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Topical Applications of Thiosulfinate-Enriched Allium sativum Extract Accelerates Acute Cutaneous Wound Healing in Murine Model

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Chinese Journal of Integrative Medicine 2020年第11期26卷 812-818页

作者： Juan Luis Santiago Eva Maria Galan-Moya Jose Ramon Munoz-Rodriguez miguel angel de la Cruz-Morcillo Francisco Javier Redondo-Calvo Ignacio Gracia-Fernandez Peter M.Elias Jose Manuel Perez-Ortiz Mao-Qiang Man Dermatology Service Hospital General Universitario de Ciudad RealCiudad Real(13004)Spain Translational Research Unit Hospital General Universitario de Ciudad RealCiudad Real(13004)Spain Translational Oncology Laboratory Centro Regional de Investigaciones BiomedicasUniversidad de Castilla-La ManchaAlbacete(02008)Spain Instituto de Tecnologia Quimica y Medioambiental Universidad de Castilla-La ManchaCiudad Real(13004)Spain Dermatology Service Vetera ns Affairs Medical Centerand Department of DermatologyUniversity of CaliforniaSan FranciscoCA(94121)USA Dermatology Hospital Southern Medical UniversityGuangzhou(510091)China

Objective To determine whether topical applications of thiosulfinate-enriched Allium sativum extract(TASE)can accelerate acute cutaneous wound healing(WH)in a murine *** Keratinocyte viability and in vitro wound closure were assessed in keratinocyte *** of topical TASE(0.5μg/mL of allicin in 97%ethanol)on acute cutaneous WH were determined in a murine model of acute cutaneous *** mice were alternately assigned to the vehicle-and TASE-treated groups(n=6 per group).Expression levels of mRNA for keratinocyte differentiation marker-related proteins(filaggrin,loricrin and involucrin)and lipid synthetic enzymes(elongation of very long chain fatty acids protein 4(ELOVL4),fatty acid synthase(FA2H),3-hydroxy-3-methyl-glutaryl-coenzyme A reductase(HMGCoA),and serine palmitoyltransferase(SPT))were assessed using real-time quantitative polymerase chain reaction on day 3 and 8 after wounding,while transepidermal water loss(TEWL)rates were measured in wounded *** TASE accelerated WH both in vivo(40%vs.22%reduction in wound area,P<0.01)and in vitro(90%vs.65%reduction in wound area,P<0.01).Moreover,topical applications of TASE upregulated the expression levels of epidermal mRNA for ELOVL4,HMGCoA,SPT,filaggrin,loricrin and involucrin(P<0.05 ***-treated controls)on day 3 after ***,TASE significantly lowered TEWL rates in comparison with vehicle alone on day 8(33.06±2.09 g/(m^2·h)vs.24.60±2.04 g/(m^2·h),P<0.01).Conclusions Topical applications of TASE stimulated keratinocyte proliferation and formation of epidermal permeability barrier function,leading to acceleration of acute cutaneous *** products containing TASE could be used to manage acute cutaneous WH.

关键词： Allium sativum thiosulfinate wound healing permeability barrier keratinocytes proliferation

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运动表现分析的发展及展望

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体育学刊 2016年第2期23卷 112-117页

作者：刘鸿优崔一雄张绍良 miguel-angel GOMEZ 华南师范大学体育科学学院广东广州510006 马德里理工大学身体锻炼与体育科学学院西班牙马德里28040

采用文献计量学的方法,对运动表现分析的历史、主要教材和主要期刊论文刊载情况进行简要的概述。结果显示运动表现分析于20世纪70—80年代开始在运动科学领域站稳脚跟,90年代后期至今则进入了高速平稳发展期。作为一个学科门类,运动表... 详细信息

采用文献计量学的方法,对运动表现分析的历史、主要教材和主要期刊论文刊载情况进行简要的概述。结果显示运动表现分析于20世纪70—80年代开始在运动科学领域站稳脚跟,90年代后期至今则进入了高速平稳发展期。作为一个学科门类,运动表现分析拥有较为完善的学科体系和人才培养机制,同时拥有权威的教材和广泛的教师与学生群体基础。作为一个科研领域,运动表现分析拥有庞大的、逐步增长的论文、研究者数量和被引用次数,但该领域内活跃的作者、期刊、研究机构、国家(或地区)绝大多数都集中于欧美和大洋洲等经济发达地区。同时运动表现分析领域的研究范围覆盖了绝大多数奥运会比赛项目。

