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A Novel Intermediary Framework for Dynamic Edge Service Composition

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Journal of Computer Science & Technology 2012年第2期27卷 281-297页

作者： Claudia Canali michele Colajanni Delfina Malandrino Vittorio Scarano Raffaele Spinelli Department of Information Engineering University of Modena and Reggio Emilia Department of Computer Science University of Salerno

Multimedia content,user mobility and heterogeneous client devices require novel systems that are able to support ubiquitous access to the Web *** this scenario,solutions that combine flexibility,efficiency and scalability in offering edge services for ubiquitous access are *** propose an original intermediary framework,namely Scalable Intermediary Software Infrastructure （SISI）,which is able to dynamically compose edge services on the basis of user preferences and device *** SISI framework exploits a per-user profiling mechanism,where each user can initially set his/her personal preferences through a simple Web interface,and the system is then able to compose at run-time the necessary *** basic framework can be enriched through new edge services that can be easily implemented through a programming model based on APIs and internal *** experiments demonstrate that flexibility and edge service composition do not affect the system *** show that this framework is able to chain multiple edge services and to guarantee stable performance.

关键词： ubiquitous Web edge service intermediary framework service flow performance

Prevalence of musculoskeletal injuries and a proposal for neuromuscular training to prevent lower limb injuries in Brazilian Army soldiers:an observational study

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Military Medical Research 2019年第1期6卷 45-52页

作者： michele Zukauskas de Andrade Gomes Carlos Eduardo Pinfildi Department of Human Movement Science Federal University of Sao Paulo(UNIFESP)Campus Baixada Santista Human Movement Science and Rehabilitation Department of Human Movement ScienceFederal University of Sao Paulo-Physical TherapyCampus Baixada Santista

Background: The activities carried out by soldiers in the army involve great physical demands and require intense trainings to perform combat-specific tasks. Musculoskeletal injury is a potential threat to the health and physical integrity of the soldier. This study aimed to evaluate the prevalence of lower limb musculoskeletal injuries among soldiers and to propose a training protocol to prevent the most frequent ***: This observational(cross-sectional) study recruited a sample of 103 soldiers who required medical attention,from a total 202 new battalion soldiers. The medical records(paper and online) had a form of running text. All data collected were recorded by the registered physicians of the battalion medical post. The records were analyzed by the following variables: medical diagnosis, injury site, mechanism, type of treatment, time loss, existence of previous injury,and recurring ***: A total of 112 musculoskeletal injuries were diagnosed in 71 soldiers, and other types of diseases/injuries were diagnosed in the other soldiers. Joint pain accounted for 55.4% of the diagnoses. The knee was the most affected site, while trauma and overload were the most common mechanisms of injury. Drug treatment was used most frequently, accounting for 58% of the cases. The majority of the sample obtained a temporary leave of absence for1 to 6 days or not at all. Previous injuries and recurrence were not presented as risk factors for injury. With the data received, a protocol for the prevention of injuries to the lower limbs was ***: This study indicated that the most frequent site of injury is the knee, and joint pain is the most common diagnosis. These results may support the necessity to develop a neuromuscular training protocol to prevent lower limb injuries, which we suggest to be applied in future studies.

关键词： Physical therapy Wounds and injuries Primary prevention Lower extremity Proprioception Military personnel

Surgery for hepatocellular carcinoma can provide the same life-expectancy as transplant of that of general population

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Hepatobiliary Surgery and Nutrition 2019年第2期8卷 151-152页

作者： Giorgio Ercolani michele Cucchi Department of Medical and Surgical Sciences DIMECAlma Mater StudiorumUniversity of BolognaBolognaItaly General Surgery MorgagniPierantoni HospitalForlì(FC)Italy

When deciding for the optimal treatment to adopt in patients suffering from hepatocellular carcinoma(HCC),the surgical approach is commonly considered as the most curative option(1,2).The scarcity of donors for liver transplantation(LT)led surgeons to bridge patients until an eventual future transplant(salvage LT),opting in first instance and when feasible for hepatic resection(HR)also for those patients otherwise transplantable(2).In the study published by Pinna and colleagues in Annals of Surgery 2018,it was verified in what measure LT and HR can provide for HCC the same mortality expected in the general population,defining the so called"statistical cure"(3).

关键词： Surgery hepatocellular otherwise

Classification and guidelines of hemorrhoidal disease: Present and future

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World Journal of Gastrointestinal Surgery 2019年第3期11卷 117-121页

作者： michele Rubbini Simona Ascanelli Department of Morphology Surgery and Experimental Medicine University of Ferrara Department of Surgery Azienda Ospedaliero-Universitaria Sant'annaFerrara

Classification and guidelines of hemorrhoidal disease are based on the subdivision in Grades of prolapse followed by any aspect related to both the treatment and its technique. When taking the proposals for classification and guidelines issued by prolific scientific societies into consideration, it is evident that strong contradictions and interpretative limits emerge in finding the best treatment to be adopted. After a critical examination of these limitations, a methodological proposal is shared to achieve a new classification, which plays a part in forming a new guideline for hemorrhoidal disease, identifying its evolution, dynamism of the prolapse, symptomatology, enteropathogenesis and gender characteristics.

