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Changes in hepatic fibrosis and incidence of HCC following direct-acting antiviral treatment of F3 chronic hepatitis c patients:a prospective observational study

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Hepatoma Research 2022年第1期8卷 340-351页

作者： Gamal Shiha Reham Soliman Ayman AHassan Nabiel N.H.mikhail Egyptian Liver Research Institute and Hospital(ELRIAH) SherbinMansoura 35111Egypt Hepatology and Gastroenterology Unit Internal Medicine DepartmentFaculty of MedicineMansoura UniversityMansoura 35516Egypt Tropical Medicine Department Faculty of MedicinePort Said UniversityPort Said 42526Egypt Biostatistics and Cancer Epidemiology Department South Egypt Cancer InstituteAssiut UniversityAssiut 71515Egypt

Aim:Studies of clinical outcomes in chronic hepatitis C(CHC)patients with pretreatment advanced liver fibrosis(F3)after sustained virologic response(SVR)are scarce,and most studies are of small cohorts and retrospective in *** aim was to assess the clinical outcomes following direct acting antiviral(DAA)treatment among hepatitis C F3 patients after ***:This study included 1517 chronic hepatitis C patients with F3 fibrosis receiving DAAs in the out-patient clinics at the Egyptian Liver Research Institute and Hospital(ELRIAH).We included patients 18 years or older with HCV who received DAAs,have F3 by transient elastography,and have no history of hepatocellular carcinoma(HCC).Patients were followed up every six months after end of treatment using ultrasonography and ***:Significant improvement of fibrosis occurred with decreases in LSM,FIB-4,APRI,and *** changes in LSM were categorized depending on delta LSM,873 patients(57.5%)showed regression,454(29.9%)were stable,and 190 patients(12.5%)showed progression of ***,33 cases developed HCC during follow-up with incidence rate of 0.915/100 py(95%CI:0.64-1.27).Incidence was high with progression of liver fibrosis(6.17/100 py)compared to patients with stable fibrosis(1.09/100 py)and regression of liver fibrosis(0.75/100 py).There were no significant differences as regards fibrosis indicators at baseline(LSM,FIB-4,APRI,and FIB-6)between those who developed HCC and those who did ***:CHC Patients with F3 fibrosis showed a high rate of regression of fibrosis and decreased HCC incidence after achieving SVR following DAAs.

关键词： HCC fibrosis changes F3 DAAs

Micro-arc oxidation of magnesium alloys:A review

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Journal of Materials Science & Technology 2022年第23期118卷 167-189页

作者： Wenhui Yao Liang Wu Jingfeng Wang Bin Jiang Dingfei Zhang Maria Serdechnova Tatsiana Shulha Carsten Blawert mikhail L.Zheludkevich Fusheng Pan College of Materials Science and Engineering Chongqing UniversityChongqing 400044China National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China Institute of Surface Science Helmholtz-Zentrum HereonMax-Planck Str.1Geesthacht 21502Germany Institute of Materials Science Faculty of EngineeringCAU Kiel UniversityKaiser Str.2Kiel 24143Germany

Magnesium(Mg)and its alloys present great potential to be extensively applied in different ***,the relatively poor resistance to corrosion and wear significantly restricts their applications in *** one of strategies of surface treatment,micro-arc oxidation(MAO)process attracts a lot of attention,since it does not use neither expensive equipment,nor complicated *** review systematically discusses MAO mechanism and some typical models,which still need to be further developed to provide a better understanding and guide for future ***,main influencing factors of MAO process are analyzed in ***,some popular applications of MAO coatings are respectively reviewed,including biomedical application,decoration,thermal control,corrosion and wear resistance,and industrial applications in *** existing issues and future perspectives are finally discussed to further accelerate extensive applications of Mg alloys.

关键词： Micro-arc oxidation Magnesium alloys Review Main MAO applications Existing issues and future perspective

Towards electrochemical hydrogen storage in liquid organic hydrogen carriers via proton-coupled electron transfers

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Journal of Energy Chemistry 2022年第10期31卷 292-300,I0007页

作者： Hamid Ghorbani Shiraz mikhail Vagin Tero-Petri Ruoko Viktor Gueskine Krzysztof Karon Mieczystaw tapkowski Tobias Abrahamsson Thomas Ederth Magnus Berggren Xavier Crispin Laboratory of Organic Electronics Department of Science and Technology(ITN)Linkoping UniversitySE-60174 NorrkopingSweden Smart Photonic Materials Facuty of Engineering and Natural SciencesTampere UniversiyPBox 541.Tampere Fl-33101Finland Silesian University of Technology.Faculty of Chemistry Deparment of Physical Chemistry and Technology of PolymersM.Strzody 9.44-100 GliwicePoland dDepartment of Physics Chemistry and Biology(IFM)Linkoping UniversiySE-58183 LinkopingSweden

