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Highly sensitive ratiometric fluorescent fiber matrices for oxygen sensing with micrometer spatial resolution

Bio-Design and Manufacturing 2024年第3期7卷 292-306页

作者： Giuliana Grasso Valentina Onesto stefania Forciniti Eliana D’Amone Francesco Colella Lara Pierantoni Valeria Famà Giuseppe Gigli Rui L.Reis J.miguel Oliveira Loretta L.del Mercato nstitute of nanotechnology National Research Council(CNR-NANOTEC)c/o Campus Ecoteknevia Monteroni73100 LecceItaly Department of Mathematics and Physics“Ennio De Giorgi” University of Salentoc/o Campus Ecoteknevia Monteroni73100 LecceItaly 3B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVs/3B’s-PT Government Associate Laboratory 4806-909 Braga/GuimarãesPortugal Department of Experimental Medicine University of Salentoc/o Campus Ecoteknevia Monteroni73100 LecceItaly

Oxygen(O_(2))-sensing matrices are promising tools for the live monitoring of extracellular O_(2) consumption levels in long-term cell *** this study,ratiometric O_(2)-sensing membranes were prepared by electrospinning,an easy,low-cost,scalable,and robust method for fabricating ***(ε-caprolactone)and poly(dimethyl)siloxane polymers were blended with tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II)dichloride,which was used as the O_(2)-sensing probe,and rhodamine B isothiocyanate,which was used as the reference *** functionalized scaffolds were morphologically characterized by scanning electron microscopy,and their physicochemical profiles were obtained by Fourier transform infrared spectroscopy,thermogravimetric analysis,and water contact angle *** sensing capabilities were investigated by confocal laser scanning microscopy,performing photobleaching,reversibility,and calibration curve studies toward different dissolved O_(2)(DO)*** sensing nanofibers showed a high response to changes in DO concentrations in the physiological-pathological range from 0.5%to 20%and good stability under ratiometric *** addition,the sensing systems were highly biocompatible for cell growth promoting adhesiveness and growth of three cancer cell lines,namely metastatic melanoma cell line sK-MEL2,breast cancer cell line MCF-7,and pancreatic ductal adenocarcinoma cell line Panc-1,thus recreating a suitable biological environment in *** O_(2)-sensing biomaterials can potentially measure alterations in cell metabolism caused by changes in ambient O_(2)content during drug testing/validation and tissue regeneration processes.

关键词： Electrospinning Ruthenium(II)dichloride Oxygen sensors Ratiometric imaging Fluorescence

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Piling up multidecker pyrgos[n]cages as antibacterial materials

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science China Materials 2024年

作者： miguel A.Liuzzi-Vaamonde Jackson B.Lancaster samantha A.Mason Yuanning Feng Department of Chemistry and Biochemistry The University of Oklahoma

The development of antibiotics is regarded as one of the most significant scientific advances in modern *** the commercialization of antibiotics,infectious diseases were catastrophic throughout history[1].Penicillin was used to treat serious infections in the 1940s,but unfortunately,with the introduction of antibiotics came the emergence of antibiotic resistance[2,3].Evolved and adapted methicillin-resistant staphylococcus aureus （MRsA） strains are presently impacting community and healthcare systems across the globe[4].

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Peripheral nerve regeneration through nerve conduits evokes differential expression of growth-associated protein-43 in the spinal cord

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neural Regeneration Research 2023年第8期18卷 1852-1856页

作者： Jesús Chato-Astrain Olga Roda David sánchez-Porras Esther Miralles miguel Alaminos Fernando Campos Óscar Darío garcía-garcía Víctor Carriel Department of Histology(Tissue Engineering Group) University of GranadaInstituto de Investigación Biosanitaria ibs.GRANADAGranadaSpain Department of Human Anatomy and Embryology University of GranadaGranadaSpain Unit of Clinical neurophysiology University Hospital San CecilioGranadaSpain

Growth-associated protein 43 plays a key role in neurite outgrowth through cytoskeleton *** have previously demonstrated that structural damage of peripheral nerves induces growth-associated protein 43 upregulation to promote growth cone ***,the limited regenerative capacity of the central nervous system due to an inhibitory environment prevents major changes in neurite outgrowth and should be presumably associated with low levels of growth-associated protein 43 ***,central alterations due to peripheral nerve damage have never been assessed using the growthassociated protein 43 *** this study,we used the tubulization technique to repair 1 cm-long nerve gaps in the rat nerve injury/repair model and detected growth-associated protein 43 expression in the peripheral and central nervous ***,histological analysis of the regeneration process confirmed an active regeneration process of the nerve gaps through the conduit from 10 days *** growth-associated protein 43 expression profile varied across regions and follow-up times,from a localized expression to an abundant and consistent expression throughout the regeneration tissue,confirming the presence of an active nerve regeneration ***,spinal cord changes were also histologically assessed,and no apparent changes in the structural and cellular organization were observed using routine staining ***,remarkable differences and local changes appeared in growth-associated protein 43 expression at the spinal cord level,in particular at 20 days post-repair and ***-associated protein 43 protein was first localized in the gracile fasciculus and was homogeneously distributed in the left posterior *** findings differed from the growth-associated protein 43 pattern observed in the healthy control,which did not express growth-associated protein 43 at these *** results revealed a differential expression in growth-associate

