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indocyanine green-based fluorescence imaging in visceral and hepatobiliary and pancreatic surgery:State of the art and future directions

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World Journal of Gastroenterology 2018年第27期24卷 2921-2930页

作者： Gian Luca Baiocchi michele Diana Luigi Boni Department of Clinical and Experimental Sciences University of BresciaBrescia 25125Italy IHU-Strasbourg Institute of Image-Guided SurgeryStrasbourg 67000France General and Emergency Surgery IRCCS-Ca’Granda-Policlinico HospitalMilan 20122Italy

In recent years, the use of fluorescence-guided surgery(FGS) to treat benign and malignant visceral, hepatobiliary and pancreatic neoplasms has significantly increased. FGS relies on the fluorescence signal emitted by injected substances(fluorophores) after being illuminated by ad hoc laser sources to help guide the surgical procedure and provide the surgeon with real-time visualization of the fluorescent structures of interest that would be otherwise invisible. This review surveys and discusses the most common and emerging clinical applications of indocyanine green(ICG)-based fluorescence in visceral, hepatobiliary and pancreatic surgery. The analysis, findings, and discussion presented here rely on the authors' significant experience with this technique in their medical institutions, an up-to-date review of the most relevant articles published on this topic between 2014 and 2018, and lengthy discussions with key opinion leaders in the field during recent conferences and congresses. For each application, the benefits and limitations of this technique, as well as applicable future directions, are described. The imaging of fluorescence emitted by ICG is a simple, fast,relatively inexpensive, and harmless tool with numerous different applications in surgery for both neoplasms and benign pathologies of the visceral and hepatobiliary systems. The ever-increasing availability of visual systems that can utilize this tool will transform some of these applications into the standard of care in the near future. Further studies are needed to evaluate the strengths and weaknesses of each application of ICG-based fluorescence imaging in abdominal surgery.

关键词： indocyanine green fluorescence imaging gastrointestinal surgery liver surgery biliary surgery pancreatic surgery visceral perfusion biliary anatomy peritoneal carcinomatosis

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Energy flow in negative index materials

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Chinese Optics Letters 2004年第7期2卷 428-430页

作者： Lorenzo Bolla michele Midrio Carlo G.Someda The Istituto Nazionale per la Fisica della Materia (I. N. F. M.) Dipartimento di Ingegneria Elettrica Gestionale e Meccanica Universita degli Studi di Udine viale delle Scienze 208 33100 Udine ItalyThe Istituto Nazionale per la Fisica della Materia (I. N. F. M.) Dipartimento di Ingegneria Elettrica Gestionale e Meccanica Universita degli Studi di Udine viale delle Scienze 208 33100 Udine ItalyI. N. F. M. Dipartimento di Ingegneria dell'Informazione via G. Gradenigo 6/B 35131 Padova Italy

Prom Maxwell's equations, we compute the speed and the direction of propagation of active power refracted from air into a negative index material. We prove, both analytically and numerically that the power may refract positively even if phase fronts refract negatively. Considerations on the usage of ray optics in problems involving negative index materials are drawn.

关键词： Energy flow in negative index materials

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Anti-money laundering in Banks:Towards a Model for Training Evaluation

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Management Studies 2022年第2期10卷 115-124页

作者： michele Samuele Borgia Maura la Torre University G.D’Annunzio PescaraItaly

This paper aims to propose an evaluation model specific for anti-money laundering training in *** model was structured taking from some of the most popular training evaluation models proposed in the literature the evaluation levels considered suitable for evaluating anti-money laundering training *** additional evaluation levels are included,which assess possible exposure of training activity to the risks associated with knowledge *** originality of the proposed model lies in the fact that,to the best of the authors’knowledge,to date,there is still no specific model for evaluating anti-money laundering training in *** the limitations of this study is the fact that,for the moment,the proposed model is a in a purely theoretical formulation.

