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Correcting distortions of thin-walled machined parts by machine hammer peening

Chinese Journal of Aeronautics 2024年第6期37卷 439-453页

作者： Aitor MADARIAGA mikel cuesta Gorka ORTIZ-DE-ZARATE Eneko SAENZ-DE-ARGANDONA Denis SORIANO Michael B.PRIME Pedro Jose ARRAZOLA Department of Materials University of ManchesterOxford RoadManchester M139PLUnited Kingdom Mechanical and Industrial Production Department Faculty of EngineeringMondragon UnibertsitateaArrasate 20500Spain Los Alamos National Laboratory Los AlamosNew MexicoUSA

Thin-walled aerostructural components frequently get distorted after the machining *** to correct distortions or eventually rejecting parts significantly increases the *** paper proposes a new approach to correct distortions in thin-walled components by strategically applying hammer peening on target surfaces of a machined *** alloy 7475-T7351 was chosen for this *** study was divided in two ***,the residual stresses(RS)induced by four different pneumatic hammer peening conditions(modifying the stepover distance and initial offset)were characterised in a test coupon,and one of the conditions was selected for the next *** the second stage,a FEM model was used to predict distortions caused by machining in a representative ***,the RS induced by hammer peening were included in an FEM model to define two hammer peening strategies(varying the coverage area)to analyse the capability to reduce *** workpieces were machined and then treated with the simulated hammer peening strategies for experimental *** in the test coupon showed that pneumatic hammer peening can generate high compressive RS(-50 to350 MPa)up to 800 lm depth,with their magnitude increasing with a reduced stepover *** of hammer peening over 4% of the surface of the representative workpiece reduced the machininginduced distortions by 37%,and a coverage area of 100% led to and overcorrection by a factor of *** confirms that hammer peening can be strategically applied(in target areas and changing the percentage of coverage)to correct low or severe distortions.

关键词： Aeronautics Machining,Hammer Peening Aluminium alloy Distortions Residual Stress

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Improving surface integrity when drilling CFRPs and Ti-6Al-4V using sustainable lubricated liquid carbon dioxide

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Chinese Journal of Aeronautics 2023年第7期36卷 129-146页

作者： In˜igo RODRIGUEZ Pedro Jose´ARRAZOLA mikel cuesta Luka STERLE Franci PUSˇAVEC Faculty of Engineering Mondragon UnibertsitateaArrasate-Mondragon 20500Spain Faculty of Mechanical Engineering University of LjubljanaLjubljana 1000Slovenia

In the quest for decreasing fuel consumption and resulting gas emissions in the aeronautic sector,lightweight materials such as Carbon Fiber Reinforced Polymers(CFRPs)and Ti-6Al-4V alloys are being *** materials,with excellent weight-to-strength ratios,are widely used for structural applications in aircraft *** date,several studies have been published showing that the use of metalworking fluids(MWFs),special tool geometries,or advanced machining techniques is required to ensure a surface quality that meets aerospace component *** MWFs pose a number of environmental and worker health hazards and also degrade the mechanical properties of CFRPs due to water absorption in the ***,a transition to more environmentally friendly cooling/lubrication techniques that prevent moisture problems in the composite is *** research shows that lubricated LCO_(2) is a viable option to improve the quality of drilled CFRP and titanium aerospace components compared to dry machining,while maintaining clean work *** results show that the best combination of tool geometry and cooling conditions for machining both materials is drilling with Brad point drills and lubricated LCO_(2).Drilling under these conditions resulted in a 90%improvement in fiber pullout volume compared to dry machined CFRP *** addition,a 33% reduction in burr height and a 15% improvement in surface roughness were observed compared to dry drilling of titanium.

关键词： Carbon fibers Cryogenics Green manufacturing Machining Solid lubricants Surface morphology Titanium alloys

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Identification and functional characterization of fish IL‑17 receptors suggest important roles in the response to nodavirus infection

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Marine Life Science & Technology 2024年第2期6卷 252-265页

作者： Carmen González‑Fernández Miguel A.García‑Álvarez Alberto cuesta Department of Cell Biology and Histology Faculty of BiologyUniversity of Murcia30100 MurciaSpain Laboratoire d’écotoxicologie Centre de Lyon-VilleurbanneINRAEUR RiverLy69625 VilleurbanneFrance