关键词： growth-associated protein 43(GAP-43) immunohistochemistry nerve guide nerve tissue regeneration peripheral nerve repair spinal cord tissue engineering

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Biometric and ICL-related risk factors associated to sub-optimal vaults in eyes implanted with implantable collamer lenses

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Eye and Vision 2021年第5期8卷 253-262页

作者： santiago Cerpa Manito Angel sánchez Trancón Oscar Torrado sierra António Manuel Baptista Pedro miguel serra Research and Development Department Ophthalmology Clinic Vista Sánchez TrancónBuilding TecnolaserRoom 14 Calle La Violeta06005 BadajozSpain Center of Physics University of MinhoBragaPortugal Optics and Optometry Department Instituto Superior de Educação e CiênciasLisbonPortugal

Background:To identify biometric and implantable collamer lens(ICL)-related risk factors associated with suboptimal postoperative vault in eyes implanted with phakic ***:This study reports a retrospective case series of the first operated eye in 360 patients implanted with myopic spherical or toric ***,white-to-white(WTW),central keratometry(Kc)and central corneal thickness(CCT)were measured using the ***-segment optical coherence tomography(As-OCT,Visante)was applied preoperatively for measuring the horizontal anterior-chamber angle-to-angle distance(ATA),internal anterior chamber depth(ACD),crystalline lens rise(CLR),anterior-chamber angle(ACA)and postoperatively the *** were divided into three vault groups:low(LVG:≤250μm),optimal(OVG:>250 andnd high(HVG:≥1000μm).Multinomial logistic regression(MLR)was used to find the sub-optimal vault ***:MLR showed that CLR,ICL size minus the ATA(ICL size-ATA),age,ICL spherical equivalent(ICLsE)and ICL size as contributing factors for sub-optimal vaults(pseudo-R2=0.40).Increased CLR(OR:1.01,CI:1.00-1.01)and less myopic ICLsE(OR:1.22,CI:1.07-1.40)were risk factors for low *** ICL size-ATA(OR:41.29,CI:10.57-161.22)and the 13.7mm ICL(OR:7.08,CI:3.16-15.89)were risk factors for high vaults,whereas less myopic ICLsE(OR:0.85,CI:0.76-0.95)and older age(OR:0.92,CI:0.88-0.98)were protective ***:High CLR and low ICLsE were the major risk factors in eyes presenting low *** the opposite direction,ICL size-ATA was the major contributor for high *** relationship was more critical in higher myopic ICLsE,younger eyes and when 13.7mm ICL were *** findings show that factors influencing the vault have differentiated weight of influence depending on the type of vault(low,optimal or high).

关键词： Implantable collamer lens Refractive surgery Vault Risk factors

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当代中国人群牙齿可观测特征的多样性研究

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基因组学与应用生物学 2024年第1期43卷 150-171页

作者：罗浩陈颖洁杨光睿 Kaustubh Adhikari 夏斌 Andrés Ruiz-Linares miguel Delgado 复旦大学生命科学学院现代人类学教育部重点实验室人类遗传学与人类学系上海200438 开放大学科学技术工程和数学学院数学与统计学院英国伦敦MK76AA 北京大学口腔医学院北京100086 拉普拉塔国立大学自然科学及博物馆学院人类学科阿根廷拉普拉塔1900

本研究基于当代中国人群3D牙齿模型数据,参照拉美人群进化和多样性研究联合会(consortium for the analysis of the diversity and evolution of Latin America,CAnDELA)所使用的牙齿特征点标记方法,使用牙齿特征点间的欧几里得线性距离... 详细信息

