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Circulating microRNA expression and nonalcoholic fatty liver disease in adolescents with severe obesity

World Journal of Gastroenterology 2024年第4期30卷 332-345页

作者： Yi-Jie Li Brittney O Baumert Nikos Stratakis Jesse A Goodrich Hao-Tian Wu Jing-Xuan He Yin-Qi Zhao Max T Aung Hong-Xu Wang Sandrah P Eckel Douglas I Walker Damaskini Valvi michele a la merrill Justin R Ryder Thomas H Inge Todd Jenkins Stephanie Sisley Rohit Kohli Stavra A Xanthakos Andrea A Baccarelli Rob McConnell David V Conti Lida Chatzi Department of Population and Public Health Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90032United States Barcelona Institute of Global Health Barcelona Institute of Global HealthBarcelona 08036Spain Department of Environmental Health Sciences Mailman School of Public HealthColumbia UniversityNew YorkNY 10032United States Gangarosa Department of Environmental Health Rollins School of Public HealthEmory UniversityAtlantaGA 30329United States Department of Environmental Medicine and Public Health Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Department of Environmental Toxicology University of CaliforniaDavisCA 95616United States Department of Surgery Lurie Children’s Hospital of ChicagoChicagoIL 60611United States Northwestern University Feinberg School of Medicine Northwestern UniversityChicagoIL 60611United States Division of Biostatistics and Epidemiology Cincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States Department of Pediatrics University of Cincinnati College of MedicineCincinnatiOH 45229United States Department of Pediatrics Children’s Nutrition Research Center USDA/ARSBaylor College of MedicineHoustonTX 77030United States Department of Gastroenterology Children’s Hospital Los AngelesLos AngelesCA 90027United States Division of Gastroenterology Hepatology and NutritionCincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases in children and *** ranges in severity from isolated hepatic steatosis to nonalcoholic steatohepatitis(NASH),wherein hepatocellular inflammation and/or fibrosis coexist with *** microRNA(miRNA)levels have been suggested to be altered in NAFLD,but the extent to which miRNA are related to NAFLD features remains *** analysis tested the hypothesis that plasma miRNAs are significantly associated with histological features of NAFLD in *** To investigate the relationship between plasma miRNA expression and NAFLD features among adolescents with *** This study included 81 adolescents diagnosed with NAFLD and 54 adolescents without NAFLD from the Teen-Longitudinal Assessment of Bariatric Surgery ***-operative core liver biopsies were collected from participants and used to characterize histological features of *** samples were collected during surgery for miRNA profiling.A total of 843 plasma miRNAs were profiled using the HTG EdgeSeq *** examined associations of plasma miRNAs and NAFLD features using logistic regression after adjusting for age,sex,race,and other key *** Pathways Analysis was used to identify biological functions of miRNAs that were associated with multiple histological features of *** We identified 16 upregulated plasma miRNAs,including miR-193a-5p and miR-193b-5p,and 22 downregulated plasma miRNAs,including miR-1282 and miR-6734-5p,in adolescents with ***,52,16,15,and 9 plasma miRNAs were associated with NASH,fibrosis,ballooning degeneration,and lobular inflammation,***,16 miRNAs were associated with two or more histological features of *** those miRNAs,miR-411-5p was downregulated in NASH,ballooning,and fibrosis,while miR-122-5p,miR-1343-5p,miR-193a-5p,miR-193b-5p,and miR-7845-5p were consistently and posi

关键词： MicroRNA Nonalcoholic fatty liver disease Non-alcoholic steatohepatitis Liver fibrosis Lobular inflammation Ballooning degeneration

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产前杀虫剂DDT暴露与女性50岁前确诊高血压:一项纵向出生队列研究

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环境与职业医学 2013年第8期30卷 607-607页

作者： michele la merrill Piera M.Cirillo Mary Beth Terry Nickilou Y.Krigbaum Julie D.Flom Barbara A.Cohn

[背景]在成年人研究中已知杀虫剂DDT（二氯二苯三氯乙烷）水平升高与血压和高血压呈正相关。越来越多的流行病学和毒理学证据表明，成年期高血压也可能受到生命早期和产前环境的影响。[目的]评估产前杀虫剂DDT暴露是否会增加成人高血压... 详细信息

