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Detrimental and synergistic role of epilepsy——Alzheimer’s disease risk factors

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Neural Regeneration Research 2019年第8期14卷 1376-1377页

作者： mikhail A. Filippov Vasily V. Vorobyov International Medical Cluster Skolkovo Moscow Region Russia Institute of Cell Biophysics Russian Academy of Sciences Pushchino Moscow Region Russia

Identification of individuals at risk for developing Alzheimers disease (AD) is an important issue for its pretreatment. Perspective studies predicting the disease are based on the genetic approaches emerging from the nucleotide polymorphism analysis in different loci through the entire genome in AD patients. Considerable diversity of genes located in these regions raise the question of this diversity's peculiar role in the disease development. The mechanisms of AD have been shown to be associated with the gene variation, increased beta-amyloid production and concomitant epileptiform activity/epilepsy in particular (Palop and Mucke, 2009).

关键词： Detrimental synergistic role disease risk factors

Application of aluminum foil for “strain sensing” at fatigue damage evaluation of carbon fiber composite

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Science China(Physics,Mechanics & Astronomy) 2014年第1期57卷 59-64页

作者： PANIN Sergey BURKOV mikhail LYUBUTIN Pavel ALTUKHOV Yurii Laboratory of Polymer Composite Materials Institute of Strength Physics and Material Science 634021 Akademicheskii avenue 2/4Tomsk Russia National Research Tomsk Polytechnic University 634050 Lenina avenue 30 office 127 Tomsk Russia

Surface layer of a loaded solid is an individual structural level of deformation that was shown numerously within concept oI physical mesomechanics. This gives rise to advance in its deformation development under loading as well as allows using this phenomenon to sense the strain induced structure changes. It is of specific importance for composite materials since they are highly heterogeneous while estimating their mechanical state is a topical applied problem. Fatigue tests of carbon fiber compo- site specimens were carried out for cyclic deformation estimation with the use of strain sensors made of thin （80 jam） alumi- num foil glued to the specimen＇s surface. The surface images were captured by DSLR camera mounted onto an optical micro- scope. Strain relief to form during cyclic loading was numerically estimated using different parameters： dispersion, mean square error, universal image quality index, fractal dimension and energy of Fourier spectrum. The results are discussed in view of deformation mismatch in thin foil and bulk specimen and are offered to be applied for the development of Structural Health Monitoring （SHM） approach.

关键词： fatigue carbon fiber composite strain sensor structural health monitoring

Combination of Instrumented Nanoindentation and Scanning Probe Microscopy for Adequate Mechanical Surface Testing

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Journal of Materials Science & Technology 2009年第1期25卷 63-68页

作者： Enrico Tam mikhail Petrzhik Dmitry Shtansky Marie-Paule Delplancke-Ogletree Université Libre de Bruxelles Moscow State Institute of Steel and Alloys

The elastic indentation modulus and hardness of standard bulk materials and advanced thin films were determined by using the nanoindentation technique followed by the Oliver- Pharr post-treatment. After measurements with different loading/unloading schemes on chemically polished bulk titanium a substantial decrease of both modulus and hardness vs an increasing loading time was found. Then, hard nanostructured TiBN and TiCrBN thin films deposited by magnetron sputtering （using multiphase targets） on substrates of high roughness （sintered hard metal） and low roughness （silicon） were studied. Experimental modulus and hardness characterized by using two different nanoindenter tools were within the limits of standard deviation. However, a strong effect of roughness on the spread of the experimental values was observed and it was found that hardness and elastic indentation modulus obeyed a Gaussian distribution. The experimental data were discussed together with scanning probe microscopy （SPM） images of typical imprints taken after the nanoindentation tests and the local topographyls strong correlation with the results of nanoindentation was described.

