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Comment on:“Completion pancreatectomy or a pancreas-preserving procedure during relaparotomy for pancreatic fistula after pancreatoduodenectomy:a multicentre cohort study and meta-analysis”

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 94-96页

作者： Régis Souche Jean-michel Fabre Department of Oncologic and Minimally Invasive Digestive Surgery Hospital Saint EloiUniversity Hospital of MontpellierMontpellierFrance

We read with great interest the recently published article of Groen et *** the Dutch Pancreatic Cancer Group(1)appeared on British Journal of *** authors compared salvage completion pancreatectomy with a pancreas-preserving procedure in patients undergoing relaparotomy for severe pancreatic fistula after pancreatoduodenectomy(PD).This retrospective multi center cohort study included patients who underwent relaparotomy for pancreatic fistula after PD from 2005-2018 and provided a systematic review with a meta-analysis on postoperative *** the literature,large retrospective studies dedicated to this question are rare and no randomized study is available to date.

关键词： pancreas fistula

Kinematics of whip spider pedipalps: a 3D comparative morpho-functional approach

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Integrative Zoology 2022年第1期17卷 156-167页

作者： michel SCHMIDT Roland R.MELZER Russell D.C.BICKNELL Bavarian State Collection of Zoology Bavarian Natural History CollectionsMunichGermany Department Biology II Ludwig-Maximilians-Universität MünchenMunichGermany GeoBio-Center Ludwig-Maximilians-Universität MünchenMunichGermany Palaeoscience Research Centre School of Environmental and Rural ScienceUniversity of New EnglandArmidaleAustralia

Amblypygi are tropical and subtropical ambush predators that use elongated,raptorial pedipalps for different *** pedipalp use in predation and courtship has been explored in videography in vivo analyses,kinematic ex vivo examination of these appendages has not been ***,we rectify this lack of data by using microCT scans to 3D-kinematically model the appendage morphology and the range of motion(ROM)of the joints for Damon medius and Heterophrynus *** illustrate the successful application of this technique to terrestrial euarthropods in determining the maximum ROM values for each pedipalp *** also note that,in life,these values would be lower due to motion restricting structures like tendons,arthrodial membranes,and *** further compare our maximum values obtained here with data from video-based motion *** ROM of each joint shows the greatest flexibility in the femur-tibia joint(140–150°),the lowest in the basitarsus-claw joint(35–40°).ROM in the tibia-basitarsus joint is markedly distinct(***:44°;***:105°).This disparity reflects how *** uses the joint in the capture basket,while *** uses the femur-tibia joint to form the capture *** further illustrate notable vertical motion of the *** pedipalp compared to *** difference reflects the retro-ventral trochanter apophysis of *** study opens the possibility to further whip spider kinematic *** of other taxa using this approach will result in a more comprehensive understanding of the ecological significance and ethological implications of this unique arachnid group.

关键词： 3D kinematic analyses Amblypygi arthropod joints Autodesk Maya Damon medius Heterophrynus elaphus range of motion analyses

A Cross-sectional Real-life Study of the Prevalence,Severity,and Determinants of Metabolic Dysfunction-associated Fatty Liver Disease in Type 2 Diabetes Patients

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Journal of Clinical and Translational Hepatology 2023年第6期11卷 1377-1386页

作者： Quentin Binet Audrey Loumaye michel P Hermans Nicolas Lanthier Service d’Hépato-Gastroentérologie Cliniques universitaires Saint-LucUCLouvainBrusselsBelgium Service d’Endocrinologie et Nutrition Cliniques universitaires Saint-LucUCLouvainBrusselsBelgium

Background and Aims:Most data on liver assessment in type 2 diabetes mellitus(T2DM)patients are from retrospective cohorts with selection *** aimed at appraising the feasibility,results,and benefits of an outpatient systematic noninvasive screening for metabolic dysfunction-associated fatty liver disease(MAFLD)severity and determinants in T2DM ***:We conducted a 50-week crosssectional study enrolling adult T2DM outpatients from a diabetes *** algorithm based on guidelines was applied using simple bioclinical scores and,if applicable,ultrasound and/or ***:Two hundred and thirteen patients were *** age and body mass index were 62 years and 31 kg/m^(2) and 29% of patients had abnormal transaminase *** acceptance rate of additional liver examinations was 92%.The prevalence of MAFLD,advanced fibrosis and cirrhosis was 87%,11%,and 4%,*** than half of the cases of advanced fibrosis had not been suspected and were detected by this *** was associated with poor glycemic control,elevated transaminases,low HDL-C and the absence of peripheral arterial *** fibrosis was linked to high waist circumference and excessive alcohol consumption,which should be interpreted with caution owing to the small number of patients reporting excessive ***:Simple bioclinical tools allowed routine triage of T2DM patients for MAFLD severity,with high adherence of high-risk patients to subsequent noninvasive exams.

