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Intraperitoneally Administered Lidocaine Attenuates Thermal Allodynia in a Murine “Two-Hit” Chronic Constriction Injury Model

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Open Journal of Animal Sciences 2016年第3期6卷 217-233页

作者： Selina E. I. van der Wal Sandra A. S. van den Heuvel Lisa Cornelissen michiel vaneker Monique A. H. Steegers Gert-Jan Scheffer Kris C. P. Vissers Department of Anesthesiology Pain and Palliative Medicine Radboud University Nijmegen Medical Center (RUNMC) Nijmegen Netherlands

Background: Mechanical ventilation (hit one) during surgery (hit two) is often needed and both induce an inflammatory response. Dysregulation of the inflammatory response can cause chronic postoperative pain. Methods: Healthy C57BL6 mice (n = 56) were mechanically ventilated (MV) and allocated to receive sham (MV-sham) or mechanically ventilation with chronic constriction injury (MV-CCI) surgery in the left hind paw. Plasma interleukin (IL)-1β, IL-6, IL-10, keratinocyte derived chemokine (KC) and tumor necrosis factor (TNF)-α were determined on day 0 and 16. Sensory testing was performed on day 0, 3, 7 and 16 by cold plate test (number of lifts (NOL) and cumulative reaction time (CRT)) and von Frey test. The effect of lidocaine on cytokines and sensory testing was analyzed. Results: MV-Sham showed an increase in IL-1β and TNF-α, and MV- CCI-lido increased levels of KC compared with MV on day 0. No difference in cytokine levels was observed on day 16. NOL of the left paw versus the right was increased in MV-CCI on day 7, and in MV-CCI-lido on day 7 and 16. The NOL of the left paw was decreased in MV-sham and MV-CCI-lido compared with MV-CCI on day 16. The CRT of the left paw was increased for MV-CCI on day 3 and 7, and for MV-CCI-lido on day 7. On day 16, MV-sham and MV-CCI-lido showed a decreased CRT of the left paw compared with MV-CCI. Conclusion: Nerve injury and not systemic inflammatory response seems mandatory for development of neuropathic pain in this “two-hit” model. Lidocaine attenuates cold allodynia in mice.

关键词： Inflammation Neuropathic Pain Allodynia Lidocaine Murine Model

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Standaertsite公园,根特,比利时

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世界建筑 2024年第6期 60-65页

作者：无 michiel De Cleene(摄影) Jef Geldof(摄影) Joshua Delissen(摄影) Murmuur建筑事务所 Carton123建筑事务所 AE-建筑事务所不详

前身为自助商店“Standaert”的旧址与莱德贝格两条人口稠密的中心街道相连。除此以外,该场地还深入内部区域,被花园围墙和附属建筑所环绕。通过移除一部分场地周边的环境,设计师在城市中打开了一个开口,使其突然出现了一个景观。设计... 详细信息

前身为自助商店“Standaert”的旧址与莱德贝格两条人口稠密的中心街道相连。除此以外,该场地还深入内部区域,被花园围墙和附属建筑所环绕。通过移除一部分场地周边的环境,设计师在城市中打开了一个开口,使其突然出现了一个景观。设计师的主要意图是尽可能保持公园的规模,同时也对这个密集城市结构中的两条街道产生影响。有限的建筑空间被合理利用。

关键词：附属建筑内部区域主要意图人口稠密公园街道比利时

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Contrast-enhanced and targeted ultrasound

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World Journal of Gastroenterology 2011年第1期17卷 28-41页

作者： michiel Postema Odd Helge Gilja Emmy Noether Research Group Institute of Medical EngineeringDepartment of Electrical Engineering and Information SciencesRuhr-Universit t Bochum44780 BochumGermany Department of Physics and Technology Un versity of Bergen5007 BergenNorway Department of Engineering The University of HullKingston upon Hull HU6 7RXUnited Kingdom Centre de Biophysique Moléculaire UPR 4301 CNRS affiliated to the University of Orléans45071 OrléansFrance National Center for Ultrasound in Gastroenterology Department of MedicineHaukeland University Hospital5021 BergenNorway Institute of Medicine University of Bergen 5007 BergenNorway

