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A short review on cell-based biosensing:challenges and breakthroughs in biomedical analysis

The Journal of Biomedical Research 2021年第4期35卷 255-263页

作者： mihaela gheorghiu Biosensors Department International Centre of BiodynamicsBucharest 060101Romania.

Current cell-based biosensors have progressed substantially from mere alternatives to molecular bioreceptors into enabling tools for interfacing molecular machineries and gene circuits with microelectronics and for developing groundbreaking sensing and theragnostic *** recent literature concerning whole-cell biosensors is reviewed with an emphasis on mammalian cells,and the challenges and breakthroughs brought along in biomedical analyses through novel biosensing concepts and the synthetic biology *** recent innovations allow development of cell-based biosensing platforms having tailored performances and capable to reach the levels of sensitivity,dynamic range,and stability suitable for high analytic/medical *** also pave the way for the construction of flexible biosensing platforms with utility across biological research and clinical *** work is intended to stimulate interest in generation of cell-based biosensors and improve their acceptance and exploitation.

关键词： biosensing electro-optical assays synthetic biology cell dynamics cell physiology theranostics

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High-resolution impedance mapping using electrically activated quantitative phase imaging

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Light(Science & Applications) 2021年第2期10卷 186-196页

作者： Cristina Polonschii mihaela gheorghiu Sorin David Szilveszter Gáspár Sorin Melinte Hassaan Majeed Mikhail E.Kandel Gabriel Popescu Eugen gheorghiu International Centre of Biodynamics 060101 BucharestRomania Institute of Information and Communication Technologies Electronics and Applied MathematicsUniversite Catholique de Louvain1348 Louvain-la-NeuveBelgium Quantitative Light Imaging Laboratory Beckman Institute for Advanced Science and TechnologyUniversity of Illinois at Urbana-ChampaignUrbanaIL 61801USA

Retrieving electrical impedance maps at the nanoscale rapidly via nondestructive inspection with a high signal-to-noise ratio is an unmet need,likely to impact various applications from biomedicine to energy *** this study,we develop a multimodal functional imaging instrument that is characterized by the dual capability of impedance mapping and phase quantitation,high spatial resolution,and low temporal *** achieve this,we advance a quantitative phase imaging system,referred to as epi-magnified image spatial spectrum microscopy combined with electrical actuation,to provide complementary maps of the optical path and electrical *** demonstrate our system with high-resolution maps of optical path differences and electrical impedance variations that can distinguish nanosized,semi-transparent,structured coatings involving two materials with relatively similar electrical *** map heterogeneous interfaces corresponding to an indium tin oxide layer exposed by holes with diameters as small as~550 nm in a titanium(dioxide)over-layer deposited on a glass *** show that electrical modulation during the phase imaging of a macro-electrode is decisive for retrieving electrical impedance distributions with submicron spatial resolution-and beyond the limitations of electrode-based technologies(surface or scanning technologies).The findings,which are substantiated by a theoretical model that fits the experimental data very well enable achieving electro-optical maps with high spatial and temporal *** virtues and limitations of the novel optoelectrochemical method that provides grounds for a wider range of electrically modulated optical methods for measuring the electric field locally are critically discussed.

关键词： impedance resolution phase

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