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liver failure after Bacillus cereus food poisoning,an underrecognized entity:A case report

World Journal of Hepatology 2024年第11期16卷 1339-1347页

作者： Olivier Chatelanat mikaël de lorenzi-tognon laurent Spahr Abdessalam Cherkaoui Roger Stephan Marie Ongaro laurent Kaiser Nicolas Goossens department of Gastroenterology and Hepatology Geneva University HospitalsGeneva 1205Switzerland department of Infectious Diseases Geneva University HospitalsGeneva 1205Switzerland department of Genetics and laboratory Medicine Geneva University HospitalsGeneva 1205Switzerland Institute for Food Safety and Hygiene University of ZürichZurich 8057Switzerland

BACKGROUND Bacillus cereus(***)is known to cause 2 types of foodborne diseases;the diarrheal and emetic *** are largely underreported due to their usually self-limiting *** and sometimes fatal cases of liver failure,pulmonary hemorrhage and cerebral oedema have been reported mainly in children and young *** present here a case of liver failure associated with *** food poisoning in a middle-aged *** SUMMARY A 48-year-old female patient presented to the emergency department for emesis,diarrhea,chills without fever,asthenia and diffuse abdominal cramps that started less than 30 minutes after eating a rice *** past medical history was relevant for cholecystectomy and a cured Hashimoto’s *** did not take any medication,drugs and declared a consumption of one glass of wine per *** the emergency department,she was treated with acetaminophen,metoclopramide,ondansetron,and an intravenous normal saline *** gas analysis revealed a metabolic acidosis with hyperlactatemia,coagulation revealed a low prothrombin activity[32%;normal values(N):70-140]and a low Factor V activity(15%;N:>70).Transaminases were elevated with hyperbilirubinemia,elevated lipase and rhabdomyolysis.N-acetylcysteine treatment was *** echography revealed no signs of chronic hepatopathy or *** after the admission,psychomotor activity improved,transaminases and lipase started *** gradually worsened to peak on day *** tests for liver disease were negative for viral and autoimmune cause of liver *** cultures were positive for colonies of the *** group which were also identified in the rice salad samples processed whereas blood cultures were *** patient’s condition improved gradually including her liver function parameters and psychomotor activity which allowed her discharged home on day *** We describe a rare case of hepatocellular dysfunction due t

关键词： liver failure Foodborne intoxication Bacillus cereus Toxin cereulide Emetic syndrome Acetaminophen Case report

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Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

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Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels Julie D.de Schutter lies de Groef lieve Moons Steven Bergmans KU leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

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Personal Information Self-Management:A Survey of Technologies Supporting Administrative Services

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Journal of Computer Science & Technology 2021年第3期36卷 664-692页

作者： Paul Marillonnet Maryline laurent mikaël Ates Entr'ouvert Paris 75014France SAMOVAR Télécom SudParisInstitut Polytechnique de ParisEvry 91000France

This paper presents a survey of technologies for personal data self-management interfacing with administrative and territorial public service *** classifies a selection of scientific technologies into four categories of solutions:Personal Data Store(PDS),Identity Manager(IdM),Anonymous Certificate System and Access Control delegation *** category,along with its technological approach,is analyzed thanks to 18 identified functional criteria that encompass architectural and communication aspects,as well as user data lifecycle *** originality of the survey is ***,as far as we know,there is no such thorough survey covering such a panel of a dozen of existing ***,it is the first survey addressing Personally Identifiable Information(PII)management for both administrative and private service ***,this paper achieves a functional comparison of solutions of very different technical *** outcome of this paper is the clear identification of functional gaps of each *** a result,this paper establishes the research directions to follow in order to fill these functional gaps.

关键词： personal information management privacy enforcement user-centric solution technological survey

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Recent Advances in Catalytic Carbonylation Reactions in Alternative Reaction Media

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Chinese Journal of Chemistry 2024年第4期42卷 406-429页

作者： Csaba Árvai lászló T.mika department of Chemical and Environmental Process Engineering Faculty of Chemical Technology and BiotechnologyBudapest University of Technology and EconomicsMűegyetem rkp.3H-1111 BudapestHungary

Since the discovery of the hydroformylation(oxo-synthesis or Roelen reaction)and the Reppe-reaction,the transition metal-catalyzed carbonylation reactions,providing versatile,facile,and even atom-economic methods for the selective incorporation of C=O functionality to various skeletons,have gained tremendous importance in synthetic organic chemistry from laboratories to industrial *** carbonylation of carbon-carbon multiple bonds,aromatic halides,triflates,etc.,in the presence of various nucleophiles has led the way to produce aldehydes,carboxylic acids,esters,amides,etc.,in the fine chemical ***,these protocols usually proceed in conventional,fossil-based,and usually toxic reaction ***,several attempts have been directed to developing efficient carbonylation methods in alternative,less harmful,non-fossil-based and even in renewable reaction *** this review,we overview the recent applications of alternative solvents such as water,biomass-based alcohols,γ-valerolactone(GVl),2-methyltetrahydrofuran(2-MeTHF),ionic liquids(Ils),deep eutectic solvents(deS),alkyl levulinates,limonene,α-pinene,and dimethyl carbonate as well as fluorous media to improve efficiency,safety and environmentally benign nature of carbonylation protocols.