Ultrasonic imaging is becoming the most popular medical imaging modality,owing to the low price per examination and its ***,blood is a poor scatterer of ultrasound waves at clinical diagnostic transmit *** perfusion imaging,markers have been designed to enhance the contrast in B-mode *** so-called ultrasound contrast agents consist of microscopically small gas bubbles encapsulated in biodegradable *** this review,the physical principles of ultrasound contrast agent microbubble behavior and their adjustment for drug delivery including sonoporation are ***,an outline of clinical imaging applications of contrast-enhanced ultrasound is *** is a challenging task to quantify and predict which bubble phenomenon occurs under which acoustic condition,and how these phenomena may be utilized in ultrasonic *** by high-speed photography,our improved understanding of encapsulated microbubble behavior will lead to more sophisticated detection and delivery *** sophisticated methods use quantitative approaches to measure the amount and the time course of bolus or reperfusion curves,and have shown great promise in revealing effective tumor responses to anti-angiogenic drugs in humans before tumor shrinkage *** are beginning to be accepted into clinical *** the long term,targeted microbubbles for molecular imaging and eventually for directed anti-tumor therapy are expected to be tested.

关键词： Ultrasound Drug delivery systems Drug targeting Sonoporation Contrast media Liver Pancreas Gastrointestinal tract

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Irreducibility Properties of Keller Maps

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Algebra Colloquium 2016年第4期23卷 663-680页

作者： michiel de Bondt Dan Yan Department of Mathematics Radboud University Nijmegen The Netherlands Department of Mathematics and Computer ScienceHunan Normal University Changsha 410006 China

Jedrzejewicz showed that a polynomial map over a field of characteristic zero is invertible, if and only if the corresponding endomorphism maps irreducible polynomials to irreducible polynomials. Furthermore, he showed that a polynomial map over a field of characteristic zero is a Keller map, if and only if the corresponding endomorphism maps irreducible polynomials to square-free polynomials. We show that the latter endomorphism maps other square-free polynomials to square-free polynomials as well. In connection with the above classification of invertible polynomial maps and the Jacobian Conjecture, we study irreducibility properties of several types of Keller maps, to each of which the Jacobian Conjecture can be reduced. Herewith, we generalize the result of Bakalarski that the components of cubic homogeneous Keller maps with a symmetric Jacobian matrix （over C and hence any field of characteristic zero） are irreducible. Furthermore, we show that the Jacobian Conjecture can even be reduced to any of these types with the extra condition that each affinely linear combination of the components of the polynomial map is irreducible. This is somewhat similar to reducing the planar Jacobian Conjecture to the so-called （planar） weak Jacobian Conjecture by Kaliman.

关键词： Jacobian Conjecture Keller map irreducible square-free weak JacobianConjecture

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Gricean and Confucian Pragmatics:A Contrastive Analysis

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外国语 2006年第6期29卷 2-21页

作者： michiel Leezenberg University of Amsterdam

A contrastive study confronting the influential paradigm of Gricean pragmatics with Confucius’ rather less well-known doctrines on language and language usage may explicate the hidden assumptions in both, and suggest new lines of research. Grice’s famous account of conversational implicature not only assumes speaker’s intentions (that is, private mental states) as basic explanatory notions; it also appears to rely on strong assumptions about speaker’s agency, and about communication as normally or essentially cooperative and power-free. In other words, Grice presumes both methodological individualism and what we may call a social contract view of communication. The Confucian Analects share neither of these assumptions. They attach little importance to the inner, and even less to mental states as explanatory notions. They do not assume individual actors’ agency to be given or primitive, and do not take language to be consensual or contractual in nature. Instead, the famous doctrine of the ‘correction of names’ (正名) displays an articulate awareness of both the performative dimensions of communication and the role of authority or power in it: in correcting names, the ruler constitutes the very social realities he is describing, and the social roles (and by extension, the very personalities or subjectivities) of the persons he is naming. When contrasted with the Gricean framework, Confucian pragmatics allows for a more radical questioning of, among others, the role of speaker’s intentions in explaining communication; the relation between literal and figurative usage; and strategies and aims of indirect language usage. The absence of any appeal to the law and to any universal or codified rules of correct language usage in Confucius also opens up new dimensions for the discussion of linguistic normativity. Finally, a contrastive study raises questions about the variable interrelationship between folk theories or language ideologies and linguistic practices.

