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Analysis of doping control test results in individual and team sports from 2003 to 2015

Journal of Sport and Health Science 2020年第2期9卷 160-169页

作者： millan aguilar-navarro Jesus Munoz-Guerra Maria del Mar Plara Juan Del Cosoa Exercise Physiology Laboratory Camilo Jose Cela UniversityMadrid28692Spain Faculty of Education Francisco de Vitoria UniversityMadrid28223Spain Department for Doping Control Spanish Agency for Health Protection in SportMadrid28016Spain Department of Education Spanish Agency for Health Protection in SportMadrid28016Spain

Background:Determining the prevalence of doping in sport might be useful for anti-doping authorities to gauge the effectiveness of anti-doping policies implemented to prevent positive attitudes toward *** questionnaires and personal interviews,previous investigations have found that the prevalence of doping might be different among different sports disciplines;however,there is no sport-specific information about the proportion of adverse and atypical findings(AAF) in samples used for doping *** aim of the present investigation was to assess the differences in the frequency of adverse analytical and atypical findings among sports using the data made available by the World Anti-Doping ***:The data included in this investigation were gathered from the Testing Figures Reports made available annually from 2003 to 2015 by the World Anti-Doping *** Testing Figures Reports include information about the number of samples analyzed,the number of AAFs reported,and the most commonly found drugs in the urine and blood samples analyzed.A total of 1,347,213 samples were analyzed from the individual sports selected for this investigation,and 698,371 samples were analyzed for disciplines catalogued as team ***:In individual sports,the highest proportions of AAF were 3.3%±1.0% in cycling,3.0%±0.6% in weightlifting,and 2.9%±0.6% in *** team sports,the highest proportions of AAF were 2.2%±0.5% in ice hockey,2.0%±0.5% in rugby,and 2.0%±0.5% in *** and skating had the lowest proportions at(≤1.0%) for individual sports,and field hockey,volleyball and football had the lowest proportions for team sports(≤1.4%).Conclusion:As suggested by the analysis,the incidence of AAF was not uniform across all sports disciplines,with the different proportions pointing to an uneven use of banned substances depending on the *** information might be useful for increasing the strength and efficacy of anti-doping policies in those s

关键词： Anti-doping Attitude Banned drugs Elite athlete Type of sport

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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： Danko Jeremic Lydia Jiménez-Díaz Juan D.navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(AD)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in AD,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

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Efficient hexane isomers separation in isoreticular bipyrazolate metal-organic frameworks:The role of pore functionalization

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Nano Research 2021年第2期14卷 532-540页

作者： Rebecca Vismara Corrado Di Nicola Rodrigo Gil-San millan Kostiantyn V.Domasevich Claudio Pettinari Jorge A.R.navarro Simona Galli Dipartimento di Scienza e Alta Tecnologiay University delVInsubria 22100 ComoItaly School of Science and Technology University ofCamerino62032 Camerino(MC)Italy Departamento de Quimica Inorganica Universidad de Granada18071 GranadaSpain Taras Shevchenko National University of Kyiv 01601 KyivUkraine School of Pharmacy University of Camerino62032 Camerino(MC)Italy Istituto di Chimica dei Composti Organometallici(ICCOM-CNR) 50019 Sesto FiorentinoItaly Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali 50121 FirenzeItaly Department of Chemistry University of LiverpoolLiverpool L73NYUK

Hydrocarbons separation in petrochemical industries is a key,energy-consuming stage in the manufacture of high-quality added-value products—hence the need for more efficient materials and environmentally friendly methodologies to improve this *** this context,we have studied the effect of metal-organic frameworks(MOFs)pore functionalization in hexane isomers separation,isolating the robust isoreticular zinc(ll)bipyrazolates Zn(BPZ),showing no pore decoration,Zn(Me_(2)BPZ),the pores of which are decorated with apolar methyl groups,and Zn(BPZ(NH_(2))_(2)),the spacers of which possess polar Lewis-basic functions(H_(2)BPZ=1H,1'H-4,4'-bipyrazole;H_(2)Me_(2)BPZ=3,3'-dimethyl-1H,1'H-4,4'-bipyrazole;H_(2)BPZ(NH_(2))_(2)=3,5-diamino-1H,1'H-4,4'-bipyrazole;DMF=dimethylformamide).After characterizing Zn(BPZ(NH_(2))_(2))as per its crystal structure and thermal behaviour,and all the three MOFs as per their textural properties,we investigated,from the experimental and computational points of view,the impact of the square one-dimensional channels decoration on the separation of the hexane isomers,demonstrating the relevance of pore constrictions in the resolution of the title alkanes mixture.

