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Evaluation of Serum Anti-Müllerian Hormone (AMH) Values for 28,016 Bulgarian Women: Prognostic Statistical Model of Age Specific AMH Declining

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Open Journal of Obstetrics and Gynecology 2024年第5期14卷 651-673页

作者： Martin Vladimirov Evan Gatev Desislava Tacheva Aleksandra Kalacheva milena bojilova Serpil Izet Alexander Angelov Nedyalko Kalatchev Iavor K. Vladimirov Sbalagrm-Sofia Sofia Bulgaria Bulgarian Academy of Science Institute of Molecular Biology Sofia Bulgaria Department of Cytology-Histology and Embryology Sofia University &#8220St. Kliment Ohridski&#8221 Sofia Bulgaria Cibalab Boulevard &#8220Akademik Ivan Evstratiev Geshov&#8221 Sofia Bulgaria Synevo Bulgaria Sofia Bulgaria

The present study aims to establish a relationship between serum AMH levels and age in a large group of women living in Bulgaria, as well as to establish reference age-specific AMH levels in women that would serve as an initial estimate of ovarian age. A total of 28,016 women on the territory of the Republic of Bulgaria were tested for serum AMH levels with a median age of 37.0 years (interquartile range 32.0 to 41.0). For women aged 20 - 29 years, the Bulgarian population has relatively high median levels of AMH, similar to women of Asian origin. For women aged 30 - 34 years, our results are comparable to those of women living in Western Europe. For women aged 35 - 39 years, our results are comparable to those of women living in the territory of India and Kenya. For women aged 40 - 44 years, our results were lower than those for women from the Western European and Chinese populations, close to the Indian and higher than Korean and Kenya populations, respectively. Our results for women of Bulgarian origin are also comparable to US Latina women at age 30, 35 and 40 ages. On the base on constructed a statistical model to predicting the decline in AMH levels at different ages, we found non-linear structure of AMH decline for the low AMH 3.5) the dependence of the decline of AMH on age was confirmed as linear. In conclusion, we evaluated the serum level of AMH in Bulgarian women and established age-specific AMH percentile reference values based on a large representative sample. We have developed a prognostic statistical model that can facilitate the application of AMH in clinical practice and the prediction of reproductive capacity and population health.

关键词： Anti-Müllerian Hormone Women Age Ovarian Response Ethnicity Prognostic Statistical Model

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Evaluation of Serum Anti-Müllerian Hormone (AMH) Values for 28,016 Bulgarian Women:Prognostic Statistical Model of Age Specific AMH Declining

引用

Open Journal of Obstetrics and Gynecology（妇产科期刊） 2024年第5期 651页

作者： Martin Vladimirov Evan Gatev Desislava Tacheva Aleksandra Kalacheva milena bojilova Serpil Izet Alexander Angelov Nedyalko Kalatchev Iavor K.Vladimirov

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