关键词：语用论对比分析研究方式孔子《论语》

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Evolution of plant reproduction:From fusion and dispersal to interaction and communication

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Chinese Science Bulletin 2009年第14期54卷 2390-2403页

作者： WILLEMSE michiel T M Laboratory of Plant Cytology and Morphology Wageningen University6717LM EdeThe Netherlands

Based on the existing data concerning the evolution of the sexual reproduction, it is argued that the processes of sex differentiation and interactions play a key role in evolution. From the beginning environment and organism are unified. In a changing dynamic environment life originates and the interaction between life and environment develops from simple to more complex organisms. Sexual reproduction is introduced after the origin of meiosis and is a key process in evolution. The asexual reproduction process prepares to dispersal. Sexual reproduction process adds the genome renewal and the gamete-gamete interaction. Reproduction and dispersal are connected and the process of reproduction has similarities between asexual and sexual reproduction. Unicellular algae develop the physiological and morphological sex differentiation. Sex differentiation is connected with the way of dispersal. The step to multicellular plants introduces cell isolation after meiosis and by the stay on the mother plant within a cell or organ, plant-cell apoplastic interaction originates and by prolonged stay the plant-plant interaction. This stay influences the type of dispersal. A life cycle with alternation of generations and two moments of dispersal permits plants to go on land. In ferns a shift in the moment of sex differentiation to meiospore happens and the stay of the macrospore leads to the seed plants. In water all types of sexual reproduction, interactions and the alternation of generations are prepared and these are used to conquest land. On land the biotic dispersal is realized. The phylogeny of sexual reproduction reveals that the sex differentiation and interaction are the main causes in the evolution of sexual reproduction. Sexual reproduction shows interactions during gamete fusion, between organism and environment and in multicellular plants between organisms. With respect to other types of interaction as in symbiosis or the nutrient chain, interaction is considered as an im

关键词：基因组蕨类植物植物细胞有性生殖

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Predicting the aquatic risk of realistic pesticide mixtures to species assemblages in Portuguese river basins

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Journal of Environmental Sciences 2015年第5期27卷 12-20页

作者： Emília Silva michiel A.Daam Maria José Cerejeira Centro de Engenharia dos Biossistemas (CEER) Instituto Superior de Agronomia (ISA) University of Lisbon (UL) Tapada da Ajuda1349-017 Lisbon Portugal

Although pesticide regulatory tools are mainly based on individual substances, aquatic ecosystems are usually exposed to multiple pesticides from their use on the variety of crops within the catchment of a river. This study estimated the impact of measured pesticide mixtures in surface waters from 2002 and 2008 within three important Portuguese river basins（＇Mondego＇, ＇Sado＇ and ＇Tejo＇） on primary producers, arthropods and fish by toxic pressure calculation. Species sensitivity distributions（SSDs）, in combination with mixture toxicity models, were applied. Considering the differences in the responses of the taxonomic groups as well as in the pesticide exposures that these organisms experience, variable acute multi-substance potentially affected fractions（ms PAFs） were obtained. The median msP AF for primary producers and arthropods in surface waters of all river basins exceeded 5%, the cut-off value used in the prospective SSD approach for deriving individual environmental quality standards. A ranking procedure identified various photosystem II inhibiting herbicides, with oxadiazon having the relatively largest toxic effects on primary producers, while the organophosphorus insecticides, chlorfenvinphos and chlorpyrifos, and the organochloride endosulfan had the largest effects on arthropods and fish, respectively. These results ensure compliance with European legislation with regard to ecological risk assessment and management of pesticides in surface waters.

关键词： Pesticides Mixtures Risk assessment Multi-substance potentially affected fraction Surface waters

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Development of an analytical method based on solid-phase extraction and LC-MS/MS for the monitoring of current-use pesticides and their metabolites in human urine

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Journal of Environmental Sciences 2022年第1期34卷 153-163页

作者： Beibei Gao Giulia Poma Govindan Malarvannan Catalina Dumitrascu michiel Bastiaensen Minghua Wang Adrian Covaci Toxicological Centre University of AntwerpWilrijk 2610Belgium Department of Pesticide Science College of Plant ProtectionState and Local Joint Engineering Research Center of Green Pesticide Invention and ApplicationNanjing Agricultural UniversityNanjing 210095China