关键词：竞赛与训练运动表现分析综述

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Malignant colorectal polyps

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World Journal of Gastroenterology 2010年第25期16卷 3103-3111页

作者： Luis Bujanda angel Cosme Ines Gil Juan I Arenas-Mirave Department of Gastroenterology Donostia Hospital Uni-versity of Basque Country Centro de Investigación Biomédica en Enfermedades Hepáticas y Digestivas 20010 San Sebastián Guipúzcoa Spain University of Basque Country Centro de Investigación Biomédica en Enfermedades Hepáticas y Digestivas 20010 San Sebastián Guipúzcoa Spain

Nowadays, the number of cases in which malignant colorectal polyps are removed is increasing due to colorectal cancer screening programmes. Cancerous polyps are classified into non-invasive high grade neoplasia (NHGN), when the cancer has not reached the muscularis mucosa, and malignant polyps, classed as T1, when they have invaded the submucosa. NHGN is considered cured with polypectomy, while the prognosis for malignant polyps depends on various morphological and histological factors. The prognostic factors include, sessile or pedunculated morphology of the polyp, whether partial or en bloc resection is carried out, the degree of differentiation of the carcinoma, vascular or lymphatic involvement, and whether the polypectomy resection margin is tumor free. A malignant polyp at T1 is considered cured with polypectomy ifit is a pedunculated polyp (Ip of the Paris classification), it has been completely resected, it is not poorly differentiated, the resection edge is not affected by the tumor and there is no vascular or lymphatic involvement. The sessile malignant polyp (Is of the Paris classification) at T1 is considered not cured with polypectomy. Only in some cases (e.g. older people with high surgical risk) local excision(polypectomy or endoscopic submucosal dissection or conventional endoscopic mucosal resection) is considered the definitive treatment.

关键词： Favourable histology Follow-up Malignant polyps Non-invasive high grade neoplasia Treatment

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Chemotherapy for gastric cancer

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World Journal of Gastroenterology 2006年第2期12卷 204-213页

作者： Javier Sastre Jose angel García-Saenz Eduardo Díaz-Rubio Servicio de Oncologia Médica HCU San Carlosc/Martín Lagos s/n 28040 MadridSpain Servicio de Oncologia Médica HCU San Carlosc/Martía Lagos s/n 28040 MadridSpain

Metastatic gastric cancer remains a non-curative disease. Palliative chemotherapy has been demonstrated to prolong survival without quality of life compromise. Many single-agents and combinations have been confirmed to be active in the treatment of metastatic disease. Objective response rates ranged from 10-30% for single-agent therapy and 30-60% for polychemotherapy. Results of phase Ⅱ and Ⅲ studies are reviewed in this paper as well as the potential efficacy of new drugs. For patients with localized disease, the role of adjuvant and neoadjuvant chemotherapy and radiation therapy is discussed. Most studies on adjuvant chemotherapy failed to demonstrate a survival advantage, and therefore, it is not considerecl as standard treatment in most centres. Adjuvant immunochemotherapy has been developed fundamentally in Korea and Japan. A meta-analysis of phase Ⅲ trials with OK-432 suggested that immunochemotherapy may improve survival of patients with curatively resected gastric cancer. Based on the results of US Intergroup 0116 study, postoperative chemoradiation has been accepted as standard care in patients with resected gastric cancer in North America. However, the results are somewhat confounded by the fact that patients underwent less than a recommended D1 lymph node dissection and the pattern of recurrence suggested a positive effect derived from local radiotherapy without any effect on micrometastatic disease. Neoadjuvant chemotherapy or chemoradiation therapy remains experimental, but several phase Ⅱ studies are showing promising results. Phase Ⅲ trials are needed.

