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Characterization of Malalignment between Atrial and Ventricular Septa in Overriding/Straddling Tricuspid and Mitral Valves

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Congenital Heart Disease 2021年第1期16卷 1-16页

作者： mika saito Dragulescu Andreea Shi-Joon Yoo The Labatt Family Heart Centre The Hospital for Sick ChildrenUniversity of TorontoTorontoCanada Division of Cardiology Department of PaediatricsThe Hospital for Sick ChildrenUniversity of TorontoTorontoCanada Department of Diagnostic Imaging The Hospital for Sick ChildrenUniversity of TorontoTorontoCanada

Objective:Overriding/straddling of an atrioventricular valve is a consequence of atrial-ventricular septal *** sought to characterize the malalignment by analogizing it to a flap-door and using structured ***:The echocardiograms and magnetic resonance images of 35 patients with overriding/straddling tricuspid or mitral valve were evaluated to assess the following modifiers;the malaligned part of the septum,the reference structure,and the mechanism,direction and severity of ***:The pathology included classic overriding tricuspid valve in 15,classic overriding mitral valve in 12,and overriding tricuspid valve with left juxtaposition of atrial appendages in *** classic overriding tricuspid valve,the ventricular septum was hinged to the anterior interventricular groove and its insertion to the posterior interventricular groove was displaced toward the right *** VSD primarily involved the inlet but also extended toward the anterior interventricular *** classic overriding mitral valve,the ventricular septum was hinged to the posterior interventricular groove and crux *** insertion to the anterior interventricular groove was displaced toward the left *** VSD primarily involved the anterior part but also extended toward the *** tricuspid valve with left juxtaposition of atrial appendages had a mild degree of malalignment with displacement/rotation of the atrioventricular *** spaced short-axis images were most helpful in characterizing the ***:Overriding/straddling atrioventricular valves can be easily understood by analogizing the atrial-ventricular septal malalignment to a flap-door and describing the pathology in a structured *** to what has previously been known,the VSD is not limited to the inlet or outlet part of the ventricular septum.

关键词： Malalignment ventricular septal defect overriding straddling tricuspid mitral

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Trade and the Crisis:Protect or Recover

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China's Foreign Trade 2011年第1期 46-51页

作者： Rob Gregory Christian Henn Brad McDonald mika saito Strategy Policyand Review DepartmentIMF

The pace of trade reforms waned from the mid-2000s as protectionist sentiment began to *** the onset of the global financial crisis,

关键词：贸易保护主义金融危机改革

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Transcatheter arterial embolization for traumatic injury to the pharyngeal branch of the ascending pharyngeal artery:Two case reports

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World Journal of Clinical Cases 2022年第32期10卷 12015-12021页

作者： Daisuke Yunaiyama Yuki Takara Takehiro Kobayashi mika Muraki Taro Tanaka Mitsuru Okubo Toru Saguchi Motoki Nakai Kazuhiro saito Kiyoaki Tsukahara Yuri Ishii Hiroshi Homma Department of Radiology Tokyo Medical University HospitalShinjuku-ku 160-0023Japan Department of Otorhinolaryngology Head and Neck SurgeryTokyo Medical University HospitalShinjuku-ku 160-0023Japan Department of Emergency and Critical Care Medicine Tokyo Medical University HospitalShinjuku-ku 160-0023Japan

BACKGROUND The ascending pharyngeal artery(APhA)comprises the pharyngeal trunk(PT)and neuromeningeal *** PT feeds the nasopharynx and adjacent tissue,which potentially connects with the sphenopalatine artery(SPA),branched from the internal maxillary artery(IMA).Due to its location deep inside the body,the PT is rarely injured by ***,we present two cases that underwent transcatheter arterial embolization(TAE)of the PT of the APhA due to trauma and iatrogenic *** SUMMARY Case 1 is a 49-year-old Japanese woman who underwent transoral endoscopy under sedation for a medical *** nasal airway was inserted as glossoptosis occurred during *** from the nasopharynx was observed during the endoscopic *** the bleeding continued,the patient was referred to our hospital for further ***-enhanced computed tomography(CT)demonstrated extravasation in the nasopharynx originating from the right Rosenmuller *** was performed and the extravasation disappeared after *** 2 is a 28-year-old Japanese woman who fell from the sixth floor of a building and was transported to our *** CT demonstrated a complex facial fracture accompanying extravasation in the left pterygopalatine fossa to the *** demonstrated an irregular third portion of the *** angiography after TAE of the IMA demonstrated extravasation from the PT of the APhA,additional TAE to the artery was *** bleeding stopped after the *** Radiologists should be aware that the PT of the APhA can be a bleeding source,which has a potential connection with the SPA.