关键词： training evaluation knowledge risks model banks

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Interindividual variation and consistency of migratory behavior in the Eurasian woodcock

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Current Zoology 2020年第2期66卷 155-163页

作者： Alessandro TEDESCHI michele SORRENTI michele BOTTAZZO Mario SPAGNESI Ibon TELLETXEA Ruben IBANEZ Nicola TORMEN Federico DE PASCALIS laura GUIDOLIN Diego RUBOLINI Associazione"Amici di Scolopax" Via Roma57Mugnano del CardinaleAVI-83027Italy Federazione Italiana della Caccia Ufficio Avifauna MigratoriaVia Salaria 298/ARoma1-00199Italy Veneto Agricoltura Viale dell’Universita 14LegnaroP D1-35020Italy Ekoclub International Via per Volano 45Volano di CodigoroFE1-44020Italy Club de Cazadores de Becada Avda.Schulz 84 dchaGijonE-33208Spain Dipartimento di Biologia Universita degli Studi di PadovaVia U.Bassi 58/bPadova1-35131Italy Dipartimento di Scienze e Politiche Ambientali Universita degli Studi di Milanovia Celoria 26Milano1-20133Italy

Diverse spatio-temporal aspects of avian migration rely on relatively rigid endogenous ***,flexibility in migratory behavior may allow effective coping with unpredictable variation in ecological conditions that can occur during *** aimed at characterizing inter-and intraindividual variation of migratory behavior in a forest-dwelling wader species,the Eurasian woodcock Scolopax rusticola,focusing on spatio-temporal consistency across repeated migration *** satellite-tracking birds from their wintering sites along the Italian peninsula to their breeding areas,we disclosed a remarkable variability in migration distances,with some birds flying more than 6,000 km to Central Asian breeding grounds(up to 101°E).Prebreeding migration was faster and of shorter duration than postbreeding *** moving over longer distances migrated faster during prebreeding migration,and those breeding at northernmost latitudes left their wintering areas ***,birds making longer migrations departed earlier from their breeding *** site fidelity was very high,whereas fidelity to wintering areas increased with *** routes were significantly consistent,both among repeated migration episodes and between pre-and postbreeding *** migration departure date was not significantly repeatable,whereas arrival date to the breeding areas was highly ***,interindividual variation in migratory behavior of woodcocks was mostly explained by the location of the breeding areas,and spatial consistency was relatively large through the entire annual *** in prebreeding migration departure date may suggest that environmental effects have a larger influence on temporal than on spatial aspects of migratory behavior.

关键词： arrival date breeding latitude flexibility repeatability satellite tracking wading birds

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Acute biliary pancreatitis and cholecystolithiasis in a child: one time treatment with laparoendoscopic "Rendez-vous" procedure

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World Journal of Gastroenterology 2006年第11期12卷 1782-1785页

作者： Gaetano la Greca michele Di Blasi Francesco Barbagallo Manuela Di Stefano Saverio latteri Domenico Russello Department of Surgical Sciences Transplantation and Advanced Technologies University of Catania Cannizzaro HospitalVia Messina 829-95100CataniaItaly

尖锐胆汁的胰腺炎(ABP ) 在童年是稀罕的，内视镜的括约肌切开术应该由于在内视镜的过程和胆囊炎之间的最佳的预定仍然是的早、迟了的复杂并发症，但是，必要时的风险在孩子被避免不明确。有尖锐胆汁的胰腺炎的九个岁孩子经历了成功的 l... 详细信息

尖锐胆汁的胰腺炎(ABP ) 在童年是稀罕的，内视镜的括约肌切开术应该由于在内视镜的过程和胆囊炎之间的最佳的预定仍然是的早、迟了的复杂并发症，但是，必要时的风险在孩子被避免不明确。有尖锐胆汁的胰腺炎的九个岁孩子经历了成功的 laparo 内视镜的“约会”胆总管和 laparoscopic 胆囊炎的内视镜的排水同时在被执行的过程。这是在一个孩子 laparo 内视镜的约会报导的第一个案例。这个病人的优秀结果和有关为如此的案例的治疗的另外的可得到的选择的文学的评论建议这个过程提供大优点特别在孩子，减少治疗的要求的数字，低效率的风险，麻醉的数字，医院停留的长度和因医生之治疗而引的病态的风险。

