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Bioactive fibrous scaffolds with programmable release of polypeptides regulate inflammation and extracellular matrix remodeling

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Regenerative Biomaterials 2023年第1期10卷 522-532页

作者： Zehong Xiang Xinghua Guan Zhifang Ma Qiang Shi mikhail panteleev Fazly I.Ataullakhanov State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchunJilin 130022China University of Science and Technology of China HefeiAnhui 230026China Key Laboratory of Polymeric Materials Design and Synthesis for Biomedical Function Soochow UniversitySuzhou 215123China Dmitry Rogachev National Research Center of Pediatric Hematology Oncology and ImmunologyMoscow 117198Russia Faculty of Physics Lomonosov Moscow State UniversityMoscow 119991Russia

Inflammation manipulation and extracellular matrix(ECM)remodeling for healthy tissue regeneration are critical requirements for tissue engineering *** this end,the bioactive polycaprolactone(PCL)-based scaffolds are fabricated to release aprotinin and thymosinβ4(Tβ4)in a programmable *** core part of the fiber is composed of hyaluronic acid and Tβ4,and the shell is PCL,which is further coated with heparin/gelatin/aprotinin to enhance *** in vitro assay demonstrates that the controlled release of aprotinin prevents initial excessive *** subsequent release of Tβ4 after 3 days induces the transition of macrophages from M1 into M2 *** manipulation of inflammatory response further controls the expression of transforming growth factor-βand fibroblast activation,which oversee the quantity and quality of ECM *** addition,the gradual degradation of the scaffold allows cells to proliferate within the *** vivo implant evaluation convinces that PCL-based scaffolds possess the high capability to control the inflammatory response and restore the ECM to normal ***,our work paves a new way to develop tissue engineering scaffolds for inflammation manipulation and ECM remodeling with peptide-mediated reactions.

关键词： bioactive scaffolds inflammation control extracellular matrix remodeling polypeptide release electrospinning

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An application of space-filling curves to improve results of turbulent aerodynamics modeling with convolutional neural networks

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Chinese Journal of Aeronautics 2024年第2期37卷 81-92页

作者： mikhail PETROV Sofia ZIMINA Moscow Institute of Physics&Technology Dolgoprudny 141701Russia

When carrying out calculations for turbulent flow simulation,one inevitably has to face the choice between accuracy and speed of *** order to simultaneously obtain both a computationally efficient and more accurate model,a surrogate model can be built on the basis of some fast special model and knowledge of previous calculations obtained by more accurate base models from various test bases or some results of serial *** objective of this work is to construct a surrogate model which allows to improve the accuracy of turbulent calculations obtained by a special model on unstructured *** this purpose,we use 1D Convolutional Neural Network(CNN)of the encoder-decoder architecture and reduce the problem to a single dimension by applying space-filling *** an approach would have the benefit of being applicable to solutions obtained on unstructured *** this work,a non-local approach is applied where entire flow fields obtained by the special and base models are used as input and ground truth output ***-Allmaras(SA)model and Near-wall Domain Decomposition(NDD)method for SA are taken as the base and special models *** efficiency and accuracy of the obtained surrogate model are demonstrated in a case of supersonic flow over a compression corner with different values for angleαand Reynolds number *** conducted an investigation into interpolation and extrapolation by Re and also into interpolation byα.

关键词： Space-filling curves Convolutional neural network Domain decomposition Turbulent flows Unstructured mesh

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Medicine has always been "Modern" and "Scientific" from ancient times to the present day

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Journal of Integrative Medicine 2019年第4期17卷 229-237页

作者： mikhail Teppone Bionion Sdn Bhd 1 Jalan Sungai Jeluh Bhmed INC PTE.LTD.

