography

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Endo-anesthesia:a primer

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Gastroenterology Report 2022年第1期10卷 207-216页

作者： Fateh Bazerbachi Rodger M.White Nauzer Forbes Basavana Goudra barham K.Abu Dayyeh Vinay Chandrasekhara BobbieJean Sweitzer CentraCare Interventional Endoscopy ProgramSt.Cloud HospitalSt CloudMNUSA Department of Anesthesia Massachusetts General HospitalBostonMAUSA Department of Medicine Division of Gastroenterology and HepatologyUniversity of CalgaryCalgaryAlbertaCanada Department of Anesthesiology and Critical Care Medicine Hospital of the University of PennsylvaniaPhiladelphiaPAUSA Division of Gastroenterology and Hepatology Mayo ClinicRochesterMNUSA Systems Director University of VirginiaPreoperative MedicineInovaHealthFalls ChurchVAUSA

Gastrointestinal(GI)endoscopy has witnessed a Cambrian explosion of techniques,indications,and expanding target *** endoscopy encompasses traditional domains that include preventive measures,palliation,as alternative therapies in patients with prohibitive risks of more invasive procedures,and indicated primary ***,it has expanded to include therapeutic and diagnostic interventional endosonography,luminal endoscopic resection,third space endotherapy,endohepatology,and *** lines between surgery and endoscopy are blurred on many occasions within this ***,patients with high degrees of co-morbidity and complex physiology require more nuanced peri-endoscopic *** rising demand for endoscopy services has resulted in the development of endoscopy referral centers that offer these invasive procedures as directly booked referrals for regional and rural *** further necessitates specialized programs to ensure appropriate evaluation,risk stratification,and optimization for safe sedation and general anesthesia if *** landscape is conducive to the organic evolution of endo-anesthesia to meet the needs of these focused and evolving *** this primer,we delineate important aspects of endo-anesthesia care and provide relevant clinical and logistical considerations pertaining to the breadth of procedures.

关键词： endoscopic procedures endoscopy anesthesia

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Turnkey algorithmic approach for the evaluation of gastroesophageal reflux disease after bariatric surgery

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Gastroenterology Report 2023年第1期11卷 123-130页

作者： Omar M.Ghanem Rabih Ghazi Farah Abdul Razzak Fateh Bazerbachi Karthik Ravi Leena Khaitan Shanu N.Kothari barham K.Abu Dayyeh Department of Surgery Mayo ClinicRochesterMNUSA Department of Medicine Mayo ClinicRochesterMNUSA CentraCare Interventional Endoscopy ProgramSt Cloud HospitalSt CloudMNUSA Department of Surgery CaseWestern Reserve UniversityClevelandOHUSA Department of Surgery Prisma HealthGreenvilleSCUSA

Bariatric surgeries are often complicated by de-novo gastroesophageal reflux disease(GERD)or worsening of pre-existing *** growing rates of obesity and bariatric surgeries worldwide are paralleled by an increase in the number of patients requiring post-surgical GERD ***,there is currently no standardized approach for the assessment of GERD in these *** this review,we delineate the relationship between GERD and the most common bariatric surgeries:sleeve gastrectomy(SG)and Roux-en-Y gastric bypass(RYGB),with a focus on pathophysiology,objective assessment,and underlying anatomical and motility *** suggest a stepwise algorithm to help diagnose GERD after SG and RYGB,determine the underlying cause,and guide the management and treatment.

关键词： RYGB sleeve gastrectomy bariatric surgery gastroesophageal reflux disease GERD

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Effects on physiologic measures of appetite from intragastric balloon and endoscopic sleeve gastroplasty: results of a prospective study

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Chinese Medical Journal 2022年第10期135卷 1234-1241页

作者： Babusai Rapaka Daniel B.Maselli Gontrand Lopez-Nava Inmaculada Bautista-Castano Reem Matar Veeravich Jaruvongvanich Eric J.Vargas Andrew C.Storm Andres Acosta barham K.Abu Dayyeh Division of Gastroenterology and Hepatology Mayo ClinicRochesterMN 55905USA Madrid Sanchinarro University Hospital MadridSpain

Background: Endoscopic bariatric therapies can help address widening management gaps in obesity. Their ability to facilitate weight loss is largely tied to influences on appetite through perturbations of gastric emptying and accommodation. As these tools gain traction in obesity therapy, their physiologic underpinnings require exploration, which may enhance efficacy, tolerance, and patient-tailored ***: We prospectively assessed consecutive subjects with fluid-filled intragastric balloons (IGBs) (n = 18) placed between October 2016 and June 2017 or underwent endoscopic sleeve gastroplasty (ESG) (n = 23) from March 2018 to June 2018. Patients underwent physiologic appraisal at 3 months with13C-spirulina-based gastric emptying breath test to determine time to half emptying (T50), as well as maximum tolerated volume (MTV) of a standard nutrient drink test. Changes in T50 and MTV at 3 months were compared with percent total body weight loss (%TBWL) at 3 and 6 months using best-fit linear ***: The change in T50 at 3 months correlated with %TBWL at 3 months for IGB (P = 0.01) and ESG (P = 0.01) but with greater impact on %TBWL in IGB compared to ESG (R2 = 0.42vs. 0.26). Change in T50 at 3 months was predictive of weight loss at 6 months for IGB (P = 0.01) but not ESG (P = 0.11). ESG was associated with greater decrease in MTV compared to IGB (340.25 ± 297.97 mLvs. 183.00 ± 217.13 mL,P = 0.08), indicting an enhanced effect on satiation through decreased gastric accommodation. Changes in MTV at 3 months did not correlate with %TBWL for either IGB (P = 0.26) or ESG (P = 0.49) but trended toward significance for predicting %TBWL at 6 months for ESG (P = 0.06) but not IGB (P = 0.19).Conclusion: IGB and ESG both induce weight loss but likely through distinct gastric motor function phenotypes, and gastric emptying may predict future weight loss in patients with IGB.

