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Emerging role of microRNAs in liver diseases

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World Journal of Gastroenterology 2009年第45期15卷 5633-5640页

作者： Shashi Bala miguel marcos Gyongyi Szabo Department of Medicine University of Massachusetts Medical School WorcesterMA 01605 United States

MicroRNAs are a class of small non-coding RNAs that are found in plants, animals, and some viruses. They modulate the gene function at the post-transcriptional level and act as a fine tuner of various processes, such as development, proliferation, cell signaling, and apopto-sis. They are associated with different types and stages of cancer. Recent studies have shown the involvement of microRNAs in liver diseases caused by various factors, such as Hepatitis C, Hepatitis B, metabolic disorders, and by drug abuse. This review highlights the role of microRNAs in liver diseases and their potential use as therapeutic molecules.

关键词： MicroRNA Hepatitis Fatty liver Fibrosis Cirrhosis

Behavior of wood basic density according to environmental variables

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Journal of Forestry Research 2022年第2期33卷 497-505页

作者： Gabriel marcos Vieira Oliveira JoséMárcio de Mello Carlos Rogério de Mello JoséRoberto Soares Scolforo Eder Pereira miguel Thiago Campos Monteiro Brazil Institute of Agricultural and Forestry Defense of Espírito Santo(IDAF) Av.Lourival Lugon Moulinnº300CentroJerônimo MonteiroES CEP:29.550-000Brazil Department of Forestry Sciences Universidade Federal de Lavras-UFLACaixa Postal 3037LavrasMG CEP:37.200-000Brazil Engineering Department Universidade Federal de Lavras-UFLACaixa Postal 3037LavrasMG CEP:37.200-000Brazil Forestry Engineering Department Faculdade de TecnologiaUniversity of Brasilia-UnBCampus Universitário Darcy RibeiroCaixa Postal 4357Asa Norte-BrasíliaDF CEP:70910-900Brazil Department of Forestry Engineering and Technology Universidade Federal do Paraná-UFPRAv.Pref.Lothário Meissner632Jardim BotânicoCuritibaPR CEP:80.210-170Brazil

The relationships between climate conditions and wood density in tropical forests are still poorly *** quantify spatial dependence of wood density in the state of Minas Gerais(MG,Brazil),map spatial distribution of density,and correlate density with climate variables,we extracted data from the Forest Inventory of Minas Gerais for 1988 trees scaled throughout the territory and measured wood density of discs removed from the *** variables were extracted from the database of the Ecological-Economic Zoning of Minas *** spatial analysis,tree densities were measured at 44 georeferenced sampling *** data were subjected to exploratory analysis,variography,cross-validation,model selection,and ordinary *** relationships between wood density and environmental variables were calculated using dispersion matrices,linear correlation,and *** density proved to be highly spatially dependent,reaching a correlation of 96%,and was highly continuous over a distance of 228 *** distribution of wood density followed a continuous gradient of 514-659 kg m^(−3),enabling corre-lation with environment *** was correlated with mean annual precipitation(−0.57),temperature(0.63),and evapotranspiration(0.83).Geostatistical methods proved useful in predicting wood density in native tropical forests with different climate *** results confirmed the sensitivity of wood density to climate change,which could affect future carbon stock in forests.

关键词： Biomass Climate variables Geostatistics Hardwood Forest inventory Minas Gerais

Bile duct hamartomas-the von Meyenburg complex

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Hepatobiliary & Pancreatic Diseases International 2007年第1期6卷 108-109页

作者： Valdemir José Alegre Salles Alexandre Marotta Jorge miguel Kather Netto Manlio Basílio Speranzini marcos Roberto Martins University of Taubaté Department of Medicine So Paulo Brazil

: Hamartomas of the bile duct (von Meyenburg complex) are benign neoplasms of the liver, constituted histologically cystic dilatations of the bile duct, encompassed by fibrous stroma. We report a 42-year-old female patient with symptomatic cholecystitis, whose gross and ultrasonic appearance suggestive of multiple liver metastases. Magnetic resonance imaging and liver biopsy are the gold standards for diagnosis of this rare hepatobiliary condition.

关键词： bile duct hamartoma von Meyenburg complex nonparasitic hepatic cyst, surgery

Role of microRNAs in alcohol-induced liver disorders and non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2018年第36期24卷 4104-4118页

作者： Jorge-Luis Torres Ignacio Novo-Veleiro Laura Manzanedo Lucía Alvela-Suárez Ronald Macías Francisco-Javier Laso miguel marcos Department of Internal Medicine University Hospital of SalamancaInstitute of Biomedical Research of Salamanca-IBSAL Spanish Working Group on Alcohol and Alcoholism Spanish Society of Internal Medicine Department of Internal Medicine University Hospital of Santiago de Compostela Department of Internal Medicine HM Rosaleda HospitalSantiago de Compostela Department of Medicine Faculty of MedicineUniversity of Salamanca