本研究基于当代中国人群3D牙齿模型数据,参照拉美人群进化和多样性研究联合会(consortium for the analysis of the diversity and evolution of Latin America,CAnDELA)所使用的牙齿特征点标记方法,使用牙齿特征点间的欧几里得线性距离(Euclidean linear distances,ELD)表示的牙齿表型作为牙齿可观测特征的度量,探究个体因素(年龄、性别)和群体因素(民族)对当代中国人群牙齿可观测特征多样性的影响。通过对牙齿标记特征点的典型变量分析(canonical variate analysis,CVA)、交叉验证(cross validation,CV)、主成分分析(principal component analysis,PCA)以及对牙齿表型的Pearson相关性分析和差异分析,本研究发现进化上相近的群体牙齿可观测特征往往更接近。具体来说,汉族的上颌牙齿可观测特征和壮族、苗族较为接近而不同于蒙古族的,而藏族的上、下颌牙齿可观测特征不同于维吾尔族的;南北中汉族牙齿表型的差异具有明确的方向性,下颌牙齿差异比上颌更明显;从性别角度看,男女牙齿表型差异主要体现在尖牙上,男性尖牙平均宽度和高度显著大于女性的;对不同年龄群体的差异分析表明,遗传外因素对牙齿可观测特征的影响主要体现在尖牙、上颌第一磨牙、下颌第一前磨牙上。

关键词：当代中国人群牙齿可观测特征表型差异

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Animal models used to study direct peripheral nerve repair: a systematic review

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neural Regeneration Research 2020年第3期15卷 491-502页

作者： Francisco Javier Vela Guadalupe Martínez-Chacón Alberto Ballestín JoséLuis Campos Francisco miguel sánchez-Margallo Elena Abellán Department of Microsurgery Jesús Usón Minimally Invasive Surgery CentreCáceresSpain scientific Director Jesús Usón Minimally Invasive Surgery CentreCáceresSpain

Objective:Peripheral nerve repair is required after traumatic *** common condition represents a major public health problem *** after nerve repair depends on several factors,including the severity of the injury,the nerve involved,and the surgeon’s technical *** the precise microsurgical repair of nerve lesions,adequate functional recovery is not always achieved and,therefore,the regeneration process and surgical techniques are still being ***-clinical animal models are essential for this research and,for this reason,the focus of the present systematic review(according to the PRIsMA statement)was to analyze the different animal models used in pre-clinical peripheral nerve repair *** sources:Original articles,published in English from 2000 to 2018,were collected using the Web of science,scopus,and PubMed *** selection:Only preclinical trials on direct nerve repair were included in this *** articles were evaluated by the first two authors,in accordance with predefined data *** measures:The primary outcomes included functional motor abilities,daily activity and regeneration *** outcomes included coaptation technique and animal ***:This review yielded 267 articles,of which,after completion of the screening,49 studies were *** were 1425 animals in those 49 studies,being rats,mice,guinea pigs,rabbits,cats and dogs the different pre-clinical *** nerves used were classified into three groups:head and neck(11),forelimb(8)and hindlimb(30).The techniques used to perform the coaptation were:microsuture(46),glue(12),laser(8)and mechanical(2).The follow-up examinations were histology(43),electrophysiological analysis(24)and behavioral observation(22).Conclusion:The most widely used animal model in the study of peripheral nerve repair is the *** animal models are also used but the cost-benefit of the rat model provides several strengths over the ***

关键词： nerve microsurgery peripheral nerve regeneration repair reconstruction direct nerve repair animal model coaptation PRIsMA systematic review

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nitrate reduction capacity of the oral microbiota is impaired in periodontitis:potential implications for systemic nitric oxide availability

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International Journal of Oral science 2024年第1期16卷 52-61页

作者： Bob T.Rosier William Johnston miguel Carda-Diéguez Annabel simpson Elena Cabello-Yeves Krystyna Piela Robert Reilly Alejandro Artacho Chris Easton Mia Burleigh shauna Culshaw Alex Mira Department of Genomics and Health FISABIO FoundationCenter for Advanced Research in Public HealthValenciaSpain Department of Biological and Biomedical sciences Glasgow Caledonian UniversityGlasgowUK Oral sciences University of Glasgow Dental SchoolSchool of MedicineDentistry and NursingCollege of MedicalVeterinary and Life SciencesUniversity of GlasgowGlasgowUK sport and Physical Activity Research Institute University of the West of ScotlandBlantyreScotland Instituto de Biomedicina de Valencia Consejo Superior de Investigaciones Científicas(IBV-CSIC)ValenciaSpain CIBER Center for Epidemiology and Public Health MadridSpain

