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Retinal regeneration requires dynamic Notch signaling

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Neural Regeneration Research 2022年第6期17卷 1199-1209页

作者： Leah J.Campbell Jaclyn L.Levendusky Shannon A.Steines David R.hyde Department of Biological Sciences Center for Zebrafish ResearchCenter for Stem Cells and Regenerative MedicineUniversity of Notre DameNotre DameINUSA

Retinal damage in the adult zebrafish induces Müller glia reprogramming to produce neuronal progenitor cells that proliferate and differentiate into retinal *** signaling,which is a fundamental mechanism known to drive cell-cell communication,is required to maintain Müller glia in a quiescent state in the undamaged retina,and repression of Notch signaling is necessary for Müller glia to reenter the cell *** dynamic regulation of Notch signaling following retinal damage also directs proliferation and neurogenesis of the Müller glia-derived progenitor cells in a robust regeneration *** contrast,mammalian Müller glia respond to retinal damage by entering a prolonged gliotic state that leads to additional neuronal death and permanent vision *** the dynamic regulation of Notch signaling in the zebrafish retina may aid efforts to stimulate Müller glia reprogramming for regeneration of the diseased human *** findings identified DeltaB and Notch3 as the ligand-receptor pair that serves as the principal regulators of zebrafish Müller glia *** addition,multi-omics datasets and functional studies indicate that additional Notch receptors,ligands,and target genes regulate cell proliferation and neurogenesis during the regeneration time ***,our understanding of Notch signaling during retinal regeneration is *** fully appreciate the complex regulation of Notch signaling that is required for successful retinal regeneration,investigation of additional aspects of the pathway,such as post-translational modification of the receptors,ligand endocytosis,and interactions with other fundamental pathways is *** we review various modes of Notch signaling regulation in the context of the vertebrate retina to put recent research in perspective and to identify open areas of inquiry.

关键词： differentiation gliosis Müller glia neuronal progenitor cell Notch signaling proliferation quiescence retinal development retinal regeneration zebrafish

Fungal community succession on decomposing leaf litter across five phylogenetically related tree species in a subtropical forest

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Fungal Diversity 2022年第4期115卷 73-103页

作者： Danushka S.Tennakoon Chang‑Hsin Kuo Witoon Purahong Eleni Gentekaki Chayakorn Pumas Itthayakorn Promputtha Kevin D.hyde Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Research Center of Microbial Diversity and Sustainable Utilization Chiang Mai UniversityChiang Mai 50200Thailand Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Department of Plant Medicine National Chiayi University300 Syuefu RoadChiayi City 60004Taiwan Department of Soil Ecology UFZ-Helmholtz Centre for Environmental ResearchTheodor-Lieser-Str.406120 Halle(Saale)Germany Innovative Institute for Plant Health Zhongkai University of Agriculture and EngineeringHaizhu DistrictGuangzhou 510225People’s Republic of China Environmental Science Research Center Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand

Fungi are an essential component of the *** play an integral role in the decomposition of leaf litter and return nutrients to the ecosystem through nutrient *** are considered as the“key players”in leaf litter decomposition,because of their ability to produce a wide range of extracellular ***-related changes of fungal communities during leaf litter decomposition have been relatively ***,it has not been established how the tree species,tree phylogeny,and leaf litter chemistry influence fungal communities during *** direct observations and a culturing approach,this study compiles fungi found in freshly collected leaf litter from five phylogenetically related,native tree species in Taiwan:Celtis formosana(CF),Ficus ampelas(FA),Ficus septica(FS),Macaranga tanarius(MT),and Morus australis(MA).We investigated(i)the effects of tree species(including tree phylogeny)and leaf litter chemistry on fungal community succession,and(ii)specific patterns of fungal succession(including diversity and taxonomic community assembly)on decomposing leaf litter across the selected tree *** hypothesized that host species and leaf litter chemistry significantly affect fungal community succession.A total of 1325 leaves(CF:275,FA:275,FS:275,MT:275 and MA:225)were collected and 236 fungal taxa were recorded(CF:48,FA:46,FS:64,MT:42 and MA:36).Tree species relationships had variable associations on the fungal communities,as even closely related tree species had strongly differing communities during decomposition.A high number of species were unique to a single tree species and may indicate‘host-specificity’to a particular leaf *** overlap of microfungal species in pair wise comparisons of tree species was low(7–16%),and only 1–2%of microfungal species were observed in leaves of all tree *** percentage of occurrences of fungal communities using Hierarchical Cluster Analyses(HCA)showed that there were at least f

