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Noninvasive Low-Intensity Focused Ultrasound Mediates Tissue Protection following Ischemic Stroke

Biomedical Engineering Frontiers 2022年第1期3卷 356-366页

作者： Alexandra M.Kaloss Lauren N.Arnold Eman Soliman Maya Langman Nathalie Groot Eli Vlaisavljevich michelle h.theus Department of Biomedical Sciences and Pathobiology Virginia TechBlacksburgVA 24061USA Department of Biomedical Engineering and Mechanics Virginia TechBlacksburg VA 24061USA Center for Engineered health Virginia TechBlacksburg Virginia 24061USA

Objective and Impact *** study examined the efficacy and safety of pulsed,low-intensity focused ultrasound(LIFU)and determined its ability to provide neuroprotection in a murine permanent middle cerebral artery occlusion(pMCAO)*** ultrasound(FUS)has emerged as a new therapeutic strategy for the treatment of ischemic stroke;however,its nonthrombolytic properties remain ***,we examined how LIFU influenced neuroprotection and vascular changes following *** to the critical role of leptomeningeal anastomoses or pial collateral vessels,in cerebral blood flow restoration and tissue protection following ischemic stroke,we also investigated their growth and *** were exposed to transcranial LIFU(fundamental frequency:1.1 Mhz,sonication duration:300 ms,interstimulus interval:3 s,pulse repetition frequency:1 khz,duty cycle per pulse:50%,and peak negative pressure:-2.0 MPa)for 30 minutes following induction of pMCAO and then evaluated for infarct volume,blood-brain barrier(BBB)disruption,and pial collateral remodeling at 24 hrs *** found significant neuroprotection in mice exposed to LIFU compared to mock *** findings correlated with a reduced area of IgG deposition in the cerebral cortex,suggesting attenuation of BBB breakdown under LIFU *** also observed increased diameter of CD31-postive microvessels in the ischemic *** observed no significant difference in pial collateral vessel size between FUS and mock treatment at 24 hrs *** data suggests that therapeutic use of LIFU may induce protection through microvascular remodeling that is not related to its thrombolytic activity.

关键词： Focus repetition treatment

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