关键词： Gastric cancer Chemotherapy Adjuvant treatment

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The Explicitly Covariant Stress-Energy-Momentum Balance Equation for Electromagnetism in Material Media

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Journal of Physical Science and Application 2012年第4期2卷 123-127页

作者： Ignacio Campos Flores Jose Luis Jimenez Ramirez miguel angel Lopez Marino Departamento de Fisica Facultad de Ciencias Universidad Naeional Aut6noma de Mdxico Apartado Postal 21-463 Mexieo D.F. 04000 Mdxico Departamento de Fisica Division de Ciencias Basicas e Ingenieria Universidad Aut6noma Metropolitana Iztapalapa Av. SanRafael Atlixco # 186 Col. Vicentina Apartado Postal 21-463 Mexico D. F. 04000 Mexico Departamento de Ingenieria Tecnol6gico de Monterrey Campus Central de Veracruz Av. E. Garza Sada # 1 Apartado Postal 314 C6rdoba Veracruz 94500 Mexico

Beginning with the explicitly covariant Maxwell equations in media, we deduce an explicitly covariant stress-energy-momentum balance equation in material media. Proceeding in this way we avoid mixing external fields and self fields, as occurs if one begins with Lorentz＇s law, the most usual approach appearing in textbooks. Indeed our deduction implies a generalized force density in which the total fields appear. As an application of the present deduction, we discuss briefly the Abraham-Minkowski controversy, showing its relation to open or closed electromagnetic systems. This approach will be interesting for scholars as well as graduate students interested in conceptual problems of relativistic electromagnetism.

关键词： Maxwell's equations balance equation electromagnetic force density.

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Plants and heterotrimeric G proteins:Expect the unexpected

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Molecular Plant 2023年第3期16卷 506-508页

作者： angel Ferrero-Serrano David Chakravorty Biology Department Penn State University208 Mueller LaboratoryUniversity ParkPA 16802USA

The United Nations estimates that by 2050 the world population will reach 9.7 billion(United Nations Department of Economic and Social Affairs,Population Division,2022),which will increase food ***,predictions anticipate global crop yield declines of 5.6%–18.2%as a result of climate change(Zhao et al.,2017).Climate change will result in extreme weather events that are already occurring and that will become more frequent and variable in the ***,more than ever,we need plants that can cope with unpredictable weather events such as drought or heat ***,understanding and controlling plant stress responses is likely to be one of several fundamental advances crucial to meeting increased crop production *** is an urgent necessity to develop crops that tolerate multiple stresses without a deleterious reduction in fitness under optimal ***,efforts to release such varieties have often failed because of an unacceptable trade-off between growth and stress tolerance.

关键词： weather crops likely

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The Application of the Generalized Finite Difference Method (GFDM) for Modelling Geophysical Test

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Journal of Geoscience and Environment Protection 2019年第4期7卷 1-17页

作者： angel Muelas Eduardo Salete Juan José Benito Francisco Urena Luis Gavete miguel Urena UNED ETS Ingenieros IndustrialesC/Juan del RosalMadridSpain UCLM IMACICiudad RealSpain UPM ETSIMMadridSpain

The possibility of using a nodal method allowing irregular distribution of nodes in a natural way is one of the main advantages of the generalized finite difference method (GFDM) with regard to the classical finite difference method. Moreover, this feature has made it one of the most-promising meshless methods because it also allows us to reduce the time-consuming task of mesh generation and the numerical solution of integrals. This characteristic allows us to shape geological features easily whilst maintaining accuracy in the results, which can be a source of great interest when dealing with this kind of problems. Two widespread geophysical investigation methods in civil engineering are the cross-hole method and the seismic refraction method. This paper shows the use of the GFDM to model the aforementioned geophysical investigation tests showing precision in the obtained results when comparing them with experimental data.