关键词：胆汁胰腺炎胆石疾病内窥镜

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Successful endoscopic repair of an unusual colonic perforation following polypectomy using an endoclip device

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World Journal of Gastroenterology 2007年第20期13卷 2889-2891页

作者： Francesco Barbagallo Giorgio Castello Saverio latteri Emanuele Grasso Salvatrice Gagliardo Gaetano la Greca michele Di Blasi Department of Surgical Sciences Transplantation and Advanced TechnologiesUniversity of CataniaPadiglione 29Policlinico UniversitarioVia S. SofiaCatania 95100Italy Digestive Endoscopic Unit University of CataniaP.O. CannizzaroVia Messina 829Catania 95126Italy

Colonic perforation during endoscopic diagnostic or therapeutic procedures,represents an uncommon occurrence even if,together with haemorrhage,it is still the most common complication of colonoscopy,with an incidence ranging between 0.1% and 2% of all colonoscopic procedures. The ideal treatment in these cases remains elusive as the endoscopist and the surgeon have to make a choice case by case,depending on many factors such as how promptly the rupture is identified,the condition of the patient,the degree of contamination and the evidence of peritoneal irritation. Surgical interventions both laparotomic and laparoscopic,and other medical non-operative solutions are described in the literature. Only three cases have been reported in the literature in which the endoscopic apposition of endoclips was used to repair a colonic perforation during colonoscopy. Ours is the first case that the perforation itself was caused by the improper functioning of a therapeutic device.

关键词：息肉切除术结肠穿孔内窥镜气腹

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The airway epithelium dysfunction in the pathogenesis of asthma: The evidence

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Health 2013年第2期5卷 331-338页

作者： Salvatore Leonardi Alfina Coco michele Miraglia Del Giudice Gianluigi L. Marseglia Mario la Rosa Clinical Pediatric 2nd University of Naples Naples Italy IRCCS University Hospital San Martino University of Pavia Pavia Italy Pediatric Bronchopneumology and Cystic Fibrosis Unit Department of Medical and Paediatric Sciences University of Catania Catania Italy

Asthma is traditionally defined as a chronic, multisystem, multicellular disease characterized by bronchial hyper-responsiveness (BHR) and lung inflammation. In this illness is particularly involving the airway epithelium as the place where the inflammation begins, develops and often returns through airway remodelling. In specific way there is also an evolving awareness of the active participation of structural elements, such as the airway epithelium, airway smooth muscle, and endothelium, in this process. The airway inflammation and remodelling together likely explain the clinical manifestations of asthma that is demonstrated by complicated respiratory manifestations in which wheeze occurring secondary to bronchoconstriction in the setting of airway hyper-responsiveness and mucous hypersecretion. This is confirmed by also the histopathological analyses of bronchial biopsies from asthmatic subjects. For this reason is very important to understand the physiological role of the airway epithelium and their changes during the exacerbation of disease.

关键词： Airway Epithelium Dysfunction Asthma Evidence

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Growth phenology adjusts to seasonal changes in water availability in coexisting evergreen and deciduous mediterranean oaks

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Forest Ecosystems 2023年第5期10卷 535-546页

作者： Filipe Campelo Alvaro Rubio-Cuadrado Fernando Montes michele Colangelo Cristina Valeriano J.Julio Camarero Department of Life Sciences University of CoimbraCalçada Martim de FreitasCoimbra3000-456Portugal Departamento de Sistemas y Recursos Naturales Escuela Tecnica Superior de Ingeniería de MontesForestal y Del Medio NaturalUniversidad Politecnica de MadridCiudad Universitaria S/n28040MadridSpain Instituto Pirenaico de Ecología(IPE-CSIC) Avda.Montanana 1005E-50192ZaragozaSpain Departamento de Dinamica y Gestion Forestal Instituto de Ciencias Forestales(ICIFOR-INIA-CSIC)Ctra.La Coruna Km 7.528040MadridSpain Scuola di Scienze Agrarie ForestaliAlimentari e AmbientaliUniversita Della BasilicataViale Dell’Ateneo Lucano 1085100PotenzaItaly