The reduction of nitrate to nitrite by the oral microbiota has been proposed to be important for oral health and results in nitric oxide formation that can improve cardiometabolic conditions. studies of bacterial composition in subgingival plaque suggest that nitrate-reducing bacteria are associated with periodontal health, but the impact of periodontitis on nitrate-reducing capacity(nRC)and, therefore, nitric oxide availability has not been evaluated. The current study aimed to evaluate how periodontitis affects the nRC of the oral microbiota. First, 16s rRnA sequencing data from five different countries were analyzed, revealing that nitratereducing bacteria were significantly lower in subgingival plaque of periodontitis patients compared with healthy individuals(P n all five datasets with n = 20–82 samples per dataset). secondly, subgingival plaque, saliva, and plasma samples were obtained from 42 periodontitis patients before and after periodontal treatment. The oral nRC was determined in vitro by incubating saliva with 8 mmol/L nitrate(a concentration found in saliva after nitrate-rich vegetable intake) and compared with the nRC of 15healthy individuals. salivary nRC was found to be diminished in periodontal patients before treatment(P s 90 days post-treatment. Additionally, the subgingival levels of nitrate-reducing bacteria increased after treatment and correlated negatively with periodontitis-associated bacteria(P no significant effect of periodontal treatment on the baseline saliva and plasma nitrate and nitrite levels was found, indicating that differences in the nRC may only be revealed after nitrate intake. Our results suggest that an impaired nRC in periodontitis could limit dietary nitrate-derived nitric oxide levels, and the effect on systemic health should be explored in future studies.

关键词： impaired intake nitrate

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Hyoid metastasis an unusual location from lung cancer

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World Journal of Clinical Oncology 2024年第7期15卷 796-798页

作者： miguel Montijano Abrahams Ocanto Felipe Couñago Department of Radiation Oncology San Francisco de Asís University HospitalGenesis CareMadrid 28002Spain Department of Radiation Oncology Vithas La Milagrosa University HospitalGenesis CareMadrid 28010Spain national Director Genesis CareMadrid 28043Spain

Bone metastases from lung cancer account for 8.5%,with those located in the hyoid bone being extremely *** this editorial,we made a review about Hsu et al case report highlighted the importance of palliative radiotherapy,even with an unusual but effective scheme in pain control in a patient with non-small cell lung cancer in stage IV.

关键词： Lung cancer Metastases Radiotherapy Palliative care Chemotherapy

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An update on the molecular biology of glioblastoma,with clinical implications and progress in its treatment

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Cancer Communications 2022年第11期42卷 1083-1111页

作者： Elena Verdugo Iker Puerto miguelÁngel Medina Department of Molecular Biology and Biochemistry University of MálagaMálagaMálaga E-29071Spain Biomedical Research Institute of Málaga(IBIMA-Plataforma Bionand) MálagaMálaga E-29071Spain spanish Biomedical Research network Center for Rare Diseases(CIBERER) Spanish Health Institute Carlos III(ISCIII)MálagaMálaga E-29071Spain

Glioblastoma multiforme(GBM)is the most aggressive and common malig-nant primary brain *** with GBM often have poor prognoses,with a median survival of∼15 *** understanding of the molecular biology of central nervous system tumors has led to modifications in their classifications,the most recent of which classified these tumors into new categories and made some changes in their nomenclature and grading *** review aims to give a panoramic view of the last 3 years’findings in glioblastoma characterization,its heterogeneity,and current advances in its *** molecular parameters have been used to achieve an accurate and personalized characterization of glioblastoma in patients,including epigenetic,genetic,transcriptomic and metabolic features,as well as age-and sex-related patterns and the involvement of several noncoding RnAs in glioblastoma ***-like neural stem cells and outer radial glial-like cells from the subven-tricular zone have been proposed as agents involved in GBM of IDH-wildtype origin,but this remains *** metabolism is characterized by upregulation of the PI3K/Akt/mTOR signaling pathway,promotion of the gly-colytic flux,maintenance of lipid storage,and other *** metabolism also contributes to glioblastoma’s resistance to conventional *** heterogeneity,a hallmark of GBM,has been shown to affect the genetic expresion,modulation of metabolic pathways,and immune system ***’s aggressive invasion potential is modulated by cell-to-cell crosstalk within the tumor microenvironment and altered expressions of specific genes,such as AnXA2,GBP2,Fn1,PHIP,and ***,the rising number of active clinical trials illustrates the efforts to identify new targets and drugs to treat this *** is still relevant for research purposes,given the amount of ongoing clinical trials based on this strategy to treat GBM,and neoantigen and nuclei

关键词： cancer molecular biology diagnosis glioblastoma multiforme ongoing clinical trials targeted therapy tumor heterogeneity tumor metabolism

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Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

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neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo Adriana Cortés Mercedes Lachén-Montes Elena Anaya-Cubero Joaquín Fernández-Irigoyen Enrique santamaría Clinical neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

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