Throughout human history, doctors and healers have gathered and refined the knowledge inherited from the previous generations. Different methods of effective therapy have been designed during various historical periods;when each was developed, it was considered "modern scientific medicine" for their time. Mankind has gone through natural and social disasters and survived;hence, history has proved there was no time when medical knowledge was eironeous or ineffective. Classic medicine has grown to be divided into narrow, specialized branches, causing it to lose its holistic approach and general view on health, sickness and therapeutic methods. Many of traditional medicine's effective methods have been forgotten and removed from the mainstream medicine. It would be good for modern medical education to incorporate the general knowledge of historically effective therapeutic modalities and study practical cases. Medical students should be taught how to choose a "good method" or "good medicine" independent of when that method or remedy was discovered. However, he has to keep in mind the primary goal of medicine:"I will use treatment to help the sick according to my ability and judgment..."(from Hippocratic Oath).

关键词： Integrative medicine Alternative medicine Traditional Chinese medicine Homeopathy Cellular therapy

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From Dyakonov-Cherenkov radiation to Dyakonov surface optics

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Light(Science & Applications) 2022年第4期11卷 453-454页

作者： mikhail Dyakonov University of Montpellier MontpellierFrance

Cherenkov radiation by swift charged particles in a dielectric medium has been used for a long time as an effective means for particle detection and measurements of their *** a team led by *** Luo from Singapore considers a situation when the particle emits surface electromagnetic waves at the interface between an isotropic and a uniaxial-birefringent medium(Dyakonov surface waves6).The resulting Dyakonov-Cherenkov radiation is shown to be highly sensitive to both the value and the direction of the particle *** particular,it is shown that close to the Cherenkov threshold,the radiation intensity can be several orders of magnitude greater than that in traditional Qierenkov *** new features allow to determine simultaneously the magnitude and direction of particle velocities on a compact platform(Fig.1).

关键词： optics particle surface

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Fritz Ackermann:a true and unequalled friend

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Geo-Spatial Information Science 2023年第2期26卷 151-152页

作者： Ed mikhail Professor Emeritus&Former Head Geomatics Engineering Purdue UniversityWest LafayetteINUSA

I am certain that several other contributors to this memorial volume have expounded on the many attributes,both professional and personal,of Professor Fritz *** is unquestionable that he was a giant in our field,on whose shoulders current and future practitioners shall stand in order to keep the wheels of progress and advancement moving forward.

关键词： moving Fritz Ackermann

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Self-propelled automatic chassis of Lunokhod-1： History of creation in episodes

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Frontiers of Mechanical Engineering 2016年第1期11卷 60-86页

作者： mikhail MALENKOV Science and Technology Center 'ROCAD' CJSC PolytechnicalUniversity Saint-Petersburg Russia

This report reviews the most important episodes in the history of designing the self-propelled automatic chassis of the first mobile extraterrestrial vehicle in the world, Lunokhod-1. The review considers the issues in designing moon rovers, their essential features, and the particular construction properties of their systems, mechanisms, units, and assemblies. It presents the results of exploiting the chassis of Lunokhod-1 and Lunokhod-2. Analysis of the approaches utilized and engineering solutions reveals their value as well as the consequences of certain defects.

关键词： moon rover self-propelled chassis propulsion wheel suspension soil properties cross-country ability

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Pre-processing for time domain image formation in SS-BSAR system

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Journal of Systems Engineering and Electronics 2012年第6期23卷 875-880页

作者： Michail Antoniou mikhail Cherniakov School of Electronic Electrical and Computer EngineeringUniversity of BirminghamBirmingham B15 2TTUK

A pre-processing procedure is designed for a space-surface bistatic synthetic aperture radar （SS-BSAR） system when a time domain image formation algorithm is employed. Three crucial technical issues relating to the procedure are fully discussed. Firstly, unlike image formation algorithms operating in the frequency domain, a time domain algorithm requires the accurate global navigation satellite system （GNSS） time and position. This paper proposes acquisition of this information using a time-and-spatial transfer with precise ephemeris and interpolation. Secondly, synchronization errors and compensation methods in SS-BSAR are analyzed. Finally, taking the non-ideal factors in the echo and the compatibility of image formation algorithms into account, a matched filter based on the minimum delay is constructed. Experimental result using real data suggest the pre-processing is functioning properly.

