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Takotsubo cardiomyopathy: Pathophysiology,diagnosis and treatment

World Journal of Cardiology 2014年第7期6卷 602-609页

作者： Kazuo Komamura miho fukui Toshihiro Iwasaku Shinichi Hirotani Tohru Masuyama Cardiovascular Division Department of Internal MedicineHyogo College of Medicine

In 1990,takotsubo cardiomyopathy(TCM)was first discovered and reported by a Japanese cardiovascular *** then,this heart disease has gained worldwide acceptance as an independent disease *** is an important entity that differs from acute myocardial *** occurs more often in postmenopausal elderly women,is characterized by a transient hypokinesis of the left ventricular(LV)apex,and is associated with emotional or physical *** motion abnormality of the LV apex is generally transient and resolves within a few days to several *** prognosis is generally ***,there are some reports of serious TCM complications,including hypotension,heart failure,ventricular rupture,thrombosis involving the LV apex,and torsade de *** has been suggested that coronary spasm,coronary microvascular dysfunction,catecholamine toxicity and myocarditis might contribute to the pathogenesis of ***,its pathophysiology is not clearly understood.

关键词： Cardiomyopathy Catecholamine Heart failure Myocardial Infarction Stress

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"Commissural drop"wiring technique facilitates catheter crossing of severely stenotic aortic valve

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Chinese Medical Journal 2021年第2期134卷 245-246页

作者： Yu Du Paul Sorajja miho fukui Go Hashimoto Aisha Ahmed Mario Gössl Valve Science Center Minneapolis Heart Institute FoundationAbbott Northwestern HospitalMN 55407USA Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China

To the Editor:An 82-year-old man with symptomatic severe calcific aortic valve stenosis(peak velocity:5.19 m/s;mean gradient:78.0 mmHg;aortic valve area:0.48 cm2)underwent transfemoral transcatheter aortic valve *** the procedure,a 0.035-inch straight-tip glide wire(Terumo,Somerset,NJ,USA)supported by a 6 Fr Judkins Right 4(JR4)coronary catheter(Medtronic,Minneapolis,MN,USA)were used to cross the severely stenotic aortic ***,the JR4 catheter could not pass the aortic valve because the wire crossed the aortic valve in the left/right coronary commissure creating an unfavorable angle and limited pushability for the *** of switching to a differently shaped catheter(eg,an Amplatz left 1 catheter),we advanced the glide wire and therefore the more supportive portion of the wire further through the aortic ***,both wire and JR4 catheter dropped into the non/left coronary commissure,allowing the JR4 catheter to cross the valve ***,a 34 mm self-expanding Evolut R valve(Medtronic)was implanted,and the patient was discharged uneventfully(Figure 1A-E and Supplementary Video 1,http://***/CM9/A353["Commissural drop"wiring technique.]).

关键词： catheter valve Figure

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Unusual nonribosomal peptide synthetase involved in the biosynthesis of a classic antibiotic,Streptothricine

Unusual nonribosomal peptide synthetase involved in the bios...

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The 12th Japan-China-Korea Joint Symposium on Enzyme Engineering

作者： Chitose Maruyama Junya Toyoda Yasuo Kato miho Izumikawa Motoki Takagi Kazuo Shin-ya Hajime Katano Takashi Utagawa Yoshimitsu Hamano Department of Bioscience Fukui Prefectural University Department of Biotechnology Toyama Prefectural University

＜正＞Introduction Streptothricins（STs）are traditional antibiotics produced by Streptomyces bacteria that contain L-β-lysine oligopeptides（1-7residues）in their chemical structures（1）.STs inhibit protein biosynthesis in prokaryotic cells,and strongly inhibit the growth of eukaryotes such as yeasts,fungi,protozoa,insects,and *** are used as effective selective agents for recombinant DNA work in some of these organisms;however,they are not currently

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