关键词： Noninvasive tests MAFLD Outpatient Steatosis Fibrosis

Kinetic Slip Boundary Condition for Isothermal Rarefied Gas Flows through Static Non-Planar Geometries Based on the Regularized Lattice-Boltzmann Method

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Communications in Computational Physics 2022年第3期31卷 816-868页

作者： Jean-michel Tucny David Vidal Sebastien Leclaire Francois Bertrand Mechanical Engineering Department Polytechnique MontralP.O.Box 6079Stn.CVMontrealQCCANADAH3C 3A7 Chemical Engineering Department Polytechnique MontralP.O.Box 6079Stn.CVMontrealQCCANADAH3C 3A7

The simulation of rarefied gasflows through complex porous media is chal-lenging due to the tortuousflow pathways inherent to such *** Lattice Boltzmann method(LBM)has been identified as a promising avenue to solveflows through complex geometries due to the simplicity of its scheme and its high parallel computational *** has been proposed to model the stress-strain relationship with the extended Navier-Stokes equations rather than attempting to directly solve the Boltzmann ***,a regularization technique is required tofilter out non-resolved higher-order components with a low-order velocity *** slip boundary conditions(BCs)have been proposed for the non-regularized multiple relaxation time LBM(MRT-LBM)for planar geometries,previous slip BCs have never been verified extensively with the regularization *** this work,following an extensive literature review on the imposition of slip BCs for rarefiedflows with the LBM,it is proven that earlier values for kinetic parameters developed to impose slip BCs are inaccurate for the regularized MRT-LBM and differ between the D2Q9 and D3Q15 *** error was eliminated for planarflows and good agreement be-tween analytical solutions for arrays of cylinders and spheres was found with a wide range of Knudsen numbers.

关键词： Lattice Boltzmann method(LBM) boundary condition(BC) rarefiedflow nonplanar geometry

A Solvation Model for Performance Enhancement of Dye-Sensitized Solar Cells

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Fluid Dynamics & Materials Processing 2022年第6期18卷 1569-1579页

作者： Adel Daoud Ali Cheknane Jean michel Nunzi Afak Meftah Laboratoire des Matériaux Semi-Conducteurs et Métalliques(LMSM) Universitéde BiskraBiskraAlgeria Laboratoire des Semi-Conducteurs et Matériaux Fonctionnels(LSMF) UniversitéAmar Telidji de LaghouatLaghouatAlgérie Department of Chemistry Queen’s UniversityKingstonCanada Department of Engineering Physics and Astronomy Queen’s UniversityKingstonCanada

A solubility model for Merocyanine-540 dye together with the interface’s electron transfer kinetics of MC-540/TiO2 has been investigated(Merocyanine 540-based dye has been used effectively in dye-sensitized solar cells).The highest absorption peaks were recorded at 489 nm and 493 nm in Water and Ethanol solvent,*** vacuum phase which yielded 495 nm(associated with a modest electron injection-free energy value(Ginj)of−2.34 eV for both Water and Ethanol solvents).The time-dependent density functional theory(TD-DFT)method approach has been applied in this ***,the electronic structure and simulated UV-Vis spectra of the dye in different solvents have been determined,and the alignment with the solar spectrum has been discussed to a certain *** energy level diagrams and electron density of the primary molecular orbitals are shown,and the major issues that have an impact on our new interface’s performance are *** is concluded that the proposed Solvation Model(SM)can improve the performance of Dye-Sensitized Solar Cells.

关键词： Mc-540-based dye DFT method electron injection n-DSSCs

Genetics of congenital hypothyroidism: Modern concepts

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Pediatric Investigation 2022年第2期6卷 123-134页

作者： Athanasia Stoupa Dulanjalce Kariyawasam michel Polak Aurore Carre Department of Paediatric Endocrinology Gynaecology and DiabetologyIle de France Regional Neonatal Screening Centre(CRDN)Necker Enfants-Malades University HospitalParisFrance Institut IMAGINE INSERM U1163ParisFrance Institut Cochin INSERM U1016ParisFrance Centre des maladies endocriniennes rares de la croissance et du dévelopement ParisFrance Universitéde Paris Cité ParisFrance