Green hydrogen is identified as one of the prime clean energy carriers due to its high energy density and a zero emission of CO_(2).A possible solution for the transport of H_(2)in a safe and low-cost way is in the form of liquid organic hydrogen carriers(LOHCs).As an alternative to loading LOHC with H_(2)via a two-step procedure involving preliminary electrolytic production of H_(2)and subsequent chemical hydrogenation of the LOHC,we explore here the possibility of electrochemical hydrogen storage(EHS)via conversion of proton of a proton donor into a hydrogen atom involved in covalent bonds with the LOHC(R)via a protoncoupled electron transfer(PCET)reaction:2nH^(+)+2ne^(-)+Rox■n H_(2)^(0)*** chose 9-fluorenone/fluorenol(Fnone/Fnol)conversion as such a model PCET *** electrochemical activation of Fnone via two sequential electron transfers was monitored with in-situ and operando spectroscopies in absence and in presence of different alcohols as proton donors of different reactivity,which enabled us to both quantify and get the mechanistic insight on *** possibility of hydrogen extraction from the loaded carrier molecule was illustrated by chemical activation.

关键词： Proton-coupled electron transfer Electrochemical hydrogen storage Hydrogen bonding agent Anion-radical Comproportionation

Flash Lamps as Ignition and Initiation Sources of the VS-2 Pyrotechnic Composition

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含能材料 2022年第4期30卷 370-378页

作者： Sergey I.Gerasimov mikhail A.Ilyushin Sergey M.Putis Sergey A.Dushenok Irina V.Shugalei Andrey M.Sudarikov Russian Federal Nuclear Center‑All‑Russian Research Institute of Experimental Physics SarovRussia Sarov Institute of Physics and Technology is a Branch of the Scientific Research Nuclear University MEPhI SarovRussia Nizhny Novgorod State Technical University Named after R.E.Alekseev Nizhny NovgorodRussia RAS Institute for Studying Problems in Mechanical Engineering ‑is a Branch of the RAS Applied Physics InstituteNizhny NovgorodRussia "Technologist"Special Design and Technological Bureau St.PetersburgRussia Saint‑Petersburg State Institute of Technology(Technical University) St.PetersburgRussia Russian State Hydro‑meteorological University St.PetersburgRussia

In the present work it is found that the pyrotechnic composition VS⁃2 can be initiated with flash lamps IFC⁃500 and ***⁃2 pyrotechnic composition contains 90%of mercury(Ⅱ)5⁃hydrazinotetrazolate perchlorate and 10%of optically trans⁃parent copolymer of 2⁃methyl⁃5⁃vinyltetrazole and methacrylic acid(PVMT).We have found that the flash lamps make it possi⁃ble to initiate combustion of VS⁃2 composition with its transition to detonation both in cylindrical charges placed in brass caps of 5 mm diameter and 2 mm high,and film charges with 10 mm×80 mm in size and surface weights of 60 mg·cm^(-2)and 90 mg·cm^(-2),showing ignition delay times 10μs and 3μs,*** also measured detonation velocities for VS⁃2 composition film charges,which were 4375-4505 m·s^(-1)(of the charge being surface mass 60 mg·cm^(-2))and 4221-4281 m·s^(-1)(of the charge be⁃ing surface mass 90 mg·cm^(-2))and their blasting action on the aluminum *** depths of the normal shock wave imprints at the charge⁃barrier interface were 0.6-0.7 mm(for surface mass of the film charges 60 mg·cm^(-2))and 1.2-1.3 mm(for surface mass of the film charges 90 mg·cm^(-2))

关键词： VS⁃2 pyrotechnic composition flash lamps ignition transition of combustion to detonation blasting action

Micro-alloyed Mg-Ca:Corrosion susceptibility to heating history and a plain problem-solving approach

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Journal of Magnesium and Alloys 2023年第4期11卷 1193-1205页

作者： Min Deng Linqian Wang Darya Snihirova Jan Bohlen Gerrit Kurz Sviatlana V.Lamaka Daniel Höche mikhail L.Zheludkevich Institute of Surface Science Helmholtz-Zentrum HereonMax-Planck Str.1Geesthacht 21502Germany Institute of Material and Process Design Helmholtz-Zentrum HereonGeesthacht 21502Germany Institute of Materials Science Faculty of EngineeringKiel UniversityKiel 24143Germany