关键词： Hemorrhoids Calssification Guidelines Gender

Gsα^(R201C)and estrogen reveal different subsets of bone marrow adiponectin expressing osteogenic cells

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Bone Research 2022年第4期10卷 784-798页

作者： Biagio Palmisano Rossella Labella Samantha Donsante Cristina Remoli Emanuela Spica Ilenia Coletta Giorgia Farinacci michele Dello Spedale Venti Isabella Saggio Marta Serafini Pamela Gehron Robey Alessandro Corsi Mara Riminucci Department of Molecular Medicine Sapienza University of RomeRome 00161Italy Tettamanti Research Center Department of PediatricsUniversity of Milano Bicocca/Fondazione MBBMMonza 20900Italy Department of Biology and Biotechnology Sapienza University of RomeRome 00185Italy Institute of Structural Biology and School of Biological Sciences Nanyang Technological University 639798 SingaporeSingapore CNR Institute of Molecular Biology and Pathology Piazzale Aldo Moro 5Rome 00185Italy Skeletal Biology Section National Institute of Dental and Craniofacial ResearchNational Institutes of HealthDepartment of Health and Human ServicesBethesdaMD 20892USA

The Gsα/cAMP signaling pathway mediates the effect of a variety of hormones and factors that regulate the homeostasis of the post-natal ***,the dysregulated activity of Gsαdue to gain-of-function mutations (R201C/R201H)results in severe architectural and functional derangements of the entire bone/bone marrow *** the consequences of gain-of-function mutations of Gsαhave been extensively investigated in osteoblasts and in bone marrow osteoprogenitor cells at various differentiation stages,their effect in adipogenically-committed bone marrow stromal cells has remained *** generated a mouse model with expression of Gsα^(R201C) driven by the Adiponectin(Adq)***-Gsα^(R201C) mice developed a complex combination of metaphyseal,diaphyseal and cortical bone *** the metaphysis,Gsα^(R201C) caused an early phase of bone resorption followed by bone *** bone formation was sustained by cells that were traced by Adq-Cre and eventually resulted in a high trabecular bone mass *** the diaphysis,Gsα^(R201C),in combination with estrogen,triggered the osteogenic activity of Adq-Cre-targeted perivascular bone marrow stromal cells leading to intramedullary bone ***,consistent with the previously unnoticed presence of Adq-Cre-marked pericytes in intraosseous blood vessels,Gsα^(R201C) caused the development of a lytic phenotype that affected both cortical(increased porosity)and trabecular(tunneling resorption)*** results provide the first evidence that the Adq-cell network in the skeleton not only regulates bone resorption but also contributes to bone formation,and that the Gsα/cAMP pathway is a major modulator of both functions.

关键词： estrogen sustained skeleton

Rapid Manufacturing of Non-Assembly Complex Micro-Devices by Microstereolithography

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Tsinghua Science and Technology 2009年第S1期14卷 164-167页

作者： Svetan Ratchev michele Turitto Joel Segal School of Mechanical Materials and Manufacturing Engineering University of Nottingham Nottingham NG7 2RD UK

This paper introduces a non-assembly manufacturing case with microstereolithography technology. The design and manufacturing process of a pneumatic thrust bearing is described, and a special tessellation method is developed to further improve the capability of the manufacturing system thus bigger products can also be easily manufactured. Implemented in a layer-by-layer fashion, stereolithography has been used for the rapid manufacturing of complex devices, and it avoids the expensive assembly process in the traditional manufacturing. This paper presents that microstereolithography can produce high-resolution products with intricate details, small openings, and smooth surfaces. The potential of the microstereolithograhy technique is explored for the rapid manufacturing of small and complex objects.

关键词： microstereolithography micro devices precision engineering

Feasibility of therapeutic endoscopic ultrasound in the bridge-to-surgery scenario:The example of pancreatic adenocarcinoma

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World Journal of Gastroenterology 2022年第10期28卷 976-984页

作者： Giuseppe Vanella Domenico Tamburrino Gabriele Capurso Michiel Bronswijk michele Reni Giuseppe Dell'Anna Stefano Crippa Schalk Van der Merwe Massimo Falconi Paolo Giorgio Arcidiacono Pancreatobiliary Endoscopy and EUS Division Pancreas Translational&Clinical Research CenterIRCCS San Raffaele Scientific InstituteVita-Salute San Raffaele UniversityMilan 20132Italy Pancreatic Surgery Unit Pancreas Translational&Clinical Research CenterIRCCS San Raffaele Scientific InstituteVita-Salute San Raffaele UniversityMilan 20132Italy Department of Gastroenterology and Hepatology University Hospital GasthuisbergUniversity of LeuvenLeuven 3000Belgium Department of Gastroenterology and Hepatology Imelda HospitalBonheiden 2820Belgium Department of Medical Oncology Pancreas Translational&Clinical Research CenterIRCCS San Raffaele Scientific InstituteMilan 20132Italy