MicroRNAs(miRNAs) are small non-coding RNAs that regulate multiple physiological and pathological functions through the modulation of gene expression at the post-transcriptional level. Accumulating evidence has established a role for miRNAs in the development and pathogenesis of liver disease. Specifically, a large number of studies have assessed the role of miRNAsin alcoholic liver disease(ALD) and non-alcoholic fatty liver disease(NAFLD), two diseases that share common underlying mechanisms and pathological characteristics. The purpose of the current review is to summarize and update the body of literature investigating the role of miRNAs in liver disease. In addition, the potential use of miRNAs as biomarkers and/or therapeutic targets is discussed. Among all miRNAs analyzed, miR-34 a, miR-122 and miR-155 are most involved in the pathogenesis of NAFLD. Of note, these three miRNAs have also been implicated in ALD, reinforcing a common disease mechanism between these two entities and the pleiotropic effects of specific miRNAs. Currently, no single miRNA or panel of miRNAs has been identified for the detection of, or staging of ALD or NAFLD. While promising results have been shown in murine models, no therapeutic based-miRNA agents have been developed for use in humans with liver disease.

关键词： Alcohol use disorder Alcoholic liver disease Non-alcoholic fatty liver disease Steatosis Obesity miRNA Biomarkers

Nanotechnology in aquaculture: Applications, perspectives and regulatory challenges

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Aquaculture and Fisheries 2022年第2期7卷 185-200页

作者： Carlos Fajardo Gonzalo Martinez-Rodriguez Julian Blasco Juan miguel Mancera Bolaji Thomas marcos De Donato School of Tourism and Maritime Technology Polytechnic of Leiria(MARE-IPLeiria)Santuario de Nossa Senhora dos RemediosCampus 4Peniche2520-641Portugal Department of Biology Faculty of Marine and Environmental SciencesInstituto Universitario de Investi-gaci´on Marina(INMAR)Campus de Excelencia Internacional del Mar(CEI⋅MAR)University of Cadiz(UCA)Puerto Real11519Spain Institute of Marine Sciences of Andalusia(ICMAN) Department of Marine Biology and AquacultureSpanish National Research Council(CSIC)Puerto Real11519Spain Department of Biomedical Sciences Rochester Institute of TechnologyRochester14623USA Tecnologico de Monterrey Escuela de Ingenieria y CienciasQueretaro76130Mexico

Aquaculture is considered one of the most important food production systems both in terms of economic impact and food security,and the ongoing development of this industry is a key factor in the strategy to guarantee global nutritional ***,different types of nanotechnology-based systems have been employed to increase its production,efficiency and *** efforts have been made in the fields of health management,enhancement of fish and shellfish development by dietary supplementation with nutraceuticals,but also in the processing and preservation of seafood and water treatment,among ***,nanotechnology has a significant role to play in the improvement of the efficiency and the environmental impact of this *** this perspective,we propose to review the current situation of nanotechnology in the field of aquaculture and fisheries,emphasizing not only in current applications,and future prospects,but also in the ethical and governance aspects associated with this topic.

关键词： Health management Nano-regulation Nutraceuticals Preservation of seafood Risk assessment

Objective tinnitus secondary to palatal tremor:Two case reports and brief literature review

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Journal of Otology 2022年第2期17卷 107-110页

作者： Raúl Mellidez Acosta miguel Saro-Buendía Lidia Torres García Maria Antonia marcos Pena Carlos De Paula Vernetta Hospital Universitarii Politecnic LaFe Institutode Investigacion Sanitaria LaFeUniversity of ValenciaSpain

Objective tinnitus is defined as a type of tinnitus perceived by both the patient and external *** paper presents two cases of objective tinnitus related to palatal tremor,along with a literature *** tremor is a condition characterized by soft palate involuntary *** types of palatal tremor have been described:symptomatic palatal tremor and essential palatal tremor,with different clinical *** workup is based on medical history and physical examination,including direct oropharynx exploration and cavum visualization through *** MRI is mandatory in all *** a secondary origin is suspected,additional lab tests should be performed based on clinical ***-line treatment is botulinum toxin injection into the levator veli palatini and tensor veli palatini muscles,with velopharyngeal insufficiency being its main adverse *** medications have not been shown to be effective.

关键词： Objetive tinnitus Palatal tremor Botox injection

Are models of volumetric production at the diametric distribution and total stand level mutually compatible?