The exceptionally low corrosion rate(∼0.1 mm y^(–1)in concentrated NaCl solution for 7 days)enables lean Mg-Ca alloys great potential for diverse applications,particularly if relevant properties(*** strength,electrochemical performance,etc.)can be enhanced by thermomechanical ***,herein it is demonstrated that the corrosion performance of lean Mg-Ca is susceptible to the heating *** corrosion rate of Mg-0.15 wt%Ca alloy is remarkably accelerated after annealing even for a short time(4 h at 400℃)because Fe precipitation readily takes ***,it is found that micro-alloying with dedicated additional elements is able to solve this ***,the problem-solving capability is dependent on the element category,particularly the ability of the alloying element to constrain the Fe *** the three studied elements(***,Ge and In),only In shows good competence of restricting the formation of Fe-containing precipitates,thereby contributing to retention of the superior corrosion resistance after annealing even at a rigorous condition(24 h at 450℃).The finding creates good foundation for follow-up work of developing lean Mg-Ca-based alloys combining high corrosion resistance,superior electrochemical performance with excellent mechanical properties for applications as biodegradable implants and anode materials for aqueous batteries.

关键词： Magnesium Micro-alloying Thermomechanical processing Corrosion Impurity

Biodegradation behaviour of Fe-based alloys in Hanks’Balanced Salt Solutions:Part *** evolution of local pH and dissolved oxygen concentration at metal interface

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Bioactive Materials 2022年第1期7卷 412-425页

作者： Cheng Wang Christabelle Tonna Di Mei Joseph Buhagiar mikhail L.Zheludkevich Sviatlana V.Lamaka Institute of Surface Science Helmholtz-Zentrum HereonGeesthacht21502Germany Department of Metallurgy and Materials Engineering University of MaltaMsidaMalta School of Materials Science and Engineering&Henan Key Laboratory of Advanced Magnesium Alloy Zhengzhou UniversityZhengzhou450001PR China Institute for Materials Science Faculty of EngineeringKiel UniversityKiel24103Germany

Commercially pure Fe,Fe35Mn,and(Fe35Mn)5Ag alloys were prepared by uniaxial pressing of the mixture of individual powders,followed by *** influence of the alloying elements Mn and Ag on the corrosion behaviour of these Fe-based alloys was investigated in Hanks’Balanced Salt Solution(HBSS).Furthermore,the role of the components in HBSS,particularly Ca^(2+)ions during alloys degradation was *** of local pH and dissolved oxygen concentration was measured 50μm above the interface of the degrading *** results revealed that 5 wt%Ag addition to Fe35Mn alloy triggered micro-galvanic corrosion,while uniform corrosion dominated in pure Fe and *** precipitation of Ca-P-containing products on the surface of these Fe-based alloys buffered local pH at the metal interface,and blocked oxygen diffusion at the initial stages of *** the(Fe35Mn)5Ag,the detachment or structural changes of Ca-P-containing products gradually diminished their barrier *** findings provided valuable insights into the degradation mechanism of promising biodegradable Fe-based alloys.

关键词： Local pH Dissolved oxygen Fe alloys Biodegradable metals Powder metallurgy

Biodegradation behaviour of Fe-based alloys in Hanks’Balanced Salt Solutions:Part *** characterisation and corrosion testing

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Bioactive Materials 2022年第1期7卷 426-440页

作者： Christabelle Tonna Cheng Wang Di Mei Sviatlana V.Lamaka mikhail L.Zheludkevich Joseph Buhagiar Department of Metallurgy and Materials Engineering University of MaltaMsidaMalta Institute of Surface Science Helmholtz-Zentrum HereonGeesthacht21502Germany School of Materials Science and Engineering&Henan Key Laboratory of Advanced Magnesium Alloy Zhengzhou UniversityZhengzhou450001PR China Institute for Materials Science Faculty of EngineeringKiel UniversityKiel24103Germany

Research on Fe-based biodegradable alloys for implant applications has increased considerably over the past ***,there is limited information on the influence of testing electrolytes on corrosion product formation and general corrosion *** this work,the effect of Hanks’Balanced Salt Solution(HBSS)with or without Ca^(2+)on the corrosion of Fe,Fe35Mn and(Fe35Mn)5Ag powder-processed coupons has been studied using potentiodynamic polarisation,Electrochemical Impedance Spectroscopy(EIS),and preliminary localised measurement of pH and dissolved oxygen concentration in close proximity to the metal *** Fe35Mn and(Fe35Mn)5Ag alloys showed accelerated corrosion when compared to pure Fe based on potentiodynamic testing results,with FeMnAg exhibiting the highest corrosion rate in Ca^(2+)-containing *** results indicate that in Ca^(2+)-containing HBSS,the formation of a partially protective Ca/P layer decelerates the corrosion progress,whereas the Fe-and Mn-phosphates formed in Ca^(2+)-free HBSS do not have the same *** Ca/P layer on(Fe35Mn)5Ag experienced a reduction in resistance following several hours of testing,indicating partial loss of its protective effect.