关键词： Nanoindentation Thin films Coatings Scanning probe microscopy

Shift to a low carbon society through energy systems design

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Science China(Technological Sciences) 2010年第1期53卷 134-143页

作者： Toshihiko NAKATA mikhail RODIONOV Diego SILVA Joni JUPESTA Department of Management Science and Technology Graduate School of EngineeringTohoku UniversityAoba-yama 6-6-11-815Sendai 980-8579Japan

Concern about global warming calls for an advanced approach for designing an energy system to reduce carbon emissions as well as to secure energy security for each *** energy systems tend to introduce different technologies with high conversion efficiency,leading to a higher average *** energy systems can be achieved not by an aggregate form of conversion technologies but by an innovative system design *** concept of LCS(low carbon society) is a unique approach having multi-dimensional considerations such as social,economic and environmental *** LCS aims at an extensive restructuring of worldwide energy supply/demand network system by not only replacing the conventional parts with the new ones,but also integrating all the necessary components and designing absolutely different energy *** a core tool for the LCS design,energy-economic models are applied to show feasible solutions in future with alternatives such as renewable resources,combined heat and power,and smart grid *** can introduce changes in energy markets,technology learning in capacity,and penetration of innovative technologies,leading to an optimum system configuration under priority *** paper describes recent trials of energy models application related to waste-to-energy,clean coal,transportation and rural *** the modelling approach is still under investigation,the output clearly shows possible options having variety of technologies and linkages between supply and demand *** of the LCS means an energy systems design with the modelling approach,which gives solution for complex systems,choices among technologies,technology feasibility,R&D targets,and what we need to start.

关键词： low carbon society(LCS) energy systems systems approach clean energy technologies energy models

Magnetic nanoparticles and concentrated magnetic nanofluids:Synthesis,properties and some applications

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China Particuology 2007年第1期5卷 43-49页

作者： Ladislau Vks Doina Bica mikhail V. Avdeev Lab Magnetic Fluids CFATR Romanian Academy-Timisoara Division Timisoara Romania National Center for Engineering of Systems with Complex Fluids Univ. Politehnica Timisoara Timisoara Romania Lab Magnetic Fluids CFATR Romanian Academy-Timisoara Division Timisoara Romania Frank Laboratory of Neutron Physics Joint Institute for Nuclear Research Dubna Russia

This paper reviews some recent results concerning chemical synthesis of magnetic nanoparticles and preparation of various types of magnetic nanofluids. Structural properties and behaviour in external magnetic field of magnetic nanofluids will be emphasized with relation to their use in leakage-free rotating seals and in biomedical applications.

关键词： Magnetic nanoparticle Magnetic nanofluid Rotating seal Biomedical application Chemical co-precipitation Structural characterization

Electrically tunable third-harmonic generation using intersubband polaritonic metasurfaces

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Light(Science & Applications) 2024年第8期13卷 1666-1674页

作者： Seongjin Park Jaeyeon Yu Gerhard Boehm mikhail A.Belkin Jongwon Lee Department of Electrical Engineering Ulsan National Institute of Science and Technology(UNIST)UlsanRepublic of Korea Walter Schottky Institute Technical University of MunichGarchingGermany

Nonlinear intersubband polaritonic metasurfaces,which integrate giant nonlinear responses derived from intersubband transitions of multiple quantum wells(MQWs)with plasmonic nanoresonators,not only facilitate efficient frequency conversion at pump intensities on the order of few tens of kW cm^(-2)but also enable electrical modulation of nonlinear responses at the individual meta-atom level and dynamic beam *** electrical modulation characteristics of the magnitude and phase of the nonlinear optical response are realized through Stark tuning of the resonant intersubband *** this study,we report,for the first time,experimental implementations of electrical modulation characteristics of mid-infrared third-harmonic generation(THG)using an intersubband polaritonic metasurface based on MQW with electrically tunable third-order nonlinear ***,we achieved a 450%modulation depth of the THG signal,86%suppression of zero-order THG diffraction tuning based on local phase tuning exceeding 180 degrees,and THG beam steering using phase *** work proposes a new route for electrically tunable flat nonlinear optical elements with versatile functionalities.

关键词： tunable tuning pump

High-sensitivity infrared vibrational nanospectroscopy in water

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Light(Science & Applications) 2017年第1期6卷 330-334页

作者： Mingzhou Jin Feng Lu mikhail A Belkin Department of Electrical and Computer Engineering Microelectronics Research CenterThe University of Texas at Austin10100 Burnet RoadAustinTX 78758USA

Mid-infrared vibrational spectroscopy is a universal label-free tool for identifying molecular compounds in chemical and biological samples on the basis of their‘fingerprint’vibrational absorption *** spectroscopy with nanometer spatial resolution can reveal the chemical composition of samples at the nanoscale,and several scanning-probe techniques have been developed to address this need1–*** is also highly desirable to study biological and chemical samples in their native aqueous environments rather than in *** aqueous environments,however,the sensitivity of the current vibrational nanospectroscopy techniques deteriorates dramatically7,***,we report the first mid-infrared nanospectroscopy technique that retains nanoscale sensitivity and spatial resolution when the sample and the scanning probe are completely immersed in *** method overcomes challenges including water absorption and scattering and the mechanical damping of cantilever *** further demonstrate spectroscopy and imaging of 20-to 50-nmthick polymer samples with a 25-nm spatial resolution in the biologically relevant Amide I and II spectral regions.