[背景]在成年人研究中已知杀虫剂DDT（二氯二苯三氯乙烷）水平升高与血压和高血压呈正相关。越来越多的流行病学和毒理学证据表明，成年期高血压也可能受到生命早期和产前环境的影响。[目的]评估产前杀虫剂DDT暴露是否会增加成人高血压患病风险。[方法]检测一个妇女亚组（n=527）的产前血清样本中DDT（p，p＇和o，p＇-）及其代谢产物p，p＇-DDE（二氯二苯二氯乙烯）的浓度，这些妇女在怀孕期间（1959-1967年）参加了旧金山湾地区一项前瞻性儿童健康和发育出生队列研究。2005--2008年，通过电话采访调查年龄为39—47岁的女儿，以获取自述医师诊断为高血压和高血压药物的使用信息。在Cox比例风险模型的基础上，采用多变量回归分析来估计产前DDT暴露与成年后高血压药物治疗之间关联的相对率，以孕产妇、生命早期和成年期暴露调整潜在的混杂因素。[结果]产前p，p＇DDT暴露与高血压相关联[相对于最低三分位数，P，p＇DDT中、高三分位数校正风险比（aHR）分别为：aHR=3．6，95％CI：1．8-7．2；aHR=2．5，95％CI：1．2-5．330调整独立的高血压危险因素以及敏感性分析后，p，p＇DDT与高血压之间的这些关联更强。[结论]这些研究结果提示，DDT暴露与高血压之间的关联可能源自发育的早期。

关键词：血压 DDT 高血压生命历程产前

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The management of the long head of the biceps in rotator cuff repair:A comparative study of high *** tenodesis

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Journal of Sport and Health Science 2023年第5期12卷 613-618页

作者： Edoardo Franceschetti Edoardo Giovannetti de Sanctis Alessio Palumbo michele Paciotti Luca la Verde Nicola Maffulli Francesco Franceschi Department of Orthopaedic and Trauma Surgery Campus Biomedico University of RomeVia Alvaro del Portillo 20000100 RomeItaly Department of Orthopaedics and Traumatology Catholic UniversityAgostino Gemelli Hospital00100 RomeItaly Anca Surgical Center Via Francesco Maidalchini 20Roma00152RomeItaly Department of Musculoskeletal Disorders Via Salvador Allende4384081 BaronissiSalernoItaly Centre for Sports and Exercise Medicine Barts and The London School of Medicine and DentistryMile End Hospital275 Bancroft RoadLondon E14DGEnglandUK School of Pharmacy and Bioengineering Keele University School of MedicineThornburrow DriveStoke on Trent ST4EnglandUK

Background:Tenodesis of the long head of the biceps(LHB)is commonly undertaken during arthroscopic rotator cuff *** assessed the clinical and structural outcomes after high arthroscopic tenodesis(HAT)or mini-open subpectoral tenodesis(ST).We hypothesized that the clinical and structural results after HAT and ST are ***:We included 40 patients with rotator cuff tear and LHB *** patients(7 women and 13 men;mean age:57.9 years;range:56-63 years)were treated using HAT,and 20 patients(8 women and 12 men;mean age:58.5 years;range:55-64 years)were treated using *** evaluation was performed preoperatively and at 6 weeks,6 months,and 1 year after surgery,using the Constant Murley Score and Simple Shoulder Test scores;the LHB was evaluated using the LHB score.A Visual Analogue Scale was administered to all patients preoperatively and 2 days after ***:The postoperative total and pain subscale’s Constant scores were significantly higher in the ST ***,2 LHB score values were significantly different between the *** postoperative LHB total score in the ST and HAT groups averaged 86.9±4.1(mean±SD)points and 73.3±6.4 points,*** Pain/Cramps subscale in the ST and HAT groups averaged 47.1±5.9 and 33.2±4.6 points,*** 2 groups showed no difference in Visual Analogue Scale values(5.5 in the HAT group;5.8 in the ST group)*** patient in the HAT group reported a secondary onset of Popeye ***:Both high arthroscopic and mini-open ST of the LHB tendon produced reliably good functional results,but the ST group was associated with better postoperative clinical outcomes.

