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Space-charge effect on photogenerated-current and-voltage inⅢ-nitride optoelectronic semiconductors

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Photonics Research 2021年第9期9卷 1820-1828页

作者： DONG-PYO HAN MOTOAKI IWAYA TETSUYA TAKEUCHI SATOSHI kamiyama ISAMU AKASAKI Faculty of Science and Technology Meijo UniversityNagoya 468-8502Japan Akasaki Research Center Nagoya UniversityNagoya 464-8603Japan

In this study,we attempted to elucidate the carrier dynamics behind the abnormal characteristics of photogenerated current and voltage(IPhand VPh)at cryogenic temperature inⅢ-nitride optoelectronic semiconductors by employing space-charge *** this end,we carefully investigated and analyzed excitation-powerdependentⅠ-Ⅴ(PDIV)curves operated by quasiresonant excitation of an Al Ga In N-based p-i-n junction semiconductor at 300 K and 15 *** 300 K,the curves exhibited typical characteristics and were well described by the conventional ***,the PDIV curves at 15 K could no longer be described by the conventional *** elucidate the mechanism behind this phenomenon,we proposed a model in which the space-charge effect(SCE)plays a key *** on this model,we proposed the modified Shockley diode equation,which can explain the PDIV characteristic at 15 K,including the *** also discussed the SCE on the efficiency of devices.

关键词： optoelectronic Shockley charge

Molecular biomarkers for the detection of metastatic colorectal cancer cells

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World Journal of Gastroenterology 2014年第27期20卷 8928-8938页

作者： Hidenori kamiyama Hiroshi Noda Fumio Konishi Toshiki Rikiyama Department of Surgery Saitama Medical Center Jichi Medical University Department of Surgery Chichibu Municipal Hospital

Approximately half of all patients with colorectal cancer develop local recurrence or distant metastasis during the course of their illness. Recently, the molecular detection of metastatic cancer cells in various types of clinical samples, such as lymph nodes, bone marrow, peripheral blood, and peritoneal lavage fluid, has been investigated as a potential prognostic marker. The prognostic value of molecular tumor cell detection was independent of the type of detection method used. As assays become more sensitive and quantitative, a more thorough assessment of the cancer status of patients will be based on molecular markers alone. At present, it is difficult to conclude that one specific molecular marker is superior to others. Comparative analyses are recommended to assess the prognostic impact of molecular analyses in the same patient and determine the biomarkers that provide the most accurate prognostic information.

关键词： Molecular biomarker Metastatic colorectal cancer cell Circulating tumor cell Disseminated tumor cell Peritoneal lavage fluid Colorectal cancer

Nanometer-size Na cluster formation in micropore of hard carbon as origin of higher-capacity Na-ion battery

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npj Computational Materials 2021年第1期7卷 440-447页

作者： Yong Youn Bo Gao Azusa kamiyama Kei Kubota Shinichi Komaba Yoshitaka Tateyama Center for Green Research on Energy and Environmental Materials(GREEN)and International Center for Materials Nanoarchitectonics(MANA) National Institute for Materials Science(NIMS)IbarakiJapan Department of Applied Chemistry Tokyo University of ScienceTokyoJapan Elements Strategy Initiative for Catalysts and Batteries(ESICB) Kyoto UniversityKyotoJapan

Development of high-energy-density anode is crucial for practical application of Na-ion battery as a post Li-ion *** carbon(HC),though a promising anode candidate,still has bottlenecks of insufficient capacity and unclear microscopic *** of the micropore has been recently discussed,however,the underlying sodiation mechanism is still *** we examined the origin for the high-capacity sodiation of HC,based on density functional theory *** demonstrated that nanometersize Na cluster with 3–6 layers is energetically stable between two sheets of graphene,a model micropore,in addition to the adsorption and intercalation *** finding well explains the extended capacity over typical 300 mAhg^(−1),up to 478 mAhg^(−1) recently found in the MgO-templated *** also clarified that the MgO-template can produce suitable nanometersize micropores with slightly defective graphitic domains in *** present study considerably promotes the atomistic theory of sodiation mechanism and complicated HC science.

关键词： battery cluster size

Fluorescent SiC and its application to white light-emitting diodes

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Journal of Semiconductors 2011年第1期32卷 24-26页

作者： Satoshi kamiyama Motoaki Iwaya Tetsuya Takeuchi Isamu Akasaki Mikael Syvjrvi Rositza Yakimova Department of Materials Science and Engineering Meijo University Department of Physics Chemistry and Biology Linkping University

Fluorescent-SiC （f-SiC）, which contains donor and acceptor impurities with optimum concentrations, has high conversion efficiency from NUV to visible light caused by donor-acceptor-pair （DAP） recombination. This material can be used as a substrate for a near UVlight-emitting diode （LED） stack, and leads to monolithic white LED device with suitable spectral property for general lighting applications. In this paper, we describe basic technologies of the white LED, such as optical properties of f-SiC substrate, and epitaxial growth of NUV stack on the f-SiC substrate.