关键词： Fungal diversity Ecology Leaf litter decomposition Percentage of occurrences Taxonomy

Live-cell imaging:new avenues to investigate retinal regeneration

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Neural Regeneration Research 2017年第8期12卷 1210-1219页

作者： Manuela Lahne David R.hyde Department of Biological Sciences University of Notre Dame Notre Dame IN USA

Sensing and responding to our environment requires functional neurons that act in concert. Neuronal cell loss resulting from degenerative diseases cannot be replaced in humans, causing a functional impairment to integrate and/or respond to sensory cues. In contrast, zebrafish（Danio rerio） possess an endogenous capacity to regenerate lost neurons. Here, we will focus on the processes that lead to neuronal regeneration in the zebrafish retina. Dying retinal neurons release a damage signal, tumor necrosis factor α, which induces the resident radial glia, the Müller glia, to reprogram and re-enter the cell cycle. The Müller glia divide asymmetrically to produce a Müller glia that exits the cell cycle and a neuronal progenitor cell. The arising neuronal progenitor cells undergo several rounds of cell divisions before they migrate to the site of damage to differentiate into the neuronal cell types that were lost. Molecular and immunohistochemical studies have predominantly provided insight into the mechanisms that regulate retinal regeneration. However, many processes during retinal regeneration are dynamic and require live-cell imaging to fully discern the underlying mechanisms. Recently, a multiphoton imaging approach of adult zebrafish retinal cultures was developed. We will discuss the use of live-cell imaging, the currently available tools and those that need to be developed to advance our knowledge on major open questions in the field of retinal regeneration.

关键词： multiphoton microscopy live-cell imaging zebrafish interkinetic nuclear migration tissue culture retinal regeneration Miiller glia neuronal progenitor cell differentiation phagocytosis

A POTENTIAL METHOD FOR DETERMINING THE HAZ PROPERTIES IN WELDS USING TWO-MATERIAL IMPRESSION CREEP TEST

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Acta Metallurgica Sinica(English Letters) 2004年第4期17卷 591-596页

作者： W.Sun T.H.hyde School of Mechanical Materials and Manufacturing Engineering University of Nottingham Nottingham NG7 2RD UKSchool of Mechanical Materials and Manufacturing Engineering University of Nottingham Nottingham NG7 2RD UK

The results of a theoretical and finite element (FE) investigation of a two-material impression creep test method, using a rectangular indenter, are presented. The method uses a general formulation for steady-state creep deformation for multi-material components in conjunction with the results of FE analyses. The practical application of the proposed technique, in determining the secondary creep properties of heat-affected zone (HAZ) materials in welds, for which conventional creep testing methods cannot be used, is considered. A number of numerical examples are used to describe solution procedures and to verify the method.

关键词： two-material impression creep general formulation creep property welds HAZ

Epitypification:should we epitypify?

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第10期9卷 842-846页

作者： Kevin D. hyde Ying ZHANG International Fungal Research and Development Centre the Research Institute of Resource Insects Chinese Academy of Forestry Kunming 650224 China Fungal Research Group School of Science Mae Fah Luang University Tasud Muang Chiang Rai 5 7100 Thailand Centre for Research in Fungal Diversity School of Biological Sciences University of Hong Kong Hong Kong China

Epitypification can solve many taxonomic problems and stabilize the understanding of species, genera, families or orders. The aim of this paper is to illustrate how to epitypify. A few examples where taxa have been epitypified are considered and the benefits and disadvantages of epitypification are discussed. We also outline some examples of taxa which need to be epitypi-fied with reasons.