关键词： Long head of the biceps Shoulder Shoulder arthroscopy Subpectoral TenodesisTagedEnd

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Thermal conductivity of glasses: first-principles theory and applications

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npj Computational Materials 2023年第1期9卷 1253-1274页

作者： michele Simoncelli Francesco Mauri Nicola Marzari Theory of Condensed Matter Group of the Cavendish laboratory University of CambridgeCambridgeUK Dipartimento di Fisica Universitàdi Roma La SapienzaRomaItaly Theory and Simulation of Materials(THEOS)and National Centre for Computational Design and Discovery of Novel Materials(MARVEL) École Polytechnique Fédérale de LausanneLausanneSwitzerland

Predicting the thermal conductivity of glasses from first principles has hitherto been a very complex *** established Allen-Feldman and Green-Kubo approaches employ approximations with limited validity—the former neglects anharmonicity,the latter misses the quantum Bose-Einstein statistics of vibrations—and require atomistic models that are very challenging for first-principles ***,we present a protocol to determine from first principles the thermal conductivityκ(T)of glasses above the plateau(i.e.,above the temperature-independent region appearing almost without exceptions in theκ(T)of all glasses at cryogenic temperatures).The protocol combines the Wigner formulation of thermal transport with convergence-acceleration techniques,and accounts comprehensively for the effects of structural disorder,anharmonicity,and Bose-Einstein *** validate this approach in vitreous silica,showing that models containing less than 200 atoms can already reproduceκ(T)in the macroscopic *** discuss the effects of anharmonicity and the mechanisms determining the trend ofκ(T)at high temperature,reproducing experiments at temperatures where radiative effects remain negligible.

关键词： glasses conductivity harmonic

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Different xylogenesis responses to atmospheric water demand contribute to species coexistence in a mixed pine–oak forest

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Journal of Forestry Research 2023年第1期34卷 51-62页

作者： Marín Pompa-García J.Julio Camarero michele Colangelo Facultad de Ciencias Forestales y Ambientales de la Universidad Juárez del Estado de Durango Río Papaloapan y Blvd.Durango S/N Col.Valle del SurDurangoMéxico Instituto Pirenaico de Ecología(IPE-CSIC) Avda.Montanna 1005ZaragozaSpain School of Agricultural ForestFood and Environmental SciencesUniv.BasilicataPotenzaItaly

Seasonal patterns of wood formation(xylogenesis)remain understudied in mixed pine-oak forests despite their contribution to tree coexistence through temporal niche *** was assessed in three pine species(Pinus cembroides,Pinus leiophylla,Pinus engelmannii)and one oak(Quercus grisea)coexisting in a semi-arid Mexican *** main xylogenesis phases(production of cambium cells,radial enlargement,cell-wall thickening and maturation)were related to climate data considering 5-15-day temporal *** pines,cambium activity maximized from mid-March to April as temperature and evaporation increased,whereas cell radial enlargement peaked from April to May and was constrained by high evaporation and low ***-wall thickening peaked from June to July and in August-September as maximum temperature and vapour pressure deficit(VPD)*** of earlywood and latewood tracheids occurred in May-June and June-July,enhanced by high minimum temperatures and VPD in *** and *** oak,cambial onset started in March,constrained by high minimum temperatures,and vessel radial enlargement and radial increment maximized in April as temperatures and evaporation increased,whereas early wood vessels matured from May to June as VPD ***,15-day wet conditions enhanced cell radial enlargement in *** and ***,whereas early-summer high 15-day temperature and VPD drove cell-wall thickening in *** night conditions and high evaporation rates during spring and summer enhanced *** earlier growth peak in oak and a higher responsiveness to spring-summer water demand in pines contributed to their coexistence.