关键词： Arteries Catheters Hemorrhage Injury Trauma Case report

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On-treatment predictions of success in peg-interferon/ribavirin treatment using a novel formula

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World Journal of Gastroenterology 2010年第1期16卷 89-97页

作者： Hidetsugu saito Hirotoshi Ebinuma Keisuke Ojiro Kanji Wakabayashi mika Inoue Shinichiro Tada Toshifumi Hibi Department of Internal Medicine School of MedicineKeio University

AIM:To predict treatment success using only simple clinical data from peg-interferon plus ribavirin therapy for chronic hepatitis C. METHODS:We analyzed the clinical data of 176 patients with chronic hepatitis and hepatitis C virus genotype 1 who received 48 wk standard therapy, derived a predictive formula to assess a sustained virological response of the individual patient using a logistic regression model and confirmed the validity of this *** formula was constructed using data from the first 100 patients enrolled and validated using data from the remaining 76 patients. RESULTS:Sustained virological response was obtained in 83(47.2%)of the patients and we derived formulae to predict sustained virological response at pretreatment and weeks 4,12 and *** likelihood of sustained virological response could be predicted effectively bythe formulae at weeks 4,12 and 24(the area under the curve of the receiver operating characteristic:0.821, 0.802,and 0.891,respectively),but not at baseline (0.570).The formula at week 48 was also constructed and validation by test data achieved good prediction with 0.871 of the area under the curve of the receiver operating *** by this formula was always superior to that by viral kinetics. CONCLUSION:These results suggested that our formula combined with viral kinetics provides a clear direction of therapy for each patient and enables the best tailored treatment.

关键词： Logistic regression analysis Predictive formula Prolongation of the therapy Response-guided therapy Viral kinetics

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A successful birth of severe secondary recurrent miscarriage case after a decline of phosphatidylserine-dependent anti-prothrombin antibody by intravenous immunoglobulin administration

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Open Journal of Obstetrics and Gynecology 2012年第2期2卷 156-160页

作者： mika Kanaya Kunihiko Nagasawa Tsuyoshi Baba Shinichi Ishioka Hideto Yamada Toshiaki Endo Tsuyoshi saito Department of Obstetrics and Gynecology School of Medicine Kobe University Kobe Japan Department of Obstetrics and Gynecology School of Medicine Sapporo Medical University Sapporo Japan mika Ladies Clinic Sapporo Japan

A 33 years old woman was referred to our hospital since her sixth pregnancy had been revealed. In fact, at 19 years of age she had diagnosed as having systemic lupus erythematosus without organ failure. In addition, she had a past history of uncontrollable severe pregnancy-induced hypertension occurred during the second pregnancy, resulting in extremely premature delivery and following postpartum HELLP syndrome. It was so severe that we employed administration of dexamethasone and plasma exchange to ameliorate a life-threatening situation. In the course of her recovery it was revealed that she had been complicated with antiphospholipid antibodies, and at the same time we observed that phosphatidylserine-dependent anti-prothrombin antibody IgG levels were declining as her condition was getting better. There-after, she became pregnant three times, but all pregnancies ended in miscarriage despite administration of prednisolone and anticoagulant therapy. Therefore, we realized that her recurrent miscarriages could not be prevented with generally acceptable therapies, so we tried intravenous immunoglobulin shortly after fetal heart beats were detected. In fact, her sixth pregnancy was going well, but we had to terminate it at the 35th week of gestation due to the onset of HELLP syndrome-like condition. However, she could achieve an almost intact pregnancy outcome without neonatal complications or persistently worsening postpartum HELLP syndrome-like condition. Considering the etiologic relation overlapping between systemic lupus erythematosus, antiphospholipid syndrome and recurrent miscarriage, intravenous immunoglobulin can be one of the treatment options for severe secondary recurrent miscarriage, although the evidence of the treatment is always certain. In addition, a decline of phosphatidylserine-dependent anti-prothrombin antibody IgG levels we observed in this case may represent its therapeutic immunomodulatory effects.

关键词： Antiphospholipid Antibody Antiphospholipid Syndrome Intravenous Immunoglobulin Recurrent Miscarriage Systemic Lupus Erythematosus

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