Th17 is a lymphocyte T helper(Th)subpopulation relevant in the control and regulation of the immune response characterized by the production of interleukin(IL)-*** crucial cytokine family acts through their binding to the IL-17 receptors(IL-17R),having up to six *** the biology of fish Th17 is well-recognized,the molecular and functional characterization of IL-17 and IL-17R has been ***,our aim was to identify and characterize the IL-17R repertory and regulation in the two main Mediterranean cultured fish species,the gilthead seabream(Sparus aurata)and the European sea bass(Dicentrarchus labrax).Our in silico results showed the clear identification of six members in each fish species,from IL-17RA to IL-17RE-like,with well-conserved gene structure and protein domains with their human *** of them showed wide and constitutive transcription in naïve tissues but with highest levels in mucosal tissues,namely skin,gill or *** leucocytes,T mitogens showed the strongest up-regulation in most of the il17 receptors though il17ra resulted in inhibition by most ***,in vivo nodavirus infection resulted in alterations on the transcription of il17 *** nodavirus infection led to some increments in the il17ra,il17rb,il17rc and il17rd transcripts in the susceptible European sea bass,many down-regulations were observed in the resistant gilthead *** data identify the presence and conservation of six coding IL-17R in gilthead seabream and European sea bass as well as their differential regulation in vitro and upon nodavirus infection.

关键词： Th17 cells IL-17 receptors Immunity Teleost fish Nodavirus(NNV) Aquaculture

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A prototype for on-site generation of chlorinated disinfectant for use in rural aqueducts

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Water Science and Engineering 2024年第1期17卷 33-40页

作者： Diana Marcela cuesta Parra Felipe Correa Mahecha Andrés Felipe Rubio Pinzon Davidcamilo Ramirez Bustos Leonel Alveyro Teran Llorente Miguel Fernando Jimenez Jimenez Chemical and Environmental Engineering Department Fundacion Universidad de AmericaBogota 117111Colombia Chemical Engineering Department Fundacion Universidad de AmericaBogota 117111Colombia Mecanical Engineering Department Fundacion Universidad de AmericaBogota 117111Colombia

Sodium hypochlorite has significant potential as a sanitation solution in hard-to-reach *** studies have investigated the optimal electrolysis parameters for its production with volumes greater than 1o *** study evaluated sodium hypochlorite production through electrolysis in a 22-L prototype and identified the optimal operating *** were performed using graphite electrodes with areas of 68.4 cm^(2) at the laboratory scale and 1865.0 cm^(2) at the prototype scale.A design for experiments with different operating times,chloride concentrations,and electric current intensities was *** optimal operating time,sodium chloride concentration,and current intensity at the laboratory scale were 120 min,150 g of chloride per liter,and 3 A,respectively,leading to the production of 5.02 g/L of the disinfectant with an energy efficiency of 12.21 mg of Cl_(2) per *** the prototype scale,the maximum sodium hypochlorite concentration of 3.99 g of chloride per liter was achieved with an operating time of 120 min,a sodium chloride concentration of 100 g of chloride per liter,and a current intensity of 70 A,reaching an energy efficiency of 42.56 mg of Cl_(2) per *** addition,this study evaluated the influences of the chloride concentration,current intensity,and operating time on the production of sodium hypochlorite at the two scales,and formulated the equations showing the trends of sodium hypochlorite production and energy efficiency in the electrochemical *** 22-L prototype model for production of this oxidizing substance is promising for disinfection of large volumes of water in areas that are difficult to access.

关键词： Disinfection Electrolysis Energy efficiency Optimization Sodium hypochlorite

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Protective effects of cyclosporine and its analog NIM-811 in a murine model of hepatic ischemia-reperfusion injury

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Liver Research 2024年第1期8卷 46-53页

作者： Joshua Hefler Rena Pawlick Braulio A.Marfil-Garza Aducio Thiesen Nerea cuesta-Gomez Sanaz Hatami Darren H.Freed Constantine Karvellas David L.Bigam A.M.James Shapiro Department of Surgery Faculty of Medicine&DentistryUniversity of AlbertaEdmontonABCanada Department of Medicine Faculty of Medicine&DentistryUniversity of AlbertaEdmontonABCanada CHRISTUS-LatAm Hub Excellence&Innovation Center MonterreyMexico Alberta Diabetes Institute University of AlbertaEdmontonABCanada Clinical Islet Transplant Program University of AlbertaEdmontonABCanada Department of Laboratory Medicine&Pathology Faculty of Medicine&DentistryUniversity of AlbertaEdmontonABCanada