关键词： Bimodal growth Drought Vapour pressure deficit Wood formation Xylem phenology

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A blockchain architecture for industrial applications

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Blockchain(Research and Applications) 2022年第4期3卷 1-13页

作者： Lodovica Marchesi michele Marchesi Roberto Tonelli Maria Ilaria Lunesu Department of Mathematics and Computer Science University of CagliariCagliari09124Italy

Blockchain and the programs running on it,called smart contracts,are increasingly applied in all fields where trust and strong certifications are *** work focuses on industrial applications of blockchains and not on cryptocurrencies or *** use frameworks to compare public and permissioned blockchains specifically suited for industrial *** also propose a complete solution based on Ethereum to implement a decentralized application,putting together in an original way,components and patterns already used and *** solution is characterized by a set of validator nodes running the blockchain using Proof-of-Authority or similar efficient consensus algorithms,by the use of an explorer enabling users to check the blockchain state,and the source code of the smart contracts running on *** time to time,the hash digest of the last mined block is written into a public blockchain to guarantee *** right to send transactions is granted by validator nodes to users by endowing them with the Ethers mined ***,the proposed approach has the same transparency and immutability as a public blockchain,largely reducing its drawbacks.

关键词： Permissioned blockchain Industrial application Information system Software application Ethereum

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Assessing the effects of alternative fuel treatments to reduce wildfire exposure

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Journal of Forestry Research 2023年第2期34卷 373-386页

作者： Roghayeh Jahdi Liliana Del Giudice Massimo Melis Raff aella Lovreglio michele Salis Bachisio Arca Pierpaolo Duce Institute of BioEconomy(CNR IBE) National Research Council of ItalySassariItaly Faculty of Agriculture and Natural Resources University of Mohaghegh ArdabiliArdabilIran Sardinia Forest Service LanuseiItaly Department of Agriculture University of SassariSassariItaly

Effective landscape-scale fuel management strategies are essential for reducing wildfire risk in Mediterranean fire-prone *** this study,the minimum travel time(MTT)fire-spread algorithm as implemented in FlamMap was applied to assess the potential of alternative fuel treatments for lowering wildfire losses in a 5,740-ha study area in eastern Sardinia,***-seven wildfires at 10-m resolution were simulated considering three wind speeds(15,18,and 21 km h-1)to compare fuel treatments:no treatment(NT),irrigated agroforestry areas with shrub clearing(T1),prescribed fire in eucalyptus stands(T2),and irrigated grasslands(T3).The simulations replicated a recent large wildfire that occurred in the study area(Orrìwildfire,2019)and considered the weather and fuel moisture conditions associated with this *** average wildfire exposure outputs(burned area,probability of burning,conditional flame length,potential crown fire occurrence,and surfaces withflame lengths above 2.5 m)decreased after fuel treatments,compared to no treatment.T1 was the most effective strategy in mitigating wildfire hazards and provided the most significant performance for several wildfire exposure *** only 0.5%of the study area(~30 ha)resulted in a decrease in all wildfire exposure metrics to~10%within the study *** addition,the total surface characterized by high flame length(average>2.5 m)was the lowest in the T1 *** study can help land and fire managers optimize fuel treatment opportunities and wildfire risk mitigation strategies in Mediterranean areas.

关键词： Fuel treatment strategies Fire prevention Mediterranean areas Minimum travel time(MTT) Wildfi re exposure

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Optimizing proton pump inhibitors in Helicobacter pylori treatment:Old and new tricks to improve effectiveness

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World Journal of Gastroenterology 2019年第34期25卷 5097-5104页

作者： Enzo Ierardi Giuseppe Losurdo Rosa Federica la Fortezza Mariabeatrice Principi michele Barone Alfredo Di Leo Section of Gastroenterology Department of Emergency and Organ Transplantation University of Bari

The survival and replication cycle of Helicobacter pylori(***)is strictly dependant on intragastric pH,since *** enters replicative phase at an almost neutral pH(6-7),while at acid pH(3-6)it turns into its coccoid form,which is resistant to *** these bases,it is crucial to increase intragastric pH by proton pump inhibitors(PPIs)when an antibiotic-based eradicating therapy needs to be ***,several tricks need to be used to optimize eradication rate of different *** administration of the highest dose as possible of PPI,by doubling or increasing the number of pills/day,has shown to be able to improve therapeutic outcome and has often proposed in rescue therapies,even if specific trials have not been performed.A pre-treatment with PPI before starting antibiotics does not seem to be effective,therefore it is ***,the choice of PPI molecule could have a certain weight,since second-generation substances(esomeprazole,rabeprazole)are likely more effective than those of first generation(omeprazole,lansoprazole).A possible explanation is due to their metabolism,which has been proven to be less dependent on cytochrome P450(CYP)2C19 genetic ***,vonoprazan,a competitive inhibitor of H+/K+-ATPase present on luminal membrane of gastric parietal cells has shown the highest efficacy,due to both its highest acid inhibition power and rapid pharmacologic *** current data come only from Eastern Asia,therefore its strong power needs to be confirmed outside this geographic area in Western countries as well as related to the local different antibiotic resistance rates.