关键词： adsorption molecular sieving nitrogen-donor ligands gas separation pow der diffraction variable-tem perature pulse gas chromatography

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Stressful living in lower-quality habitats?Body mass,feeding behavior and physiological stress levels in wild wood mouse populations

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Integrative Zoology 2019年第1期14卷 114-126页

作者： Álvaro navarro-CASTILLA Isabel BARJA Department of Biology Unit of ZoologyFaculty of SciencesAutonomous University of MadridSpain

Wild populations are continuously subjected to changes in environmental factors that pose different *** condition and hormones have been commonly used as health indicators due to their potential correlation with *** the present study,we analyzed whether habitats of different quality influenced body mass,food intake and physiological stress levels in wild wood mice(Apodemus sylvaticus).Field work was seasonally carried out in Holm oak woods and pine forests in central Spain.A total of 93 wood mice from 4 different populations(2 per habitat type)were *** each captured individual we noted body mass and food intake,measured as the amount of bait remaining in each *** physiological stress levels were measured non-inva-sively in collected fresh feces by quantifying fecal corticosterone metabolites(FCM)with a 5a-pregnane-3ß,11ß,21-triol-20-one enzyme *** mice abundances decreased from spring to summer,were higher in Holm oak woods than in pine forests and also resulted in different age-class distribution between both *** inhabiting pine forests showed a lower body mass and increased food intake,probably because of the comparatively lower food quality and availability in this ***,these individuals showed increased physiological stress levels,likely due to the lower quality habitat in relation to both food and vegetation cover ***,besides affecting local wood mouse abundance,our study underscores the effect of habitat quality on body mass,food intake and the endocrine stress *** the wood mouse’s piv-otal position in ecosystems,these results could help in the understanding of environmental traits hampering the viability of wild populations.

关键词： Apodemus sylvaticus body condition corticosterone environmental factors fecal corticosterone metabolites feeding behavior

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Continuous frequency and phase spectrograms: a study of their 2D and 3D capabilities and application to musical signal analysis

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第2期9卷 199-206页

作者： Laurent navarro Guy COURBEBAISSE Jean-Charles PINOLI Ecole Nationale Supérieure des Mines de Saint-Etienne Centre Ingénierie et Santé (CIS) and LPMG UMR 5148 CNRS 158 cours Fauriel 42023 Saint-Etienne cedex 2 France Medical Imaging Research Center (CREATIS-LRMN) UMR 5220 CNRS U630 INSERM Université Lyon 1 INSA Lyon Bat. Blaise Pascal 7 Av. Jean Capelle 69621 Villeurbanne France

A new lighting and enlargement on phase spectrogram （PS） and frequency spectrogram （FS） is presented in this paper. These representations result from the coupling of power spectrogram and short time Fourier transform （STFT）. The main contribution is the construction of the 3D phase spectrogram （3DPS） and the 3D frequency spectrogram （3DFS）. These new tools allow such specific test signals as small slope linear chirp, phase jump case of musical signal analysis is reported. The main objective is to and small frequency jump to be analyzed. An application detect small frequency and phase variations in order to characterize each type of sound attack without losing the amplitude information given by power spectrogram

关键词： Frequency spectrogram (FS) Phase spectrogram (PS) Time-frequency representations Musical signals

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CD47:a new player in phagocytosis and xenograft rejection

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Cellular & Molecular Immunology 2011年第4期8卷 285-288页

作者： Nalu navarro-Alvarez Yong-Guang Yang Columbia Center for Translational Immunology Columbia University Medical CenterNew YorkNYUSA

Organ transplantation is limited by the availability of human donor *** transplantation of organs and tissues from other species(xenotransplantation)would supply an unlimited number of organs and offer many other advantages for which the pig has been identified as the most suitable ***,the robust immune responses to xenografts remain a major obstacle to clinical application of *** more vigorous xenograft rejection relative to allograft rejection is largely accounted for by the extensive genetic disparities between the donor and *** activate host immunity not only by expressing immunogenic xenoantigens that provide the targets for immune recognition and rejection,but also by lacking ligands for the host immune inhibitory *** review is focused on recent findings regarding the role of CD47,a ligand of an immune inhibitory receptor,signal regulatory protein alpha(SIRPa),in phagocytosis and xenograft rejection.

关键词： CD47 macrophage signal-regulatory protein alpha xenotransplantation

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Citation distributions and research evaluations:The impossibility of formulating a universal indicator

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Journal of Data and Information Science 2024年第4期9卷 24-48页

作者： Alonso Rodríguez-navarro Department of Biotechnology-Plant Biology Polytechnic University of MadridMadrid 28040Spain