关键词： white LED phosphor SiC donor-acceptor-pair GaN general lighting

RECENT PROGRESS IN CAVITATION RESEARCH IN THE INSTITUTE OF HIGH SPEED MECHANICS TOHOKU UNIVERSITY

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Journal of Hydrodynamics 1989年第4期1卷 1-10页

作者： S.kamiyama Institute of High Speed Mechanics Tohoku UniversitySendaiJapan

Recent activities on cavitation research in the Institute of High Speed Mechanics,Tohoku University,Japan are ***,our recent research project on cavitation occurrence in various liquids other than water is explained in relation to the thermodynamic and gas content ***,study on cavitation damage is *** this field,the mechanism of a single bubble collapse near solid wall and the related pit formation in soft test materials have been ***,the effects of fluid properties on the cavitation damage are ***,a special study on shock wave propagating through gas- liquid two-phase magnetic fluid is explained to extend further developments of cavitation research.

关键词： test RECENT PROGRESS IN CAVITATION RESEARCH IN THE INSTITUTE OF HIGH SPEED MECHANICS TOHOKU UNIVERSITY

Woofer–tweeter adaptive optical structured illumination microscopy

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Photonics Research 2017年第4期5卷 329-334页

作者： QINGGELE LI MARC REINIG DAICH kamiyama BO HUANG XIAODONG TAO ALEX BARDALES JOEL KUBBY W.M.Keck Center for Adaptive Optical Microscopy Baskin Engineering University of California Department of Pharmaceutical Chemistry University of California Department of Cellular Biology University of Georgia

A woofer–tweeter adaptive optical structured illumination microscope(AOSIM) is presented. By combining a low-spatial-frequency large-stroke deformable mirror(woofer) with a high-spatial-frequency low-stroke deformable mirror(tweeter), we are able to remove both large-amplitude and high-order aberrations. In addition, using the structured illumination method, as compared to widefield microscopy, the AOSIM can accomplish highresolution imaging and possesses better sectioning capability. The AOSIM was tested by correcting a large aberration from a trial lens in the conjugate plane of the microscope objective aperture. The experimental results show that the AOSIM has a point spread function with an FWHM that is 140 nm wide(using a water immersion objective lens with NA=1.1) after correcting a large aberration(5.9 μm peak-to-valley wavefront error with 2.05 μm RMS aberration). After structured light illumination is applied, the results show that we are able to resolve two beads that are separated by 145 nm, 1.62× below the diffraction limit of 235 nm. Furthermore, we demonstrate the application of the AOSIM in the field of bioimaging. The sample under investigation was a green-fluorescentprotein-labeled Drosophila embryo. The aberrations from the refractive index mismatch between the microscope objective, the immersion fluid, the cover slip, and the sample itself are well corrected. Using AOSIM we were able to increase the SNR for our Drosophila embryo sample by 5×.

关键词： AO SIM Woofer tweeter adaptive optical structured illumination microscopy

α-fetoprotein,vascular endothelial growth factor receptor-1 and early recurrence of hepatoma

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World Journal of Gastroenterology 2012年第4期18卷 340-348页

作者： Toshiya kamiyama Masato Takahashi Kazuaki Nakanishi Hideki Yokoo Hirofumi Kamachi Nozomi Kobayashi Michitaka Ozaki Satoru Todo Department of General Surgery Graduate School of MedicineHokkaido University Department of Transplantation Surgery Graduate School of MedicineHokkaido University Department of Molecular Surgery Graduate School of MedicineHokkaido University

AIM:To investigate whether α-fetoprotein (AFP) and vascular endothelial growth factor receptor (VEGFR)-1 correlate with early recurrence of hepatoma/hepatocel-lular carcinoma (HCC).METHODS:From 2000 to 2005,114 consecutive pa-tients with HCC underwent primary curative *** mean age was 60.7 (8.7) years and 94 patients were *** median follow-up period was 71.2 mo (range:43-100 mo).Immediately prior to commencing laparotomy,5 mL bone marrow was aspirated from thesternum and collected in citrate-coated test *** initial 2 mL of bone marrow aspirate was discarded in each *** mRNA and VEGFR-1 mRNA in the bone marrow and peripheral blood (BM-and PH-AFP mRNA and BM-and PH-VEGFR-1 mRNA,respectively) were measured by real-time quantitative reverse transcription polymerase chain *** normal controls,VEGFR-1 mRNA in the bone marrow and peripheral blood was also measured in 11 living liver *** data were evaluated for any correlation with early recurrence,comparing clinical and pathological ***:The cut-off value of the BM-AFP mRNA and PH-AFP mRNA level in patients with HCC was set at 1.92 × 10-7 and zero,respectively,based on data from the controls.A total of 34 (29.8%) and six (5.4%) patients were positive for BM-AFP mRNA and PH-AFP mRNA,*** BM-VEGFR-1 mRNA levels in all HCC patients were higher than those in the normal con-trols,and this was the case also for *** 25-percentile values for the BM-and PH-VEGFR-1 mRNA in HCC patients were used as the cut-off values for assigning the patients into two groups based on these transcript *** High group for BM-VEG-FR-1 mRNA contained 81 (71.1%) HCC cases and the Low group was assigned 33 (28.9%) *** numbers for PH-VEGFR-1mRNA were 78 (75.0%) and 26 (25.0%),*** recurred in 80 patients;in the remnant liver in 48 cases,in the remnant liver and remote tissue in 20,and in the remote tissue alone in ***-AFP mRNA-positive cases