Congenital hypothyroidism (CH) is the most common neonatal endocrine disorder and one of the most common preventable causes of intellectual disability in the world. CH may be due to developmental or functional thyroid defects (primary or peripheral CH) or be hypothalamic-pituitary in origin (central CH). In most cases, primary CH is caused by a developmental malformation of the gland (thyroid dysgenesis, TD) or by a defect in thyroid hormones synthesis (dyshormonogenesis, DH). TD represents about 65% of CH and a genetic cause is currently identified in fewer than 5% of patients. The remaining 35% are cases of DH and are explained with certainty at the molecular level in more than 50% of cases. The etiology of CH is mostly unknown and may include contributions from individual and environmental factors. In recent years, the detailed phenotypic description of patients, high-throughput sequencing technologies, and the use of animal models have made it possible to discover new genes involved in the development or function of the thyroid gland. This paper reviews all the genetic causes of CH. The modes by which CH is transmitted will also be discussed, including a new oligogenic model. CH is no longer simply a dominant disease for cases of CH due to TD and recessive for cases of CH due to DH, but a far more complex disorder.

关键词： Congenital hypothyroidism Development Genetic High-throughput sequencing Thyroid dysgenesis Dyshormonogenesis Oligogenism

Pulsed export of carbon in the north-western Mediterranean Sea

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Journal of Oceanology and Limnology 2023年第1期41卷 189-202页

作者： michel DENIS Dominique LEFEVRE Melilotus THYSSEN Ian RJENKINSON Gérald GRÉGORI Aix Marseille Université Universitéde ToulonCNRS/INSUIRDInstitut Méditerranéen d'Océanologie(MIO)Marseille cedex09 13288France Key Laboratory of Marine Ecology and Environmental Sciences Institute of OceanologyChinese Academy of SciencesQingdao 266071China Agency for Consultation and Research in Oceanography Lavergne19320 La Roche CanillacFrance

The short term(hourly scale)variability of heterotrophic prokaryote(HP)vertical distribution and respiratory activity,was investigated in the north-western(NW)Mediterranean *** vertical distribution was determined on board by flow cytometry analysis of seawater samples collected by series of CTD *** counts and viability were determined for all *** respiratory rates were determined later in the laboratory from filtered seawater samples(23 dm^(3))from 300-1150-m *** average cell viability was 94.8%±2.2%(n=240).There was no accumulation of dead cells,due to quick decay of damaged *** the epipelagic layer,three HP groups were distinguished,two(HNA1,HNA2)who se cells exhibited a high nucleic acid content and one(LNA)with low nucleic acid content ***2 was most populated at 50 m but not detected at 90 m and below,presumably aerobic anoxygenic photoheterotrophic bacteria(AAPs).The variability in HP abundance was mainly confined in the upper 80 m.A few secondary peaks of HP abundance were observed(80-150 m)in connection with abundance troughs in the surface *** cells were continuously present in a wide layer around 500 m(mean 191×10^(3)cells/cm^(3)).Below this layer,HP abundance randomly exhibited peaks,coupled to respiratory rate *** HP abundance and variability in the water column was suppressed during a strong wind *** observed sporadic variability was tentatively interpreted through a pulsed carbon-export mechanism induced by the microorganism production of dissolved poly saccharide s,followed by flocculation and rapid *** mechanism would thus contribute to(ⅰ)preventing organic matter accumulation in the epipelagic layer,(ⅱ)seeding the water column with live HP cells,and(ⅲ)supplying the aphotic water column with fre sh and labile organic *** important vertical flux mechanism needs further observations and modelling.

关键词： north-western Mediterranean Sea heterotrophic prokaryote(HP) cell viability cell respiration transparent exopolymeric particle(TEP) aggregation flow cytometry

Profile of Full-Term Births in Maternity Wards of Public Hospitals in Douala Cameroon

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Open Journal of Obstetrics and Gynecology 2024年第5期14卷 705-720页

作者： Henri Essome Merlin Boten Bounyom Astrid Ndolo Kondo Ingrid Doriane Ofakem Ilick Fulbert Mangala Nkwele Irène Cyrielle Edjoa Mboe michel Roger Ekono Alphonse Ngalame Nyong Robert Tchounzou Moustapha Bilkissou Junie Ngaha Yaneu Marga Vanina Ngono Akam Gervais Mounchikpou Ngouhouo Grâce Tocki Toutou Théophile Nana Njamen Valère Mve Koh Pascal Foumane Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Laquintinie Hospital Douala Cameroon Faculty of Health Sciences University of Bamenda Bamenda Cameroon Faculty of Health Sciences University of Buea Buea Cameroon Faculty of Medicine and Biomedical Sciences University of Yaound&#233 1 Yaound&#233 Cameroon Faculty of Medicine and Pharmaceutical Sciences of Sangmelima University of Ebolowa Ebolowa Cameroon