Different leaf(evergreen *** habit)and xylem(***-porous wood)traits represent contrasting strategies to face seasonal changes in water availability and ***,how contrasting leaf and xylem habits of coexisting tree species affect stem wood formation and tree-ring development remains poorly ***,we investigated the spatio-temporal patterns of wood formation in two deciduous oaks(Quercus faginea and Quercus petraea)and two evergreen oaks(Quercus ilex and Quercus suber)coexisting in seasonally dry Mediterranean forests along an aridity gradient in *** hypothesized that growth responses to drought and intra-and inter-annual growth patterns would differ between functional *** simulated intra-and interannual growth using a modified version of the Vaganov-Shashkin(VS)process-based,growth *** VS model simulations were used to estimate growth changes under a high emission scenario(RCP 8.5)for the current distribution of the study oak species and to forecast their future performance under warm(4.8℃)conditions in the Iberian *** simulations indicate that climate warming would induce a shortening of the ringgrowth season and a reduction of radial growth in evergreen and deciduous Mediterranean oaks,particularly in dry sites from southern and eastern Iberia currently occupied by *** and *** oaks may better recover after dry periods than deciduous oaks by resuming growth after the summer *** soil water availability in spring would be more detrimental to growth of deciduous ***-based growth models should be refined and validated to better forecast changes in tree growth as a function of climate.

关键词： Process-based growth model Quercus ilex Quercus suber Quercus faginea Quercus petraea Tree-ring growth

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Neural plasticity and adult neurogenesis: the deep biology perspective

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Neural Regeneration Research 2019年第2期14卷 201-205页

作者： Anna Maria Colangelo Giovanni Cirillo Lilia Alberghina michele Papa Hans V.Westerhoff laboratory of Neuroscience "R.Levi-Montalcini" Dept.of Biotechnology and Biosciences University of Milano-Bicocca SYSBIO Centre of Systems Biology University of Milano-Bicocca NeuroMI Milan Center for Neuroscience University of Milano-Bicocca laboratory of Morphology of Neuronal Network Department of Public Medicine University of Campania "Luigi Vanvitelli" Synthetic Systems Biology and Nuclear Organization University of Amsterdam Molecular Cell Physiology VU University Amsterdam and Infrastructure Systems Biology at NL (ISBE.NL) Amsterdam NL and Systems Biology School for Chemical Engineering and Analytical Science University of Manchester

The recognition that neurogenesis does not stop with adolescence has spun off research towards the reduction of brain disorders by enhancing brain regeneration. Adult neurogenesis is one of the tougher problems of developmental biology as it requires the generation of complex intracellular and pericellular anatomies, amidst the danger of neuroinflammation. We here review how a multitude of regulatory pathways optimized for early neurogenesis has to be revamped into a new choreography of time dependencies. Distinct pathways need to be regulated, ranging from neural growth factor induced differentiation to mitochondrial bioenergetics, reactive oxygen metabolism, and apoptosis. Requiring much Gibbs energy consumption, brain depends on aerobic energy metabolism, hence on mitochondrial activity. Mitochondrial fission and fusion, movement and perhaps even mitoptosis, thereby come into play. All these network processes are interlinked and involve a plethora of molecules. We recommend a deep thinking approach to adult neurobiology.

关键词： neurogenesis adult brain neuroregeneration neuron differentiation nerve growth factor energy homeostasis mitochondria deep biology systems biology

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Considerazioni sulle massime d'esperienza

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证据科学 2009年第2期17卷 162-173页

作者： michele Taruffo 意大利帕维亚大学教授上海交通大学凯原法学院副教授

1. Origine e limiti del *** è noto, il concetto di massima d'esperienza viene formulato per la prima volta da FriedrichStein nel 1893, nella sua opera sul sapere privato del giudice. Stein elabora in questo lavoro

关键词： Si la Considerazioni sulle massime d’esperienza

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