关键词： Intragastric balloon Endoscopic sleeve gastroplasty Gastric emptying Gastric accommodation Obesity

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Paradox-driven adventures in the development of cancer immunology and immunotherapy

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Genes & Diseases 2019年第3期6卷 224-231页

作者： Whitney barham Joanina K.Gicobi Yiyi Yan Roxana S.Dronca Haidong Dong Mayo Clinic Medical Scientist Training Program Mayo ClinicRochesterMNUSA Mayo Clinic Graduate School of Biomedical Sciences Mayo ClinicRochesterMNUSA Department of Immunology Mayo ClinicRochesterMNUSA Department of Urology Mayo ClinicRochesterMNUSA Department of Medical Oncology Mayo ClinicRochesterMNUSA Division of Hematology and Medical Oncology Mayo ClinicJacksonvilleFLUSA

After more than one hundred years of documented trials,immunotherapy has become a standard of care in the treatment of human *** of the knowledge that led to recent breakthroughs seems quite logical from today’s point of ***,what we now cite as facts were originally considered paradoxes,meaning something contrary to expectations or perceived opinion at the *** order to make gains in the field of immunotherapy,one had to be willing to confront ideas and concepts that seemed to contradict one another,and reconcile how each could be *** is what led to new knowledge and ***,we highlight some of these paradoxes and the milestone discoveries that followed,each one critical for our understanding of immune checkpoint *** outlining some of the steps that we took and the challenges that we overcame,we hope to inspire and encourage future generations of researchers to confront the paradoxes that still permeate the field.

关键词： Biomarker Cancer immunotherapy Cytotoxic T cells Hyperprogression Immune checkpoints PD-L1 PD-1

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Percutaneous transluminal angioplasty balloons for endoscopic ultrasound-guided pancreatic duct interventions

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World Journal of Gastrointestinal Endoscopy 2022年第8期14卷 487-494页

作者： Jad P AbiMansour barham K Abu Dayyeh Michael J Levy Andrew C Storm John A Martin Bret T Petersen Ryan J Law Mark D Topazian Vinay Chandrasekhara Department of Gastroenterology and Hepatology Mayo ClinicRochesterMN 55905United States

BACKGROUND Endoscopic ultrasound(EUS)-guided main pancreatic duct(PD)access may be used when conventional endoscopic retrograde cholangiopancreatography(ERCP)techniques *** use of a percutaneous transluminal angioplasty balloon(PTAB),originally developed for vascular interventions,can be used to facilitate transmural(e.g.,transgastric)PD access and to dilate high-grade pancreatic *** To describe the technique,efficacy,and safety of PTABs for EUS-guided PD *** Patients who underwent EUS with use of a PTAB from March 2011 to August 2021 were retrospectively identified from a tertiary care medical center supply *** included 3-4 French angioplasty catheters with 3-4 mm balloons designed to use over a 0.018-inch *** primary outcome was technical *** outcomes included incidence of adverse events(AEs)and need for early *** A total of 23 patients were identified(48%female,mean age 55.8 years).Chronic pancreatitis was the underlying etiology in 13(56.5%)patients,surgically altered anatomy(SAA)with stricture in 7(30.4%),and SAA with post-operative leak in 3(13.0%).Technical success was achieved in 20(87%)*** AE rate was 26%(n=6).All AEs were mild and included 1 pancreatic duct leak,2 cases of post-procedure pancreatitis,and 3 admissions for post-procedural *** patients required early *** EUS-guided use of PTABs for PD access and/or stricture management is feasible with an acceptable safety profile and can be considered in patients when conventional ERCP cannulation fails.

关键词： Dilating balloon Pancreatic duct intervention Chronic pancreatitis Anastomotic stricture

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SPATIAL AND TEMPORAL CHANGES IN THE BRAHMAPUTRA RIVER BED

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International Journal of Sediment Research 2006年第2期21卷 123-131页

作者： Prabhata K. SWAMEE barham PARKASH Santanu SARMA Dept. of Civil Engrg. Indian Inst. of Tech. Roorkee Roorkee 247 667 India Emeritus Fellow Dept. of Earth Sciences Indian Inst. of Tech. Roorkee Roorkee 247 667 India Emeritus Fellow Department of Geology Cotton College Guwahati-781 001 India Lecturer

A mathematical model based on data for the period 1957-1988 representing changes in space and time in the bed morphology of the 623 km long alluvial reach of the Brahmaputra River in Assam State, India has been developed. This model reveals that in the upper reaches the bed level decreases downstream exponentially with distance from a reference point, while in the lower reaches the exponential decrease is at a smaller rate probably due to differences in tectonic setting. The lower reach is marked by sinusoidal oscillations with a time period of about 9 yr. High runoff in 1977 seems to have caused a significant change as the maximum, average, and minimum bed level were decreasing before 1977 and these increased just after 1977 and then started decreasing at a lower rate than before. Smaller changes in shorter reaches governed by input of discharge and sediment from tributaries are superimposed on the overall degradation/aggradation character. The variation in degradation/aggradation with time is sinusoidal with a wavelength of 4,450 km before 1977 that reduces to about 1,038 km after 1977.

关键词： Alluvial stream Brahmaputra River Cross section Depth Morphology Riverbed level Mean discharge

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