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Dynamics along the epithelial-cancer biointerface:Hidden system complexities

BIOCELL 2023年第11期47卷 2321-2334页

作者： IVANA PAJIC-LIJAKOVIC milan milivojevic Faculty of Technology and Metallurgy Department of Chemical EngineeringUniversity of BelgradeBelgradeSerbia

The biointerface dynamics influence any cancer spreading through the epithelium since it is documented in the early stages some malignancies(like epithelial cancer).The altered rearrangement of epithelial cells has an impact on the development of ***,it is necessary to comprehend the underlying biological and physical mechanisms of this biointerface dynamics for early suppression of *** the biological mechanisms include cell signaling and gene expression,the physical mechanisms are several physical parameters such as the epithelial-cancer interfacial tension,epithelial surface tension,and compressive stress accumulated within the *** the segregation of epithelia-cancer co-cultured systems was widely investigated,the role of these physical parameters in cell reorganization is still not fully ***,this review is focused on clarifying the role that some physical parameters have during cell reorganization within the epithelial cell clusters and cancer spread within co-cultured *** have applied the developed biophysical model to point out the inter-relations among physical parameters that influence cell reorganization within epithelial-cancer co-cultured *** main results of this theoretical consideration have been assessed by integrating the biophysical model with biological and bio-mechanical experiments from the available *** epithelial-cancer interfacial tension leads to the reduction of the biointerface area,which leads to an increase in the compressive residual stress within the epithelial clusters depending on the viscoelasticity of the epithelial *** stress impacts epithelial rearrangement and the dynamics along the biointerface by influencing the epithelial surface tension and epithelial-cancer interfacial ***,the interrelation between the epithelial surface tension and epithelial-cancer interfacial tension influences the spread of cancer cells.

关键词： Collective cell migration Cell compressive residual stress Viscoelasticity Epithelial surface tension Epithelial-cancer interfacial tension Supracellular actin network

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Surface activity of cancer cells:The fusion of two cell aggregates

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BIOCELL 2023年第1期47卷 15-25页

作者： IVANA PAJIC-LIJAKOVIC milan milivojevic Faculty of Technology and Metallurgy Belgrade UniversityBelgradeSerbia

A key feature that distinguishes cancer cells from all other cells is their capability to spread throughout the *** how cancer cells collectively migrate by following molecular rules which influence the state of cell-cell adhesion contacts has been comprehensively formulated,the impact of physical interactions on cell spreading remains less *** effects of physical interactions exist as the interplay between various physical parameters such as(1)tissue surface tension,(2)viscoelasticity caused by collective cell migration,and(3)solid stress accumulated in the cell aggregate core *** review aims to point out the role of these physical parameters in cancer cell spreading by considering and comparing the rearrangement of various mono-cultured cancer and epithelial model systems such as the fusion of two cell *** epithelial cells undergo volumetric cell rearrangement driven by the tissue surface tension,which directs cell movement from the surface to the core region of two-aggregate systems,cancer cells rather perform surface cell *** cells migrate toward the surface of the two-aggregate system driven by the solid stress while the surface tension is significantly *** solid stress,accumulated in the core region of the two-aggregate system,is capable of suppressing the movement of epithelial cells that can undergo the jamming state transition;however,this stress enhances the movement of cancer *** have focused here on the multi-scale rheological modeling approaches that aimed at reproducing and understanding these biological systems.

关键词： Collective cell migration Tissue surface tension Surface activity of cancer cells Viscoelasticity Solid stress The state of cell-cell adhesion contacts

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