Introduction: Pregnancy as much as childbirth constitutes a risky situation, potentially fraught with sometimes dramatic complications: maternal death. Objective: We conducted this study with the aim of establishing the profile of those giving birth in our context with the aim to anticipate operationally in the future on morbidity but more on maternal deaths. Methodology: We conducted, using a structured questionnaire, a prospective descriptive study in representative maternity wards in the city of Douala;the study variables were socio-economic, anthropometric, obstetrical and clinical. Statistical analyses were carried out with CS Pro 7.3 and SPSS version 25.0 software. The Student, Chi-square and Fischer tests were used to compare the means of the variables and the percentages. Results: We recruited 305 births for our study. The average age of our births was 28.7 years ± 6.1 with an average height of 161.6 cm ± 5.06;an average body mass index at the start of pregnancy of 28.0 kilograms/square meter and 31.3 kilograms/square meter at delivery;the average weight gain was 8.4 g ± 5.37;an average gestation of 2.84±1.90;an average parity of 2.2 ± 2.1 with an average birth interval of 27.7 months ± 23.7. The average gestational age was 39.2 weeks ± 1.21 with pregnancy pathology dominated by malaria;85.9% began their prenatal follow-up before the 14th week of amenorrhea. Conclusion: The profile of childbirth in urban Cameroon does not seem potentially dystocic compared to that of the same regional and racial area.

关键词： Profile Delivery Term Malaria Douala

Screening of Myocardial Cardiotoxicity Induced by Anticancer Chemotherapy and the Importance of Global Longitudinal Strain

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World Journal of Cardiovascular Diseases 2024年第6期14卷 381-391页

作者： Marguerite Téning Diouf Fatou Aw Hussein Khadra Sophie Ba Doudou Diouf michel Ngonar Sarr Joseph Salvador Mingou Malick Ndiaye Simon Antoine Sarr Momar Dioum Aliou Alassane Ngaide Serigne Mor Beye Simon Manga Alain Affangla Youssou Diouf Khadimu Rassoul Diop Malick Bodian Mohamed Leye Mouhamadou Bamba Ndiaye Alassane Mbaye Adama Kane Maboury Diao Abdoul Kane Cardiology Department of the Dalal Jamm Hospital Dakar Senegal Cardiology Department Hospital Aristide Le Dantec Dakar Senegal Cardiology Department Hospital Fann Dakar Senegal UFR2S Saint Louis Saint Louis Senegal UFR Ziguinchor Ziguinchor Senegal Training and Research in Health Sciences Unit University of Thies Thies Senegal Cardiology Department Hospital General Idrissa Pouye Dakar Senegal

Introduction: The improvement of survival in patients with cancer and the expansion of therapeutic options have led to the emergence of a new profile of cardiotoxicity, specifically associated with antimitotic agents. Our study aimed to assess the incidence of chemotherapy-induced myocardial toxicity in patients with cancer. Patients and Methods: We conducted a looking-forward longitudinal cohort study including all patients admitted to the Cardiology departments of Aristide le Dantec Hospital and Dalal Jamm National Hospital Centre for apre-chemotherapy check-up. The included patients did not undergo any pre-existing cardiopathy. Results: Over a period of two years ranging from January 2019 to December 2021, a total of 37 patients were included in the study. Notably, there was a female predominance (92%) with an average age of 49.7 years ± 13.69. Breast cancer accounted for 70% of the neoplasms. Laboratory findings revealed moderate anemia in 19 patients (51%). At inclusion, the left ventricle (LV) was of normal size (LV diastole at 44.46 ± 4.97 mm). The systolic function of the left ventricle was normal in all patients, with an average ejection fraction (EF) of 63.1% ± 5.80 and a mean global longitudinal strain (GLS) of −20.4% ± 2.58. The most commonly used agents were anthracyclines. During follow-up, 3 patients (8.1%) developed clinical symptoms of left heart failure, and LV dysfunction on echocardiography was observed in 5 (13.5%) patients, with a significant decrease in EF Conclusion: The incidence of cardiac toxicity is not negligible, hence the importance of early screening. Strain imaging is an essential tool that should be performed as part of the assessment before chemotherapy and re-evaluated during treatment.

关键词： Cancer Chemotherapy Global Longitudinal Strain Cardiotoxicity