关键词： vibrational spectroscopy absorption

Optimization of Artificial Viscosity in Production Codes Based on Gaussian Regression Surrogate Models

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Communications on Applied Mathematics and Computation 2024年第3期6卷 1521-1550页

作者： Vitaliy Gyrya Evan Lieberman Mark Kenamond mikhail Shashkov Applied Mathematics and Plasma Physics Theoretical DivisionMail Stop B284Los Alamos National LaboratoryLos AlamosNM 87545USA Continuum Models and Numerical Methods Group X-Computational Physics DivisionMail Stop F644Los Alamos National LaboratoryLos AlamosNM 87545USA Lagrangian Codes Group X-Computational Physics DivisionMail Stop T086Los Alamos National LaboratoryLos AlamosNM 87545USA

To accurately model flows with shock waves using staggered-grid Lagrangian hydrodynamics, the artificial viscosity has to be introduced to convert kinetic energy into internal energy, thereby increasing the entropy across shocks. Determining the appropriate strength of the artificial viscosity is an art and strongly depends on the particular problem and experience of the researcher. The objective of this study is to pose the problem of finding the appropriate strength of the artificial viscosity as an optimization problem and solve this problem using machine learning (ML) tools, specifically using surrogate models based on Gaussian Process regression (GPR) and Bayesian analysis. We describe the optimization method and discuss various practical details of its implementation. The shock-containing problems for which we apply this method all have been implemented in the LANL code FLAG (Burton in Connectivity structures and differencing techniques for staggered-grid free-Lagrange hydrodynamics, Tech. Rep. UCRL-JC-110555, Lawrence Livermore National Laboratory, Livermore, CA, 1992, 1992, in Consistent finite-volume discretization of hydrodynamic conservation laws for unstructured grids, Tech. Rep. CRL-JC-118788, Lawrence Livermore National Laboratory, Livermore, CA, 1992, 1994, Multidimensional discretization of conservation laws for unstructured polyhedral grids, Tech. Rep. UCRL-JC-118306, Lawrence Livermore National Laboratory, Livermore, CA, 1992, 1994, in FLAG, a multi-dimensional, multiple mesh, adaptive free-Lagrange, hydrodynamics code. In: NECDC, 1992). First, we apply ML to find optimal values to isolated shock problems of different strengths. Second, we apply ML to optimize the viscosity for a one-dimensional (1D) propagating detonation problem based on Zel’dovich-von Neumann-Doring (ZND) (Fickett and Davis in Detonation: theory and experiment. Dover books on physics. Dover Publications, Mineola, 2000) detonation theory using a reactive burn model. We compare re

关键词： Optimization Artificial viscosity Gaussian regression surrigate model

Dielectric tunability of magnetic properties in orthorhombic ferromagnetic monolayer CrSBr

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npj Computational Materials 2023年第1期9卷 1514-1523页

作者： Alexander N.Rudenko Malte Rösner mikhail I.Katsnelson Radboud University Institute for Molecules and MaterialsHeijendaalseweg 1356525AJ NijmegenThe Netherlands

Monolayer CrSBr is a recently discovered semiconducting spin-3/2 ferromagnet with a Curie temperature of around 146 *** contrast to many other known 2D magnets,the orthorhombic lattice of CrSBr gives rise to spatial anisotropy of magnetic excitations within the 2D *** magnetic anisotropy and considerable magnetic dipolar interactions in CrSBr challenge its theoretical description in terms of spin ***,we employ a Green’s function formalism combined with first-principles calculations to study the magnetic properties of monolayer CrSBr in different regimes of surrounding dielectric *** the free-standing limit,the system is close to an easy-plane magnet,whose long-range ordering is partially *** the contrary,in the regime of large external screening,monolayer CrSBr behaves like an easy-axis ferromagnet with more stable magnetic *** findings suggest that anisotropic layered magnets form a potentially promising platform for studying the effects of substrate screening on magnetic ordering in 2D.

关键词： monolayer orthorhombic anisotropy