关键词： Helicobacter pylori Proton pump inhibitors Eradication Cytochrome P450 Optimization

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Red-emitting tetraphenylethylene derivative with aggregation-induced enhanced emission for luminescent solar concentrators:A combined experimental and density functional theory study

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Aggregate 2022年第2期3卷 177-186页

作者： Cosimo micheletti Qinfan Wang Francesco Ventura michele Turelli Ilaria Ciofini Carlo Adamo Andrea Pucci Department of Chemistry and Industrial Chemistry University of PisaPisaItaly École nationale supérieure de chimie de Paris Centre national de la recherche scientifiqueInstitute of Chemistry for Life and Health SciencesPSL Research UniversityParisFrance Institut Universitaire de France ParisFrance

This study examines the use of an aggregation-induced enhanced emission fluorophore(TPE-MRh)to prepare red-emitting luminescent solar concentrators(LSCs)based on poly(methyl methacrylate)(PMMA)and poly(cyclohexyl methacrylate)(PCMA).TPE-MRh is a tetraphenylethylene(TPE)derivative bearing two dimethylamino push groups and a 3-methyl-rhodanine pull moiety,with absorption maxima at around 500 nm and fluorescence peak at 700 nm that strongly increases in ***-MRh displays a typical crystallizationinduced enhanced emission that has been rationalized by modeling the compound behavior in solution and solid-state via density functional theory calculations with the inclusion of the ***-MRh dispersed into 5×5 cm2 polymer films with a thickness of 25±5μm has revealed a partial fluorescence quenching with fluorophore *** yields(QYs)below 10%for the 2 wt.%of doping have been addressed to the formation of less emissive micro-sized clusters of *** slabs with the same surface size but 3 mm of thickness and 200 ppm of TPE-MRh have provided QY of 36.5%thanks to the attenuation of the detrimental effects of fluorophore *** feature is reflected in the LSCs performance,with devices achieving the largest power collected by the photovoltaic cell.

关键词： aggregation-induced enhanced emission density functional theory luminescent solar concentrators poly(methyl methacrylate) tetraphenylethylene core

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Müller-Weiss disease:Four case reports

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World Journal of Orthopedics 2020年第11期11卷 507-515页

作者： Antonio Volpe Luca Monestier Teresa Malara Giacomo Riva Giuseppe la Barbera michele FrancescoSurace Foot and Ankle Clinic Policlinico Abano TermeAbano Terme 35031Italy Orthopedic and Trauma Unit ASST Sette LaghiVarese 21100Italy Department of Biomedical Science and Functional Images Universitàdi MessinaMessina 98122Italy Interdisciplinary Research Centre for Pathology and Surgery of the Musculoskeletal System Department of Biotechnology and Life Sciences(DBSV)University of InsubriaVarese 21020Italy

BACKGROUND Müller-Weiss disease(MWD)is an idiopathic foot condition characterized by spontaneous tarsal“scaphoiditis”in *** bilateral and affecting females during the 4th-6th decades of life,the pathogenesis of MWD remains unclear:It has been traditionally considered a spontaneous osteonecrosis of the *** typical presentation of MWD is a long period of subtle discomfort followed by prolonged standing,atraumatic,disabling ***,there is no gold standard for the treatment of patients with *** support initial conservative *** treatment should be considered for failure of conservative therapies longer than 6 *** indication for surgery is severity of symptoms rather than severity of *** treatment options include core decompression,internal fixation of the tarsal navicular,open or arthroscopic triple fusion,talo-navicular or talo-navicular-cuneiform arthrodesis,and navicular excision with reconstruction of the medial *** SUMMARY In this study,we report four patients affected by *** and radiographic assessment,follow-up and treatment are *** As it is frequently misdiagnosed,MWD is challenging for orthopedic *** diagnosis and effective treatment are mandatory to avoid sequelae.

关键词： Müller-Weiss Etiopathogenesis Review Treatment Case report

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