关键词：刺盘孢基因银行分子系统发育微生物学

An immuno-epidemiological model for transient immune protection:A case study for viral respiratory infections

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Infectious Disease Modelling 2023年第3期8卷 855-864页

作者： A.Hoyer-Leitzel S.M.Iams A.J.Haslam-hyde M.L.Zeeman N.H.Fefferman Department of Mathematics and Statistics Mount Holyoke College50 College StSouth HadleyMA01075USA John A.Paulson School of Engineering and Applied Sciences Harvard UniversityUSA Department of Mathematics and Statistics Boston UniversityUSA Department of Mathematics Bowdoin CollegeUSA Dept of Mathematics&Dept of Ecology and Evolutionary Biology&NIMBioS University of TennesseeKnoxvilleUSA

The dynamics of infectious disease in a population critically involves both within-host pathogen replication and between host pathogen *** modeling efforts have recently explored how within-host dynamics contribute to shaping population transmission,fewer have explored how ongoing circulation of an epidemic infectious disease can impact within-host immunological *** present a simple,influenza-inspired model that explores the potential for re-exposure during a single,ongoing outbreak to shape individual immune response and epidemiological potential in non-trivial *** show how even a simplified system can exhibit complex ongoing dy-namics and sensitive thresholds in *** also find epidemiological stochasticity likely plays a critical role in reinfection or in the maintenance of individual immunological protection over time.

关键词： Flow-kick dynamics Immuno-epidemiology Viral-immune mathematical model Immune boosting Priming number

Opportunities to participate in multi-authored papers

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Opportunities to participate in multi-authored papers

Polycephalomycetaceae,a new family of clavicipitoid fungi segregates from Ophiocordycipitaceae

中国菌物学会2023年学术年会

作者： Kevin D.hyde Center of Excellence in Fungal Research Mae Fah Luang University

Participation in topical or key multi-authored papers are important contributions tomycology and should be considered by researchers of all disciplines,where *** toparticipate in four important areas are provided in this presentation.1) The Outline of Fungi and fungus-like taxa is presently being *** will involve two papers,an Introduction to the Global Consortium and the next Outline *** you have expertise in classification above the specieslevel,you should be involved in these important compilations.2) We are preparing a series of paperscalled Fungalpedia which will each provide entries for 300+ genera and higher taxa as well asterminology *** example,we will prepare one paper on fungicolous *** arenumerous other topics needing papers and you might consider participation.3) A paper on Living Eminent Mycologists is under *** will provide details of the lives,research andachievements of living *** will be based on SCOPUS and Web of Science metrics,students supervised,books published and other contributions to *** Chinese names areoften quite similar(e.g.,Zhang Ying) it is easy to overlook contributions of Chinese mycologists inthe Web of ***,if you consider yourself an eminent mycologist you should participatein the *** please suggest Chinese mycologists that might be included.4) A paper is inpreparation on 300+ benefits of *** entry will comprise 1-2 *** you have an interestingnovel biotech topic or want to write up a traditional topic,please consider participating in this *** will be a discussion of the value of participating in multi-authored *** contact theauthor of this abstract if you would like to participate in any of the above.

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Fungal Diversity 2023年第3期120卷 1-76页

作者： Yuan‑Pin Xiao Yuan Bing Wang Kevin D.hyde Gentekaki Eleni Jing‑zu Sun Yu Yang Juan Meng Hong Yu Ting‑Chi Wen State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityGuiyang 550025China The Engineering Research Center of Southwest Bio‑Pharmaceutical Resources Ministry of EducationGuizhou UniversityGuiyang 550025GuizhouChina Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Yunnan Key Laboratory for Fungal Diversity and Green Development Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Yunnan Herbal Laboratory School of Ecology and Environmental ScienceYunnan UniversityKunming 650091China Innovative Institute of Plant Health Zhongkai University of Agriculture and EngineeringHaizhu DistrictGuangzhou 510225China State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China The Mushroom Research Centre Guizhou UniversityGuiyang 550025China School of Pharmaceutical Engineering Guizhou Institute of TechnologyGuiyang 550003GuizhouChina