Upfront resection is becoming a rarer indication for pancreatic ductal adenocarcinoma,as biologic behavior and natural history of the disease has boosted indications for neoadjuvant ***,gastric outlet obstruction and acute cholecystitis can frequently complicate this window of opportunity,resulting in potentially deleterious chemotherapy discontinuation,whose resumption relies on effective,prompt and long-lasting management of these *** therapeutic endoscopic ultrasound(t-EUS)can potentially offer some advantages over comparators,its use in potentially resectable patients is primal and has unfairly been restricted for fear of potential technical difficulties during subsequent *** is a narrative review of available evidence regarding EUS-guided choledochoduodenostomy,gastrojejunostomy and gallbladder drainage in the bridge-to-surgery ***-ofconcept evidence suggests no influence of t-EUS procedures on outcomes of eventual subsequent ***,the very high efficacy-invasiveness ratio over comparators in managing pancreatic cancer-related symptoms or complications can provide a powerful weapon against chemotherapy discontinuation,potentially resulting in higher subsequent *** evidence is discussed in this short paper,together with technical notes that might be useful for endoscopists and surgeons operating in this *** published evidence supports restricting t-EUS in potential surgical candidates,especially in the setting of pancreatic cancer patients undergoing neoadjuvant ***-to-surgery tEUS deserves further prospective evaluation.

关键词： Endosonography Gastrojejunostomy Choledochoduodenostomy Gallbladder drainage Pancreatic cancer Pancreatic surgery

indocyanine green-based fluorescence imaging in visceral and hepatobiliary and pancreatic surgery:State of the art and future directions

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World Journal of Gastroenterology 2018年第27期24卷 2921-2930页

作者： Gian Luca Baiocchi michele Diana Luigi Boni Department of Clinical and Experimental Sciences University of BresciaBrescia 25125Italy IHU-Strasbourg Institute of Image-Guided SurgeryStrasbourg 67000France General and Emergency Surgery IRCCS-Ca’Granda-Policlinico HospitalMilan 20122Italy

In recent years, the use of fluorescence-guided surgery(FGS) to treat benign and malignant visceral, hepatobiliary and pancreatic neoplasms has significantly increased. FGS relies on the fluorescence signal emitted by injected substances(fluorophores) after being illuminated by ad hoc laser sources to help guide the surgical procedure and provide the surgeon with real-time visualization of the fluorescent structures of interest that would be otherwise invisible. This review surveys and discusses the most common and emerging clinical applications of indocyanine green(ICG)-based fluorescence in visceral, hepatobiliary and pancreatic surgery. The analysis, findings, and discussion presented here rely on the authors' significant experience with this technique in their medical institutions, an up-to-date review of the most relevant articles published on this topic between 2014 and 2018, and lengthy discussions with key opinion leaders in the field during recent conferences and congresses. For each application, the benefits and limitations of this technique, as well as applicable future directions, are described. The imaging of fluorescence emitted by ICG is a simple, fast,relatively inexpensive, and harmless tool with numerous different applications in surgery for both neoplasms and benign pathologies of the visceral and hepatobiliary systems. The ever-increasing availability of visual systems that can utilize this tool will transform some of these applications into the standard of care in the near future. Further studies are needed to evaluate the strengths and weaknesses of each application of ICG-based fluorescence imaging in abdominal surgery.

关键词： indocyanine green fluorescence imaging gastrointestinal surgery liver surgery biliary surgery pancreatic surgery visceral perfusion biliary anatomy peritoneal carcinomatosis

New approach to anal cancer:Individualized therapy based on sentinel lymph node biopsy

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World Journal of Gastroenterology 2012年第44期18卷 6349-6356页

作者： Paola De Nardi michele Carvello Carlo Staudacher Surgical Department San Raffaele Scientific Institute20132 MilanItaly

Oncological treatment is currently directed toward a tailored therapy *** cell carcinoma of the anal canal could be considered a suitable platform to test new therapeutic strategies to minimize treatment *** of care for patients with anal canal cancer consists of a combination of radiotherapy and *** treatment has led to a high rate of local control and a 60% cure rate with preservation of the anal sphincter,thus replacing surgical abdominoperineal *** node metastases represent a critical independent prognostic factor for local recurrence and *** and iliac lymph nodes are usually included in the radiation field,whereas the inclusion of inguinal regions still remains controversial because of the subsequent adverse side *** lymph node biopsies could clearly identify inguinal node-positive patients eligible for therapeutic groin irradiation.A sentinel lymph node navigation procedure is reported here to be a feasible and effective method for establishing the true inguinal node status in patients suffering from anal canal *** on the results of sentinel node biopsies,a selective approach could be proposed where node-positive patients could be selected for inguinal node irradiation while node-negative patients could take advantage of inguinal sparing irradiation,thus avoiding toxic side effects.

关键词：鳞状细胞癌肿瘤治疗淋巴结活检基础肛门个体毒副作用