Background and aim:The liver is susceptible to ischemia-reperfusion injury(IRI)during hepatic surgery,when the vessels are compressed to control bleeding,or liver transplantation,when there is an obligate period of *** hallmark of IRI comprises mitochondrial dysfunction,which generates reactive oxygen species,and cell death through necrosis or ***(CsA),which is a well-known immunosuppressive agent that inhibits calcineurin,has the additional effect of inhibiting the mito-chondrial permeability transition pore(mPTP),thereby,preventing mitochondrial swelling and ***-811,which is the nonimmunosuppressive analog of CsA,has a similar effect on the *** this study,we tested the effect of both agents on mitigating warm hepatic IRI in a murine *** and methods:Before ischemic insult,the mice were administered with intraperitoneal normal saline(control);CsA at 2.5,10,or 25 mg/kg;or NIM-811 at 10 mg/***,the mice were subjected to partial warm hepatic ischemia by selective pedicle clamping for 60 min,followed by 6 h of recovery after *** alanine transaminase(ALT)was measured,and the liver tissue was examined histologically for the presence of apoptosis and the levels of inflammatory ***:Compared with the control mice,the mice treated with 10 and 25 mg/kg of CsA and NIM-811 had significantly lower ALT levels(P<0.001,0.007,and 0.031,respectively).Moreover,the liver tissue showed reduced histological injury scores after treatment with CsA at 2.5,10,and 25 mg/kg and NIM-811(P=0.041,<0.001,0.003,and 0.043,respectively)and significant decrease in apoptosis after treatment with CsA at all doses(P=0.012,0.007,and<0.001,respectively).Levels of the pro-inflammatory cyto-kines,particularly interleukin(IL)-1β,IL-2,IL-4,IL-10,and keratinocyte chemoattractant/human growth-regulated oncogene significantly decreased in the mice treated with the highest dose of CsA(25 mg/kg)than those in the control ***

关键词： Cyclosporine(CsA) Cyclosporine analogue Liver surgery Ischemia-reperfusion injury(IRI) Animal model NIM-811

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Spoon-assisted autologous particulate bone graft harvesting technique

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Chinese Journal of Plastic and Reconstructive Surgery 2024年第2期6卷 106-108页

作者： Inigo Aragon Nino Clara Lopez Martínez Carolina cuesta Urquía Agustín Pascual Camps Jose Luis Del Castillo Pardo de Vera Jose Luis Cebrian Carretero Oral and Maxillofacial Surgery Department La Paz University Hospital28046 MadridSpain

Particulate bone plays a crucial role in various oral and maxillofacial surgical procedures,including reconstruction,implantation,and craniofacial *** bone and deproteinized bovine bone xenografts are the two primary resources used for such procedures,with the former demonstrating superior cost-effectiveness and reduced comorbidity rates,particularly in cases involving donor ***,a significant challenge lies in acquiring uniformly sized autologous particulate bone specimens,with existing tools often yielding coarse particles at a high ***,commercial bone xenograft solutions are frequently favored despite lower *** technical note introduces a novel technique for swiftly,safely,and efficiently obtaining autologous particulate bone *** procedure involves the use of a motor handpiece fitted with a micro drill and surgical spoon to collect the bone *** continuous irrigation with saline maintains a clear surgical field during the milling *** collected bone particles are then transferred to a metal capsule for further *** technique offers a promising solution to the challenge of inconsistent particle size associated with harvesting using traditional methods,providing surgeons with a reliable and efficient method of obtaining autologous particulate bone samples.

关键词： Bone grafting Reconstructive surgery Craniofacial surgery Implant surgery Autologous bone

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Endoscopic vacuum assisted closure therapy for esophagopericardial fistula in a 16-year-old male:A case report

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World Journal of Gastrointestinal Endoscopy 2024年第9期16卷 533-539页

作者： Simón Muñoz-González Samir Quejada-cuesta Daniel González-Arroyave Carlos M Ardila Department of Surgery University of AntioquiaMedellin 050010AntioquiaColombia Department of Surgery Pontificia Universidad BolivarianaMedellín 050031AntioquiaColombia Department of Basic Sciences University of AntioquiaMedellín 050010AntioquiaColombia

BACKGROUND Esophagopericardial fistula(EPF)is a rare,life-threatening condition with limited scientific literature and no established management *** case report highlights a successful multidisciplinary approach and the innovative use of endoscopic vacuum assisted closure(endoVAC)therapy in treating this complex *** SUMMARY A 16-year-old male with a history of esophageal atresia and colon interposition presented with progressive chest pain,fever,and *** revealed an EPF with associated pleural and pericardial *** management with an esophageal stent failed,prompting the use of an endoVAC *** patient underwent multiple endoVAC device changes and received broad-spectrum antibiotics and nutritional *** fistula successfully closed,and the patient recovered,demonstrating no new symptoms at a 6-month *** EndoVAC therapy can effectively manage EPF,providing a minimally invasive treatment option.