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Journal of Forestry Research 2020年第5期31卷 1691-1698页

作者： marcos Felipe de Oliveira Valeriano Eder Pereira miguel Pedro Guilherme de Andrade Vasconcelos Mauro Eloi Nappo Humberto a.gelo Alba Valeria Rezende Renan Augusto Miranda Matias Leonardo Job Biali Ilvan Medeiros Lustosa Junior Department of Forestry Engineering University of Brasilia(UnB)Brası´liaBrazil Federal Institute of Brasılia(IFB) BrasıliaBrazil

The objective of this work was to compare estimates generated by a diametric distribution model and a total stand model against the pre-cut *** model efficiency was also *** were evaluated from 30 permanent sample plots in a Eucalyptus urophylla stand,comprising 24 sample plots used for model fitting,and six sample plots for *** volume of wood per hectare was estimated for different productive units(sites),using 7 years as the reference *** model adjustment quality was verified by adjustment and precision statistics:the correlation between observed and predicted variables,root mean square error percentage,graphical analysis of residual distribution,and a frequency histogram for classes of relative errors and *** the two-parameter Weibull probability density function adhered to the data for tree evolution in diameter classes for the reference age(7 years)in the different productivity classes,it generated imprecise estimates of the number of ***,it produced inaccurate volumetric production *** total stand model provided reliable projections of production volumes in different productivity classes for both adjustment types,showing compatibility with the pre-cut inventory according to a Tukey *** summary,the total stand model generated estimates that were compatible with the pre-cut inventory while the diametric distribution model did not.

关键词： Clutter model Diameter class Eucalyptus Prognosis

Dimensions of emotional distress among Brazilian workers in a COVID-19 reference hospital:A factor analytical study

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World Journal of Psychiatry 2022年第6期12卷 843-859页

作者： marcos O Carvalho-Alves Vitor A Petrilli-Mazon Andre R Brunoni Andre Malbergier Pedro Fukuti Guilherme V Polanczyk Euripedes C miguel Felipe Corchs Yuan-Pang Wang Department of Psychiatry School of MedicineUniversity of Sao PauloSao Paulo 05403-010Brazil Program in Neuroscience and Behavior Department of Experimental PsychologyInstitute of PsychologyUniversity of Sao PauloSao Paulo 01060-970Brazil Department and Institute of Psychiatry University of Sao PauloSao Paulo 05403-010Brazil

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic is an unprecedented challenge for public health and has caused the loss of millions of lives *** workers play a key role in averting the collapse of the health system,but the mental health of many has deteriorated during the *** studies have been devoted to identifying the needs of workers on frontline *** To investigate dimensions of common emotional symptoms and associated predictors among Brazilian workers in a COVID-19 reference *** This is an observational study of the mental health of professionals in a COVID-19 hospital in the city of São *** invited all hospital employees to respond to an online survey between July and August 2020,during the first peak of the *** of 1000 participants who completed the survey were analyzed(83.9%were women and 34.3%were aged 30 to 40).Hospital workers selfreported the presence of symptoms of depression,anxiety,trauma-related stress,and burnout through the Patient Health Questionnaire-9,the Generalized Anxiety Disorder-7,the Impact of Event Scale-Revised and the Mini-Z Burnout Assessment *** were assembled and subjected to exploratory factor analysis to reveal workers’core emotional *** linear regression models were subsequently carried out to estimate the likelihood of dimensions of distress using questions on personal motivation,threatening events,and institutional *** Around one in three participants in our sample scored above the threshold of depression,anxiety,post-traumatic stress disorder,and *** factor analysis revealed a three-factor structure that explained 58%of the total data *** distressing emotional domains were avoidance and re-experience,depression-anxiety,and sleep *** analysis revealed that institutional support was a significant protective factor for each of these dimensions(βrange=-0.41 to-0.20,P<0.001).However,partici

关键词： COVID-19 Pandemics Health personnel Mental health Psychological distress Occupational medicine

An Insight into Spatial-Temporal Trends of Fire Ignitions and Burned Areas in the European Mediterranean Countries

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Journal of Earth Science and Engineering 2013年第7期3卷 497-505页

作者： marcos Rodrigues Jesfis San miguel Sandra Oliveira Francisco Moreira Andrea Camia Institute for Environment and Sustainability Joint Research Centre Varese 21027 Italy Department of Geography and Land Management University of Zaragoza Zaragoza 50009 Spain Centre of Forestry Studies Institute of Agronomy Technical University of Lisbon Lisbon 1349-017 Portugal Centre of Applied Ecology Institute of Agronomy Technical University of Lisbon Lisbon 1349-017 Portugal

This paper presents an analysis of the fire trends in southern European countries, where forest fires are a major hazard. Data on number of fires and burned area size from 1985 until 2009 were retrieved from the European Fire Database in the European Forest Fire Information System and used to study the temporal and spatial variability of fire occurrence at three different spatial scales： the whole European Mediterranean region, country level and province level （NUTS3）. The temporal trends were assessed with the Mann-Kendall test and Sen＇s slope in the period 1985-2009. At regional （supranational） level, our results suggest a significant decreasing trend in the burned area for the whole study period. At country level, the trends vary by country, although there is a general increase in number of fires, mainly in Portugal, and a decrease in bumed areas, as is the case of Spain. A similar behavior was found at NUTS3 level, with an increase of number of fires in the Spanish and Portuguese provinces and a generalized decrease of the burned area in most provinces of the region. These results provide an important insight into the spatial distribution and temporal evolution of fires, a crucial step to investigate the underlying causes and impacts of fire occurrence in this region.

关键词： Fire ignition burned area wildfire trend test Mann-Kendall.