关键词： α-fetoprotein Vascular endothelial growth factor receptor-i mRNA Early recurrence Hepatocellular carcinoma

High HbA1c is a risk factor for complications after hepatectomy and influences for hepatocellular carcinoma without HBV and HCV infection

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Hepatobiliary Surgery and Nutrition 2021年第4期10卷 454-463页

作者： Shingo Shimada Toshiya kamiyama Tatsuya Orimo Akihisa Nagatsu Hirofumi Kamachi Akinobu Taketomi Department of Gastroenterological Surgery I Hokkaido University Graduate School of MedicineSapporoJapan

Background:Currently,the population with type 2 diabetes mellitus(DM)is increasing ***,the influence of DM or hyperglycemia on the outcome of resected hepatocellular carcinoma(HCC)is ***:We analyzed 756 patients with HCC who underwent *** patients were assigned to an HbA1c≥7.0%(H-A1c;n=100)or HbA1c<7.0%(L-A1c;n=656)group depending on their HbA1c level at *** investigated prognoses,clinicopathological characteristics and surgical outcomes including morbidities of HCC patients with high HbA1c,prognoses according to the treatment for DM were also ***:Among all patients and those with hepatitis B virus(HBV)and hepatitis C virus(HCV)infection,overall survival(OS)and relapse-free survival(RFS)did not differ significantly between the H-A1c and L-A1c *** contrast,the 5-year OS rate of the H-A1c group was 55%and that of the L-A1c group 71%among patients without HBV and HCV(NBNC patients)(P=0.03).Among NBNC patients,the median RFS of the H-A1c group was 13 months,and that of the L-A1c group was 26 months(P=0.02).In addition,metformin use was an independent favorable factor for both OS and *** H-A1c group had significantly higher rates of hyperbilirubinemia,wound infection,and ***:HCC patients with high HbA1c might have poor prognoses for both survival and recurrence in *** HbA1c may also be a risk factor for morbidities after *** use may constitute a good option for NBNC patients with HCC.

关键词： Hepatocellular carcinoma(HCC) HbA1c diabetes mellitus(DM) hepatectomy metformin

Non-invasive determination of hepatic steatosis by acoustic structure quantification from ultrasound echo amplitude

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World Journal of Gastroenterology 2012年第29期18卷 3889-3895页

作者： Hidekatsu Kuroda Keisuke Kakisaka Naohisa kamiyama Takayoshi Oikawa Mio Onodera Kei Sawara Kanta Oikawa Ryujin Endo Yasuhiro Takikawa Kazuyuki Suzuki Division of Gastroenterology and Hepatology Department of Internal MedicineIwate Medical UniversityIwate 020-8505Japan Ultrasound Systems Division Toshiba Medical Systems CorporationTochigi 324-8550Japan

AIM:To use leptin-deficient(ob/ob) mice with demonstrated differences in steatosis levels to test a new diagnostic method using the acoustical structure quantification(ASQ) mode and the associated analytical parameter,"focal disturbance ratio"(FD-ratio).METHODS:Nine ob/ob mice,at 5,8,and 12 wk of age(n = 3 in each age group),were used as models for hepatic *** signals obtained from ultrasonography in the mice were analyzed by ASQ,which uses a statistical analysis of echo amplitude to estimate inhomogeneity in the diagnostic ***-ratio,as calculated from this analysis,was the focus of the present ***-ratio and fat droplet areas and sizes were compared between age ***:No fibrosis or inflammation was observed in any of the *** fat droplet area significantly(P < 0.01) increased with age from 1.25% ± 0.28% at 5 wk to 31.07% ± 0.48% at 8 wk to 51.69% ± 3.19% at 12 *** median fat droplet size also significantly(P < 0.01) increased with age,from 1.33(0.55-10.52) m at 5 wk,2.82(0.61-44.13) m at 8 wk and 6.34(0.66-81.83) m at 12 *** mean FD-ratio was 0.42 ± 0.11 at 5 wk,0.11 ± 0.05 at 8 wk,and 0.03 ± 0.02 at 12 *** FD-ratio was significantly lower at 12 wk than at 5 wk and 8 wk(P < 0.01).A significant negative correlation was observed between the FD-ratio and either the fat droplet area(r =-0.7211,P = 0.0017) or fat droplet size(r =-0.9811,P = 0.0052).CONCLUSION:This tool for statistical analysis of signals from ultrasonography using the FD-ratio can be used to accurately quantify fat in vivo in an animal model of hepatic steatosis,and may serve as a quantitative biomarker of hepatic steatosis.

关键词： Non-alcoholic fatty liver disease Quantitation of hepatic steatosis Animal model Focal disturbance ratio Acoustic structure quantification Ultrasonography