关键词： Meshless Methods Generalized Finite Difference Method Geophysics

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EEGcorco: a computer program to simultaneously calculate and statistically analyze EEG coherence and correlation

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Journal of Biomedical Science and Engineering 2011年第12期4卷 774-787页

作者： miguel angel Guevara Marisela Hernández-González Araceli Sanz-Martin Claudia Amezcua 不详

EEGcorco is a computer program designed to analyze the degree of synchronization between two electroencephalographic signals (EEG) by mean the analysis of correlation and coherence index. The correlation and coherence values permit the quantitative determination of the similarity among EEG signals from homologous areas of the cerebral hemispheres (interhemispheric), and among localized areas within one cerebral hemisphere (intrahemispheric). EEG coherence is a function of frequency;thus it is commonly presented in a spectral manner (coherence values in every frequency of the spectrum), in contrast, the correlation function has been employed mainly to search periodic components of bioelectrical signals, and normally appears as punctual values defined in time, hence it is not common calculate correlation spectra. EEGcorco offers an easy and novel way to calculate correlation spectra by mean the application of the Fast Fourier Transformation (FFT) to digitized EEG signals. Both, correlation and coherence spectra are obtained in both independent frequencies and frequencies grouped in wide bands. Moreover, the program applies parametric statistical analyses to those coherence and correlation spectra also, for each individual frequency and for the frequencies grouped in bands. The program functions on any PC-compatible computer equipped with a Pentium or superior processor and a minimum of 512 Mb of RAM memory (though the higher the capacity the better). The space required on the hard disk depends on the signals to be analyzed, as the output takes the form of files in text format that occupy very little space. The program has been elaborated completely in the Delphi environment for the Windows operating system. The efficacy and versatility of EEGcorco allow it to be easily adapted to different experimental and clinical needs.

关键词： EEG EEG Coherence EEG Correlation

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Isobars Separation (137Cs-137mBa-137Ba) from Marine Sediments, in Order to Evaluate Directly Their Radioactive Contamination by Mass Spectrometry

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World Journal of Nuclear Science and Technology 2020年第1期10卷 32-38页

作者： Karla Fernández Juan Manuel Navarrete miguel angel Zúñ iga Ernesto Hernández Department of Inorganic and Nuclear Chemistry Faculty of ChemistryNational Autonomous University of MexicoMexico CityMexico

Marine sediments contamination by fission product 137Cs-137mBa is a fact since the period 1945-65, when plus than two thousand atomic explosion tests were performed mainly in the southern seas, earth region with minor population density. However, marine flows have produced dissemination of this radioactive pair through the sea bottom all over the world, at different levels, because the sea movement and natural decaying of radioactive pair: parent 137Cs (t1/2 = 30.17 years) and daughter 137mBa (t1/2 = 2.55 minutes). Radioactive detection of these contaminants, compared as percentage with that of natural 40K (t1/2 = 1.28 × 109 years, 0.0118% of elementary K) leads to radiation contamination factor (RCF), as one possible unit to measure the radioactive contamination intensity in different regions, as well to determine if there is some other possible source of this contaminant, for example water cooling from power nuclear reactors when it is discharged at sea. However, radioactive detection always implies an unavoidable statistical variation, which makes more difficult to appreciate the changes as function of time and region. But at beginning of this century, mass spectrometry has got impressive advances, which makes it much more precise and sensible than radioactive detection [1]. This paper attempts to measure with other units the radioactive contamination: 137Cs atoms number per gram of sample, instead radioactivity, which could be more direct and with minor standard deviation that radioactive detection, solving at same time the isobars separation: 137Cs versus 137mBa plus elementary 137Ba (11.23% of Ba element).

关键词： Isobars Separation 137Cs-137mBa-137Ba

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Properties of Chemical Bath Deposited PbS Thin Films Doped with Cd2＋

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材料科学与工程（中英文A版） 2011年第6期1卷 759-767页

作者： Oscar Portillo moreno Melissa Chavez Portillo Miriam moreno Flores Javier Martinez Juarez Gustavo Abarca Avila Rosendo Lozada Morales Orlando Zelaya angel Facultad de Ciencias Quimicas BUAP C. U. Puebla Mexico CIDS-ICUAP C. U. Puebla Mexico Facultad de Ciencias Fisicomatematicas BUAP C. U. Puebla Mexico Departamento de Fisiea Centro de Investigacion y de Estudios Avanzados Av. IPN 2508 Col San Pedro Zacatenco Mexico

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