关键词： Esophagopericardial fistula Endoscopic vacuum assisted closure Esophageal atresia Multidisciplinary approach Pleural effusion Case report

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Social Isolation in Male Rats During Adolescence Inhibits the Wnt/β-Catenin Pathway in the Prefrontal Cortex and Enhances Anxiety and Cocaine-Induced Plasticity in Adulthood

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Neuroscience Bulletin 2020年第6期36卷 611-624页

作者： Santiago cuesta Alejandrina Funes Alejandra M.Pacchioni Area Toxicologia Departamento de Ciencias de los Alimentos y del MedioambienteFacultad de Ciencias Bioquimicas y FarmaceuticasUniversidad Nacional de RosarioSuipacha 5312000 RosarioSanta FeArgentina Consejo Nacional de Investigaciones Cientificas y Tecnicas RosarioArgentina Present Address:Department of Microbiology University of Texas Southwestern Medical CenterDallasTX 75390USA

In adult animals,it is well established that stress has a proactive effect on psychostimulant ***,whether only a short period of stress during adolescence can also affect cocaine responses later in life and what mechanisms are involved are ***,we showed that 5 days of social isolation during rat adolescence had a long-term impact on anxiety-like behaviors,cocaine-induced conditioned place preference,and the expression of sensitization during *** the molecular level,social isolation decreased the activity of the Wnt/β-catenin pathway in the prefrontal cortex(PFC).Furthermore,after the expression of cocaine sensitization,isolated rats showed an increase in this pathway in the nucleus ***,these findings suggest that,adolescent social isolation by altering the Wnt/β-catenin pathway in the developing PFC might increase the cocaine responses during adulthood,introducing this pathway as a novel neuroadaptation in the cortical-accumbens connection that may mediate a stress-induced increase in vulnerability to drugs.

关键词： Social isolation Adolescence Cocaine vulnerability Wnt/(i-catenin pathway

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Endovascular treatment for early hepatic artery occlusion after liver transplantation: Angioplasty or stent

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Hepatobiliary & Pancreatic Diseases International 2022年第6期21卷 614-615页

作者： mikel Gastaca Javier Gomez Ignacio Terreros Hepatobiliary Surgery and Liver Transplantation Unit Biocruces Bizkaia Health Research InstituteHospital Universitario CrucesBilbaoSpain University of the Basque Country BilbaoSpain Servicio de Cirugía General y Aparato Digestivo Hospital Universitario San CecilioGranadaSpain Interventional Radiology Unit Hospital Universitario CrucesBilbaoSpain

To the Editor:We read with great interest the recent article by Zhu et al.[1].In the study,the authors analyzed the outcomes of 26 patients diagnosed with hepatic artery occlusion(HAO)and treated with an endovascular approach(EVT)within the first 30 days after ortho-topic liver transplantation(LT).The median interval from LT to EVT was 7 days,most patients were treated with angioplasty and only two(7.7%)needed stent *** authors should be congrat-ulated as they achieved a 100%of success rate with an 80.8%of 1-year survival rate.

关键词： liver artery after

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Vibrations characterization in milling of low stiffness parts with a rubber-based vacuum fixture

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Chinese Journal of Aeronautics 2021年第6期34卷 54-66页

作者： Antonio RUBIO-MATEOS mikel CASUSO Asuncion RIVERO Eneko UKAR Aitzol LAMIKIZ TECNALIA Basque Research and Technology Alliance(BRTA)Paseo Mikeletegi 7Pcirque TecnologicoE-20009 San SebastianSpain University of the Basque Country(UPV/EHU) ETTSII–Department of Mechanical EngineeringC/Alameda de Urquijo s/nE-48013 BilbaoSpain

Fixtures are a critical element in machining operations as they are the interface between the part and the *** components are responsible for the precise part location on the machine table and for the proper dynamic stability maintenance during the manufacturing *** these two features are deeply related,they are usually studied *** the one hand,diverse adaptable solutions have been developed for the clamping of different variable ***,the stability of the part has been long studied to reduce the forced vibration and the chatter effects,especially on thin parts machining operations typically performed in the aeronautic field,such as the skin panels *** present work proposes a commitment between both features by the presentation of an innovative vacuum fixture based on the use of a vulcanized rubber *** solution presents high flexibility as it can be adapted to different geometries while providing a proper damping capacity due to the viscoelastic and elastoplastic behaviour of these ***,the sealing properties of these elastomers provide the perfect combination to transform a rubber layer into a flexible vacuum ***,in order to validate the suitability of this fixture,a test bench is manufactured and tested under uniaxial compression loads and under real finish milling conditions over AA2024 part ***,a roughness model is proposed and analysed in order to characterize the part vibration sources.

关键词： AA2024 aeronautic skin Chatter Damping Finish milling Rubber characterization Vacuum clamping

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