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Serum omentin and vaspin levels in cirrhotic patients with and without portal vein thrombosis

World Journal of Gastroenterology 2017年第14期23卷 2613-2624页

作者： michal Kukla Marek Waluga michal zorniak Agnieszka Berdowska Piotr Wosiewicz Tomasz Sawczyn Rafal J Buldak Marek Ochman Katarzyna Ziora Tadeusz Krzemiński Marek Hartleb Department of Gastroenterology and Hepatology Medical University of Silesia in Katowice Department of Microbiology and Biotechnology Jan Dlugosz University Department of Physiology Medical University of Silesia in Katowice Department of Biochemistry in Zabrze Medical University of Silesia in Katowice Department of Cardiac Surgery and Transplantation Silesian Center for Heart Diseases Department of Pediatrics Medical University of Silesia in Katowice Department of Pharmacology Medical University of Silesia in Katowice

AIMTo investigate serum omentin and vaspin levels in cirrhotic patients; and to assess the relationship of these levels with hemostatic parameters, metabolic abnormalities, cirrhosis severity and ***-one cirrhotic patients (17 with portal vein thrombosis) were analyzed. Serum omentin and vaspin levels were measured with commercially available direct enzyme-linked immunosorbent assays (ELISAs). To assess platelet activity, the following tests were performed using a MULTIPLATE®PLATELET FUNCTION ANALYZER: (1) an ADP-induced platelet activation test; (2) a cyclooxygenase dependent aggregation test (ASPI test); (3) a von Willebrand factor and glycoprotein Ib-dependent aggregation (using ristocetin) test (RISTO test); and (4) a test for thrombin receptor-activating peptide-6 induced activation of the thrombin receptor, which is sensitive to IIb/IIIa receptor ***, but not vaspin, serum concentrations were significantly decreased in patients with portal vein thrombosis (PVT) (P = 0.01). Prothrombin levels were significantly increased in patients with PVT (P = 0.01). The thrombin receptor activating peptide (TRAP) test results were significantly lower in the PVT group (P = 0.03). No significant differences in adipokines serum levels were found regarding the etiology or severity of liver cirrhosis assessed according to the Child-Pugh or Model of End-Stage Liver Disease (MELD) scores. There was a significant increase in the TRAP (P = 0.03), ASPI (P = 0.001) and RISTO high-test (P = 0.02) results in patients with lower MELD scores. Serum omentin and vaspin levels were significantly down-regulated in patients without insulin resistance (P = 0.03, P = 0.02, respectively). A positive relationship between omentin and vaspin levels were found both when all of the patients were analyzed (r = 0.41, P = 0.01) and among those with PVT (r = 0.94, P < 0.001).CONCLUSIONSerum omentin levels are increased in patients without PVT. Cirrhosis

关键词： Omentin Vaspin Cirrhosis Adipokine Portal vein thrombosis Portal hypertension

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From the stomach to other organs:Helicobacter pylori and the liver

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World Journal of Hepatology 2015年第18期7卷 2136-2146页

作者： Marek Waluga michal Kukla michal zorniak Agata Bacik Rafal Kotulski School of Medicine in Katowice Medical University of SilesiaDepartment of Gastroenterology and Hepatology Municipal Hospital

Many recent studies have examined the importance of Helicobacter pylori(H. pylori) infection in the pathogenesis of the diseases outside the stomach and explored the significance of this bacterium in the pathogenesis of some metabolic and cardiovascular diseases. Recent studies have provided evidence that H. pylori is also involved in the pathogenesis of some liver diseases. Many observations have proved that H. pylori infection is important in the development of insulin resistance, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, liver fibrosis and cirrhosis. The worsening of liver inflammation of different origins also occurs during H. pylori infection. Some studies have indicated that H. pylori infection induces autoimmunological diseases in the liver and biliary tract. The potential significance of this bacterium in carcinogenesis is unclear, but it is within the scope of interest of many studies. The proposed mechanisms through which H. pylori impacts the development of hepatobiliary diseases are complex and ambiguous. The importance of other Helicobacter species in the development of hepatobiliary diseases is also considered because they could lead to the development of inflammatory, fibrotic and necrotic injuries of the liver and, consequently, to hepatocellular carcinoma. However, many contrary viewpoints indicate that some evidence is not convincing, and further studies of the subject are needed. This review presents the current knowledge about the importance of H. pylori in the pathogenesis of liver and in biliary diseases.

关键词： Helicobacter pylori Non-alcoholic fatty liver dise

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