Pyrethroids,organophosphorus pesticides and fipronil have been listed as priority chemicals in human biomonitoring studies because of their wide use and potential health effects in *** determination of 13 pesticides,including pyrethroids(deltamethrin,cypermethrin,permethrin,cyfluthrin,bifenthrin),organophosphorus(chlorpyrifos,chlorpyrifosmethyl,and malathion),fipronil,neonicotinoids(imidacloprid,acetamiprid and thiacloprid)and triazole(prothioconazole),together with 13 corresponding metabolites in human urine samples was achieved by solid-phase extraction and analysis by liquid chromatography coupled to tandem mass *** targeted compounds,except malathion dicarboxylic acid,were measured with a mean within-accuracy(n=5)of 71%–114%(RSD:1%–14%)and between-run(n=15)accuracy of 80%–118%(RSD:2%–14%).Limits of quantitation of the targeted analytes ranged from 0.1 to 16 pg/m *** detection result of urine samples from 25 volunteers indicated that the detection frequencies of 3,5,6-trichloro-2-pyridinol(median:448 pg/m L),6-chloropyridine-3-carboxylic acid(median:193 pg/m L),2-methyl-3-phenylbenzoic acid(median:181 pg/m L),3-phenoxybenzoic acid(median:99 pg/m L),2-isopropyl-6-methyl-4-pyrimidinol(median:77 pg/m L),cyfluthrin(median:59 pg/m L),cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid(cis-DCCA,median:53 pg/m L),trans-DCCA(median:25 pg/m L),prothioconazole(median:21 pg/m L),imidacloprid(median:7 pg/m L),and prothioconazole-desthio(median:1 pg/m L)were>50%.The obtained results show that the validated method is suitable for the human biomonitoring of these currentuse pesticides and their metabolites.

关键词： Pyrethroids Organophosphorus Fipronil Neonicotinoids Urine Biomonitoring

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Compact representations of microstructure images using triplet networks

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npj Computational Materials 2020年第1期6卷 369-379页

作者： michiel Larmuseau Michael Sluydts Koenraad Theuwissen Lode Duprez Tom Dhaene Stefaan Cottenier Center for Molecular Modeling Ghent UniversityTechnologiepark 46B-9052 ZwijnaardeBelgium Department of Electrical Energy MetalsMechanical Constructions and SystemsGhent UniversityTechnologiepark 46B-9052 ZwijnaardeBelgium IDLab Department of Information TechnologyGhent University-IMECTechnologiepark 126B-9052 ZwijnaardeBelgium OCAS NV/ArcelorMittal Global R&D Gent Pres.J.F.Kennedylaan 3B-9060 ZelzateBelgium

The microstructure of a material,typically characterized through a set of microscopy images of two-dimensional cross-sections,is a valuable source of information about the material and its *** pixel of the image is a degree of freedom causing the dimensionality of the information space to be extremely *** makes it difficult to recognize and extract all relevant information from the *** experts circumvent this by manually creating a lower-dimensional representation of the ***,the question of how a microstructure image can be best represented remains *** the field of deep learning,we present triplet networks as a method to build highly compact representations of the microstructure,condensing the relevant information into a much smaller number of *** demonstrate that these representations can be created even with a limited amount of example images,and that they are able to distinguish between visually very similar *** discuss the interpretability and generalization of the *** compact microstructure representations,it becomes easier to establish processing–structure–property links that are key to rational materials design.

关键词： networks Compact microstructure

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Changes in nectar supply： A possible cause of widespread butterfly decline

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Current Zoology 2012年第3期58卷 384-391页

作者： michiel F. WALLISDEVRIES Chris A.M. Van SWAAY Calijn L. PLATE De Vlinderstichting / Dutch Butterfly Conservation EO. Box 506 6700 AM Wageningen The Netherlands Wageningen University Lab of Entomology EO. Box 8031 6700 EH Wageningen The Netherlands Statistics Netherlands （CBS） P.O. Box 24500 2490 HA The Hague The Netherlands

Recent studies have documented declining trends of various groups of flower-visiting insects, even common butterfly species. Causes of these declines are still unclear but the loss of habitat quality across the wider countryside is thought to be a major factor. Nectar supply constitutes one of the main resources determining habitat quality. Yet, data on changes in nectar abundance are lacking. In this study, we provide the first analysis of changes in floral nectar abundance on a national scale and link these data to trends in butterfly species richness and abundance. We used transect data from the Dutch Butterfly Monitoring Scheme to compare two time periods： 1994-1995 and 2007-2008. The results show that butterfly decline can indeed be linked to a substantial decline in overall flower abundance and specific nectar plants, such as thistles. The decline is as severe in reported flower generalists as in flower specialists. We suggest that eutrophication is a main cause of the decline of nectar sources [Current Zoology 58 （3）： 384-391, 2012].

关键词： Butterflies Eutrophication Habitat quality Land use Nectar resources Pollinators

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