关键词： Carbonylation Catalysis Solvents Green chemistry Carbon monoxide Transition metals Homogeneous catalysis Palladium

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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao de-En Xu Ming-lei Wu Ji-Chuan liu Zi-ling Shi Quan-Hong Ma department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith Jessica l.Williams department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

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Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota l.Matsuoka department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

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Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling lü Chunchi Zhang Dong liang lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

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Viscosity and structure relationship with equimolar substitution of CaO with MgO in the CaO–MgO–Al_(2)O_(3)–SiO_(2)slag melts

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 70-79页

作者： Yong Hou Shuo Zhang Jie Dang Jia Guo Hanghang Zhou Xuewei lü College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing 400044China

Currently,the Al_(2)O_(3)content in the high-alumina slag systems within blast furnaces is generally limited to 16wt%–18.5wt%,making it challenging to overcome this *** most studies that concentrated on managing the MgO/Al_(2)O_(3)ratio or basicity,this paper explored the effect of equimolar substitution of MgO for CaO on the viscosity and structure of a high-alumina CaO-MgO-Al_(2)O_(3)-SiO_(2)slag system,providing theoretical guidance and data to facilitate the application of high-alumina *** results revealed that the viscosity first decreased and then increased with higher MgO substitution,reaching a minimum at 15mol%MgO *** transform infrared spectroscopy(FTIR)results found that the depths of the troughs representing[SiO_(4)]tetrahedra,[AlO_(4)]tetrahedra,and Si-O-Al bending became progressively deeper with increased MgO *** of the Raman spectra showed that the average number of bridging oxygens per Si atom and the X_(Q^(3))/X_(Q^(2))(X_(Q^(i))is the molar fraction of Q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectively,indicating a progressive polymerization of the silicate structure.X-ray photoelectron spectroscopy(XPS)results highlighted that non-bridging oxygen content decreased from 77.97mol% to 63.41mol% with increasing MgO concentration,whereas bridging oxygen and free oxygen contents *** analysis demonstrated a gradual increase in the polymerization degree of the tetrahedral structure with the increase in MgO ***,bond strength is another important factor affecting the slag *** occurrence of a viscosity minimum can be attributed to the complex evolution of bond strengths of non-bridging oxygens generated during depolymerization of the[SiO_(4)]and[AlO_(4)]tetrahedral structures by CaO and MgO.

关键词： aluminosilicate viscosity structure spectroscopy

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萘系和聚羧酸高效减水剂与几种不同水泥品种间的相容性问题(长期结果)(英文)

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硅酸盐学报 2010年第9期38卷 1631-1637页

作者： COPPOlA l BUOSO A lorenzi S Faculty of Engineering University of Bergamo Italy

研究了水泥与减水剂的相容性。采用萘系(naphthalene,NSF)和聚羧酸(polycarboxylate-based,PCE)系两类高效减水剂,5批次的6种广泛分布于意大利不同区域的水泥为原料。通过改变高效减水剂的掺入量使拌和后的砂浆和混凝土具有恒定的工作性... 详细信息

研究了水泥与减水剂的相容性。采用萘系(naphthalene,NSF)和聚羧酸(polycarboxylate-based,PCE)系两类高效减水剂,5批次的6种广泛分布于意大利不同区域的水泥为原料。通过改变高效减水剂的掺入量使拌和后的砂浆和混凝土具有恒定的工作性;通过测定拌合后1h内的流动度保持度以表征每种减水剂的工作性经时损失。还测定了砂浆和混凝土1,7d和28d的抗压强度。结果表明:与萘系高效减水剂相比,聚羧酸高效减水剂的减水效果和流动度保持性较好;萘系高效减水剂的作用几乎与水泥的品种及批次无关。混凝土的流变性能和力学性能与其砂浆的测试结果一致。

关键词：萘系高效减水剂聚羧酸高效减水剂水泥–高效减水剂相容性性能多变性高效减水剂

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