Clavicipitoid fungi comprise three families,namely Clavicipitaceae,Cordycipitaceae,and *** are found worldwide and are specialized pathogens of invertebrate,plant and fungal *** the last decade,morphology-and phylogeny-based studies on clavicipitoid fungi have *** latter have revealed that Polycephalomyces,Perennicordyceps and Pleurocordyceps consistently cluster *** genera are currently considered as members of ***,information with regard to their diversity and ecology remains *** fill this gap,we collected 29 fresh specimens from insect and fungal substrates from tropical and subtropical evergreen forests in Thailand and southwestern *** performed detailed morphological analyses and constructed photoplates for all isolated *** used extensive taxon sampling and a dataset comprising internal transcribed spacer gene region(ITS),small subunit ribosomal RNA gene region(SSU),large subunit rRNA gene region(LSU),translation elongation factor 1-alpha gene region(TEF-1α),RNA polymerase II largest subunit gene region(RPB1)and RNA polymerase II second largest subunit(RPB2)to infer order-,family and genus-level phylogenetic *** on these biphasic analyses,we segregate Polycephalomyces,Perennicordyceps,and Pleurocordyceps from Ophiocordycipitaceae and introduce the new family Polycephalomycetaceae to accomodate these three *** majority of species in this family have a vast range of insect and fungal *** sexual morph of Polycephalomycetaceae has stromatic ascomata,long stipes,thick peridium,and cylindrical secondary *** asexual morph is characterized by colonies on the host surface or synnemata with stipes on the host,one or two types of phialides,and cylindrical to fusiform *** expand the number of taxa in the new family by introducing seven new species(Polycephalomyces albiramus,Perennicordyceps lutea,Pleurocordyceps parvicapitata,Pleurocordyceps lan

关键词： 8 new taxa Ophiocordyceps Polycephalomyces Hypocreales Clavicipitoid fungi Taxonomy New family Morphology Phylogeny

Taxonomic monograph of epifoliar fungi

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Fungal Diversity 2023年第4期121卷 139-334页

作者： D.S.Marasinghe S.Hongsanan X.Y.Zeng E.B.G.Jones P.Chomnunti S.Boonmee K.D.hyde Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand Innovative Institute for Plant Health Zhongkai University of Agriculture and EngineeringGuangzhou 510225People’s Republic of China Faculty of Sciences Research Center of Microbial Diversity and Sustainable UtilizationChiang Mai UniversityChiang Mai 50200Thailand Department of Plant Pathology College of AgricultureGuizhou UniversityGuiyang 550025China Nantgaredig 33B St.Edwards RoadSouthsea PO53DHHantsUK Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O Box 2455Riyadh 11451Kingdom of Saudi Arabia Shenzhen Key Laboratory of Microbial Genetic Engineering College of Life Sciences and OceanographyShenzhen UniversityShenzhen 518060GuangdongPeople’s Republic of China

Epifoliar fungi are one of the significant fungal groups typically living on the surface of leaves. They are usually recordedas saprobes, obligate parasites and commensals and are widely distributed in tropical and subtropical regions. Numerousgenera within this group remain inadequately understood, primarily attributed to limited taxonomic knowledge and insufficientmolecular data. Furthermore, the taxonomic delineation of epifoliar fungi remained uncertain, with scattered andliterature-based data often intermixed with other follicolous fungi. Herein, a comprehensive taxonomic monograph of 124genera in (32) Asterinales, (18) Capnodiales, (15) Chaetothyriales, (8) Meliolales, (8) Micropeltidales, (10) Microthyriales,(32) Parmulariales and (1) Zeloasperisporiales was provided re-describing with illustrations and line drawings. Notes onecological and economic importance of the families are also provided. Representatives type herbarium materials of Campoapulcherrima, Cycloschizon brachylaenae, Ferrarisia philippina, Hysterostomella guaranitica, Palawaniella orbiculata andPseudolembosia orbicularis of Parmulariaceae were re-examined and provided updated illustrations with descriptions. Abackbone phylogenetic tree and divergence estimation analysis for epifoliar fungi based on LSU and 5.8s ITS sequence dataare provided.

关键词： Divergence Follicolous Obligate Parmulariaceae Tropical