关键词： image formation space-surface bistatic syntheticaperture radar (SS-BSAR) global navigation satellite system(GNSS) synchronization range compression.

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The current status and future development of high-temperature conventional superconductivity

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National Science Review 2024年第7期11卷 18-20页

作者： mikhail I.Eremets High Pressure Chemistry and Physics Group Max-Planck-Institut für Chemie

This survey highlights key advancements in high-temperature superconductivity in hydrogen-rich materials, emphasizing the robust evidence and reproducibility of superconductivity under challenging experimental conditions of megabar pressures. In the near future, achieving room-temperature superconductivity is highly probable, and the field is expected to transition towards near-ambient-pressure superconductivity.

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Numerical simulation of roof cavings in several Kuzbass mines using finite-difference continuum damage mechanics approach

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International Journal of Mining Science and Technology 2020年第2期30卷 157-166页

作者： mikhail Eremin Gabriel Esterhuizen Igor Smolin Institute of Strength Physics and Materials Science Siberian BranchRussian Academy of SciencesTomsk 634055Russian Federation National Institute for Occupational Safety and Health PittsburghPA 15236USA National Research Tomsk State University Tomsk 634050Russian Federation

An essential stage of mine design is an estimation of the steps of the first and periodic roof caving in longwall ***,this is carried out using the field experience and can be much enhanced by numerical *** this work,the finite-difference method was applied coupled with the continuum damage mechanics(CDM)approach to simulate the stress-strain evolution of the rock mass with the underground opening during coal *** steps and stages of roof caving were estimated relying on the numerical simulation data,and they were compared with the field data from several operating mines in the south of the Kuznetsk Basin,*** dependence of the first roof caving step in simulation linearly correlates with field *** results correspond to the actual roofs of longwall panels of the flat-dipping coal seams and the average rate of face advancement is approximately 5 m/day.

关键词： Longwall mining Rock mass Underground openings Roof caving Abutment pressure Numerical simulation

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Ammoniteand bivalve-based biostratigraphy and Panboreal correlation of the Volgian Stage

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Science China Earth Sciences 2009年第12期52卷 1890-1909页

作者： ROGOV mikhail ZAKHAROV Victor Geological Institute of RAS Pyzhevski lane 7 Moscow 119017 Russia

The current ammonite- and buchiid-based biostratigraphical successions of the Volgian Stage are outlined, with an analysis of the most important data that support correlation throughout the Panboreal Superrealm. Updated ammonite zonal schemes were proposed for the Volgian of the type region (the Russian Platform) and Svalbard. The lower Volgian successions in all areas except the Russian Platform, with its eudemic virgatitid lineage and Submediterranean faunal elements, were dominated by Pectinatites and Eosphinctoceras-Subdichotomoceras. The last two genera were especially common eastwards from the Ural Mountains. During the middle Volgian, provincialism developed quickly within the ammonites, and unified assemblages with early Palvovia and Dorsoplanites at the base of the substage were replaced by numerous local eudemic faunas. Despite this, migrations of species of Crendonites, Laugeites, Epivirgatites Epipallasiceras, Epilaugeites, and Taimyrosphinctes occurred at regular intervals and these enable precise correlations between the faunal sub-provinces. The zonation of the upper Volgian is mainly based upon the succession of Craspedites (on Subcraspedites in England and North Sea), and can be traced throughout the Arctic. Zonation based on the bivalve Buchia enables correlations to be made between the successions over much of the Northern Hemisphere, including Northern California, British Columbia, Arctic areas, and the Russian Platform. Each substage of the Volgian is characterized by buchiids with different types of the ontogenetic development. Research on the infrazonal subdivision of the Volgian Stage based on buchiids is currently in progress. Our analyses of the ammonite and buchiid successions of the Panboreal Superrealm lead us to conclude that there are no major faunal gaps in Volgian successions of the Russian Platform and Northern Siberia.

关键词： Volgian Portlandian Panboreal Superrealm ammonites buchiids correlation.

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