Purpose:To analyze the diversity of citation distributions to publications in different research topics to investigate the accuracy of size-independent,rank-based *** top percentile-based indicators are the most common indicators of this type,and the evaluations of Japan are the most evident ***/methodology/approach:The distributions of citations to publications from countries and journals in several research topics were analyzed along with the corresponding global publications using histograms with logarithmic binning,double rank plots,and normal probability plots of log-transformed numbers of ***:Size-independent,top percentile-based indicators are accurate when the global ranks of local publications fit a power law,but deviations in the least cited papers are frequent in countries and occur in all journals with high impact *** these cases,a single indicator is *** of the proportions of uncited papers are the best way to predict these *** limitations:This study is fundamentally analytical,and its results describe mathematical facts that are *** implications:Respectable institutions,such as the OECD,the European Commission,and the *** Science Board,produce research country rankings and individual evaluations using size-independent percentile indicators that are misleading in many *** misleading evaluations should be discontinued because they can cause confusion among research policymakers and lead to incorrect research ***/value:Studies linking the lower tail of citation distribution,including uncited papers,to percentile research indicators have not been performed *** present results demonstrate that studies of this type are necessary to find reliable procedures for research assessments.

关键词： Scientometrics Research assessment Research indicators Citation distribution Rank analysis

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Disturbance and forest recovery in the Monarch Butterfly Biosphere Reserve,Mexico

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Journal of Forestry Research 2020年第5期31卷 1551-1566页

作者： Jose Lopez-Garcıa Rafael M.navarro-Cerrillo Instituto de Geografıa Universidad Nacional Autonoma de MexicoCiudad UniversitariaC.P.04510 CoyoacanDFMexico Departamento de Ingenierıa Forestal Universidad de CordobaCampus de RabanalesCarretera Nacional IV km 39614014 CordobaSpain

Analysis of the change in forest cover is important to determine stand dynamics and the processes involved in disturbance and *** of the core zone of the Monarch Butterfly Biosphere Reserve were studied using photo interpretation techniques,considering biennial changes between 1999 and 2013 and changes over the whole period of study 1999–*** matrices were elaborated to determine the processes of change involved in both recovery and *** biennial changes for the whole period amounted to 2274 ha;343 ha accounted as degraded in more than one biennial *** total changes in forest cover between 1999 and 2013 involved 4902 ha,out of which,2912 ha were affected by disturbance,and 1990 ha were *** density and 2013 vegetation cover maps,the overall accuracy was 95.6%and 90.2%,*** combining both maps,gradual processes were revealed that were not evident in separate *** methodology is useful for the management and conservation of natural protected areas.

关键词： Illegal logging Forest density change Forest recovery Conifer forests Monarch Butterfly Biosphere Reserve

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Foraging, feeding, and physiological stress responses of wild wood mice to increased illumination and common genet cues

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Current Zoology 2018年第4期64卷 409-417页

作者： Alvaro navarro-CASTILLA Isabel BARJA Mario DíAZ Department of Biology Faculty of Sciences Universidad Autónoma de Madrid C/Darwin 2 Campus Universitario de Cantolanco Madrid 28049 Spain Department of Biogeography and Global Change Museo Nacional de Ciencias Naturales CSIC Madrid 28006 Spain

In nature, animals are exposed to a broad range of threats imposed by predators, which may strongly influence the ecology of prey species directly or indirectly by affecting their behavior via fear of predation. Here, we studied wood mice Apodemus sylvaticus behavioral and physiological responses to simulated predation risk. Risk avoidance was analyzed by live trapping with control traps and traps treated with feces of common genet Genetta genetta （direct cue of risk） under new moon nights and following by simulated full moon conditions （indirect cue）. The time devoted to foraging behavior and capture time were analyzed by video recording mice activity around traps. Food intake was calculated based on the amount of bait remaining in each trap. Fecal cortico- sterone metabolites （FCMs） were measured by enzyme-immunoassay as indicators of physio- logical stress responses. Fewer wood mice were captured during full moon, yet only non-breeding adult males clearly avoided common genet odor. Mice were captured sooner at night during the simulated full moon conditions and later in predator-treated traps. Foraging activity was lower when individuals faced predator＇s feces, but neither food intake nor FCM levels were affected by predation risk cues. Direct and indirect cues of predation risk selectively affected wood mice behavior, although behavioral responses seem to be modulated by different costs-benefit balances related to the individual＇s perception of risk. The lack of physiological responses to predation risk cues suggests that wood mice did not perceive them as reliable stressors or the response was too small or transient to be measured by FCM.

关键词： common genet fecal predator cues feeding foraging moonlight predator avoidance

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A Note on Extreme Points in Dual Spaces

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Acta Mathematica Sinica,English Series 2013年第3期29卷 471-476页

作者： Juan Francisco MENA-JURADO Juan Carlos navarro-PASCUAL Departamento de Análisis Matemático Facultad de Ciencias Universidad de Granada Departamento de lgebra y Análisis Matemático Universidad de Almería

Given a normed space X it can be easily proven that every extreme point in Bx＊, the unit ball of X＊, is the restriction of an extreme point in Bx Our purpose is to study when the restrictions of extreme points in B... 详细信息

关键词： Extreme point Ll-predual M-ideal

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