关键词： Fe alloys Biodegradable metals Powder metallurgy Electrochemical impedance spectroscopy Local pH Local DO

Deep-water cirripedes colonizing dead shells of the cephalopod Nautilus macromphalus from New Caledonian waters

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Integrative Zoology 2019年第6期14卷 561-575页

作者： John BUCKERIDGE TomášKOČÍ Ján SCHLÖGL Adam TOMAŠovÝCH Martina KOČovÁVESELSKÁ Earth&Oceanic Systems Group RMIT UniversityMelbourneVictoriaAustralia Ivančická581 PragueCzech Republic and Palaeontological DepartmentNatural History MuseumNational MuseumPragueCzech Republic Department of Geology and Paleontology Comenius University in BratislavaBratislavaSlovakia Institute of Earth Sciences Slovak Academy of SciencesBratislavaSlovakia Department of Paleobiology and Paleoecology Institute of Geology of the Czech Academy of SciencesPragueCzech Republic Museums Victoria MelbourneVictoriaAustralia Faculty of Science Charles University in PraguePragueCzech Republic

Fossil cephalopods are frequently encrusted by epibionts;however,determining whether encrustation occurred prior to or post-mortem to the host,and whether the final environment of deposition corresponds to the habitat of encrustation is *** present paper describes cirripede epibionts,their calcareous bases and their attachment scars on 6 post-mortem shells of Nautilus macromphalus,collected from deep water off New Cale*** cirripedes have left both cemented calcareous bases of Hexelasma and scars associated with bioerosion and discoloration produced by verrucomorph *** cirripedes included a Metaverruca recta,with articulated opercular plates and organic tissue(on a shell that had been exposed on the sea floor for at least 150 years),and specimens of Hexelasma velutinum,one of which was partly attached to an internal surface of a *** disposition of verrucomorphs indicates that most Nautilus shells were colonized post-mortem rather than during a floating ***,as cirripedes are known to have colonized living Nautilus,some Hexelasma,preserved only as calcareous eroded bases,may represent specimens that settled on a living *** degree of bioerosion and discoloration induced by verrucomorph barnacles varies according to the surface preservation of Nautilus shells,with deeper and discolored traces preserved on old and degraded *** made by verrucomorphs described here are ellipsoidal and a new ichnotaxon,Anellusichnus ellipticus,is proposed to accommodate ***,verrucomorphs and other cirripede taxa with membranous bases that were attached to pristine shells may not leave any substantial scars,and,thus,will be difficult to detect in the fossil record.

关键词： Anellusichnus ellipticus isp.nov cirripedes epibionts Hexelasma velutinum Metaverruca recta

Numerical simulation of roof cavings in several Kuzbass mines using finite-difference continuum damage mechanics approach

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International Journal of Mining Science and Technology 2020年第2期30卷 157-166页

作者： mikhail Eremin Gabriel Esterhuizen Igor Smolin Institute of Strength Physics and Materials Science Siberian BranchRussian Academy of SciencesTomsk 634055Russian Federation National Institute for Occupational Safety and Health PittsburghPA 15236USA National Research Tomsk State University Tomsk 634050Russian Federation

An essential stage of mine design is an estimation of the steps of the first and periodic roof caving in longwall ***,this is carried out using the field experience and can be much enhanced by numerical *** this work,the finite-difference method was applied coupled with the continuum damage mechanics(CDM)approach to simulate the stress-strain evolution of the rock mass with the underground opening during coal *** steps and stages of roof caving were estimated relying on the numerical simulation data,and they were compared with the field data from several operating mines in the south of the Kuznetsk Basin,*** dependence of the first roof caving step in simulation linearly correlates with field *** results correspond to the actual roofs of longwall panels of the flat-dipping coal seams and the average rate of face advancement is approximately 5 m/day.

关键词： Longwall mining Rock mass Underground openings Roof caving Abutment pressure Numerical simulation